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Topoisomerase

Topoisomerase

Cat. No. Product Name CAS No. Information
CSN18021 Voreloxin 175414-77-4 Voreloxin is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II.
CSN18023 Voreloxin HCl 175519-16-1 Voreloxin HCl is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II.
CSN10116 Valrubicin 56124-62-0 Valrubicin is a chemotherapy drug used to treat bladder cancer
CSN12236 Topotecan HCl   119413-54-6 Topotecan HCl is the first topoisomerase I-directed cytotoxic agent to enter clinical trials in the United States.
CSN12049 Teniposide 29767-20-2 Teniposide, a derivative of podophyllotoxin, can interact with DNA topoisomerase II and is used in cancer medicine.
CSN13079 Rubitecan 91421-42-0 Rubitecan is an oral topoisomerase inhibitor.
CSN14282 Podocarpusflavone A 22136-74-9 Podocarpusflavone A is a DNA topoisomerase I inhibitor isolated and purified from the barks of Podocarpus macrophyllus and is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever
CSN13759 PNU-159682 202350-68-3 PNU-159682 a highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity is a topoisomerase inhibitor and ADCs cytotoxin
CSN12328 Pixantrone 144510-96-3 Pixantrone is an experimental antineoplastic drug.
CSN16100 Pefloxacin Mesylate Dihydrate   149676-40-4 Pefloxacin mesylate, antibacterial agent, can prevent bacterial DNA replication via inhibiting DNA gyrase or topoisomerse.
CSN25281 NSC745887 54490-26-5 NSC745887 can effectively inhibit the proliferation of various cancers by trapping DNA-topoisomerase cleavage. NSC745887 reduced the cell survival rate and increased the sub-G1 population in dose- and time-dependent manners in GBM cells. Moreover, NSC745887 increased expression of γH2AX and caused DNA fragmentation leading to DNA damage.NSC745887 caused apoptosis by the caspase-8/9-caspase-3-poly(ADP-ribose) polymerase cascade.
CSN10393 Nitroxoline   4008-48-4 Nitroxoline is an antibiotic towards gram negative bacilli and can to treat the urinary tract infections.
CSN11514 Nalidixic Acid   389-08-2 Nalidixic acid, synthetic 1,8-naphthyridine, is a spectrum antimicrobial agent.
CSN27362 Nalidixic acid sodium salt 3374-05-8 Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria.
CSN16703 Nadifloxacin   124858-35-1 Nadifloxacin is a fluoroquinolone broad-spectrum antibacterial, working by inhibiting the enzyme DNA gyrase and thus inhibiting the bacterial multiplication.
CSN11453 Mitoxantrone 2HCl 70476-82-3 Mitoxantrone 2HCl is an inhibitor of type II topoisomerase with antineoplastic activity.
CSN11362 Marbofloxacin   115550-35-1 Marbofloxacin can inhibit DNA-gyrase and it is an antibiotic
CSN14568 Lauterine 28200-65-9 Lauterine is a natural DNA topoisomerase inhibitor isolated and purified from the plants of Guatteria elata R. E. Fries.
CSN19462 Irinotecan     97682-44-5 Irinotecan is a camptothecin analog prevents DNA from unwinding by inhibition of topoisomerase 1.
CSN19463 Irinotecan HCl   100286-90-6 Irinotecan HCl is an inhibitor of topoisomerase 1 that prevents DNA from unwinding.
CSN12634 Irinotecan HCl 3H2O   136572-09-3 Irinotecan HCl inhibits topoisomerase 1 and prevent DNA from unwinding.
CSN21689 Intoplicine 125974-72-3 Intoplicine is a DNA topoisomerase I and II inhibitor potentially for the treatment of cancer. 
CSN17751 INNO-206 1361644-26-9 INNO-206 is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity.
CSN16766 Idarubicin HCl 57852-57-0 Idarubicin HCl is a HCl salt form of idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay.
