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VEGFR

VEGFR

Cat. No. Product Name CAS No. Information
CSN18068 ZM323881 HCl 193000-39-4 ZZZM 323881 hydrochloride is a potent and selective VEGFR2 inhibitor with IC50 of 2 nM almost no activity on VEGFR1 PDGFR FGFR1 EGFR and ErbB2
CSN15826 ZM306416   690206-97-4 ZM-306416 is an inhibitor of VEGFR Flk-1 or KDR and Flt with IC50 of 100 nM and 2 M
CSN20195 VEGFR Inhibitor TC2 N/A VEGFR inhibitor TC2 is a 4-epi-analog of tobacco cembranoid VEGFR inhibitor TC1 acts in angiogenesis inhibitory in multiple breast cancer cell lines by significantly reducing the activated VEGFR2 levels
CSN20194 α-Cembrenediol 57605-80-8 VEGFR inhibitor TC1 acts in angiogenesis inhibitory in multiple breast cancer cell lines by significantly reducing the activated VEGFR2 levels
CSN16730 Vatalanib 212141-54-3 Vatalanib is an inhibitor of VEGFR2KDR with IC50 of 37 nM, showing less potent against VEGFR1Flt-1, 18-fold against VEGFR3Flt-4.
CSN12454 Vatalanib 2HCl   212141-51-0 Vatalanib dihydrochloride is inhibitor of VEGFR2 or KDR with IC50 of 37 nM.
CSN12186 Vandetanib   443913-73-3 Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM
CSN18225 Vandetanib Trifluoroacetate 338992-53-3 Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM
CSN18317 Vandetanib HCl 524722-52-9 Vandetanib hydrochloride specially inhibits VEGFR2 with IC50 of 40 nM
CSN12667 Tivozanib   475108-18-0 Tivozanib is an inhibitor of VEGFR1, VEGFR2 and VEGFR3 with IC50s of 30 nM, 6.5 nM, 15 nM, respectively. It can also inhibit PDGFR and c-Kit.
CSN17394 TG 100801 HCl 1018069-81-2 TG 100801 is the prodrug of TG 100572 which is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 272105 nM or VEGFR1VEGFR2FGFR1SrcFyn kianse respectively
CSN12041 Telatinib 332012-40-5 Telatinib is a potent inhibitor of VEGFR23 c-Kit and PDGFR with IC50 of 6 nM4 nM 1 nM and 15 nM respectively
CSN15808 SU5416 204005-46-9 SU5416 is a selective VEGFR2 Flk-1KDR inhibitor with IC50 of 123 M
CSN20516 SU5408   15966-93-5 SU5408 is a VEGFR2 kinase inhibitor with IC50 of 70 nM in murine
CSN20604 Su5205   3476-86-6 Su5205 is an inhibitor of VEGFR2
CSN20550 SU 4312 5812-07-7 SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases IC50 values are 08 and 194 M respectively which is selective over EGFR and c-Src tyrosine kinases
CSN17169 SKLB1002 1225451-84-2 SKLB1002 is a selective inhibitor of VEGFR2 with IC50 of 32 nM
CSN15794 Z-Semaxanib   194413-58-6 Semaxanib is an inhibitor of VEGFR2 namely Flk-1 or KDR with IC50 of 123 M
CSN17854 SAR131675 1433953-83-3 SAR131675 is selective inhibitor of VEGFR3 with IC50 and Ki of 23 nM 12 nM respectively
CSN20455 SAR131675 Racemate 1092539-44-0 SAR131675 is a selective inhibitor of VEGFR-3 IC50 20 nM with antitumoral and antimetastatic activities
CSN17331 Regorafenib Monohydrate   1019206-88-2 Regorafenib is a multi-target inhibitor It can inhibit the activities of VEGFR1 VEGFR2 VEGFR3 PDGFR Kit RET and Raf-1 and their IC50 values range from 15 nM to 46 nM
CSN17185 Regorafenib HCl   835621-07-3 Regorafenib hydrochloride can inhibit many kinases including RET IC50 15 nM Raf-1 IC50 25 nM VEGFR2 IC50 42 nM VEGFR1 IC50 13 nM PDGFR IC50 22 nM and VEGFR3 IC50 46 nM
CSN16062 RAF265 927880-90-8 RAF265 is a pan-inhibitor that inhibits C-Raf B-Raf and B-Raf V600E with IC50 of 3 nM-60 nM It also shows inhibition on phosphorylation of VEGFR2 with EC50 of 30 nM
CSN18523 R1530 882531-87-5 R1530 is the multikinase inhibitor with potential antiangiogenesis and antineoplastic activities
CSN12340 Pazopanib   444731-52-6 Pazopanib is a multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR FGFR c-Kit and c-Fms with IC50 of 10 nM 30 nM 47 nM 84 nM 74 nM 140 nM and 146 nM respectively
CSN13729 Pazopanib HCl 635702-64-6 Pazopanib hydrochloride is a multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR FGFR c-Kit and c-Fms with IC50 of 10 nM 30 nM 47 nM 84 nM 74 nM 140 nM and 146 nM in cell-free assays respectively
CSN11151 Oglufanide   38101-59-6 Oglufanide is inhibitor of vascular endothelial growth factor VEGF that suppresses angiogenesis
CSN12341 BIBF 1120   656247-17-5 Nintedanib is a potent triple angiokinase inhibitor for VEGFR123, FGFR123 and PDGFR with IC50 of 34 nM13 nM13 nM, 69 nM37 nM108 nM and 59 nM65 nM.
