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TGF-beta Receptor

Cat. No. Product Name CAS No. Information
CSN16619 SD-208     627536-09-8 SD-208 is a potent, orally active ATP-competitive transforming growth factor- receptor 1 (TGF-RI) inhibitor (IC50 49 nM) and displays 100-fold and 17-fold selectivity over TGF-RII and other common kinases respectively.
CSN16734 SB-505124 694433-59-5 SB505124 is an inhibitor of TGF receptor for ALK4 (IC50 129 nM) and ALK5 (IC50 47 nM). It can also inhibit ALK7.
CSN11900 SB-431542   301836-41-9 SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold selective for ALK5 than p38 MAPK and other kinases.
CSN13435 SB-525334   356559-20-1 SB-525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6.
CSN13732 SB-505124 HCl 356559-13-2 SB-505124 hydrochloride is a selective inhibitor of TGFR for ALK4, ALK5 with IC50 of 129 nM and 47 nM, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6.
CSN12299 RepSox     446859-33-2 RepSox is a potent and selective inhibitor of the TGFR-1ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively.
CSN18520 R268712 879487-87-3 R268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM.
CSN15840 ML347 1062368-49-3 ML347 is a highly selective ALK1ALK2 inhibitor with IC50s of 4632 nM and shows 300-fold selectivity for ALK2 vs. ALK3.
CSN11348 LY364947     396129-53-6 LY364947 is a potent ATP-competitive inhibitor of TGFR-I with IC50 of 59 nM, exhibits 7-fold selectivity over TGFR-II.
CSN24275 LY-3200882 1898283-02-7 LY3200882 is a novel and highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
CSN13685 LY2157299   700874-72-2 LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM in a cell-free assay.
CSN13478 LY2109761     700874-71-1 LY2109761 is a selective TGF- receptor type III (TRIII) dual inhibitor with Ki of 38 nM and 300 nM, respectively and is shown to negatively affect the phosphorylation of Smad2.
CSN13876 LDN-214117 1627503-67-6 LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM with 100 fold selectivity for ALK5, and also inhibits BMP6 (IC50100 nM).
CSN17852 LDN-212854 1432597-26-6 LDN-212854 is an inhibitor of BMP and can inhibit ALK2 with IC50 of 1.3 nM. It is used to prevent heterotopic ossification.
CSN13848 LDN-193189 1062368-24-4 LDN-193189 is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.
CSN13849 LDN-193189 HCl   1062368-62-0 LDN-193189 HCl is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β.
CSN22554 LDN-193189 2HCl 1435934-00-1 LDN-193189 2HCl is a potent and selective ALK2 and ALK3 inhibitor.
CSN15921 K02288   1431985-92-0 K02288 is an inhibitor of type I BMP receptor. It targeting ALK2, ALK1 and ALK6 with IC50 of 1.1, 1.8, 6.4 nM, respectively.
CSN13159 GW788388 452342-67-5 GW788388 is a selective ALK5 inhibitor with IC50 of 18 nM and also inhibits TGF- type II receptor and activin type II receptor.
CSN15909 EW 7197 1352608-82-2 EW-7197 is a selective inhibitor of TGF- receptor ALK4 and ALK5 with IC50s of 13 nM and 11 nM.
CSN22227 EW-7197 HCl 1352610-25-3 EW-7197 Hydrochloride is a small-molecule ATP-competitive inhibitor of TGFRI (ALK5) with an IC50 of 12.9 nM.
CSN17559 DMH-1   1206711-16-1 DMH-1 is a potent and selective BMP inhibitor with IC50s of 27107.9 5 nM for ALK123 respectively and inactive on ALK5, BMPR2, AMPK and VEGFR2.
CSN23766 BIBF0775 334951-90-5 BIBF0775 is an inhibitor of transforming growth factor receptor I (TGFRI) by soaking into the kinase domain of TGFRI.
CSN19475 A 77-01 607737-87-1 A77-01 is a potent inhibitor of TGF- type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.
CSN24277 A 83-01 Sodium Salt N/A A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7, with IC50 values of 12, 45 and 7.5 nM, respectively.
CSN13090 A 83-01 909910-43-6 A 83-01 is a selective inhibitor of TGF- type I receptor ALK5 kinase, type I activinnodal receptor ALK4 and type I nodal receptor ALK7, with IC50 values of 12, 45 and 7.5 nM, respectively.
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