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Topoisomerase
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN18021 | Voreloxin | 175414-77-4 | Voreloxin is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II. |
| CSN18023 | Voreloxin HCl | 175519-16-1 | Voreloxin HCl is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II. |
| CSN10116 | Valrubicin | 56124-62-0 | Valrubicin is a chemotherapy drug used to treat bladder cancer |
| CSN12236 | Topotecan HCl | 119413-54-6 | Topotecan HCl is the first topoisomerase I-directed cytotoxic agent to enter clinical trials in the United States. |
| CSN12049 | Teniposide | 29767-20-2 | Teniposide, a derivative of podophyllotoxin, can interact with DNA topoisomerase II and is used in cancer medicine. |
| CSN13079 | Rubitecan | 91421-42-0 | Rubitecan is an oral topoisomerase inhibitor. |
| CSN14282 | Podocarpusflavone A | 22136-74-9 | Podocarpusflavone A is a DNA topoisomerase I inhibitor isolated and purified from the barks of Podocarpus macrophyllus and is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever |
| CSN13759 | PNU-159682 | 202350-68-3 | PNU-159682 a highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity is a topoisomerase inhibitor and ADCs cytotoxin |
| CSN12328 | Pixantrone | 144510-96-3 | Pixantrone is an experimental antineoplastic drug. |
| CSN16100 | Pefloxacin Mesylate Dihydrate | 149676-40-4 | Pefloxacin mesylate, antibacterial agent, can prevent bacterial DNA replication via inhibiting DNA gyrase or topoisomerse. |
| CSN25281 | NSC745887 | 54490-26-5 | NSC745887 can effectively inhibit the proliferation of various cancers by trapping DNA-topoisomerase cleavage. NSC745887 reduced the cell survival rate and increased the sub-G1 population in dose- and time-dependent manners in GBM cells. Moreover, NSC745887 increased expression of γH2AX and caused DNA fragmentation leading to DNA damage.NSC745887 caused apoptosis by the caspase-8/9-caspase-3-poly(ADP-ribose) polymerase cascade. |
| CSN10393 | Nitroxoline | 4008-48-4 | Nitroxoline is an antibiotic towards gram negative bacilli and can to treat the urinary tract infections. |
| CSN11514 | Nalidixic Acid | 389-08-2 | Nalidixic acid, synthetic 1,8-naphthyridine, is a spectrum antimicrobial agent. |
| CSN27362 | Nalidixic acid sodium salt | 3374-05-8 | Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria. |
| CSN16703 | Nadifloxacin | 124858-35-1 | Nadifloxacin is a fluoroquinolone broad-spectrum antibacterial, working by inhibiting the enzyme DNA gyrase and thus inhibiting the bacterial multiplication. |
| CSN11453 | Mitoxantrone 2HCl | 70476-82-3 | Mitoxantrone 2HCl is an inhibitor of type II topoisomerase with antineoplastic activity. |
| CSN11362 | Marbofloxacin | 115550-35-1 | Marbofloxacin can inhibit DNA-gyrase and it is an antibiotic |
| CSN14568 | Lauterine | 28200-65-9 | Lauterine is a natural DNA topoisomerase inhibitor isolated and purified from the plants of Guatteria elata R. E. Fries. |
| CSN19462 | Irinotecan | 97682-44-5 | Irinotecan is a camptothecin analog prevents DNA from unwinding by inhibition of topoisomerase 1. |
| CSN19463 | Irinotecan HCl | 100286-90-6 | Irinotecan HCl is an inhibitor of topoisomerase 1 that prevents DNA from unwinding. |
| CSN12634 | Irinotecan HCl 3H2O | 136572-09-3 | Irinotecan HCl inhibits topoisomerase 1 and prevent DNA from unwinding. |
| CSN21689 | Intoplicine | 125974-72-3 | Intoplicine is a DNA topoisomerase I and II inhibitor potentially for the treatment of cancer. |
| CSN17751 | INNO-206 | 1361644-26-9 | INNO-206 is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. |
| CSN16766 | Idarubicin HCl | 57852-57-0 | Idarubicin HCl is a HCl salt form of idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay. |
