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Wnt

Wnt

Cat. No. Product Name CAS No. Information
CSN11650 Pamidronic Acid   40391-99-9 Pamidronic Acid is a an amino- bisphosphonate used to prevent bone loss and treat osteoporosis.
CSN23011 NSC 668036 144678-63-7 NSC 668036 is a Wnt signaling inhibitor by binding the PDZ domain of the Dishevelled (Dvl) protein. It inhibits proliferation, migration and TGF-β-induced differentiation of fibroblasts in vitro.
CSN27659 MSAB   173436-66-3 MSAB is a selective inhibitor of Wnt/β-catenin signaling. It binds to β-catenin promoting its degradation, and specifically downregulates Wnt/β-catenin target genes.
CSN23594 Methyl Vanillate   3943-74-6 Methyl vanillate has ability to increase bone mass and activate wnt-catenin pathway It can act as a potential lead anabolic agent for anti-osteoporosis drugs
CSN22542 LF3 664969-54-4 LF3 is an inhibitor of canonical wnt signaling pathway with IC50 of less than 2 M It can disrupt the interaction between -catenin and TCF4
CSN19247 KYA1797K   1956356-56-1 KYA1797K is a highly potent and selective Wnt-catenin inhibitor with IC50 of 0.75 M (TOPflash assay).
CSN16086 KY 02111   1118807-13-8 KY02111 can inhibit Wnt signaling and promote differentiation of hPSCs to cardiomyocytes
CSN16481 IWP-2 686770-61-6 IWP-2 is an inhibitor of porcn-mediated Wnt palmitoylation and secretion with IC50 of 27 nM
CSN22864 IWP 4 686772-17-8 IWP 4 is a potent inhibitor of Wnt/β-catenin signaling with IC50 of 25 nM.
CSN11174 Isoquercitrin   482-35-9 Isoquercitrinis can inhibit Wnt-catenin and activate the mitogen-activated protein kinase (MAPK) signalling pathway. It is a natural product isolated and purified from the herbs of Prunella vulgaris L. with a good effect of expectorant, cough, asthma and anti-tumoral activity.
CSN16814 iCRT 14 677331-12-3 iCRT 14 is a potent inhibitor of -catenin-responsive transcription CRT IC50 403 nM in assays of Wnt pathway activity Thought to directly influence the interaction between -catenin and TCF4 Induces marked G0G1 cell cycle arrest in HCT-116 and HT29 cell lines
CSN26795 CWP232228 sodium 1144044-02-9 CWP232228 is a novel Wnt/β-Catenin inhibitor. It preferentially inhibits the growth of breast cancer stem-like cells. CWP232228 targets liver cancer stem cells through Wnt/β-catenin signaling: a novel therapeutic approach for liver cancer treatment.
CSN17991 CCT251545 1661839-45-7 CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM
CSN12291 BML-284   853220-52-7 BML-284 is a Wnt signaling activator with EC50 value of 07 M for inducing -catenin and TCF-dependent transcriptional activity
CSN22337 Adavivint 1467093-03-3 Adavivint is a potent and selective inhibitor of canonical Wnt signaling, with an EC50 of 19.5 nM via a high-throughput TCFLEF-reporter assay in SW480 colon cancer cells.
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