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Topoisomerase

Topoisomerase

Cat. No. Product Name CAS No. Information
CSN26782 Zabofloxacin hydrochloride 623574-00-5 Zabofloxacin, also known as DW-224; DW-224a; PB-101, is DNA topoisomerase IV inhibitor potentially for the treatment of chronic obstructive pulmonary disease. Zabofloxacin shows activity for multidrug-resistant infections due to Gram-positive bacteria. Zabofloxacin has a broad spectrum of antimicrobial activity, which is especially potent against Gram-positive bacteria.
CSN18023 Voreloxin Hydrochloride 175519-16-1 Voreloxin HCl is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II.
CSN12328 Pixantrone free base 144510-96-3 Pixantrone is an experimental antineoplastic drug.
CSN32496 PEN-866 1472614-83-7 PEN-866 is a novel esterase-cleavable conjugate of an HSP90i and a topoisomerase I inhibitor.
CSN16100 Pefloxacin mesylate dihydrate   149676-40-4 Pefloxacin mesylate, antibacterial agent, can prevent bacterial DNA replication via inhibiting DNA gyrase or topoisomerse.
CSN25281 NSC745887 54490-26-5 NSC745887 can effectively inhibit the proliferation of various cancers by trapping DNA-topoisomerase cleavage. NSC745887 reduced the cell survival rate and increased the sub-G1 population in dose- and time-dependent manners in GBM cells. Moreover, NSC745887 increased expression of γH2AX and caused DNA fragmentation leading to DNA damage.NSC745887 caused apoptosis by the caspase-8/9-caspase-3-poly(ADP-ribose) polymerase cascade.
CSN10393 Nitroxoline   4008-48-4 Nitroxoline is an antibiotic towards gram negative bacilli and can to treat the urinary tract infections.
CSN11514 Nalidixic acid   389-08-2 Nalidixic acid, synthetic 1,8-naphthyridine, is a spectrum antimicrobial agent.
CSN27362 Nalidixic acid sodium salt 3374-05-8 Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria.
CSN14568 Lauterine 28200-65-9 Lauterine is a natural DNA topoisomerase inhibitor isolated and purified from the plants of Guatteria elata R. E. Fries.
CSN21689 Intoplicine 125974-72-3 Intoplicine is a DNA topoisomerase I and II inhibitor potentially for the treatment of cancer. 
CSN12573 Gatifloxacin   112811-59-3 Gatifloxacin inhibits DNA gyrase and topoisomerase IV in bacterial. It is an antibiotic of the fourth-generation fluoroquinolone family.
CSN26783 Etoposide phosphate disodium 122405-33-8 Etoposide phosphate disodium (BMY-40481 disodium) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate disodium is the phosphate ester prodrug of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate disodium induces cell cycle arrest, apoptosis, and autophagy[1][2].
CSN10908 Enoxacin 74011-58-8 Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
CSN10163 Clinafloxacin 105956-97-6 Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae.
CSN21384 Karenitecin 203923-89-1 BNP 1350 is a topoisomerase I inhibitor, with potent anti-cancer activity.
CSN32410 Berubicin HCl 293736-67-1 Berubicin hydrochloride is the hydrochloride salt of the anthracycline derivative berubicin with potential antineoplastic activity.
CSN26396 Banoxantrone dihydrochloride 252979-56-9 Banoxantrone dihydrochloride is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.
CSN18312 Amsacrine   51264-14-3 Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity.
CSN26781 MC-DOXHZN hydrochloride 480998-12-7 Aldoxorubicin, also known as INNO-206 and Doxo-EMCH, is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin with antineoplastic activity. INNO-206 binds selectively to the cysteine-34 position of albumin via its maleimide moiety. Doxorubicin is released from the albumin carrier after cleavage of the acid-sensitive hydrazone linker within the acidic environment of tumors and, once located intracellularly, intercalates DNA, inhibits DNA synthesis, and induces apoptosis. Albumin tends to accumulate in solid tumors as a result of high metabolic turnover, rapid angiogenesis, hyervasculature, and impaired lymphatic drainage. Because of passive accumulation within tumors, this agent may improve the therapeutic effects of doxorubicin while minimizing systemic toxicity.
CSN20399 Aclacinomycin A hydrochloride 75443-99-1 Aclarubicin HCl is the HCl salt of aclarubicin, an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus.
CSN24441 Aurintricarboxylic acid 4431-00-9
CSN42220 Propanoic acid, 3-ethoxy-, 10-[[6-deoxy-2-O-(6-deoxy-3-O-methyl-α-D-galactopyranosyl)-3,4-O-[(S)-phenylmethylene]-β-D-galactopyranosyl]oxy]-5,12-dihydro-1-methyl-5,12-dioxobenzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-6-yl ester 128201-92-3
CSN68192 Intoplicine dimesylate 133711-99-6
CSN73211 (5R,5aR,8aS,9S)-5-(4-Hydroxy-3,5-dimethoxyphenyl)-9-((4-nitrophenyl)amino)-5,5a,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one 127882-73-9
CSN87898 Belotecan 256411-32-2
CSN86599 4,4'-((2R,3S)-Butane-2,3-diyl)bis(piperazine-2,6-dione) 21416-68-2
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