CSN21909 1,8-Naphthyridine-3-carboxylic acid, 7-[3-(aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, monomethanesulfonate, hydrate (2:3) 210353-56-3 Gemifloxacin mesylate inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth.
CSN12573 Gatifloxacin   112811-59-3 Gatifloxacin inhibits DNA gyrase and topoisomerase IV in bacterial. It is an antibiotic of the fourth-generation fluoroquinolone family.
CSN11026 Flumequine   42835-25-6 Flumequine is a topoisomerase II inhibitor with IC50 of 15 M It is a synthetic chemotherapeutic antibiotic
CSN16298 Etoposide   33419-42-0 Etoposide inhibits DNA synthesis by inhibiting topoisomerase II (IC50 60.3 M).
CSN10908 Enoxacin 74011-58-8 Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent.
CSN12607 Doxorubicin 23214-92-8 Doxorubicin is a topoisomerase II Top2 catalytic inhibitor also is a broad spectrum antibiotic used in the treatment of cancers with IC50 of 374 nM for Hela cells
CSN16255 Doxorubicin HCl     25316-40-9 Doxorubicin HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells.
CSN17904 DOXO-EMCH 151038-96-9 DOXO-EMCH is a 6-maleimidocaproyl hydrazone derivative of Doxorubicin, is an albumin binding prodrug.
CSN10750 Daunorubicin 20830-81-3 Daunorubicin, a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 M.
CSN16731 Daunorubicin HCl   23541-50-6 Daunorubicin HCl can inhibit both DNA synthesis (Ki = 0.02 μM) and RNA synthesis.
CSN10163 Clinafloxacin 105956-97-6 Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae.
CSN13048 Ciprofloxacin   85721-33-1 Ciprofloxacin is a fluoroquinolone antibiotic shows broad and potent antibacterial activity with MIC90 of 0024-6 M
CSN16581 Campathecin 7689-03-4 Camptothecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 M for breast cancer cell line MDA-MB-231.
CSN21384 BNP 1350 203923-89-1 BNP 1350 is a topoisomerase I inhibitor, with potent anti-cancer activity.
CSN21568 Belotecan HCl 213819-48-8 Belotecan hydrochloride, a synthetic and water-soluble camptothecin derivative, is inhibitor of topoisomerase I.
CSN10306 Amsacrine HCl 54301-15-4 Amsacrine HCl is an antineoplastic agent which can intercalate into the DNA of tumor cells.
CSN18312 Amsacrine   51264-14-3 Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity.
CSN10293 Amonafide 69408-81-7 Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage.
CSN20400 AEZS-108 139570-93-7 AEZS-108 is a peptide agonist of the gonadotropin releasing hormone-1 receptor (GnRH-1R).
CSN20398 Aclarubicin 57576-44-0 Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus.
CSN20399 Aclarubicin HCl 75443-99-1 Aclarubicin HCl is the HCl salt of aclarubicin, an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus.
CSN13080 9-Aminocamptothecin 91421-43-1 9-Aminocamptothecin, a natural product isolated and purified from the barks of Camptotheca acuminata Decne, is an active derivative of camptothecin, which belongs to the general group of chemotherapy drugs called topoisomerase inhibitors. 9-Aminocamptothecin is an inhibitor of Topo I.
CSN10176 7-Ethylcamptothecin   78287-27-1 7-Ethylcamptothecin is derived from Camptothecin with anti-cancer activity against various murine tumors through inhibition of Topo I topoisomerase
CSN15244 3-O-trans-p-Coumaroyltormentic Acid 121064-78-6 3-O-trans-p-Coumaroyltormentic acid, a natural product isolated and purified from the leaves of Eriobotrya japonica calli, induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition, and may be promising lead compound for developing an effective drug for treatment of leukemia.
CSN12283 β-Lapachone   4707-32-8 -Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties and a potent inhibitor of IDO1 (IC500.44 M).
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