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TAM Receptor
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN16090 | UNC2881 | 1493764-08-1 | UNC2881 is a Mer kinase inhibitor and can inhibit the phosphorylation of Mer with IC50 of 43 nM |
| CSN16916 | UNC2250 | 1493694-70-4 | UNC2250 is an inhibitor of Mer with IC50 of 17 nM |
| CSN17711 | Dubermatinib | 1341200-45-0 | TP-0903 is a selective Axl kinase inhibitor with IC50 of 27 nM |
| CSN17238 | SGI-7079 | 1239875-86-5 | SGI-7079 a selective Axl inhibitor inhibits tumor growth in a dose dependent manner and is a potential therapeutic target for overcoming EGFR inhibitor resistance |
| CSN22605 | 3-((3-((4-(Morpholinomethyl)-1H-pyrrol-2-yl)methylene)-2-oxoindolin-5-yl)methyl)thiazolidine-2,4-dione hydrochloride | 1265966-31-1 | S49076 hydrochloride is a potent, ATP-competitive tyrosine kinase inhibitor of MET, AXL/MER, and FGFR1/2/3 with IC50 <20 nM. |
| CSN22558 | CEP-40783 | 1437321-24-8 | RXDX-106 inhibits TAM and c-MET phosphorylation in vitro This inhibition of TAM and c-MET activation in vitro is accompanied by a decrease in downstream MAPK and PI3K signaling and cell viability It completely inhibits cellular proliferation and viability at sub-nanomolar concentrations in TAM-expressing cells |
| CSN22247 | R916562 | 1037798-41-6 | R916562 is a potential and selective AxlVEGF-R2 dual inhibitor with IC50s of 136 and 24 nM respectively |
| CSN20188 | R428 R-Enantiomer | 1037624-76-2 | R428 R-enantiomer is an R isomer of R428 a potent and selective small-molecule inhibitor IC5014 nM blocks the activities of Axl |
| CSN17144 | Bemcentinib | 1037624-75-1 | R428 is a potent and selective small-molecule inhibitor (IC5014 nM), and blocks the activities of Axl. |
| CSN25618 | ONO-7475 | 1646839-59-9 | ONO-7475 is a potent and selective inhibitor of active novel Axl/Mer tyrosine kinase with IC50 values of 0.7nM and 1nM, respectively. It potently arrested growth and induced apoptosis in acute myeloid leukemia with internal tandem duplication mutation of FMS-like tyrosine kinase 3. |
| CSN19205 | NPS-1034 | 1221713-92-3 | NPS-1034 is a dual MetAxl inhibitor with IC50 of 48 nM and 103 nM respectively |
| CSN13882 | LDC1267 | 1361030-48-9 | LDC1267 is a selective inhibitor of TAM and inhibits Tyro3, Axl and Mer with IC50 of 5 nM, 8 nM, 29 nM, respectively. |
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