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VEGFR

VEGFR

Cat. No. Product Name CAS No. Information
CSN15826 ZM 306416   690206-97-4 ZM-306416 is an inhibitor of VEGFR (Flk-1 or KDR) and Flt with IC50 of 100 nM and 2 μM. It also shows inhibition activity against Src and Abl with IC50 values of 0.33μM and 1.3μM, respectively.
CSN23885 ZD-4190 413599-62-9 ZD-4190 is an inhibitor of vascular endothelial cell growth factor receptor 2 (VEGFR2) and epidermal growth factor receptor (EGFR) signalling.
CSN16336 Tesevatinib 781613-23-8 XL647 or tesevatinib inhibits EGFR, HER2, VEGFR and EphB4 with potential antineoplastic activity.
CSN28428 Zanzalintinib 2367004-54-2 XL-092 is an ATP-competitive inhibitor of multiple receptor tyrosine kinases including MET, VEGFR2, AXL and MER, with IC50 values of 15, 1.6, 3.4, and 7.2 nM, respectively, in cell-based assays.
CSN33134 Vorolanib 1013920-15-4 Vorolanib (CM082) is an orally active, potent VEGFR/PDGFR/DHODH inhibitor.
CSN25326 Tyrphostin AG1433 168835-90-3 Tyrphostin AG1433 is a tyrosine kinases inhibitor and also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively.
CSN21277 Tyrosine kinase-IN-1 705946-27-6 Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively.
CSN16850 Taxifolin   480-18-2 Taxifolin is an inhibitor of VEGFR-2 kinase and collagenase (IC50 193.3 M) and it can be found in many plants such as taxus chinensis, siberian larch, cedrus deodara and so on.
CSN12411 Sunitinib Malate   341031-54-7 Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 Flk-1 and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit
CSN16761 Sunitinib   557795-19-4 Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 Flk-1 and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit
CSN20031 (Z)-Orantinib 210644-62-5 SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFR, VEGFR2 (Flk-1KDR), FGFR1 activity in vitro (IC50 0.01, 0.1, 3.9, and 3.8 M, respectively) and PDGFVEGFbFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target serthr kinases Aurora A, Aurora B, TBK1 (NAKT2K), and AMPK (IC50 0.85, 0.047, 1.4, and 1.8 M, respectively), as well as non-receptor TKs Lyn and Yes (IC50 4.3 and 5.8 M, respectively).
CSN21274 SU5208 62540-08-3 SU5208 is an analogue of SU5025.
CSN21922 SU1498 168835-82-3 SU1498 is a selective inhibitor of the VEGFR2 with IC50 of 700 nM.
CSN23179 N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate 212142-18-2 Potent VEGFR inhibitor; also aromatase inhibitor
CSN21067 Ponatinib hydrochloride 1114544-31-8 Ponatinib is a multi-targeted kinase inhibitor with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src respectively.
CSN12340 Pazopanib   444731-52-6 Pazopanib is a multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR FGFR c-Kit and c-Fms with IC50 of 10 nM 30 nM 47 nM 84 nM 74 nM 140 nM and 146 nM respectively
CSN25230 ODM-203 1430723-35-5 ODM-203 is a selective inhibitor of FGFR and VEGFR with IC50 values of 11, 16, 6, 35nM for recombinant FGFR1-4 and 26, 9, 5nM for VEGFR1-3, respectively.
CSN27706 NVP-ACC789   300842-64-2 NVP-ACC789 is a selective VEGFR inhibitor with IC50 values of 0.02μM, 0.18μM and 0.38μM for VEGFR2, VEGFR3 and VEGFR1, respectively, as well as with less potency to PDGFR-β with IC50 value of 1.4μM.
CSN24062 Ningetinib 1394820-69-9 Ningetinib is an inhibitor of tyrosine kinase inhibitor (TKI) and the IC50 for c-Met, VEGFR2 and Axl are 6.7 nM, 1.9 nM and <1.0 nM respectively.
CSN27655 MAZ51 163655-37-6 MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase.
CSN26936 JNJ-38158471 951151-97-6 JNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor, with an IC50 of 40 nM. JNJ-38158471 also inhibits Ret and Kit with IC50s of 180 and 500 nM, respectively .
CSN23209 N-(4-Chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine hydrochloride 196603-47-1 Inhibitor of VEGF receptor tyrosine kinase
CSN27743 GW806742X 579515-63-2 GW806742X is an ATP mimetic MLKL inhibitor with Kd value of 9.3μM, and a VEGFR2 inhibitor with IC50 value of 2nM.
