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Topoisomerase

Topoisomerase

Cat. No. Product Name CAS No. Information
CSN18021 Voreloxin 175414-77-4 Voreloxin is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II.
CSN18023 Voreloxin HCl 175519-16-1 Voreloxin hydrochloride is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II.
CSN20008 Voacamine 3371-85-5 Voacamine isolated from the plant Tabernaemontana coronaria is an antiprotozoal agent effective against a large array of trypanosomatid parasites including Indian strain of Leishmania donovani and Brazilian strains of Leishmania amazonensis and Trypanosoma cruzi by inhibiting the relaxation activity of topoisomerase IB
CSN10116 Valrubicin 56124-62-0 Valrubicin is a chemotherapy drug used to treat bladder cancer
CSN12922 Topotecan     123948-87-8 Topotecan is an inhibitor of topoisomerase I and the IC50 values in cancer cells are less than 6 M
CSN12236 Topotecan HCl   119413-54-6 Topotecan hydrochloride is the first topoisomerase I-directed cytotoxic agent to enter clinical trials in the United States.
CSN12049 Teniposide 29767-20-2 Teniposide, a derivative of podophyllotoxin, can interact with DNA topoisomerase II and is used in cancer medicine.
CSN20053 Sabarubicin 211100-13-9 Sabarubicin is a Top II inhibitor with anticancer activity
CSN13079 Rubitecan 91421-42-0 Rubitecan is an oral topoisomerase inhibitor.
CSN14282 Podocarpusflavone A 22136-74-9 Podocarpusflavone A is a DNA topoisomerase I inhibitor isolated and purified from the barks of Podocarpus macrophyllus and is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever
CSN13759 PNU-159682 202350-68-3 PNU-159682 a highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity is a topoisomerase inhibitor and ADCs cytotoxin
CSN18629 Pirarubicin HCl 95343-20-7 Pirarubicin hydrochloride is an analogue of the anthracycline anti-neoplastic doxorubicin which is an inhibitor of Topo II
CSN16100 Pefloxacin Mesylate Dihydrate   149676-40-4 Pefloxacin mesylate, antibacterial agent, can prevent bacterial DNA replication via inhibiting DNA gyrase or topoisomerse.
CSN12979 Ofloxacin   82419-36-1 Ofloxacin a fluoroquinolone compound can inhibit bacterial DNA gyrase
CSN10393 Nitroxoline   4008-48-4 Nitroxoline is an antibiotic towards gram negative bacilli and can to treat the urinary tract infections.
CSN19751 NISC-6 2097636-49-0 NISC-6 is a napthalamide-isoselenocyanate compound which acts as a dual Topoisomerase-II and Akt pathway inhibitor
CSN11514 Nalidixic Acid   389-08-2 Nalidixic acid, synthetic 1,8-naphthyridine, is a spectrum antimicrobial agent.
CSN16703 Nadifloxacin   124858-35-1 Nadifloxacin is a fluoroquinolone broad-spectrum antibacterial, working by inhibiting the enzyme DNA gyrase and thus inhibiting the bacterial multiplication.
CSN11452 Mitoxantrone   65271-80-9 Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 20 M 042 mM for HepG2 and MCF-7wt cells respectively
CSN11453 Mitoxantrone 2HCl 70476-82-3 Mitoxantrone dihydrochloride is an inhibitor of type II topoisomerase with antineoplastic activity.
CSN11362 Marbofloxacin   115550-35-1 Marbofloxacin can inhibit DNA-gyrase and it is an antibiotic
CSN19462 Irinotecan     97682-44-5 Irinotecan is a camptothecin analog prevents DNA from unwinding by inhibition of topoisomerase 1.
CSN19463 Irinotecan HCl   100286-90-6 Irinotecan hydrochloride is an inhibitor of topoisomerase 1 that prevents DNA from unwinding.
