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TLR

TLR

Cat. No. Product Name CAS No. Information
CSN10950 Toll-like Receptor Modulator 926927-42-6 Toll-like receptor modulator is a quinazolinone-derived regulator of both Toll-like receptor and -secretase.
CSN24480 TLR7/8 agonist 1 2HCl 1620278-72-9 TLR7/8 agonist 1 dihydrochloride is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline, showing substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens
CSN25310 TLR7 agonist T7 1062444-54-5 TLR7 agonist T7 is a novel Toll-like receptor 7 (TLR7) agonist, eliciting the nonspecific antitumor responses and strengthening the specific humoral and cellular immune responses.
CSN23072 RS 09 1449566-36-2 TLR4 peptide agonist; acts as an adjuvant in vivo
CSN20478 TLR2-IN-C29   363600-92-4 TLR2-IN-C29 is an inhibitor of TLR2
CSN27285 TH 1020   1841460-82-9 TH1020 is Toll-like receptor (TLR) 5/Flagellin complex antagonist with IC50 of 0.85 μM. TH1020 competes with flagellin for TLR5 binding to inhibit the TLR5:flagellin interaction and subsequent downstream TNF-α secretion.
CSN15947 TAK-242 243984-11-4 TAK-242, a small-molecule-specific inhibitor of Toll-like receptor (TLR)4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4.
CSN23121 SM 324405 677773-91-0 SM-324405 is a selective TLR7 agonist with antedrug characteristics.
CSN21096 CU-CPT22 1416324-85-0 Selective toll-like receptor 12 TLR12 inhibitor IC50 058 M Exhibits no activity at TLR2TLR6 TLR3 TLR4 and TLR7 or a panel of 10 representative kinases Inhibits the release of proinflammatory cytokines TNF- and IL-1
CSN12798 Resiquimod 144875-48-9 Resiquimod is an agonist of TLR7 and TLR8 with antiviral and antitumoral activities.
CSN11744 Polyinosinic Acid-Polycytidylic Acid 24939-03-5 Polyinosinic acid-polycytidylic acid is a TLR3 agonist and an immunostimulant. It is used in the form of its sodium salt to simulate viral infections.
CSN19974 Polygalasaponin F 882664-74-6 Polygalasaponin F, a natural product isolated and purified from the herbs of Polygala japonica Houtt.
CSN22182 PF-4878691 532959-63-0 PF-4878691 is a potent and selective Toll-like receptor 7 (TLR7) agonist.
CSN27297 Pam3CSK4   112208-00-1 Pam3CSK4 is a toll-like receptor 1/2 (TLR1/2) agonist with an EC50 of 0.47 ng/mL for human TLR1/2 .
CSN15696 Motolimod 926927-61-9 Motolimod is a Toll-like receptor 8 (TLR8) agonist with EC50 of 100 nM with immunostimulatory and antineoplastic activities.
CSN19750 MEDI9197 1359993-59-1 MEDI9197 is an imidazoquinoline analogue toll-like receptor (TLR) agonist that can be used for cancer immunotherapy based on its efficacy toward a variety of tumors.
CSN26177 MD2-TLR4-IN-1 2249801-12-3 MD2-TLR4-IN-1 is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex.
CSN21351 MD2-IN-1 111797-22-9 MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 M for the recombinant human MD2 (rhMD2).
CSN18539 Imiquimod Maleate 896106-16-4 Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.
CSN13134 Imiquimod   99011-02-6 Imiquimod is an agonist of toll-like receptor 7 with EC50 of 2.1 µM that has antiviral and antitumor activities. It is commonly used to treat warts and anal areas.
CSN18646 Imiquimod HCl 99011-78-6 Imiquimod HCl is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas.
CSN24299 IAXO-102 1115270-63-7 IAXO-102 is a novel small molecule TLR4 antagonist.
CSN25649 Hydroxychloroquine 118-42-3 Hydroxychloroquine is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR)7/9.
CSN20419 GSK2245035 Maleate 1325212-97-2 GSK2245035 maleate is a selective Toll-like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties which displays extraordinary IFN inducing potency and IFNTNF selectivity.
CSN13630 GS-9620 1228585-88-3 GS-9620 is a selective agonist of Toll-like receptor 7 (TLR-7) in chimpanzees and has anti-HBV infection activity.
CSN20270 G2013 1986-15-8 G2013 is a compoudn immunomodulatory effect on TLR2 and TLR4 in human mononuclear cells.
CSN17582 E-6446 1219925-73-1 E-6446 is a synthetic antagonist for nucleic acid-sensing TLRs and potently suppresses DNA stimulation of HEKTLR9 cells with IC50 of 10 nM.
CSN17716 E-6446 2HCl   1345675-25-3 E-6446 2HCl is an antagonist of TLRs and suppresses DNA stimulation in cancer cells with IC50 of 10 nM.
CSN22794 DSR 6434 1059070-10-8 DSR 6434 is a potent TLR7 agonist with EC50 of 7.2 nM.
CSN21261 CU-CPT-9a 2165340-32-7 CU-CPT9b is a selective inhibitor of TLR8 with IC50 and Kd of 0.7 nM and 21 nM.
CSN21262 CU-CPT-9b 2162962-69-6 CU-CPT9a is a selective Toll-like receptor 8 (TLR8) inhibitor with IC50 of 0.5 nM. It can also suppress TNF- levels.
CSN21226 CU-CPT-8m 125079-83-6 CU-CPT8m is a Toll-like receptor 8 (TLR8) specific small-molecule inhibitor that exerts “potent anti-inflammatory effects” on the tissue of patients with arthritis.
CSN20259 CU-CPT17e 2109805-75-4 CU-CPT17e is a multi-Toll-like receptor (TLR389) agonist with proinflammatory and anticancer activities.
CSN22781 CU CPT 4a 1279713-77-7 CU CPT 4a is a selective TLR3 inhibitor with IC50 of 344 M in RAW 2647 cells
CSN22764 CL 075 256922-53-9 CL 075 is a TLR8 agonist
CSN22734 C34 40592-88-9 C34 is a TLR4 inhibitor
CSN25419 Bropirimine 56741-95-8 Bropirimine is a synthetic agonist for toll-like receptor 7 (TLR7). Bropirimine inhibits differentiation of osteoclast precursor cells into osteoclasts via TLR7-mediated production of IFN-β. Bropirimine is an orally active immunomodulator that has demonstrated anticancer activity in transitional cell carcinoma in situ (CIS) in both the bladder and upper urinary tract.
CSN22347 AN-3485 1213827-99-6 AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM.
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