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Trk Receptor

Trk Receptor

Cat. No. Product Name CAS No. Information
CSN20508 TrkA Inhibitor C6t 1377503-70-2 TrkA inhibitor C6t is a potent and selective TrkA inhibitor IC50167 nM showing activity in cellular proliferation and apoptosis assays and exhibiting antiangiogenic activity
CSN20509 Trk Inhibitor C11 1614229-04-7 Trk inhibitor C11 is an orally active pan-Trk inhibitor showing efficacy in both inflammatory and neropathic pain models
CSN20506 PF-06273340 1402438-74-7 PF-06273340 is a potent selective and orally bioavailable pan-Trk inhibitor IC50 values are 1 2 and 6 nM for Trk C B and A respectively It is peripherally restricted and exhibits efficacy in a rodent model of inflammatory pain
CSN23684 Loxo-195 2097002-61-2 LOXO-195 is a TRK kinase inhibitor TKI with IC50 values of 06 nM and 25 nM for TRKA and TRKC respectively
CSN17586 LOXO-101 Sulfate 1223405-08-0 LOXO-101 sulfate blocks the ATP binding site of the TRK family of receptors with IC50 of 2 nM to 20 nM against TRKA, TRKB, and TRKC.
CSN16968 LOXO-101 1223403-58-4 LOXO-101 is an ATP-competitive inhibitor of TRK with IC50 of nanomolar range for all the family members.
CSN22901 LM22B-10   342777-54-2 LM22B-10 is an agonist of TrkB and TrkC neurotrophin receptor It can improve survival and increase neurite outgrowth in vitro
CSN15969 LM22A-4 37988-18-4 LM22A-4 is a specific agonist oftyrosine kinase receptor B
CSN13940 GW441756   504433-23-2 GW 441756 is an inhibitor of tropomyosin-related kinase A TrkA with IC50 of 2 nM
CSN15870 GNF-5837 1033769-28-6 GNF-5837 is a potent pan-Trk inhibitor which display antiproliferative effects in cellular BaF3 assays IC50 values are 7 9 and 11 nM for cells containing the fusion proteins Tel-TrkC Tel-TrkB and Tel-TrkA respectively
CSN20507 GNF-8625 1196546-33-4 GNE-8525 is a potent and selective pan-TRK inhibitor demonstrated potent antiproliferation activity with IC50 0003 M In a tumor xenograft model derived from the KM12 cell line GNE-8525 demonstrated in vivo antitumor efficacy when administered at ascending doses twice daily bid for 14 days in rats
CSN22174 CE-245677 717899-97-3 CE-245677 is a potent reversible inhibitor of Tie2 and TrkAB kinases with a cellular IC50s of 47 and 1 nM
CSN22125 AZ-23 915720-21-7 AZ-23 is a potent orally bioavailable Trk kinase inhibitor with IC50s of 2 nM TrkA 8 nM TrkB 24 nM FGFR1 52 nM Flt3 55 nM Ret 84 nM MuSk 99 nM Lck respectively
CSN15752 ANA-12   219766-25-3 ANA-12 is antagonist of TrkB with Kd of 10 nM
CSN10171 7,8-Dihydroxyflavone   38183-03-8 78-Dihydroxyflavone acts as an agonist of TrkB receptor with Kd of 320 nM with neuroprotective effect
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