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TLR
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN10950 | Toll-like Receptor Modulator | 926927-42-6 | Toll-like receptor modulator is a quinazolinone-derived regulator of both Toll-like receptor and -secretase. |
| CSN24480 | TLR7/8 agonist 1 2HCl | 1620278-72-9 | TLR7/8 agonist 1 dihydrochloride is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline, showing substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens |
| CSN25310 | TLR7 agonist T7 | 1062444-54-5 | TLR7 agonist T7 is a novel Toll-like receptor 7 (TLR7) agonist, eliciting the nonspecific antitumor responses and strengthening the specific humoral and cellular immune responses. |
| CSN23072 | RS 09 | 1449566-36-2 | TLR4 peptide agonist; acts as an adjuvant in vivo |
| CSN20478 | TLR2-IN-C29 | 363600-92-4 | TLR2-IN-C29 is an inhibitor of TLR2 |
| CSN15947 | TAK-242 | 243984-11-4 | TAK-242, a small-molecule-specific inhibitor of Toll-like receptor (TLR)4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4. |
| CSN23121 | SM 324405 | 677773-91-0 | SM-324405 is a selective TLR7 agonist with antedrug characteristics. |
| CSN21096 | CU-CPT22 | 1416324-85-0 | Selective toll-like receptor 12 TLR12 inhibitor IC50 058 M Exhibits no activity at TLR2TLR6 TLR3 TLR4 and TLR7 or a panel of 10 representative kinases Inhibits the release of proinflammatory cytokines TNF- and IL-1 |
| CSN12798 | Resiquimod | 144875-48-9 | Resiquimod is an agonist of TLR7 and TLR8 with antiviral and antitumoral activities. |
| CSN11744 | Polyinosinic Acid-Polycytidylic Acid | 24939-03-5 | Polyinosinic acid-polycytidylic acid is a TLR3 agonist and an immunostimulant. It is used in the form of its sodium salt to simulate viral infections. |
| CSN19974 | Polygalasaponin F | 882664-74-6 | Polygalasaponin F, a natural product isolated and purified from the herbs of Polygala japonica Houtt. |
| CSN22182 | PF-4878691 | 532959-63-0 | PF-4878691 is a potent and selective Toll-like receptor 7 (TLR7) agonist. |
| CSN15696 | Motolimod | 926927-61-9 | Motolimod is a Toll-like receptor 8 (TLR8) agonist with EC50 of 100 nM with immunostimulatory and antineoplastic activities. |
| CSN19750 | MEDI9197 | 1359993-59-1 | MEDI9197 is an imidazoquinoline analogue toll-like receptor (TLR) agonist that can be used for cancer immunotherapy based on its efficacy toward a variety of tumors. |
| CSN21351 | MD2-IN-1 | 111797-22-9 | MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 M for the recombinant human MD2 (rhMD2). |
| CSN18539 | Imiquimod Maleate | 896106-16-4 | Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas. |
| CSN13134 | Imiquimod | 99011-02-6 | Imiquimod is an agonist of toll-like receptor 7 with EC50 of 2.1 µM that has antiviral and antitumor activities. It is commonly used to treat warts and anal areas. |
| CSN18646 | Imiquimod HCl | 99011-78-6 | Imiquimod HCl is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas. |
| CSN24299 | IAXO-102 | 1115270-63-7 | IAXO-102 is a novel small molecule TLR4 antagonist. |
| CSN20419 | GSK2245035 Maleate | 1325212-97-2 | GSK2245035 maleate is a selective Toll-like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties which displays extraordinary IFN inducing potency and IFNTNF selectivity. |
| CSN13630 | GS-9620 | 1228585-88-3 | GS-9620 is a selective agonist of Toll-like receptor 7 (TLR-7) in chimpanzees and has anti-HBV infection activity. |
| CSN20270 | G2013 | 1986-15-8 | G2013 is a compoudn immunomodulatory effect on TLR2 and TLR4 in human mononuclear cells. |
| CSN17582 | E-6446 | 1219925-73-1 | E-6446 is a synthetic antagonist for nucleic acid-sensing TLRs and potently suppresses DNA stimulation of HEKTLR9 cells with IC50 of 10 nM. |
| CSN17716 | E-6446 2HCl | 1345675-25-3 | E-6446 2HCl is an antagonist of TLRs and suppresses DNA stimulation in cancer cells with IC50 of 10 nM. |
| CSN22794 | DSR 6434 | 1059070-10-8 | DSR 6434 is a potent TLR7 agonist with EC50 of 7.2 nM. |
| CSN21261 | CU-CPT-9a | 2165340-32-7 | CU-CPT9b is a selective inhibitor of TLR8 with IC50 and Kd of 0.7 nM and 21 nM. |
| CSN21262 | CU-CPT-9b | 2162962-69-6 | CU-CPT9a is a selective Toll-like receptor 8 (TLR8) inhibitor with IC50 of 0.5 nM. It can also suppress TNF- levels. |
| CSN21226 | CU-CPT-8m | 125079-83-6 | CU-CPT8m is a Toll-like receptor 8 (TLR8) specific small-molecule inhibitor that exerts “potent anti-inflammatory effects” on the tissue of patients with arthritis. |
| CSN20259 | CU-CPT17e | 2109805-75-4 | CU-CPT17e is a multi-Toll-like receptor (TLR389) agonist with proinflammatory and anticancer activities. |
| CSN22781 | CU CPT 4a | 1279713-77-7 | CU CPT 4a is a selective TLR3 inhibitor with IC50 of 344 M in RAW 2647 cells |
| CSN22764 | CL 075 | 256922-53-9 | CL 075 is a TLR8 agonist |
| CSN22734 | C34 | 40592-88-9 | C34 is a TLR4 inhibitor |
| CSN22347 | AN-3485 | 1213827-99-6 | AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM. |
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