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TRP Channel

Cat. No. Product Name CAS No. Information
CSN19515 Vanillyl Alcohol   498-00-0 Vanillyl alcohol is a free radical scavenger with anticonvulsive and bile secretion promoting effect. It can be extracted from the herbs of Gastrodia elata Bl..
CSN16412 SN 2 823218-99-1 SN 2 is a potent activator of TRPML3 ion channel with EC50 of 18013 M
CSN15682 SB-705498   501951-42-4 SB-705498 is a selective antagonist of transient receptor potential vanilloid 1 TRPV1 with pIC50 of 71
CSN19507 SB-366791   472981-92-3 SB-366791 is an antagonist of vanilloid receptor VR1 or TRPV1 with IC50 of 5712 nM
CSN18783 SAR7334 1333210-07-3 SAR7334 is a potent TRPC6 Transient receptor potential cation channel subfamily C member 6 inhibitor
CSN12436 SAR7334 2HCl 1333207-63-8 SAR7334 dihydrochloride is a potent and specific TRPC6 inhibitor inhibiting TRPC6 currents with IC50 of 79 nM
CSN17628 RQ-00203078   1254205-52-1 RQ-00203078 is a selective antagonist of TRPM8 with IC50 of 83 nM
CSN18624 RN-1734   946387-07-1 RN-1734 is selective antagonist of the TRPV4 channel completely antagonizes 4PDD-mediated activation of TRPV4 with comparable low micromolar IC50 values for all three species hTRPV4 IC50 23 M mTRPV4 IC50 59 M rTRPV4 IC50 32 M
CSN18152 Pyr6 245747-08-4 Pyr6 is a selective inhibitor of TRPC3 with IC50 of 049 M Ca2 influx inhibition in thapsigargin depleted native RBL-2H3 cells
CSN17688 Pyr10 1315323-00-2 Pyr 10 is a TRPC3-selective inhibitor IC50 of Ca2 influx inhibition by Pyr10 in carbachol-stimulated YFP-TRPC3-transfected HEK293 cells for ROCE and thapsigargin-depleted native RBL-2H3 cells for SOCE is 072 uM and 1308 uM
CSN21376 AM-0902 1883711-97-4 Potent and selective TRPA1 antagonist IC50 002 M for human TRPA1 Exhibits no siginificant activity against human TRPV1 or TRPV4 and rat TRPV1 TRPV3 or TRPM8 Exhibits efficacy in a rat pain model Orally bioavailable
CSN19028 Podocarpic Acid 5947-49-9 Podocarpic acid is a natural product which has the best all-round positive effect and acts as a TRPA1 activator
CSN13939 PF-4840154 1332708-14-1 PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse, with EC50 of 97 nM and 23 nM for rTrpA1 and hTrpA1, respectively.
CSN20615 PF-05105679 1398583-31-7 PF-05105679 is an orally-bioavailable and selective TRPM8 blocker IC50 103 nM which exhibits 100-fold selectivity for TRPM8 over a panel of receptors ion channels and enzymes including TRPV1 and TRPA1 ion channels
CSN17365 Optovin   348575-88-2 Optovin is a reversible and photoactive activator of TRPA1 with EC50 of 2 M in wild-type zebrafish
CSN16213 N-Vanillylnonanamide   2444-46-4 Nonivamide, an analog of capsaicin, is agonist of transient receptor potential vanilloid type 1 (TRPV1). It can be extracted from the fruits of Capsicum annuum L..
