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TNF-alpha

TNF-alpha

Cat. No. Product Name CAS No. Information
CSN15856 VGX-1027   6501-72-0 VGX-1027 is an orally active immunomodulatory agent that primarily targets macrophages, it can inhibit TNF- secretion via interference of macrophage toll-like receptor (TLR) 4 and TLR 26 signaling pathway. VGX-1027 also reduces the secretion of pro-inflammatory cytokines IL1-, IL-10 and IFN-.
CSN22521 TNF-α-IN-1 444287-49-4 TNF--IN-1 is a TNF- inhibitor extracted from patent US20030096841A1, compound example I-7.
CSN12073 Thalidomide   50-35-1 Thalidomide targets to CRBN with IC50 of 85 nM It can inhibit biosynthesis of TNF- and has anti-angiogenic and immunosuppressive effects
CSN51354 SM-7368 380623-76-7 SM-7368 inhibits TNF-alpha-induced MMP-9 upregulation in a concentration-dependent manner.
CSN23727 S-99 1124381-69-6 S-99 is an inhibitor of LPS-induced TNFalpha release.
CSN11309 Roquinimex 84088-42-6 Roquinimex is a quinoline derivative immunostimulant which increases NK cell activity and macrophage cytotoxicity and inhibits angiogenesis and reduces the secretion of TNF alpha.
CSN21166 R-7050 303997-35-5 R-7050 is an antagonist of tumor necrosis factor receptor TNFR that towards TNF
CSN12289 QNZ   545380-34-5 QNZ can inhibit the activation of NF-κB and the production of TNF-α with IC50 of 11 nM and 7 nM, respectively.
CSN13185 Pomalidomide   19171-19-8 Pomalidomide can inhibit LPS-induced TNF- release with IC50 of 13 nM in PBMCs.
CSN13185 Pomalidomide   19171-19-8 Pomalidomide can inhibit LPS-induced TNF- release with IC50 of 13 nM in PBMCs.
CSN15896 PF-3644022 1276121-88-0 PF-3644022 is a potent ATP-competitive inhibitor of mitogen-activated protein kinase MAPK-activated protein kinase-2 MK2 IC50 52 nM and Ki 3 nM It inhibits tumor necrosis factor TNF production in U937 monocytic cells and peripheral blood mononuclear cells PBMCs IC50 160 nM and exhibits oral efficacy in acute and chronic inflammatory models
CSN22471 Nedocromil sodium 69049-74-7 Nedocromil Sodium is a potent TNF- inhibitor with an IC50 value of 1.67 M for Blood eosinophils.
CSN18474 Necrostatin 2 S enantiomer 852391-20-9 Necrostatin 2 S enantiomer is a potent necroptosis inhibitor with EC50 of 50 nM
CSN15733 Necrostatin 2 racemate 852391-15-2 Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM
CSN18473 Necrostatin 2 852391-19-6 Necrostatin 2 is a potent necroptosis inhibitor EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF- is 005 M
CSN17616 Lenalidomide hydrochloride 1243329-97-6 Lenalidomide is a TNF- secretion inhibitor with IC50 of 13 nM
CSN18463 Lenalidomide hemihydrate 847871-99-2 Lenalidomide is a potent inhibitor of TNF- and has antiangiogenic effect
CSN11280 Lenalidomide     191732-72-6 Lenalidomide a analog of thalidomide is TNF- secretion inhibitor with IC50 of 13 nM
CSN11280 Lenalidomide   191732-72-6 Lenalidomide a analog of thalidomide is TNF- secretion inhibitor with IC50 of 13 nM
CSN26222 Homoplantaginin 17680-84-1 Homoplantaginin, a main flavonoid from a traditional Chinese medicine Salvia plebeia, has anti-inflammatory and anti-oxidant properties. Homoplantaginin could inhibit TNF-α and IL-6 mRNA expression, IKKβ and NF-κB phosphorylation. Homoplantaginin ameliorates endothelial insulin resistance by inhibiting inflammation and modulating cell signalling via the IKKβ/IRS-1/pAkt/peNOS pathway.
CSN17960 GSK481 1622849-58-4 GSK481 can inhibit RIP1 WT S166 phosphorylation in human vs mouse plasmids overexpressed in HEK293T cells
CSN26529 GSK2245035 1207629-49-9 GSK2245035 is a selective Toll-like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 displays extraordinary IFNα inducing potency and IFNα/TNFα selectivity. GSK2245035 shows excellent pharmaceutical properties that allow reliable delivery of doses as low as 1 ng per actuation of an intranasal spray formulation. Intranasal GSK2245035 has an acceptable safety profile at doses that induce local TLR7-mediated immune responses.
CSN14854 Grandifloroside 61186-24-1 Grandifloroside, a natural product isolated and purified from the branch of Emmenopterys henryi Oliv.
CSN10385 Geraniin 60976-49-0 Geraniin is a naturally occuring dehydroellagitannin found in geraniums which can mediates apoptosis.
CSN16027 Forsythoside B 81525-13-5 Forsythoside B is a natural product isolated and purified from the fruits of Forsythia suspensa which inhibits inflammatory response,and has antioxidant properties with potent neuroprotective effects with a favorable therapeutic time-window, reduce of cerebral ischemia and reperfusion injury degree, attenuating blood-brain barrier (BBB) breakdown, and can rescue cardiac function from I/R injury.
CSN17713 DCVC 13419-46-0 DCVC E-isomer inhibits pathogen-stimulated TNF- in human extra placental membranes in vitro
CSN18895 C 87 1609281-56-2 C 87 is a small-moleculeTNF inhibitor and potently inhibits TNF-induced cytotoxicity with an IC50 of 8.73 M.
CSN16975 Bioymifi 1420071-30-2 Bioymifi is an activatior of the TRAIL receptor DR5 in cancer cells
CSN27597 (Rac)-Benpyrine 1333714-43-4 (Rac)-Benpyrine is the racemate form of Benpyrine. Benpyrine could directly bind to TNF-α and block TNF-α-trigged signaling activation in vitro and in vivo. Administration of benpyrine by gavage significantly relieved the symptoms of collagen-induced arthritis and imiquimod-induced psoriasiform inflammation in mice.
CSN27828 UTL-5g 646530-37-2
CSN41534 Hispidol 5786-54-9
CSN38382 Loganic acid 6′-O-β-D-glucoside 176226-39-4
CSN36379 Ganoderic acid C1 95311-97-0
CSN50026 (3E)-2,3-Dihydro-3-[(3-hydroxy-4-methoxyphenyl)methylene]-6-methyl-4H-1-benzopyran-4-one 1031206-36-6
CSN51435 AN0128 872044-70-7
CSN66808 Benpyrine 2550398-89-3
CSN68617 TNF-α-IN-2 2074702-04-6
CSN81038 EJMC-1 397281-20-8
CSN84144 C 87 332420-90-3
CSN85337 UCB-5307 1515887-44-1
CSN86594 Anti-inflammatory agent 22 2721484-76-8
CSN90086 Sinulatumolin C 2570255-84-2
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