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Trk Receptor
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN20508 | TrkA Inhibitor C6t | 1377503-70-2 | TrkA inhibitor C6t is a potent and selective TrkA inhibitor IC50167 nM showing activity in cellular proliferation and apoptosis assays and exhibiting antiangiogenic activity |
| CSN20509 | Trk Inhibitor C11 | 1614229-04-7 | Trk inhibitor C11 is an orally active pan-Trk inhibitor showing efficacy in both inflammatory and neropathic pain models |
| CSN20579 | Repotrectinib | 1802220-02-5 | TPX-0005 is a potent ALKROS1TRK inhibitor with IC50 of 53 nM 101 nM 126 nM and 108 nM for SRC WT ALK ALK G1202R and ALK L1196M respectively |
| CSN27197 | Taletrectinib | 1505515-69-4 | Taletrectinib is a new-generation selective ROS1/Trk Receptor inhibitor with IC50 values of 0.207nM, 0.622nM, 2.28nM and 0.98nM for ROS1, Trk Receptor A, B and C, respectively. It induces dramatic growth inhibition of both wild type and G2032R mutant ROS1-rearranged cancers or NTRK-rearranged cancers in vitro and in vivo. |
| CSN23684 | Selitrectinib | 2097002-61-2 | LOXO-195 is a TRK kinase inhibitor TKI with IC50 values of 06 nM and 25 nM for TRKA and TRKC respectively |
| CSN17586 | Larotrectinib sulfate | 1223405-08-0 | LOXO-101 sulfate blocks the ATP binding site of the TRK family of receptors with IC50 of 2 nM to 20 nM against TRKA, TRKB, and TRKC. |
| CSN16968 | Larotrectinib | 1223403-58-4 | LOXO-101 is an ATP-competitive inhibitor of TRK with IC50 of nanomolar range for all the family members. |
| CSN22901 | LM22B-10 | 342777-54-2 | LM22B-10 is an agonist of TrkB and TrkC neurotrophin receptor It can improve survival and increase neurite outgrowth in vitro |
| CSN15969 | LM22A-4 | 37988-18-4 | LM22A-4 is a specific agonist oftyrosine kinase receptor B |
| CSN13940 | GW 441756 | 504433-23-2 | GW 441756 is an inhibitor of tropomyosin-related kinase A TrkA with IC50 of 2 nM |
| CSN15870 | GNF-5837 | 1033769-28-6 | GNF-5837 is a potent pan-Trk inhibitor which display antiproliferative effects in cellular BaF3 assays IC50 values are 7 9 and 11 nM for cells containing the fusion proteins Tel-TrkC Tel-TrkB and Tel-TrkA respectively |
| CSN20507 | Gnf-8625 | 1196546-33-4 | GNE-8525 is a potent and selective pan-TRK inhibitor demonstrated potent antiproliferation activity with IC50 0003 M In a tumor xenograft model derived from the KM12 cell line GNE-8525 demonstrated in vivo antitumor efficacy when administered at ascending doses twice daily bid for 14 days in rats |
| CSN12423 | Danusertib | 827318-97-8 | Danusertib is a pyrrolo-pyrazole and small molecule Aurora kinases inhibitor with IC50 of 13, 79, and 61 nM for Aurora A, B, and C, respectively. It is modestly potent to Abl, TrkA, c-RET and FGFR1, and less potent to Lck, VEGFR2/3, c-Kit, CDK2, etc. |
| CSN22125 | AZ-23 | 915720-21-7 | AZ-23 is a potent orally bioavailable Trk kinase inhibitor with IC50s of 2 nM TrkA 8 nM TrkB 24 nM FGFR1 52 nM Flt3 55 nM Ret 84 nM MuSk 99 nM Lck respectively |
| CSN15752 | ANA-12 | 219766-25-3 | ANA-12 is antagonist of TrkB with Kd of 10 nM |
| CSN10171 | 7,8-Dihydroxyflavone | 38183-03-8 | 78-Dihydroxyflavone acts as an agonist of TrkB receptor with Kd of 320 nM with neuroprotective effect |
| CSN40201 | N-Acetyl-5-hydroxytryptamine | 1210-83-9 | |
| CSN38326 | TrkA-IN-1 | 1680179-43-4 | |
| CSN34279 | PF-6683324 | 1799788-94-5 | |
| CSN34108 | Tavilermide | 263251-78-1 | |
| CSN34293 | PF-06737007 | 1863905-38-7 | |
| CSN51415 | 2-(2,6-Dioxopiperidin-3-yl)-4-((2-(3-(4-(6-(6-((R)-2-(3-fluorophenyl)pyrrolidin-1-yl)imidazo[1,2-b]pyridazin-3-yl)pyridin-2-yl)piperazin-1-yl)-3-oxopropoxy)ethyl)amino)isoindoline-1,3-dione | 2412055-93-5 | |
| CSN67217 | hTrkA-IN-1 | 1824664-89-2 | |
| CSN85443 | (3S,4R)-PF-6683324 | 1799789-00-6 |
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