CSN18236 N-Desethyl Sunitinib 356068-97-8 N-desethyl sunitinib is a major and pharmacologically active metabolite of sunitinib which is potent ATP-competitive VEGFR PDGFR and KIT inhibitor Ki values are 2 9 17 8 and 4 nM for VEGFR -1 -2 -3 PDGFR and KIT respectively
CSN12691 Motesanib   453562-69-1 Motesanib is an ATP-competitive inhibitor of VEGFR1 IC50 2 nM VEGFR2 IC50 3 nM VEGFR3 IC50 6 nM and Kit
CSN17192 Motesanib Diphosphate 857876-30-3 Motesanib diphosphate is ATP-competitive inhibitor of VEGFR1, VEGFR2 and VEGFR3 with IC50 of 2 nM, 3 nM and 6 nM, respectively. It also shows better inhibitory activity against c-Kit, PDGFR, and RET.
CSN13151 MGCD-265 875337-44-3 MGCD-265 an ATP-competitive inhibitor can inhibit c-Met and VEGFR1 2 3 with IC50s of 1 nM and 3 nM 3 nM 4 nM respectively It also exhibits inhibition of Ron and Tie2
CSN21405 Lenvatinib Mesylate   857890-39-2 Lenvatinib mesylate is an inhibitor of VEGFR2 with potential antineoplastic activity It can decrease vascular endothelial cell migration and proliferation
CSN15974 Lenvatinib   417716-92-8 Lenvatinib is a multi-target inhibitor mostly for VEGFR2 KDRVEGFR3 Flt-4 with IC50 of 4 nM52 nM less potent against VEGFR1Flt-1 10-fold selective for VEGFR23 against FGFR1 PDGFR
CSN15848 KRN-633 286370-15-8 KRN-633 can inhibit VEGFR1 VEGFR2 and VEGFR3 with IC50 of 170 nM 160 nM and 125 nM respectively
CSN17193 Ki8751   228559-41-9 Ki8751 is a selective VEGFR2 inhibitor with IC50 of 09 nM
CSN17542 Fruquintinib   1194506-26-7 Fruquintinib is an inhibitor of VEGFR family with IC50s of 33 nM 35 nM and 05 nM for VEGFR1 2 3 respectively
CSN17568 EG00229 1210945-69-9 EG00229 is the first small molecule inhibitor of the neuropilin-1 and VEGF-A interaction with an IC50 of inhibition of 8 M125I-VEGF binding to PAENRP1 cells
CSN17438 E-3810 1058137-23-7 E-3810 is a dual inhibitor of the VEGF and FGF receptors potently and selectively inhibits VEGFR1 VEGFR2 VEGFR3 FGFR1 and FGFR2 with IC50 of 7 nM 25 nM 10 nM 175 nM and 825 nM respectively
CSN13440 CP-547632 252003-65-9 CP-547632 is a potent inhibitor of the VEGFR-2 and basic fibroblast growth factor FGF kinases IC50 11 and 9 nM respectively It is selective relative to epidermal growth factor receptor platelet-derived growth factor and other related TKs It also inhibits VEGF-stimulated autophosphorylation of VEGFR-2 in a whole cell assay with an IC50 value of 6 nM
CSN21898 Cediranib 288383-20-0 Cediranib is a multiple RTKs inhibitor with IC50 values of 0.001M, 0.005M, 0.003M, 0.002M and 0.005M for VEGFR-2, VEGFR-1, VEGFR-3, c-Kit and PDGFR-(measured kinase activity), respectively.
CSN16877 Cabozantinib Malate 1140909-48-3 Cabozantinib S-malate is a VEGFR2 inhibitor with IC50 of 0.035 nM. It also inhibits c-Met, Ret, Kit, Flt-134, Tie2, and AXL with IC50 of 1.3 nM-11.3 nM.
CSN15710 Cabozantinib     849217-68-1 Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-134, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM11.3 nM6 nM, 14.3 nM and 7 nM, respectively.
CSN12669 Brivanib 649735-46-6 Brivanib is an ATP-competitive inhibitor against VEGFR2 with IC50 of 25 nM moderate potency against VEGFR-1 and FGFR-1 but 240-fold against PDGFR-
CSN18663 BMS-817378 1174161-69-3 BMS-798433 shows greater than 50 TGI for at least one tumor doubling time with no toxicity observed during 14 days in GTL-16 human gastric tumor xenografts model.
CSN19151 BFH772 890128-81-1 BFH772 selectively targets VEGFR2 kinase with IC50 of 3 nM.
CSN10361 Axitinib 319460-85-0 Axitinib is a multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR and c-Kit with IC50 of 01 nM 02 nM 01-03 nM 16 nM and 17 nM in Porcine aorta endothelial cells respectively
CSN17579 Apatinib Mesylate   1218779-75-9 Apatinib is a VEGFR2 inhibitor with IC50 of 1 nM and also can suppress the activities of Ret IC50 13 nM c-Kit IC50 429 nM and c-Src IC50 530 nM
CSN13818 Apatinib 811803-05-1 Apatinib is a selective inhibitor of VEGFR2 with IC50 of 1 nM
CSN16990 2,4-Pyrimidinediamine with Linker 1430089-64-7 24-Pyrimidinediamine with linker is a multikinase inhibitor with a -NH2 terminal linker
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