CSN20361 MRS1477 212200-21-0 MRS1477 is a positive allosteric modulator of TRPV1 channels targeting breast cancer cells
CSN15766 ML204   5465-86-1 ML204 is a selective antagonist of TRPC4 ion channel with IC50 of 096 M and 26 M in fluorescent and electrophysiological assays respectively
CSN19023 ML204 HCl 2070015-10-8 ML204 hydrochloride is a potent selective TRPC4 channel inhibitor with IC50 of 096 M
CSN18632 Mavatrep 956274-94-5 Mavatrep is an orally bioavailable TRPV1 antagonist Ki65 nM exhibits minimal effect on the enzymatic activity IC50 25 M of CYP isoforms 3A4 1A2 and 2D6
CSN22440 JYL 1421 401907-26-4 JYL 1421 is a TRPV1 receptor antagonist with an IC50 of 8 nM
CSN18446 JNJ-17203212 821768-06-3 JNJ-17203212 is a selective TRPV1 antagonist with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1
CSN16140 Icilin   36945-98-9 Icilin is an agonist of TRPM8 ion channel with EC50 of 036 M in HEK 293 cells
CSN18524 HC-067047 883031-03-6 HC-067047 is a TRPV4 antagonist with IC50 value of 48 6 nM in human
CSN19708 GSK2193874 1336960-13-4 GSK2193874 is a selective transient receptor potential vanilloid 4 TRPV4 blocker with IC50 value of 004 M
CSN18613 GSK1016790A 942206-85-1 GSK1016790A is a potent activator of TRPV4 transient receptor potential vanilloid 4 with EC50 of 34nM in choroid plexus epithelial cells
CSN19025 D-3263 HCl 1008763-54-9 D-3263 hydrochloride is an orally bioavailable transient receptor potential melastatin member 8 TRPM8 agonist
CSN18220 Chembridge-5861528 332117-28-9 Chembridge-5861528 is a TRPA1 channel blocker that antagonizes AITC- and 4-HNE-evoked calcium influx IC50 values are 143 and 187M respectively
CSN10542 Capsazepine 138977-28-3 Capsazepine is an antagonist of TRPV1 receptor with IC50 of 562 nM It is synthetic analogue of sensory neurone excitotoxin
CSN20616 Cannabidivarin 24274-48-4 Cannabidivarin is a non-psychoactive cannabinoid found in Cannabis that activates CB2 cannabinoid receptors as well as the transient receptor potential channels TRPA1, TRPV1, and TRPV2 (EC50s 0.42, 3.6, and 7.3 M, respectively). It is also reported to antagonize TRPM8 (IC50 0.9 M) and to inhibit diacylglycerol lipase (IC50 16.6 M).
CSN15352 Bisandrographolide A 160498-00-0 Bisandrographolide A a natural product activates TRPV4 channels could play a role in some of the effects of Andrographis extract described in traditional medicine
CSN16141 BCTC 393514-24-4 BCTC is a potent and specific inhibitor of transient receptor potential cation channel subfamily M member 8 TRPM8 in prostate cancer PCa DU145 cells
CSN20581 ASP 7663 1190217-35-6 ASP 7663 is an orally-bioavailabe selective TRPA1 activator EC50 values are 05 M in human mouse and rat which displays little or no affinity at more than 60 other related receptors channels and enzymes It stimulates 5-HT release from QGP-1 cells and exhibits an abdominal analgesic effect in vivo
CSN21956 AMG9810   545395-94-6 AMG9810 is an antagonist of TRPV1 receptor with IC50 of 17 nM and exhibits antihyperalgesic properties in rat model
CSN16537 AMG-517   659730-32-2 AMG-517 is a potent and selective TRPV1 antagonist and antagonizes capsaicin proton and heat activation of TRPV1 with IC50 of 076 nM 062 nM and 13 nM
CSN24182 AMG 333 1416799-28-4 AMG 333 is a potent and selective TRPM8 antagonist with IC50 value of 13nM.
CSN10343 α-Spinasterol 481-18-5 alpha-Spinasterol is an efficacious and safe antagonist of the TRPV1 receptor with antinociceptive effect
CSN24195 AC1903 831234-13-0 AC1903 is an inhibitor of transient receptor potential canonical channel 5 (TRPC5) with IC50 of 14.7 µM.
CSN19859 A 967079 1170613-55-4 A 967079 is a selective TRPA1 channel blocker IC50 values are 67 and 289 nM at human and rat TRPA1 receptors respectively
CSN12433 6-Gingerol   23513-14-6 6-Gingerol is activator transient receptor potential vanilloid receptor TRPV1 and TRP ankyrin receptor TRPA1 with EC50 of 3.3 M and 10.4 M. Its a natural chemical found in the rhizomes of ginger (Z. officinale).
CSN23287 2-Aminoethyl diphenylborinate   524-95-8 2-Aminoethyl diphenylborinate is an antagonist of membrane permeable IP3 receptor and a blocker of broad TRP channels including TRPC5 and TRPM2
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