Vascular Endothelial Growth Factor Receptor | Protein Tyrosine Kinase/RTK| CSNpharm

VEGFR

VEGFR
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Cat. No.	Product Name	CAS No.	Information
CSN15826	ZM 306416	690206-97-4	ZM-306416 is an inhibitor of VEGFR (Flk-1 or KDR) and Flt with IC50 of 100 nM and 2 μM. It also shows inhibition activity against Src and Abl with IC50 values of 0.33μM and 1.3μM, respectively.
CSN23885	ZD-4190	413599-62-9	ZD-4190 is an inhibitor of vascular endothelial cell growth factor receptor 2 (VEGFR2) and epidermal growth factor receptor (EGFR) signalling.
CSN16336	Tesevatinib	781613-23-8	XL647 or tesevatinib inhibits EGFR, HER2, VEGFR and EphB4 with potential antineoplastic activity.
CSN28428	XL092	2367004-54-2	XL-092 is an ATP-competitive inhibitor of multiple receptor tyrosine kinases including MET, VEGFR2, AXL and MER, with IC50 values of 15, 1.6, 3.4, and 7.2 nM, respectively, in cell-based assays.
CSN33134	Vorolanib	1013920-15-4	Vorolanib (CM082) is an orally active, potent VEGFR/PDGFR/DHODH inhibitor.
CSN25326	Tyrphostin AG1433	168835-90-3	Tyrphostin AG1433 is a tyrosine kinases inhibitor and also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively.
CSN21277	Tyrosine kinase-IN-1	705946-27-6	Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively.
CSN16850	Taxifolin	480-18-2	Taxifolin is an inhibitor of VEGFR-2 kinase and collagenase (IC50 193.3 M) and it can be found in many plants such as taxus chinensis, siberian larch, cedrus deodara and so on.
CSN12411	Sunitinib Malate	341031-54-7	Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 Flk-1 and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit
CSN16761	Sunitinib	557795-19-4	Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 Flk-1 and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit
CSN20031	(Z)-Orantinib	210644-62-5	SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFR, VEGFR2 (Flk-1KDR), FGFR1 activity in vitro (IC50 0.01, 0.1, 3.9, and 3.8 M, respectively) and PDGFVEGFbFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target serthr kinases Aurora A, Aurora B, TBK1 (NAKT2K), and AMPK (IC50 0.85, 0.047, 1.4, and 1.8 M, respectively), as well as non-receptor TKs Lyn and Yes (IC50 4.3 and 5.8 M, respectively).
CSN21274	SU5208	62540-08-3	SU5208 is an analogue of SU5025.
CSN21922	SU1498	168835-82-3	SU1498 is a selective inhibitor of the VEGFR2 with IC50 of 700 nM.
CSN23179	Vatalanib Succinate	212142-18-2	Potent VEGFR inhibitor; also aromatase inhibitor
CSN21067	Ponatinib hydrochloride	1114544-31-8	Ponatinib is a multi-targeted kinase inhibitor with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src respectively.
CSN12340	Pazopanib	444731-52-6	Pazopanib is a multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR FGFR c-Kit and c-Fms with IC50 of 10 nM 30 nM 47 nM 84 nM 74 nM 140 nM and 146 nM respectively
CSN25230	ODM-203	1430723-35-5	ODM-203 is a selective inhibitor of FGFR and VEGFR with IC50 values of 11, 16, 6, 35nM for recombinant FGFR1-4 and 26, 9, 5nM for VEGFR1-3, respectively.
CSN27706	NVP-ACC789	300842-64-2	NVP-ACC789 is a selective VEGFR inhibitor with IC50 values of 0.02μM, 0.18μM and 0.38μM for VEGFR2, VEGFR3 and VEGFR1, respectively, as well as with less potency to PDGFR-β with IC50 value of 1.4μM.
CSN24062	Ningetinib	1394820-69-9	Ningetinib is an inhibitor of tyrosine kinase inhibitor (TKI) and the IC50 for c-Met, VEGFR2 and Axl are 6.7 nM, 1.9 nM and <1.0 nM respectively.
CSN27655	MAZ51	163655-37-6	MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase.
CSN26936	JNJ-38158471	951151-97-6	JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor, with an IC50 of 40 nM. JNJ-38158471 also inhibits Ret and Kit with IC50s of 180 and 500 nM, respectively .
