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| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN16619 | SD-208 | 627536-09-8 | SD-208 is a potent, orally active ATP-competitive transforming growth factor- receptor 1 (TGF-RI) inhibitor (IC50 49 nM) and displays 100-fold and 17-fold selectivity over TGF-RII and other common kinases respectively. |
| CSN16734 | SB-505124 | 694433-59-5 | SB505124 is an inhibitor of TGF receptor for ALK4 (IC50 129 nM) and ALK5 (IC50 47 nM). It can also inhibit ALK7. |
| CSN11900 | SB-431542 | 301836-41-9 | SB431542 is a potent and selective inhibitor of ALK5 with IC50 of 94 nM, 100-fold selective for ALK5 than p38 MAPK and other kinases. |
| CSN13435 | SB 525334 | 356559-20-1 | SB-525334 is a potent and selective inhibitor of TGFβ receptor I (ALK5) with IC50 of 14.3 nM, is 4-fold less potent to ALK4 than ALK5 and inactive to ALK2, 3, and 6. |
| CSN13732 | SB-505124 hydrochloride | 356559-13-2 | SB-505124 HCl is a selective inhibitor of TGFβR for ALK4, ALK5 with IC50 of 129 nM and 47 nM, respectively, also inhibits ALK7, but does not inhibit ALK1, 2, 3, or 6. |
| CSN12299 | RepSox | 446859-33-2 | RepSox is a potent and selective inhibitor of the TGFR-1ALK5 with IC50 of 23 nM and 4 nM for ATP binding to ALK5 and ALK5 autophosphorylation, respectively. |
| CSN18520 | R-268712 | 879487-87-3 | R268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM. |
| CSN26776 | PF-06952229 | 1801333-55-0 | PF-06952229 is a potent, selective and orally active TGFbR1 inhibitor. PF-06952229 specifically binds to TGFbR1 and prevents TGFbR1-mediated signal transduction. PF-06952229 is a promising antineoplastic agent for the study solid tumors, especifically metastatic breast cancer. |
| CSN15840 | ML347 | 1062368-49-3 | ML347 is a highly selective ALK1ALK2 inhibitor with IC50s of 4632 nM and shows 300-fold selectivity for ALK2 vs. ALK3. |
| CSN11348 | LY-364947 | 396129-53-6 | LY364947 is a potent ATP-competitive inhibitor of TGFR-I with IC50 of 59 nM, exhibits 7-fold selectivity over TGFR-II. |
| CSN13685 | Galunisertib | 700874-72-2 | LY2157299 is a potent TGFβ receptor I (TβRI) inhibitor with IC50 of 56 nM in a cell-free assay. |
| CSN13478 | LY2109761 | 700874-71-1 | LY2109761 is a selective TGF- receptor type III (TRIII) dual inhibitor with Ki of 38 nM and 300 nM, respectively and is shown to negatively affect the phosphorylation of Smad2. |
| CSN13876 | LDN-214117 | 1627503-67-6 | LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM with 100 fold selectivity for ALK5, and also inhibits BMP6 (IC50100 nM). |
| CSN17852 | LDN-212854 | 1432597-26-6 | LDN-212854 is an inhibitor of BMP and can inhibit ALK2 with IC50 of 1.3 nM. It is used to prevent heterotopic ossification. |
| CSN13848 | LDN193189 | 1062368-24-4 | LDN-193189 is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β. |
| CSN13849 | LDN-193189 HCl | 1062368-62-0 | LDN-193189 HCl is a selective BMP signaling inhibitor, inhibits the transcriptional activity of the BMP type I receptors ALK2 and ALK3 with IC50 of 5 nM and 30 nM, respectively, exhibits 200-fold selectivity for BMP versus TGF-β. |
| CSN22554 | LDN-193189 2HCl | 1435934-00-1 | LDN-193189 2HCl is a potent and selective ALK2 and ALK3 inhibitor. |
| CSN15921 | K02288 | 1431985-92-0 | K02288 is an inhibitor of type I BMP receptor. It targeting ALK2, ALK1 and ALK6 with IC50 of 1.1, 1.8, 6.4 nM, respectively. |
| CSN13159 | GW788388 | 452342-67-5 | GW788388 is a selective ALK5 inhibitor with IC50 of 18 nM and also inhibits TGF- type II receptor and activin type II receptor. |
| CSN15909 | Vactosertib | 1352608-82-2 | EW-7197 is a selective inhibitor of TGF- receptor ALK4 and ALK5 with IC50s of 13 nM and 11 nM. |
| CSN22227 | Vactosertib Hydrochloride | 1352610-25-3 | EW-7197 HCl is a small-molecule ATP-competitive inhibitor of TGFβRI (ALK5) with an IC50 of 12.9 nM. |
| CSN17559 | DMH-1 | 1206711-16-1 | DMH-1 is a potent and selective BMP inhibitor with IC50s of 27107.9 5 nM for ALK123 respectively and inactive on ALK5, BMPR2, AMPK and VEGFR2. |
| CSN27624 | BMS-986260 | 2001559-19-7 | BMS-986260 is a potent, selective, and orally bioavailable TGFβR1 inhibitor, with IC50 of 1.6 nM. |
| CSN19475 | A 77-01 | 607737-87-1 | A77-01 is a potent inhibitor of TGF- type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM. |
| CSN24277 | A 83-01 sodium salt | 2828431-89-4 | A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7, with IC50 values of 12, 45 and 7.5 nM, respectively. |
| CSN13090 | A 83-01 | 909910-43-6 | A 83-01 is a selective inhibitor of TGF- type I receptor ALK5 kinase, type I activinnodal receptor ALK4 and type I nodal receptor ALK7, with IC50 values of 12, 45 and 7.5 nM, respectively. |
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