| CSN21909 | 1,8-Naphthyridine-3-carboxylic acid, 7-[3-(aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, monomethanesulfonate, hydrate (2:3) | 210353-56-3 | Gemifloxacin mesylate inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. |
| CSN12573 | Gatifloxacin | 112811-59-3 | Gatifloxacin inhibits DNA gyrase and topoisomerase IV in bacterial. It is an antibiotic of the fourth-generation fluoroquinolone family. |
| CSN11026 | Flumequine | 42835-25-6 | Flumequine is a topoisomerase II inhibitor with IC50 of 15 M It is a synthetic chemotherapeutic antibiotic |
| CSN16298 | Etoposide | 33419-42-0 | Etoposide inhibits DNA synthesis by inhibiting topoisomerase II (IC50 60.3 M). |
| CSN10908 | Enoxacin | 74011-58-8 | Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent. |
| CSN12607 | Doxorubicin | 23214-92-8 | Doxorubicin is a topoisomerase II Top2 catalytic inhibitor also is a broad spectrum antibiotic used in the treatment of cancers with IC50 of 374 nM for Hela cells |
| CSN16255 | Doxorubicin HCl | 25316-40-9 | Doxorubicin HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells. |
| CSN17904 | DOXO-EMCH | 151038-96-9 | DOXO-EMCH is a 6-maleimidocaproyl hydrazone derivative of Doxorubicin, is an albumin binding prodrug. |
| CSN10750 | Daunorubicin | 20830-81-3 | Daunorubicin, a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 M. |
| CSN16731 | Daunorubicin HCl | 23541-50-6 | Daunorubicin HCl can inhibit both DNA synthesis (Ki = 0.02 μM) and RNA synthesis. |
| CSN10163 | Clinafloxacin | 105956-97-6 | Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae. |
| CSN13048 | Ciprofloxacin | 85721-33-1 | Ciprofloxacin is a fluoroquinolone antibiotic shows broad and potent antibacterial activity with MIC90 of 0024-6 M |
| CSN16581 | Campathecin | 7689-03-4 | Camptothecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 M for breast cancer cell line MDA-MB-231. |
| CSN21384 | BNP 1350 | 203923-89-1 | BNP 1350 is a topoisomerase I inhibitor, with potent anti-cancer activity. |
| CSN21568 | Belotecan HCl | 213819-48-8 | Belotecan hydrochloride, a synthetic and water-soluble camptothecin derivative, is inhibitor of topoisomerase I. |
| CSN10306 | Amsacrine HCl | 54301-15-4 | Amsacrine HCl is an antineoplastic agent which can intercalate into the DNA of tumor cells. |
| CSN18312 | Amsacrine | 51264-14-3 | Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity. |
| CSN10293 | Amonafide | 69408-81-7 | Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. |
| CSN20400 | AEZS-108 | 139570-93-7 | AEZS-108 is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R). |
| CSN20398 | Aclarubicin | 57576-44-0 | Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. |
| CSN20399 | Aclarubicin HCl | 75443-99-1 | Aclarubicin HCl is the HCl salt of aclarubicin, an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. |
| CSN13080 | 9-Aminocamptothecin | 91421-43-1 | 9-Aminocamptothecin, a natural product isolated and purified from the barks of Camptotheca acuminata Decne, is an active derivative of camptothecin, which belongs to the general group of chemotherapy drugs called topoisomerase inhibitors. 9-Aminocamptothecin is an inhibitor of Topo I. |
| CSN10176 | 7-Ethylcamptothecin | 78287-27-1 | 7-Ethylcamptothecin is derived from Camptothecin with anti-cancer activity against various murine tumors through inhibition of Topo I topoisomerase |
| CSN15244 | 3-O-trans-p-Coumaroyltormentic Acid | 121064-78-6 | 3-O-trans-p-Coumaroyltormentic acid, a natural product isolated and purified from the leaves of Eriobotrya japonica calli, induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition, and may be promising lead compound for developing an effective drug for treatment of leukemia. |
| CSN12283 | β-Lapachone | 4707-32-8 | -Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties and a potent inhibitor of IDO1 (IC500.44 M). |
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