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Topoisomerase
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN18021 | Voreloxin | 175414-77-4 | Voreloxin is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II. |
| CSN18023 | Voreloxin HCl | 175519-16-1 | Voreloxin HCl is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II. |
| CSN12236 | Topotecan HCl | 119413-54-6 | Topotecan HCl is the first topoisomerase I-directed cytotoxic agent to enter clinical trials in the United States. |
| CSN12049 | Teniposide | 29767-20-2 | Teniposide, a derivative of podophyllotoxin, can interact with DNA topoisomerase II and is used in cancer medicine. |
| CSN13079 | Rubitecan | 91421-42-0 | Rubitecan is an oral topoisomerase inhibitor. |
| CSN12328 | Pixantrone | 144510-96-3 | Pixantrone is an experimental antineoplastic drug. |
| CSN16100 | Pefloxacin Mesylate Dihydrate | 149676-40-4 | Pefloxacin mesylate, antibacterial agent, can prevent bacterial DNA replication via inhibiting DNA gyrase or topoisomerse. |
| CSN25281 | NSC745887 | 54490-26-5 | NSC745887 can effectively inhibit the proliferation of various cancers by trapping DNA-topoisomerase cleavage. NSC745887 reduced the cell survival rate and increased the sub-G1 population in dose- and time-dependent manners in GBM cells. Moreover, NSC745887 increased expression of γH2AX and caused DNA fragmentation leading to DNA damage.NSC745887 caused apoptosis by the caspase-8/9-caspase-3-poly(ADP-ribose) polymerase cascade. |
| CSN10393 | Nitroxoline | 4008-48-4 | Nitroxoline is an antibiotic towards gram negative bacilli and can to treat the urinary tract infections. |
| CSN11514 | Nalidixic Acid | 389-08-2 | Nalidixic acid, synthetic 1,8-naphthyridine, is a spectrum antimicrobial agent. |
| CSN27362 | Nalidixic acid sodium salt | 3374-05-8 | Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria. |
| CSN16703 | Nadifloxacin | 124858-35-1 | Nadifloxacin is a fluoroquinolone broad-spectrum antibacterial, working by inhibiting the enzyme DNA gyrase and thus inhibiting the bacterial multiplication. |
| CSN11453 | Mitoxantrone 2HCl | 70476-82-3 | Mitoxantrone 2HCl is an inhibitor of type II topoisomerase with antineoplastic activity. |
| CSN23384 | Levofloxacin HCl | 177325-13-2 | Levofloxacin HCl a fluoroquinolone antibiotic is an inhibitor of DNA gyrase and topoisomerase IV |
| CSN14568 | Lauterine | 28200-65-9 | Lauterine is a natural DNA topoisomerase inhibitor isolated and purified from the plants of Guatteria elata R. E. Fries. |
| CSN19462 | Irinotecan | 97682-44-5 | Irinotecan is a camptothecin analog prevents DNA from unwinding by inhibition of topoisomerase 1. |
| CSN19463 | Irinotecan HCl | 100286-90-6 | Irinotecan HCl is an inhibitor of topoisomerase 1 that prevents DNA from unwinding. |
| CSN21689 | Intoplicine | 125974-72-3 | Intoplicine is a DNA topoisomerase I and II inhibitor potentially for the treatment of cancer. |
| CSN16766 | Idarubicin HCl | 57852-57-0 | Idarubicin HCl is a HCl salt form of idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL in a cell-free assay. |
| CSN21909 | 1,8-Naphthyridine-3-carboxylic acid, 7-[3-(aminomethyl)-4-(methoxyimino)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-, monomethanesulfonate, hydrate (2:3) | 210353-56-3 | Gemifloxacin mesylate inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. |
| CSN12573 | Gatifloxacin | 112811-59-3 | Gatifloxacin inhibits DNA gyrase and topoisomerase IV in bacterial. It is an antibiotic of the fourth-generation fluoroquinolone family. |
| CSN16298 | Etoposide | 33419-42-0 | Etoposide inhibits DNA synthesis by inhibiting topoisomerase II (IC50 60.3 M). |
| CSN10908 | Enoxacin | 74011-58-8 | Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent. |
| CSN16255 | Doxorubicin HCl | 25316-40-9 | Doxorubicin HCl is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis in tumor cells. |
| CSN16731 | Daunorubicin HCl | 23541-50-6 | Daunorubicin HCl can inhibit both DNA synthesis (Ki = 0.02 μM) and RNA synthesis. |
| CSN10163 | Clinafloxacin | 105956-97-6 | Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae. |
| CSN16581 | Campathecin | 7689-03-4 | Camptothecin is a potent DNA enzyme topoisomerase I (topo I) inhibitor with an IC50 and IC70 of 50 nM and 0.225 M for breast cancer cell line MDA-MB-231. |
| CSN21568 | Belotecan HCl | 213819-48-8 | Belotecan hydrochloride, a synthetic and water-soluble camptothecin derivative, is inhibitor of topoisomerase I. |
| CSN10306 | Amsacrine HCl | 54301-15-4 | Amsacrine HCl is an antineoplastic agent which can intercalate into the DNA of tumor cells. |
| CSN18312 | Amsacrine | 51264-14-3 | Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity. |
| CSN10293 | Amonafide | 69408-81-7 | Amonafide produces protein-associated DNA-strand breaks through a topoisomerase II-mediated reaction, but does not produce topoisomerase I-mediated DNA cleavage. |
| CSN20398 | Aclarubicin | 57576-44-0 | Aclarubicin is an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. |
| CSN20399 | Aclarubicin HCl | 75443-99-1 | Aclarubicin HCl is the HCl salt of aclarubicin, an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. |
| CSN13080 | 9-Aminocamptothecin | 91421-43-1 | 9-Aminocamptothecin, a natural product isolated and purified from the barks of Camptotheca acuminata Decne, is an active derivative of camptothecin, which belongs to the general group of chemotherapy drugs called topoisomerase inhibitors. 9-Aminocamptothecin is an inhibitor of Topo I. |
| CSN12283 | β-Lapachone | 4707-32-8 | -Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties and a potent inhibitor of IDO1 (IC500.44 M). |
| CSN20799 | 10-Hydroxycamptothecin | 64439-81-2 | -10-Hydroxycamptothecin is an inhibitor of topoisomerase I and can affect phosphorylation of histone H1 and H3 with anticancer activity It can be isolated from camptotheca acuminate |
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