CSN26565 GW768505A free base 501693-25-0 GW768505A free base is a potent dual inhibitor of VEGFR2 (KDR) and Tie-2, with a pIC50 of 7.81 for VEGFR2. GW768505A free base has anti-angiogenic activity[1]。
CSN24153 Glumetinib 1642581-63-2 Glumetinib is a novel, potent and highly selective inhibitor of c-Met.
CSN32426 Glesatinib 936694-12-1 Glesatinib is an orally bioavailable, small-molecule, multitargeted tyrosine kinase inhibitor with potential antineoplastic activity.
CSN26133 Decursin 5928-25-6 Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant. It inhibited proliferation and angiogenesis of endothelial cells to suppress diabetic retinopathy via VEGFR2.
CSN16269 CTX-0294885 1439934-41-4 CTX-0294885 is a bisanilino pyrimidine and exhibits inhibitory activity against a broad range of kinases in vitro, further developed into a Sepharose-supported kinase capture reagent. CTX-0294885 is a broad spectrum kinase inhibitor that inhibited FAK, FLT3, JAK2, JAK3, Src, Aurora kinase A, and VEGF receptor 3 (IC50s = 4, 1, 3, 28, 2, 18, and 3 nM, respectively) in an initial screen.
CSN26201 Chloropyramine hydrochloride 6170-42-9 Chloropyramine hydrochloride is a histamine receptor H1 antagonist which can also inhibit the biochemical function of VEGFR-3. Chloropyramine hydrochloride may be useful in the treatment of invasive breast cancer.
CSN15883 Agerafenib 1188910-76-0 CEP-32496 is an inhibitor of BRAF V600E (IC50 14 nM), WT (IC50 34 nM) and c-Raf (IC50 39 nM). It also exhibits certain inhibitory activity against Abl-1, c-Kit, Ret, PDGFR and VEGFR2.
CSN21898 Cediranib 288383-20-0 Cediranib is a multiple RTKs inhibitor with IC50 values of <0.001μM, 0.005μM, ≤0.003μM, 0.002μM and 0.005μM for VEGFR-2, VEGFR-1, VEGFR-3, c-Kit and PDGFR-β(measured kinase activity), respectively.
CSN15710 Cabozantinib   849217-68-1 Cabozantinib is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-134, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM11.3 nM6 nM, 14.3 nM and 7 nM, respectively.
CSN18663 BMS-817378 1174161-69-3 BMS-798433 shows greater than 50 TGI for at least one tumor doubling time with no toxicity observed during 14 days in GTL-16 human gastric tumor xenografts model.
CSN15701 BMS-690514 859853-30-8 BMS-690514 is a potent and selective inhibitor of epidermal growth factor receptor EGFR HER2 and HER4 as well as the VEGF receptor kinases
CSN25674 N-Cyclopropyl-2,4-difluoro-5-(((2-(pyridin-2-ylamino)thiazol-5-yl)methyl)amino)benzamide 639858-32-5 BMS 605541 is an ATP-competitive inhibitor of VEGFR-2 with IC50 of 23 nM.
CSN17360 BIBF 1202 894783-71-2 BIBF 1202 is the carboxylate metabolite of BIBF 1120, which is an oral triple angiokinase inhibitor targeting VEGFR, PDGFR, FGFR.
CSN19151 BFH772 890128-81-1 BFH772 selectively targets VEGFR2 kinase with IC50 of 3 nM.
CSN19120 BBT594 882405-89-2 BBT594 is a potentreceptor tyrosine kinase RET inhibitor, used for cancer treatment.
CSN10361 Axitinib 319460-85-0 Axitinib is a multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR and c-Kit with IC50 of 01 nM 02 nM 01-03 nM 16 nM and 17 nM in Porcine aorta endothelial cells respectively
CSN26521 (Z)-SKI V 927429-51-4 and a Kd of 3.06 μM. (Z)-SKI V inhibits Aurora A with an IC50 of 1.34 μM. (Z)-SKI V, a benzofuran derivative, has extensive cytotoxic effects on cancer cell lines[1].
CSN24271 AG-13958 319460-94-1 AG-13958 is a VEGFA inhibitor potentially for the treatment of age-related macular degeneration.
CSN21923 5Z-7-Oxozeaenol 253863-19-3 5Z-7-Oxozeaenol is a potent irreversible and selective inhibitor of TAK1 and VEGF-R2, with IC50s of 8 nM and 52 nM, respectively.
CSN25675 [(E)-(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]ferrocene 884338-18-5 (E)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) with IC50 of 214 nM.
CSN26199 SKLB 610 1125780-41-7
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