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Wnt

Wnt

Cat. No. Product Name CAS No. Information
CSN26794 β-catenin/CBP-IN-1 1198780-38-9 β-catenin/CBP-IN-1 is a potent and selective CBP/β-catenin antagonist, extracted from the patent WO2014092154A1. β-catenin/CBP-IN-1 has the potential for the study of liver fibrosis induced by hepatitis virus[1].
CSN19163 PNU-74654   113906-27-7 PNU-74654 is an inhibitor of Wnt-catenin pathway with an IC50 of 129.8 M in NCI-H295 cell.
CSN11650 Pamidronic acid   40391-99-9 Pamidronic Acid is a an amino- bisphosphonate used to prevent bone loss and treat osteoporosis.
CSN23011 NSC668036 144678-63-7 NSC 668036 is a Wnt signaling inhibitor by binding the PDZ domain of the Dishevelled (Dvl) protein. It inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro.
CSN27659 MSAB   173436-66-3 MSAB is a selective inhibitor of Wnt/β-catenin signaling. It binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes.
CSN23594 Methyl vanillate   3943-74-6 Methyl vanillate has ability to increase bone mass and activate wnt-catenin pathway It can act as a potential lead anabolic agent for anti-osteoporosis drugs
CSN22542 LF3 664969-54-4 LF3 is an inhibitor of canonical wnt signaling pathway with IC50 of less than 2 M It can disrupt the interaction between -catenin and TCF4
CSN19247 KYA1797K   1956356-56-1 KYA1797K is a highly potent and selective Wnt-catenin inhibitor with IC50 of 0.75 M (TOPflash assay).
CSN16086 KY02111   1118807-13-8 KY02111 can inhibit Wnt signaling and promote differentiation of hPSCs to cardiomyocytes
CSN22870 JW67 442644-28-2 JW 67 is an inhibitor of canonical Wnt pathway signaling with IC50 of 1.17 μM.
CSN13654 IWR-1 1127442-82-3 IWR-1-endo is a small-molecule inhibitor of Wnt signaling (IC50 of 180 nM in L-cells expressing Wnt3A) by stabilizing the Axin destruction complex with an EC50 of 0.2 M.
CSN16481 IWP-2 686770-61-6 IWP-2 is an inhibitor of porcn-mediated Wnt palmitoylation and secretion with IC50 of 27 nM
CSN22864 IWP-4 686772-17-8 IWP 4 is a potent inhibitor of Wnt/β-catenin signaling with IC50 of 25 nM.
CSN11174 Isoquercetin   482-35-9 Isoquercitrinis can inhibit Wnt-catenin and activate the mitogen-activated protein kinase (MAPK) signalling pathway. It is a natural product isolated and purified from the herbs of Prunella vulgaris L. with a good effect of expectorant, cough, asthma and anti-tumoral activity.
CSN21406 iCRT3   901751-47-1 iCRT3 can inhibit both Wnt and -catenin-responsive transcription
CSN16814 iCRT 14 677331-12-3 iCRT 14 is a potent inhibitor of -catenin-responsive transcription CRT IC50 403 nM in assays of Wnt pathway activity Thought to directly influence the interaction between -catenin and TCF4 Induces marked G0G1 cell cycle arrest in HCT-116 and HT29 cell lines
CSN22412 Gigantol 67884-30-4 Gigantol is a bibenzyl compound derived from several medicinal orchids Giganto shows promising therapeutic potential against cancer cells Gigantol is a novel inhibitor of the Wnt-catenin pathway
CSN17195 FH535 108409-83-2 FH535 is a compound that suppresses both Wntbeta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling.
CSN26795 CWP232228 1144044-02-9 CWP232228 is a novel Wnt/β-Catenin inhibitor. It preferentially inhibits the growth of breast cancer stem-like cells. CWP232228 targets liver cancer stem cells through Wnt/β-catenin signaling: a novel therapeutic approach for liver cancer treatment.
CSN17991 CCT251545 1661839-45-7 CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM
CSN22741 Cardionogen 1 577696-37-8 Cardionogen 1 is an inhibitor of Wnt/β-catenin signaling.
CSN12291 BML-284   853220-52-7 BML-284 is a Wnt signaling activator with EC50 value of 07 M for inducing -catenin and TCF-dependent transcriptional activity
CSN19238 BML-284 hydrochloride   2095432-75-8 AMBMP HCl is a cell permeable Wnt signaling pathway activator, which induces -catenin- and TCF-dependent transcriptional activity with EC50 of 0.7 M.
CSN22337 Adavivint 1467093-03-3 Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCFLEF-reporter assay in SW480 colon cancer cells.
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