Spleen Tyrosine Kinase | Protein Tyrosine Kinase/RTK| CSNpharm

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Cat. No.	Product Name	CAS No.	Information
CSN24785	TAK-659	1312691-33-0	TAK-659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL)[1][2][3][4].
CSN20624	TAK-659 HCl	1952251-28-3	TAK-659 HCl is a selective inhibitor of spleen tyrosine kinase (Syk) with IC50 of 3.2 nM.
CSN20342	SYK Inhibitor II	227449-73-2	SYK inhibitor II is an inhibitor of SYK
CSN19150	RO9021	1446790-62-0	RO9021 potently inhibits SYK kinase activity with an average IC50 of 5.6 nM and suppresses B-cell receptor signaling.
CSN17403	R788 Disodium	1025687-58-4	R788 disodium, the disodium form of R788, is a Syk inhibitor with IC50 of 41 nM.
CSN16059	Fostamatinib 2Na 6H2O	914295-16-2	R788 Disodium is a Syk inhibitor with IC50 of 41 nM. It is the prodrug of metabolite R406 with immunomodulatory activity.
CSN12668	R406	841290-80-0	R406 is an inhibitor of Syk with IC50 of 41 nM.
CSN16942	R406 Benzenesulfonate	841290-81-1	R406 benzenesulfonate is a selective inhibitor of Syk with IC50 of 41 nM
CSN18340	R112	575474-82-7	R112, an ATP-competitive inhibitor, can inhibit Syk kinase with Ki of 96 nM.
CSN15717	PRT062607	1370261-96-3	PRT062607 is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM with 80-fold selectivity for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.
CSN16941	PRT062607 HCl	1370261-97-4	PRT062607 HCl is an inhibitor of SYK with IC50 of 1 nM.
CSN19209	PRT060318 2HCl	N/A	PRT060318 2HCl is a selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.
CSN20186	PRT-060318	1194961-19-7	PRT-060318 is an inhibitor of Syk with IC50 of 4 nM. It is used to treat heparin-induced thrombocytopenia (HIT).
CSN12330	Piceatannol	10083-24-6	Piceatannol a natural stilbene is selective Syk inhibitor extracted from the rhizomes of Polygonum cuspidatum Sieb et Zucc
CSN23020	OXSI 2	622387-85-3	OXSI 2 is a potent Syk kinase inhibitor with IC50 of 14 nM, and also inhibits assembly of NLRP3 inflammasomes induced by Nigericin.
CSN16634	GS-9973	1229208-44-9	GS-9973 is a Syk inhibitor with IC50 value of 7.7 nM which is used for the treatment of autoimmune and oncology indications.
CSN15818	Fostamatinib	901119-35-5	Fostamatinib, a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.
CSN22810	ER 27319 Maleate	1204480-26-1	ER 27319 Maleate is a selective inhibitor of Syk kinase.
CSN16532	BAY 61-3606 2HCl	648903-57-5	BAY-61-3606 is a potent and selective inhibitor of Syk kinase (Ki 7.5 nM).
CSN18411	BAY 61-3606	732983-37-8	BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.

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