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TLR
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN42212 | VB-201 | 630112-41-3 | VB-201 is a Toll-like receptor-2 (TLR-2) antagonist. |
| CSN42525 | TLR7/8 Agonist 1 | 1258457-59-8 | TLR7/8 Agonist 1 is a dual agonist of TLR7/8 with EC50 values of 50nM and 55nM, respectively. It can be used as an immune stimulator. |
| CSN24480 | TLR7/8 agonist 1 dihydrochloride | 1620278-72-9 | TLR7/8 agonist 1 dihydrochloride is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline, showing substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens |
| CSN26562 | SM-276001 | 473930-22-2 | SM-276001 is a selective and potent TLR7 agonist. SM-276001 is can induce antitumor immune responses when dosed either intratracheally or orally. Oral administration of SM-276001 leads to the induction of IFNα, TNFα and IL-12p40 and a reduction in tumor burden in the Balb/c syngeneic Renca and CT26 models. |
| CSN33189 | Selgantolimod | 2004677-13-6 | Selgantolimod is a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B. |
| CSN26372 | Robinin | 301-19-9 | Robinin is flavonoid fraction of Vigna unguiculata leaf. Robinin inhibits upregulated expression of TLR2 and TLR4 and ameliorates oxidized low density lipoprotein (Ox-LDL) induced inflammatory insult through TLR4/NF-κB pathway[1]. |
| CSN26358 | Loxoribine | 121288-39-9 | Loxoribine, a guanosine analog, is selective agonist of Toll-like receptor 7 with anti-viral and anti-tumor activities. |
| CSN26529 | GSK2245035 | 1207629-49-9 | GSK2245035 is a selective Toll-like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 displays extraordinary IFNα inducing potency and IFNα/TNFα selectivity. GSK2245035 shows excellent pharmaceutical properties that allow reliable delivery of doses as low as 1 ng per actuation of an intranasal spray formulation. Intranasal GSK2245035 has an acceptable safety profile at doses that induce local TLR7-mediated immune responses. |
| CSN24481 | Gardiquimod diTFA | 1159840-61-5 | Gardiquimod trifluoroacetate is a specific TLR7 agonist. |
| CSN33123 | Eritoran tetrasodium | 185954-98-7 | Eritoran Tetrasodium is a TLR4 receptor antagonist potentially for the treatment of type 2 diabetes. |
| CSN33122 | 3-O-Decyl-2-deoxy-6-O-[2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[[(11Z)-1-oxo-11-octadecenyl]amino]-4-O-phosphono-beta-D-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]-alpha-D-glucopyranose1-(dihydrogenphosphat | 185955-34-4 | Eritoran is a TLR4 receptor antagonist. |
| CSN26779 | CL264 | 1510712-69-2 | CL264 is a TLR7-specific agonist for innate immune signals research[1]. |
| CSN50330 | Afimetoran | 2171019-55-7 | Afimetoran is an Oral Novel Toll-like Receptor 7 and 8 (TLR7/8) Inhibitor. |
| CSN26778 | 3M-011 | 642473-62-9 | 3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer. 3M-011 significantly inhibits H3N2 influenza viral replication in the nasal cavity. 3M-011 is also a potent adjuvant to radiotherapy that induces local and profound systemic immune responses during radiotherapy. 3M-011 strongly has antitumor action[1][2][3]. |
| CSN38026 | AXC-715 hydrochloride | 2490497-93-1 | |
| CSN35473 | TLR7 agonist 1 | 2178156-33-5 | |
| CSN50335 | LHC-165 | 1258595-14-0 | |
| CSN50538 | AXC 715 | 313350-31-1 | |
| CSN50638 | Ethyl 8-bromo-2-[(tert-butoxycarbonyl)amino]-3H-benzo[b]azepine-4-carboxylate | 926927-57-3 | |
| CSN50640 | 3H-1-Benzazepine-4,8-dicarboxamide, 2-amino-N8-[6-[4-[[(2-aminoethyl)amino]carbonyl]-1-piperidinyl]-3-pyridinyl]-N4,N4-dipropyl- (ACI) | 2244132-76-9 | |
| CSN50633 | AXC-715 trihydrochloride | 2479276-17-8 | |
| CSN50639 | 2-Amino-N8-[5-(aminomethyl)-3-pyridinyl]-N4,N4-dipropyl-3H-1-benzazepine-4,8-dicarboxamide | 1998726-22-9 | |
| CSN50632 | Ethyl 2-amino-7-bromo-3H-1-benzazepine-4-carboxylate | 1384958-64-8 | |
| CSN50637 | 1,1-Dimethylethyl N-[8-bromo-4-[(dipropylamino)carbonyl]-3H-1-benzazepin-2-yl]carbamate | 1226791-82-7 | |
| CSN50631 | 8-Bromo-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3H-1-benzazepine-4-carboxylic acid | 1226791-81-6 | |
| CSN50635 | Interferon Inducer 23 | 853792-81-1 | |
| CSN50636 | FcyB ligand 16h | 1784430-81-4 | |
| CSN50634 | Interferon Inducer 22 | 853792-80-0 | |
| CSN62477 | TLR8 agonist 2 | 2412937-64-3 | |
| CSN68241 | Enpatoran hydrochloride | 2101945-93-9 | |
| CSN67948 | TLR7/8/9-IN-1 | 2180127-82-4 | |
| CSN68020 | Guretolimod | 1488364-57-3 | |
| CSN68026 | BBIQ | 1229024-57-0 | |
| CSN67448 | TLR7/8-IN-1 | 2205095-75-4 | |
| CSN68193 | TLR7 agonist 3 | 1229024-78-5 | |
| CSN72310 | GSK1795091 | 1233589-81-5 | |
| CSN74289 | 2-(9-Chloro-2,3-dimethyl-6H-indolo[2,3-b]quinoxalin-6-yl)-N-(2-(dimethylamino)ethyl)acetamide | 872178-65-9 |
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