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VEGFR
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN15826 | ZM 306416 | 690206-97-4 | ZM-306416 is an inhibitor of VEGFR (Flk-1 or KDR) and Flt with IC50 of 100 nM and 2 μM. It also shows inhibition activity against Src and Abl with IC50 values of 0.33μM and 1.3μM, respectively. |
| CSN23885 | ZD-4190 | 413599-62-9 | ZD-4190 is an inhibitor of vascular endothelial cell growth factor receptor 2 (VEGFR2) and epidermal growth factor receptor (EGFR) signalling. |
| CSN16336 | Tesevatinib | 781613-23-8 | XL647 or tesevatinib inhibits EGFR, HER2, VEGFR and EphB4 with potential antineoplastic activity. |
| CSN28428 | Zanzalintinib | 2367004-54-2 | XL-092 is an ATP-competitive inhibitor of multiple receptor tyrosine kinases including MET, VEGFR2, AXL and MER, with IC50 values of 15, 1.6, 3.4, and 7.2 nM, respectively, in cell-based assays. |
| CSN33134 | Vorolanib | 1013920-15-4 | Vorolanib (CM082) is an orally active, potent VEGFR/PDGFR/DHODH inhibitor. |
| CSN25326 | Tyrphostin AG1433 | 168835-90-3 | Tyrphostin AG1433 is a tyrosine kinases inhibitor and also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively. |
| CSN21277 | Tyrosine kinase-IN-1 | 705946-27-6 | Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively. |
| CSN16850 | Taxifolin | 480-18-2 | Taxifolin is an inhibitor of VEGFR-2 kinase and collagenase (IC50 193.3 M) and it can be found in many plants such as taxus chinensis, siberian larch, cedrus deodara and so on. |
| CSN12411 | Sunitinib Malate | 341031-54-7 | Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 Flk-1 and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit |
| CSN16761 | Sunitinib | 557795-19-4 | Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 Flk-1 and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit |
| CSN20031 | (Z)-Orantinib | 210644-62-5 | SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFR, VEGFR2 (Flk-1KDR), FGFR1 activity in vitro (IC50 0.01, 0.1, 3.9, and 3.8 M, respectively) and PDGFVEGFbFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target serthr kinases Aurora A, Aurora B, TBK1 (NAKT2K), and AMPK (IC50 0.85, 0.047, 1.4, and 1.8 M, respectively), as well as non-receptor TKs Lyn and Yes (IC50 4.3 and 5.8 M, respectively). |
| CSN21274 | SU5208 | 62540-08-3 | SU5208 is an analogue of SU5025. |
| CSN21922 | SU1498 | 168835-82-3 | SU1498 is a selective inhibitor of the VEGFR2 with IC50 of 700 nM. |
| CSN23179 | N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate | 212142-18-2 | Potent VEGFR inhibitor; also aromatase inhibitor |
| CSN21067 | Ponatinib hydrochloride | 1114544-31-8 | Ponatinib is a multi-targeted kinase inhibitor with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src respectively. |
| CSN12340 | Pazopanib | 444731-52-6 | Pazopanib is a multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR FGFR c-Kit and c-Fms with IC50 of 10 nM 30 nM 47 nM 84 nM 74 nM 140 nM and 146 nM respectively |
| CSN25230 | ODM-203 | 1430723-35-5 | ODM-203 is a selective inhibitor of FGFR and VEGFR with IC50 values of 11, 16, 6, 35nM for recombinant FGFR1-4 and 26, 9, 5nM for VEGFR1-3, respectively. |
| CSN27706 | NVP-ACC789 | 300842-64-2 | NVP-ACC789 is a selective VEGFR inhibitor with IC50 values of 0.02μM, 0.18μM and 0.38μM for VEGFR2, VEGFR3 and VEGFR1, respectively, as well as with less potency to PDGFR-β with IC50 value of 1.4μM. |
| CSN24062 | Ningetinib | 1394820-69-9 | Ningetinib is an inhibitor of tyrosine kinase inhibitor (TKI) and the IC50 for c-Met, VEGFR2 and Axl are 6.7 nM, 1.9 nM and <1.0 nM respectively. |
| CSN27655 | MAZ51 | 163655-37-6 | MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase. |
| CSN26936 | JNJ-38158471 | 951151-97-6 | JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor, with an IC50 of 40 nM. JNJ-38158471 also inhibits Ret and Kit with IC50s of 180 and 500 nM, respectively . |
| CSN23209 | N-(4-Chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride | 196603-47-1 | Inhibitor of VEGF receptor tyrosine kinase |
