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Topoisomerase

Topoisomerase

Cat. No. Product Name CAS No. Information
CSN18021 Voreloxin 175414-77-4 Voreloxin is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II.
CSN18023 Voreloxin HCl 175519-16-1 Voreloxin HCl is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II.
CSN12049 Teniposide 29767-20-2 Teniposide, a derivative of podophyllotoxin, can interact with DNA topoisomerase II and is used in cancer medicine.
CSN12328 Pixantrone 144510-96-3 Pixantrone is an experimental antineoplastic drug.
CSN32496 PEN-866 1472614-83-7 PEN-866 is a novel esterase-cleavable conjugate of an HSP90i and a topoisomerase I inhibitor.
CSN16100 Pefloxacin Mesylate Dihydrate   149676-40-4 Pefloxacin mesylate, antibacterial agent, can prevent bacterial DNA replication via inhibiting DNA gyrase or topoisomerse.
CSN25281 NSC745887 54490-26-5 NSC745887 can effectively inhibit the proliferation of various cancers by trapping DNA-topoisomerase cleavage. NSC745887 reduced the cell survival rate and increased the sub-G1 population in dose- and time-dependent manners in GBM cells. Moreover, NSC745887 increased expression of γH2AX and caused DNA fragmentation leading to DNA damage.NSC745887 caused apoptosis by the caspase-8/9-caspase-3-poly(ADP-ribose) polymerase cascade.
CSN10393 Nitroxoline   4008-48-4 Nitroxoline is an antibiotic towards gram negative bacilli and can to treat the urinary tract infections.
CSN11514 Nalidixic Acid   389-08-2 Nalidixic acid, synthetic 1,8-naphthyridine, is a spectrum antimicrobial agent.
CSN27362 Nalidixic acid sodium salt 3374-05-8 Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria.
CSN11453 Mitoxantrone 2HCl 70476-82-3 Mitoxantrone 2HCl is an inhibitor of type II topoisomerase with antineoplastic activity.
CSN14568 Lauterine 28200-65-9 Lauterine is a natural DNA topoisomerase inhibitor isolated and purified from the plants of Guatteria elata R. E. Fries.
CSN21689 Intoplicine 125974-72-3 Intoplicine is a DNA topoisomerase I and II inhibitor potentially for the treatment of cancer. 
CSN17751 INNO-206 1361644-26-9 INNO-206 is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity.
CSN12573 Gatifloxacin   112811-59-3 Gatifloxacin inhibits DNA gyrase and topoisomerase IV in bacterial. It is an antibiotic of the fourth-generation fluoroquinolone family.
CSN26783 Etoposide phosphate disodium 122405-33-8 Etoposide phosphate disodium (BMY-40481 disodium) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate disodium is the phosphate ester prodrug of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate disodium induces cell cycle arrest, apoptosis, and autophagy[1][2].
CSN16298 Etoposide   33419-42-0 Etoposide inhibits DNA synthesis by inhibiting topoisomerase II (IC50 60.3 M).
CSN10908 Enoxacin 74011-58-8 Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
CSN10163 Clinafloxacin 105956-97-6 Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae.
CSN21384 BNP 1350 203923-89-1 BNP 1350 is a topoisomerase I inhibitor, with potent anti-cancer activity.
CSN32410 Berubicin HCl 293736-67-1 Berubicin hydrochloride is the hydrochloride salt of the anthracycline derivative berubicin with potential antineoplastic activity.
CSN26396 BAnoxantrone (dihydrochloride) 252979-56-9 Banoxantrone dihydrochloride is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.
CSN18312 Amsacrine   51264-14-3 Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity.
CSN20399 Aclarubicin HCl 75443-99-1 Aclarubicin HCl is the HCl salt of aclarubicin, an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus.
CSN12283 β-Lapachone   4707-32-8 -Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties and a potent inhibitor of IDO1 (IC500.44 M).
CSN64524 1-Ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid mesylate dihydrate   149676-40-4
CSN24441 AURINTRICARBOXYLIC ACID 4431-00-9
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