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Topoisomerase
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN18021 | Voreloxin | 175414-77-4 | Voreloxin is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II. |
| CSN18023 | Voreloxin HCl | 175519-16-1 | Voreloxin HCl is a naphthyridine analogue with antineoplastic activity and an inhibitor of Topo II. |
| CSN12049 | Teniposide | 29767-20-2 | Teniposide, a derivative of podophyllotoxin, can interact with DNA topoisomerase II and is used in cancer medicine. |
| CSN12328 | Pixantrone | 144510-96-3 | Pixantrone is an experimental antineoplastic drug. |
| CSN32496 | PEN-866 | 1472614-83-7 | PEN-866 is a novel esterase-cleavable conjugate of an HSP90i and a topoisomerase I inhibitor. |
| CSN16100 | Pefloxacin Mesylate Dihydrate | 149676-40-4 | Pefloxacin mesylate, antibacterial agent, can prevent bacterial DNA replication via inhibiting DNA gyrase or topoisomerse. |
| CSN25281 | NSC745887 | 54490-26-5 | NSC745887 can effectively inhibit the proliferation of various cancers by trapping DNA-topoisomerase cleavage. NSC745887 reduced the cell survival rate and increased the sub-G1 population in dose- and time-dependent manners in GBM cells. Moreover, NSC745887 increased expression of γH2AX and caused DNA fragmentation leading to DNA damage.NSC745887 caused apoptosis by the caspase-8/9-caspase-3-poly(ADP-ribose) polymerase cascade. |
| CSN10393 | Nitroxoline | 4008-48-4 | Nitroxoline is an antibiotic towards gram negative bacilli and can to treat the urinary tract infections. |
| CSN11514 | Nalidixic Acid | 389-08-2 | Nalidixic acid, synthetic 1,8-naphthyridine, is a spectrum antimicrobial agent. |
| CSN27362 | Nalidixic acid sodium salt | 3374-05-8 | Nalidixic acid sodium salt, a quinolone antibiotic, is effective against both gram-positive and gram-negative bacteria. Nalidixic acid acts in a bacteriostatic manner in lower concentrations and is bactericidal in higher concentrations. Nalidixic acid inhibits a subunit of DNA gyrase and topoisomerase IV and reversibly blocks DNA replication in susceptible bacteria. |
| CSN11453 | Mitoxantrone 2HCl | 70476-82-3 | Mitoxantrone 2HCl is an inhibitor of type II topoisomerase with antineoplastic activity. |
| CSN14568 | Lauterine | 28200-65-9 | Lauterine is a natural DNA topoisomerase inhibitor isolated and purified from the plants of Guatteria elata R. E. Fries. |
| CSN21689 | Intoplicine | 125974-72-3 | Intoplicine is a DNA topoisomerase I and II inhibitor potentially for the treatment of cancer. |
| CSN17751 | INNO-206 | 1361644-26-9 | INNO-206 is the 6-maleimidocaproyl hydrazone derivative prodrug of the anthracycline antibiotic doxorubicin (DOXO-EMCH) with antineoplastic activity. |
| CSN12573 | Gatifloxacin | 112811-59-3 | Gatifloxacin inhibits DNA gyrase and topoisomerase IV in bacterial. It is an antibiotic of the fourth-generation fluoroquinolone family. |
| CSN26783 | Etoposide phosphate disodium | 122405-33-8 | Etoposide phosphate disodium (BMY-40481 disodium) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate disodium is the phosphate ester prodrug of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate disodium induces cell cycle arrest, apoptosis, and autophagy[1][2]. |
| CSN16298 | Etoposide | 33419-42-0 | Etoposide inhibits DNA synthesis by inhibiting topoisomerase II (IC50 60.3 M). |
| CSN10908 | Enoxacin | 74011-58-8 | Enoxacin is a broad-spectrum 6-fluoronaphthyridinone antibacterial agent. |
| CSN10163 | Clinafloxacin | 105956-97-6 | Clinafloxacin is a fluoroquinolone that inhibits both DNA gyrase and topoisomerase IV dually in Streptococcus pneumoniae. |
| CSN21384 | BNP 1350 | 203923-89-1 | BNP 1350 is a topoisomerase I inhibitor, with potent anti-cancer activity. |
| CSN32410 | Berubicin HCl | 293736-67-1 | Berubicin hydrochloride is the hydrochloride salt of the anthracycline derivative berubicin with potential antineoplastic activity. |
| CSN26396 | BAnoxantrone (dihydrochloride) | 252979-56-9 | Banoxantrone dihydrochloride is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor. |
| CSN18312 | Amsacrine | 51264-14-3 | Amsacrine can intercalate into the DNA of tumor cells with antineoplastic activity. |
| CSN20399 | Aclarubicin HCl | 75443-99-1 | Aclarubicin HCl is the HCl salt of aclarubicin, an oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces galilaeus. |
| CSN12283 | β-Lapachone | 4707-32-8 | -Lapachone is a naturally occurring quinone obtained from the bark of the lapacho tree (Tabebuia avellanedae) with cancer chemopreventive properties and a potent inhibitor of IDO1 (IC500.44 M). |
| CSN64524 | 1-Ethyl-6-fluoro-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid mesylate dihydrate | 149676-40-4 | |
| CSN24441 | AURINTRICARBOXYLIC ACID | 4431-00-9 |
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