CSN27743	GW806742X	579515-63-2	GW806742X is an ATP mimetic MLKL inhibitor with Kd value of 9.3μM, and a VEGFR2 inhibitor with IC50 value of 2nM.
CSN26565	GW768505A free base	501693-25-0	GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2, with a pIC50 of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity[1]。
CSN24153	Glumetinib	1642581-63-2	Glumetinib is a novel, potent and highly selective inhibitor of c-Met.
CSN32426	Glesatinib	936694-12-1	Glesatinib is an orally bioavailable, small-molecule, multitargeted tyrosine kinase inhibitor with potential antineoplastic activity.
CSN26133	Decursin	5928-25-6	Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant. It inhibited proliferation and angiogenesis of endothelial cells to suppress diabetic retinopathy via VEGFR2.
CSN16269	CTX-0294885	1439934-41-4	CTX-0294885 is a bisanilino pyrimidine and exhibits inhibitory activity against a broad range of kinases in vitro, further developed into a Sepharose-supported kinase capture reagent. CTX-0294885 is a broad spectrum kinase inhibitor that inhibited FAK, FLT3, JAK2, JAK3, Src, Aurora kinase A, and VEGF receptor 3 (IC50s = 4, 1, 3, 28, 2, 18, and 3 nM, respectively) in an initial screen.
CSN26201	Chloropyramine hydrochloride	6170-42-9	Chloropyramine hydrochloride is a histamine receptor H1 antagonist which can also inhibit the biochemical function of VEGFR-3. Chloropyramine hydrochloride may be useful in the treatment of invasive breast cancer.
CSN15883	Agerafenib	1188910-76-0	CEP-32496 is an inhibitor of BRAF V600E (IC50 14 nM), WT (IC50 34 nM) and c-Raf (IC50 39 nM). It also exhibits certain inhibitory activity against Abl-1, c-Kit, Ret, PDGFR and VEGFR2.
CSN21898	Cediranib	288383-20-0	Cediranib is a multiple RTKs inhibitor with IC50 values of <0.001μM, 0.005μM, ≤0.003μM, 0.002μM and 0.005μM for VEGFR-2, VEGFR-1, VEGFR-3, c-Kit and PDGFR-β(measured kinase activity), respectively.
CSN15710	Cabozantinib	849217-68-1	Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-134, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM11.3 nM6 nM, 14.3 nM and 7 nM, respectively.
CSN18663	BMS-817378	1174161-69-3	BMS-798433 shows greater than 50 TGI for at least one tumor doubling time with no toxicity observed during 14 days in GTL-16 human gastric tumor xenografts model.
CSN15701	BMS-690514	859853-30-8	BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor EGFR HER2 and HER4 as well as the VEGF receptor kinases
CSN25674	N-Cyclopropyl-2,4-difluoro-5-(((2-(pyridin-2-ylamino)thiazol-5-yl)methyl)amino)benzamide	639858-32-5	BMS 605541 is an ATP-competitive inhibitor of VEGFR-2 with IC50 of 23 nM.
CSN17360	BIBF 1202	894783-71-2	BIBF 1202 is the carboxylate metabolite of BIBF 1120, which is an oral triple angiokinase inhibitor targeting VEGFR, PDGFR, FGFR.
CSN19151	BFH772	890128-81-1	BFH772 selectively targets VEGFR2 kinase with IC50 of 3 nM.
CSN19120	BBT594	882405-89-2	BBT594 is a potentreceptor tyrosine kinase RET inhibitor, used for cancer treatment.
CSN10361	Axitinib	319460-85-0	Axitinib is a multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR and c-Kit with IC50 of 01 nM 02 nM 01-03 nM 16 nM and 17 nM in Porcine aorta endothelial cells respectively
CSN26521	(Z)-SKI V	927429-51-4	and a Kd of 3.06 μM. (Z)-SKI V inhibits Aurora A with an IC50 of 1.34 μM. (Z)-SKI V, a benzofuran derivative, has extensive cytotoxic effects on cancer cell lines[1].
CSN24271	AG-13958	319460-94-1	AG-13958 is a VEGFA inhibitor potentially for the treatment of age-related macular degeneration.
CSN25675	[(E)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]ferrocene	884338-18-5	(E)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) with IC50 of 214 nM.
CSN26199	SKLB 610	1125780-41-7

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