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Wnt
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN11650 | Pamidronic Acid | 40391-99-9 | Pamidronic Acid is a an amino- bisphosphonate used to prevent bone loss and treat osteoporosis. |
| CSN23011 | NSC 668036 | 144678-63-7 | NSC 668036 is a Wnt signaling inhibitor by binding the PDZ domain of the Dishevelled (Dvl) protein. It inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro. |
| CSN27659 | MSAB | 173436-66-3 | MSAB is a selective inhibitor of Wnt/β-catenin signaling. It binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes. |
| CSN23594 | Methyl Vanillate | 3943-74-6 | Methyl vanillate has ability to increase bone mass and activate wnt-catenin pathway It can act as a potential lead anabolic agent for anti-osteoporosis drugs |
| CSN22542 | LF3 | 664969-54-4 | LF3 is an inhibitor of canonical wnt signaling pathway with IC50 of less than 2 M It can disrupt the interaction between -catenin and TCF4 |
| CSN19247 | KYA1797K | 1956356-56-1 | KYA1797K is a highly potent and selective Wnt-catenin inhibitor with IC50 of 0.75 M (TOPflash assay). |
| CSN16086 | KY 02111 | 1118807-13-8 | KY02111 can inhibit Wnt signaling and promote differentiation of hPSCs to cardiomyocytes |
| CSN16481 | IWP-2 | 686770-61-6 | IWP-2 is an inhibitor of porcn-mediated Wnt palmitoylation and secretion with IC50 of 27 nM |
| CSN22864 | IWP 4 | 686772-17-8 | IWP 4 is a potent inhibitor of Wnt/β-catenin signaling with IC50 of 25 nM. |
| CSN11174 | Isoquercitrin | 482-35-9 | Isoquercitrinis can inhibit Wnt-catenin and activate the mitogen-activated protein kinase (MAPK) signalling pathway. It is a natural product isolated and purified from the herbs of Prunella vulgaris L. with a good effect of expectorant, cough, asthma and anti-tumoral activity. |
| CSN16814 | iCRT 14 | 677331-12-3 | iCRT 14 is a potent inhibitor of -catenin-responsive transcription CRT IC50 403 nM in assays of Wnt pathway activity Thought to directly influence the interaction between -catenin and TCF4 Induces marked G0G1 cell cycle arrest in HCT-116 and HT29 cell lines |
| CSN26795 | CWP232228 sodium | 1144044-02-9 | CWP232228 is a novel Wnt/β-Catenin inhibitor. It preferentially inhibits the growth of breast cancer stem-like cells. CWP232228 targets liver cancer stem cells through Wnt/β-catenin signaling: a novel therapeutic approach for liver cancer treatment. |
| CSN17991 | CCT251545 | 1661839-45-7 | CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM |
| CSN12291 | BML-284 | 853220-52-7 | BML-284 is a Wnt signaling activator with EC50 value of 07 M for inducing -catenin and TCF-dependent transcriptional activity |
| CSN22337 | Adavivint | 1467093-03-3 | Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCFLEF-reporter assay in SW480 colon cancer cells. |
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