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Topoisomerase
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN18021 | Voreloxin | 175414-77-4 | Voreloxin is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II. |
| CSN18023 | Voreloxin HCl | 175519-16-1 | Voreloxin hydrochloride is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II. |
| CSN20008 | Voacamine | 3371-85-5 | Voacamine isolated from the plant Tabernaemontana coronaria is an antiprotozoal agent effective against a large array of trypanosomatid parasites including Indian strain of Leishmania donovani and Brazilian strains of Leishmania amazonensis and Trypanosoma cruzi by inhibiting the relaxation activity of topoisomerase IB |
| CSN10116 | Valrubicin | 56124-62-0 | Valrubicin is a chemotherapy drug used to treat bladder cancer |
| CSN12922 | Topotecan | 123948-87-8 | Topotecan is an inhibitor of topoisomerase I and the IC50 values in cancer cells are less than 6 M |
| CSN12236 | Topotecan HCl | 119413-54-6 | Topotecan hydrochloride is the first topoisomerase I-directed cytotoxic agent to enter clinical trials in the United States. |
| CSN12049 | Teniposide | 29767-20-2 | Teniposide, a derivative of podophyllotoxin, can interact with DNA topoisomerase II and is used in cancer medicine. |
| CSN20053 | Sabarubicin | 211100-13-9 | Sabarubicin is a Top II inhibitor with anticancer activity |
| CSN13079 | Rubitecan | 91421-42-0 | Rubitecan is an oral topoisomerase inhibitor. |
| CSN14282 | Podocarpusflavone A | 22136-74-9 | Podocarpusflavone A is a DNA topoisomerase I inhibitor isolated and purified from the barks of Podocarpus macrophyllus and is the strongest noncytotoxic non-nucleotide molecule exhibiting a specific inhibitory activity against the RNA polymerase domain of DV-NS5 and thus is promising for chemotherapy development against dengue fever |
| CSN13759 | PNU-159682 | 202350-68-3 | PNU-159682 a highly potent metabolite of the anthracycline nemorubicin with outstanding cytotoxicity is a topoisomerase inhibitor and ADCs cytotoxin |
| CSN18629 | Pirarubicin HCl | 95343-20-7 | Pirarubicin hydrochloride is an analogue of the anthracycline anti-neoplastic doxorubicin which is an inhibitor of Topo II |
| CSN16100 | Pefloxacin Mesylate Dihydrate | 149676-40-4 | Pefloxacin mesylate, antibacterial agent, can prevent bacterial DNA replication via inhibiting DNA gyrase or topoisomerse. |
| CSN12979 | Ofloxacin | 82419-36-1 | Ofloxacin a fluoroquinolone compound can inhibit bacterial DNA gyrase |
| CSN10393 | Nitroxoline | 4008-48-4 | Nitroxoline is an antibiotic towards gram negative bacilli and can to treat the urinary tract infections. |
| CSN19751 | NISC-6 | 2097636-49-0 | NISC-6 is a napthalamide-isoselenocyanate compound which acts as a dual Topoisomerase-II and Akt pathway inhibitor |
| CSN11514 | Nalidixic Acid | 389-08-2 | Nalidixic acid, synthetic 1,8-naphthyridine, is a spectrum antimicrobial agent. |
| CSN16703 | Nadifloxacin | 124858-35-1 | Nadifloxacin is a fluoroquinolone broad-spectrum antibacterial, working by inhibiting the enzyme DNA gyrase and thus inhibiting the bacterial multiplication. |
| CSN11452 | Mitoxantrone | 65271-80-9 | Mitoxantrone is a type II topoisomerase inhibitor with IC50 of 20 M 042 mM for HepG2 and MCF-7wt cells respectively |
| CSN11453 | Mitoxantrone 2HCl | 70476-82-3 | Mitoxantrone dihydrochloride is an inhibitor of type II topoisomerase with antineoplastic activity. |
| CSN11362 | Marbofloxacin | 115550-35-1 | Marbofloxacin can inhibit DNA-gyrase and it is an antibiotic |
| CSN19462 | Irinotecan | 97682-44-5 | Irinotecan is a camptothecin analog prevents DNA from unwinding by inhibition of topoisomerase 1. |
| CSN19463 | Irinotecan HCl | 100286-90-6 | Irinotecan hydrochloride is an inhibitor of topoisomerase 1 that prevents DNA from unwinding. |
| CSN12634 | Irinotecan HCl 3H2O | 136572-09-3 | Irinotecan hydrochloride inhibits topoisomerase 1 and prevent DNA from unwinding |
