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TLR
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN10950 | Toll-like Receptor Modulator | 926927-42-6 | Toll-like receptor modulator is a quinazolinone-derived regulator of both Toll-like receptor and -secretase. |
| CSN24480 | TLR7/8 agonist 1 2HCl | 1620278-72-9 | TLR7/8 agonist 1 dihydrochloride is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline, showing substantially different agonistic potencies in human TLR7 (50 nM) and TLR8 (55 nM) primary screens |
| CSN25310 | TLR7 agonist T7 | 1062444-54-5 | TLR7 agonist T7 is a novel Toll-like receptor 7 (TLR7) agonist, eliciting the nonspecific antitumor responses and strengthening the specific humoral and cellular immune responses. |
| CSN23072 | RS 09 | 1449566-36-2 | TLR4 peptide agonist; acts as an adjuvant in vivo |
| CSN20478 | TLR2-IN-C29 | 363600-92-4 | TLR2-IN-C29 is an inhibitor of TLR2 |
| CSN15947 | TAK-242 | 243984-11-4 | TAK-242, a small-molecule-specific inhibitor of Toll-like receptor (TLR)4 signaling, inhibits the production of lipopolysaccharide-induced inflammatory mediators by binding to the intracellular domain of TLR4. |
| CSN23121 | SM 324405 | 677773-91-0 | SM-324405 is a selective TLR7 agonist with antedrug characteristics. |
| CSN21096 | CU-CPT22 | 1416324-85-0 | Selective toll-like receptor 12 TLR12 inhibitor IC50 058 M Exhibits no activity at TLR2TLR6 TLR3 TLR4 and TLR7 or a panel of 10 representative kinases Inhibits the release of proinflammatory cytokines TNF- and IL-1 |
| CSN12798 | Resiquimod | 144875-48-9 | Resiquimod is an agonist of TLR7 and TLR8 with antiviral and antitumoral activities. |
| CSN11744 | Polyinosinic Acid-Polycytidylic Acid | 24939-03-5 | Polyinosinic acid-polycytidylic acid is a TLR3 agonist and an immunostimulant. It is used in the form of its sodium salt to simulate viral infections. |
| CSN19974 | Polygalasaponin F | 882664-74-6 | Polygalasaponin F, a natural product isolated and purified from the herbs of Polygala japonica Houtt. |
| CSN22182 | PF-4878691 | 532959-63-0 | PF-4878691 is a potent and selective Toll-like receptor 7 (TLR7) agonist. |
| CSN15696 | Motolimod | 926927-61-9 | Motolimod is a Toll-like receptor 8 (TLR8) agonist with EC50 of 100 nM with immunostimulatory and antineoplastic activities. |
| CSN19750 | MEDI9197 | 1359993-59-1 | MEDI9197 is an imidazoquinoline analogue toll-like receptor (TLR) agonist that can be used for cancer immunotherapy based on its efficacy toward a variety of tumors. |
| CSN21351 | MD2-IN-1 | 111797-22-9 | MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 M for the recombinant human MD2 (rhMD2). |
| CSN18539 | Imiquimod Maleate | 896106-16-4 | Imiquimod maleate is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas. |
| CSN13134 | Imiquimod | 99011-02-6 | Imiquimod is an agonist of toll-like receptor 7 with EC50 of 2.1 µM that has antiviral and antitumor activities. It is commonly used to treat warts and anal areas. |
| CSN18646 | Imiquimod HCl | 99011-78-6 | Imiquimod HCl is an immune response modifier that acts as a toll-like receptor 7 agonist and is commonly used topically to treat warts on the skin of the genital and anal areas. |
| CSN24299 | IAXO-102 | 1115270-63-7 | IAXO-102 is a novel small molecule TLR4 antagonist. |
| CSN25649 | Hydroxychloroquine | 118-42-3 | Hydroxychloroquine is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR)7/9. |
| CSN20419 | GSK2245035 Maleate | 1325212-97-2 | GSK2245035 maleate is a selective Toll-like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties which displays extraordinary IFN inducing potency and IFNTNF selectivity. |
| CSN13630 | GS-9620 | 1228585-88-3 | GS-9620 is a selective agonist of Toll-like receptor 7 (TLR-7) in chimpanzees and has anti-HBV infection activity. |
| CSN20270 | G2013 | 1986-15-8 | G2013 is a compoudn immunomodulatory effect on TLR2 and TLR4 in human mononuclear cells. |
| CSN17582 | E-6446 | 1219925-73-1 | E-6446 is a synthetic antagonist for nucleic acid-sensing TLRs and potently suppresses DNA stimulation of HEKTLR9 cells with IC50 of 10 nM. |
| CSN17716 | E-6446 2HCl | 1345675-25-3 | E-6446 2HCl is an antagonist of TLRs and suppresses DNA stimulation in cancer cells with IC50 of 10 nM. |
| CSN22794 | DSR 6434 | 1059070-10-8 | DSR 6434 is a potent TLR7 agonist with EC50 of 7.2 nM. |
| CSN21261 | CU-CPT-9a | 2165340-32-7 | CU-CPT9b is a selective inhibitor of TLR8 with IC50 and Kd of 0.7 nM and 21 nM. |
| CSN21262 | CU-CPT-9b | 2162962-69-6 | CU-CPT9a is a selective Toll-like receptor 8 (TLR8) inhibitor with IC50 of 0.5 nM. It can also suppress TNF- levels. |
| CSN21226 | CU-CPT-8m | 125079-83-6 | CU-CPT8m is a Toll-like receptor 8 (TLR8) specific small-molecule inhibitor that exerts “potent anti-inflammatory effects” on the tissue of patients with arthritis. |
| CSN20259 | CU-CPT17e | 2109805-75-4 | CU-CPT17e is a multi-Toll-like receptor (TLR389) agonist with proinflammatory and anticancer activities. |
| CSN22781 | CU CPT 4a | 1279713-77-7 | CU CPT 4a is a selective TLR3 inhibitor with IC50 of 344 M in RAW 2647 cells |
| CSN22764 | CL 075 | 256922-53-9 | CL 075 is a TLR8 agonist |
| CSN22734 | C34 | 40592-88-9 | C34 is a TLR4 inhibitor |
| CSN22347 | AN-3485 | 1213827-99-6 | AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM. |
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