CSN12634 Irinotecan HCl 3H2O   136572-09-3 Irinotecan hydrochloride inhibits topoisomerase 1 and prevent DNA from unwinding
CSN17751 INNO-206 1361644-26-9 INNO-206 is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity.
CSN19812 Idarubicin 58957-92-9 Idarubicin is a semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin
CSN16766 Idarubicin HCl 57852-57-0 Idarubicin hydrochloride is a hydrochloride salt form of idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ngmL in a cell-free assay.
CSN20002 Gepotidacin 1075236-89-3 Gepotidacin is a first in class triazaacenaphthylene antibiotic that inhibits bacterial type II DNA replication by inhibiting the activity of bacterial topoisomerase and has in vitro activity against susceptible and drug-resistant pathogens
CSN12573 Gatifloxacin   112811-59-3 Gatifloxacin inhibits DNA gyrase and topoisomerase IV in bacterial. It is an antibiotic of the fourth-generation fluoroquinolone family.
CSN11026 Flumequine   42835-25-6 Flumequine is a topoisomerase II inhibitor with IC50 of 15 M It is a synthetic chemotherapeutic antibiotic
CSN15938 Finafloxacin HCl 209342-41-6 Finafloxacin hydrochloride an 8-cyano subclass of fluoroquinolone has demonstrated potent antibacterial activity in a range of in vitro and in vivo models against Gram-negative and Gram-positive bacterial isolates
CSN16298 Etoposide   33419-42-0 Etoposide inhibits DNA synthesis by inhibiting topoisomerase II (IC50 60.3 M).
CSN10918 Epirubicin 56420-45-2 Epirubicin a semisynthetic L-arabino derivative of doxorubicin is an antineoplastic agent by inhibiting topoisomerase
CSN10908 Enoxacin 74011-58-8 Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
CSN12607 Doxorubicin 23214-92-8 Doxorubicin is a topoisomerase II Top2 catalytic inhibitor also is a broad spectrum antibiotic used in the treatment of cancers with IC50 of 374 nM for Hela cells
CSN16255 Doxorubicin HCl     25316-40-9 Doxorubicin hydrochloride is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
CSN17904 DOXO-EMCH 151038-96-9 DOXO-EMCH is a 6-maleimidocaproyl hydrazone derivative of Doxorubicin, is an albumin binding prodrug.
CSN10750 Daunorubicin 20830-81-3 Daunorubicin, a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 M.
CSN16731 Daunorubicin HCl   23541-50-6 Daunorubicin hydrochloride can inhibit both DNA synthesis (Ki 0.02 M) and RNA synthesis.
CSN10163 Clinafloxacin 105956-97-6 Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae.
CSN13048 Ciprofloxacin   85721-33-1 Ciprofloxacin is a fluoroquinolone antibiotic shows broad and potent antibacterial activity with MIC90 of 0024-6 M
CSN16581 Campathecin 7689-03-4 Camptothecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 M for breast cancer cell line MDA-MB-231.
CSN21384 BNP 1350 203923-89-1 BNP 1350 is a topoisomerase I inhibitor, with potent anti-cancer activity.
CSN15926 Balofloxacin Dihydrate 151060-21-8 Balofloxacin is a fluorinated quinolone antibiotic agent and a topoisomerase ligase inhibitor
CSN10306 Amsacrine HCl 54301-15-4 Amsacrine hydrochloride is an antineoplastic agent which can intercalate into the DNA of tumor cells.
CSN18312 Amsacrine   51264-14-3 Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity.
CSN10293 Amonafide 69408-81-7 Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage.
CSN10176 7-Ethylcamptothecin   78287-27-1 7-Ethylcamptothecin is derived from Camptothecin with anti-cancer activity against various murine tumors through inhibition of Topo I topoisomerase
CSN12283 β-Lapachone   4707-32-8 -Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties and a potent inhibitor of IDO1 (IC500.44 M).
CSN20400 AEZS-108 139570-93-7
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