| CSN27743 | GW806742X | 579515-63-2 | GW806742X is an ATP mimetic MLKL inhibitor with Kd value of 9.3μM, and a VEGFR2 inhibitor with IC50 value of 2nM. |
| CSN26565 | GW768505A free base | 501693-25-0 | GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2, with a pIC50 of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity[1]。 |
| CSN24153 | Glumetinib | 1642581-63-2 | Glumetinib is a novel, potent and highly selective inhibitor of c-Met. |
| CSN32426 | Glesatinib | 936694-12-1 | Glesatinib is an orally bioavailable, small-molecule, multitargeted tyrosine kinase inhibitor with potential antineoplastic activity. |
| CSN26133 | Decursin | 5928-25-6 | Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant. It inhibited proliferation and angiogenesis of endothelial cells to suppress diabetic retinopathy via VEGFR2. |
| CSN16269 | CTX-0294885 | 1439934-41-4 | CTX-0294885 is a bisanilino pyrimidine and exhibits inhibitory activity against a broad range of kinases in vitro, further developed into a Sepharose-supported kinase capture reagent. CTX-0294885 is a broad spectrum kinase inhibitor that inhibited FAK, FLT3, JAK2, JAK3, Src, Aurora kinase A, and VEGF receptor 3 (IC50s = 4, 1, 3, 28, 2, 18, and 3 nM, respectively) in an initial screen. |
| CSN26201 | Chloropyramine hydrochloride | 6170-42-9 | Chloropyramine hydrochloride is a histamine receptor H1 antagonist which can also inhibit the biochemical function of VEGFR-3. Chloropyramine hydrochloride may be useful in the treatment of invasive breast cancer. |
| CSN15883 | Agerafenib | 1188910-76-0 | CEP-32496 is an inhibitor of BRAF V600E (IC50 14 nM), WT (IC50 34 nM) and c-Raf (IC50 39 nM). It also exhibits certain inhibitory activity against Abl-1, c-Kit, Ret, PDGFR and VEGFR2. |
| CSN21898 | Cediranib | 288383-20-0 | Cediranib is a multiple RTKs inhibitor with IC50 values of <0.001μM, 0.005μM, ≤0.003μM, 0.002μM and 0.005μM for VEGFR-2, VEGFR-1, VEGFR-3, c-Kit and PDGFR-β(measured kinase activity), respectively. |
| CSN15710 | Cabozantinib | 849217-68-1 | Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-134, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM11.3 nM6 nM, 14.3 nM and 7 nM, respectively. |
| CSN18663 | BMS-817378 | 1174161-69-3 | BMS-798433 shows greater than 50 TGI for at least one tumor doubling time with no toxicity observed during 14 days in GTL-16 human gastric tumor xenografts model. |
| CSN15701 | BMS-690514 | 859853-30-8 | BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor EGFR HER2 and HER4 as well as the VEGF receptor kinases |
| CSN25674 | N-Cyclopropyl-2,4-difluoro-5-(((2-(pyridin-2-ylamino)thiazol-5-yl)methyl)amino)benzamide | 639858-32-5 | BMS 605541 is an ATP-competitive inhibitor of VEGFR-2 with IC50 of 23 nM. |
| CSN17360 | BIBF 1202 | 894783-71-2 | BIBF 1202 is the carboxylate metabolite of BIBF 1120, which is an oral triple angiokinase inhibitor targeting VEGFR, PDGFR, FGFR. |
| CSN19151 | BFH772 | 890128-81-1 | BFH772 selectively targets VEGFR2 kinase with IC50 of 3 nM. |
| CSN19120 | BBT594 | 882405-89-2 | BBT594 is a potentreceptor tyrosine kinase RET inhibitor, used for cancer treatment. |
| CSN10361 | Axitinib | 319460-85-0 | Axitinib is a multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR and c-Kit with IC50 of 01 nM 02 nM 01-03 nM 16 nM and 17 nM in Porcine aorta endothelial cells respectively |
| CSN26521 | (Z)-SKI V | 927429-51-4 | and a Kd of 3.06 μM. (Z)-SKI V inhibits Aurora A with an IC50 of 1.34 μM. (Z)-SKI V, a benzofuran derivative, has extensive cytotoxic effects on cancer cell lines[1]. |
| CSN24271 | AG-13958 | 319460-94-1 | AG-13958 is a VEGFA inhibitor potentially for the treatment of age-related macular degeneration. |
| CSN21923 | 5Z-7-Oxozeaenol | 253863-19-3 | 5Z-7-Oxozeaenol is a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of 8 nM and 52 nM, respectively. |
| CSN25675 | [(E)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]ferrocene | 884338-18-5 | (E)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) with IC50 of 214 nM. |
| CSN26199 | SKLB 610 | 1125780-41-7 |
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