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TNF-alpha
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN15856 | VGX-1027 | 6501-72-0 | VGX-1027 is an orally active immunomodulatory agent that primarily targets macrophages, it can inhibit TNF- secretion via interference of macrophage toll-like receptor (TLR) 4 and TLR 26 signaling pathway. VGX-1027 also reduces the secretion of pro-inflammatory cytokines IL1-, IL-10 and IFN-. |
| CSN22521 | TNF-α-IN-1 | 444287-49-4 | TNF--IN-1 is a TNF- inhibitor extracted from patent US20030096841A1, compound example I-7. |
| CSN12073 | Thalidomide | 50-35-1 | Thalidomide targets to CRBN with IC50 of 85 nM It can inhibit biosynthesis of TNF- and has anti-angiogenic and immunosuppressive effects |
| CSN51354 | SM-7368 | 380623-76-7 | SM-7368 inhibits TNF-alpha-induced MMP-9 upregulation in a concentration-dependent manner. |
| CSN23727 | S-99 | 1124381-69-6 | S-99 is an inhibitor of LPS-induced TNFalpha release. |
| CSN11309 | Roquinimex | 84088-42-6 | Roquinimex is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity and inhibits angiogenesis and reduces the secretion of TNF alpha. |
| CSN21166 | R-7050 | 303997-35-5 | R-7050 is an antagonist of tumor necrosis factor receptor TNFR that towards TNF |
| CSN12289 | QNZ | 545380-34-5 | QNZ can inhibit the activation of NF-κB and the production of TNF-α with IC50 of 11 nM and 7 nM, respectively. |
| CSN13185 | Pomalidomide | 19171-19-8 | Pomalidomide can inhibit LPS-induced TNF- release with IC50 of 13 nM in PBMCs. |
| CSN13185 | Pomalidomide | 19171-19-8 | Pomalidomide can inhibit LPS-induced TNF- release with IC50 of 13 nM in PBMCs. |
| CSN15896 | PF-3644022 | 1276121-88-0 | PF-3644022 is a potent ATP-competitive inhibitor of mitogen-activated protein kinase MAPK-activated protein kinase-2 MK2 IC50 52 nM and Ki 3 nM It inhibits tumor necrosis factor TNF production in U937 monocytic cells and peripheral blood mononuclear cells PBMCs IC50 160 nM and exhibits oral efficacy in acute and chronic inflammatory models |
| CSN22471 | Nedocromil sodium | 69049-74-7 | Nedocromil Sodium is a potent TNF- inhibitor with an IC50 value of 1.67 M for Blood eosinophils. |
| CSN18474 | Necrostatin 2 S enantiomer | 852391-20-9 | Necrostatin 2 S enantiomer is a potent necroptosis inhibitor with EC50 of 50 nM |
| CSN15733 | Necrostatin 2 racemate | 852391-15-2 | Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM |
| CSN18473 | Necrostatin 2 | 852391-19-6 | Necrostatin 2 is a potent necroptosis inhibitor EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF- is 005 M |
| CSN17616 | Lenalidomide hydrochloride | 1243329-97-6 | Lenalidomide is a TNF- secretion inhibitor with IC50 of 13 nM |
| CSN18463 | Lenalidomide hemihydrate | 847871-99-2 | Lenalidomide is a potent inhibitor of TNF- and has antiangiogenic effect |
| CSN11280 | Lenalidomide | 191732-72-6 | Lenalidomide a analog of thalidomide is TNF- secretion inhibitor with IC50 of 13 nM |
| CSN11280 | Lenalidomide | 191732-72-6 | Lenalidomide a analog of thalidomide is TNF- secretion inhibitor with IC50 of 13 nM |
| CSN26222 | Homoplantaginin | 17680-84-1 | Homoplantaginin, a main flavonoid from a traditional Chinese medicine Salvia plebeia, has anti-inflammatory and anti-oxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation. Homoplantaginin ameliorates endothelial insulin resistance by inhibiting inflammation and modulating cell signalling via the IKKβ/IRS-1/pAkt/peNOS pathway. |
| CSN17960 | GSK481 | 1622849-58-4 | GSK481 can inhibit RIP1 WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells |
| CSN26529 | GSK2245035 | 1207629-49-9 | GSK2245035 is a selective Toll-like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 displays extraordinary IFNα inducing potency and IFNα/TNFα selectivity. GSK2245035 shows excellent pharmaceutical properties that allow reliable delivery of doses as low as 1 ng per actuation of an intranasal spray formulation. Intranasal GSK2245035 has an acceptable safety profile at doses that induce local TLR7-mediated immune responses. |
| CSN14854 | Grandifloroside | 61186-24-1 | Grandifloroside, a natural product isolated and purified from the branch of Emmenopterys henryi Oliv. |
| CSN10385 | Geraniin | 60976-49-0 | Geraniin is a naturally occuring dehydroellagitannin found in geraniums which can mediates apoptosis. |
| CSN16027 | Forsythoside B | 81525-13-5 | Forsythoside B is a natural product isolated and purified from the fruits of Forsythia suspensa which inhibits inflammatory response,and has antioxidant properties with potent neuroprotective effects with a favorable therapeutic time-window, reduce of cerebral ischemia and reperfusion injury degree, attenuating blood-brain barrier (BBB) breakdown, and can rescue cardiac function from I/R injury. |
| CSN17713 | DCVC | 13419-46-0 | DCVC E-isomer inhibits pathogen-stimulated TNF- in human extra placental membranes in vitro |
| CSN18895 | C 87 | 1609281-56-2 | C 87 is a small-moleculeTNF inhibitor and potently inhibits TNF-induced cytotoxicity with an IC50 of 8.73 M. |
| CSN16975 | Bioymifi | 1420071-30-2 | Bioymifi is an activatior of the TRAIL receptor DR5 in cancer cells |
| CSN27597 | (Rac)-Benpyrine | 1333714-43-4 | (Rac)-Benpyrine is the racemate form of Benpyrine. Benpyrine could directly bind to TNF-α and block TNF-α-trigged signaling activation in vitro and in vivo. Administration of benpyrine by gavage significantly relieved the symptoms of collagen-induced arthritis and imiquimod-induced psoriasiform inflammation in mice. |
| CSN27828 | UTL-5g | 646530-37-2 | |
| CSN41534 | Hispidol | 5786-54-9 | |
| CSN38382 | Loganic acid 6′-O-β-D-glucoside | 176226-39-4 | |
| CSN36379 | Ganoderic acid C1 | 95311-97-0 | |
| CSN50026 | (E)-3-(3-Hydroxy-4-methoxybenzylidene)-6-methylchroman-4-one | 1031206-36-6 | |
| CSN51435 | AN0128 | 872044-70-7 | |
| CSN66808 | Benpyrine | 2550398-89-3 | |
| CSN68617 | TNF-α-IN-2 | 2074702-04-6 | |
| CSN81038 | EJMC-1 | 397281-20-8 | |
| CSN84144 | C 87 | 332420-90-3 | |
| CSN85337 | UCB-5307 | 1515887-44-1 | |
| CSN86594 | Anti-inflammatory agent 22 | 2721484-76-8 | |
| CSN90086 | Sinulatumolin C | 2570255-84-2 |
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