| CSN17751 | INNO-206 | 1361644-26-9 | INNO-206 is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. |
| CSN19812 | Idarubicin | 58957-92-9 | Idarubicin is a semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin |
| CSN16766 | Idarubicin HCl | 57852-57-0 | Idarubicin hydrochloride is a hydrochloride salt form of idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ngmL in a cell-free assay. |
| CSN20002 | Gepotidacin | 1075236-89-3 | Gepotidacin is a first in class triazaacenaphthylene antibiotic that inhibits bacterial type II DNA replication by inhibiting the activity of bacterial topoisomerase and has in vitro activity against susceptible and drug-resistant pathogens |
| CSN12573 | Gatifloxacin | 112811-59-3 | Gatifloxacin inhibits DNA gyrase and topoisomerase IV in bacterial. It is an antibiotic of the fourth-generation fluoroquinolone family. |
| CSN11026 | Flumequine | 42835-25-6 | Flumequine is a topoisomerase II inhibitor with IC50 of 15 M It is a synthetic chemotherapeutic antibiotic |
| CSN15938 | Finafloxacin HCl | 209342-41-6 | Finafloxacin hydrochloride an 8-cyano subclass of fluoroquinolone has demonstrated potent antibacterial activity in a range of in vitro and in vivo models against Gram-negative and Gram-positive bacterial isolates |
| CSN16298 | Etoposide | 33419-42-0 | Etoposide inhibits DNA synthesis by inhibiting topoisomerase II (IC50 60.3 M). |
| CSN10918 | Epirubicin | 56420-45-2 | Epirubicin a semisynthetic L-arabino derivative of doxorubicin is an antineoplastic agent by inhibiting topoisomerase |
| CSN10908 | Enoxacin | 74011-58-8 | Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent. |
| CSN12607 | Doxorubicin | 23214-92-8 | Doxorubicin is a topoisomerase II Top2 catalytic inhibitor also is a broad spectrum antibiotic used in the treatment of cancers with IC50 of 374 nM for Hela cells |
| CSN16255 | Doxorubicin HCl | 25316-40-9 | Doxorubicin hydrochloride is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells. |
| CSN17904 | DOXO-EMCH | 151038-96-9 | DOXO-EMCH is a 6-maleimidocaproyl hydrazone derivative of Doxorubicin, is an albumin binding prodrug. |
| CSN10750 | Daunorubicin | 20830-81-3 | Daunorubicin, a topoisomerase II inhibitor, inhibits both DNA and RNA synthesis and inhibits DNA synthesis with Ki of 0.02 M. |
| CSN16731 | Daunorubicin HCl | 23541-50-6 | Daunorubicin hydrochloride can inhibit both DNA synthesis (Ki 0.02 M) and RNA synthesis. |
| CSN10163 | Clinafloxacin | 105956-97-6 | Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae. |
| CSN13048 | Ciprofloxacin | 85721-33-1 | Ciprofloxacin is a fluoroquinolone antibiotic shows broad and potent antibacterial activity with MIC90 of 0024-6 M |
| CSN16581 | Campathecin | 7689-03-4 | Camptothecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 M for breast cancer cell line MDA-MB-231. |
| CSN21384 | BNP 1350 | 203923-89-1 | BNP 1350 is a topoisomerase I inhibitor, with potent anti-cancer activity. |
| CSN15926 | Balofloxacin Dihydrate | 151060-21-8 | Balofloxacin is a fluorinated quinolone antibiotic agent and a topoisomerase ligase inhibitor |
| CSN10306 | Amsacrine HCl | 54301-15-4 | Amsacrine hydrochloride is an antineoplastic agent which can intercalate into the DNA of tumor cells. |
| CSN18312 | Amsacrine | 51264-14-3 | Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity. |
| CSN10293 | Amonafide | 69408-81-7 | Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. |
| CSN10176 | 7-Ethylcamptothecin | 78287-27-1 | 7-Ethylcamptothecin is derived from Camptothecin with anti-cancer activity against various murine tumors through inhibition of Topo I topoisomerase |
| CSN12283 | β-Lapachone | 4707-32-8 | -Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties and a potent inhibitor of IDO1 (IC500.44 M). |
| CSN20400 | AEZS-108 | 139570-93-7 |
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