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Syk

Syk

Cat. No. Product Name CAS No. Information
CSN27615 ZAP-180013 873080-25-2 ZAP-180013 is inhibitor of zeta-chain-associated protein kinase 70 (ZAP-70) with IC50 of 1.8 μM. It inhibits the interaction of ZAP-70 SH2 domain with immunoreceptor tyrosine-based activation motif (ITAMs).
CSN24785 TAK-659 1312691-33-0 TAK-659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL)[1][2][3][4].
CSN20624 TAK-659 HCl 1952251-28-3 TAK-659 HCl is a selective inhibitor of spleen tyrosine kinase (Syk) with IC50 of 3.2 nM.
CSN20342 SYK Inhibitor II 227449-73-2 SYK inhibitor II is an inhibitor of SYK
CSN28425 SRX3207 2254693-15-5 SRX3207 is an orally active dual Syk/PI3K inhibitor with IC50 value of 30nM for Syk. It potently blocks phosphorylation of Syk at 348 site and Y525/526 site. SRX3207 reduced immunosuppressive macrophage polarization and increased infiltration and cytotoxicity of CD8+ T cells in LLC tumors and increased expression of Ifng and Gzmb in 3207 treated LLC tumors.
CSN19150 RO9021 1446790-62-0 RO9021 potently inhibits SYK kinase activity with an average IC50 of 5.6 nM and suppresses B-cell receptor signaling.
CSN17403 R788 Disodium 1025687-58-4 R788 disodium, the disodium form of R788, is a Syk inhibitor with IC50 of 41 nM.
CSN16059 Fostamatinib 2Na 6H2O   914295-16-2 R788 Disodium is a Syk inhibitor with IC50 of 41 nM. It is the prodrug of metabolite R406 with immunomodulatory activity.
CSN12668 R406   841290-80-0 R406 is an inhibitor of Syk with IC50 of 41 nM.
CSN16942 R406 Benzenesulfonate 841290-81-1 R406 benzenesulfonate is a selective inhibitor of Syk with IC50 of 41 nM
CSN18340 R112 575474-82-7 R112, an ATP-competitive inhibitor, can inhibit Syk kinase with Ki of 96 nM.
CSN15717 PRT062607 1370261-96-3 PRT062607 is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM with 80-fold selectivity for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.
CSN16941 PRT062607 HCl 1370261-97-4 PRT062607 HCl is an inhibitor of SYK with IC50 of 1 nM.
CSN19209 PRT060318 2HCl N/A PRT060318 2HCl is a selective inhibitor of the Syk tyrosine kinase, as an approach to HIT treatment.
CSN20186 PRT-060318 1194961-19-7 PRT-060318 is an inhibitor of Syk with IC50 of 4 nM. It is used to treat heparin-induced thrombocytopenia (HIT).
CSN12330 Piceatannol   10083-24-6 Piceatannol a natural stilbene is selective Syk inhibitor extracted from the rhizomes of Polygonum cuspidatum Sieb et Zucc
CSN12330 Piceatannol   10083-24-6 Piceatannol a natural stilbene is selective Syk inhibitor extracted from the rhizomes of Polygonum cuspidatum Sieb et Zucc
CSN23020 OXSI 2 622387-85-3 OXSI 2 is a potent Syk kinase inhibitor with IC50 of 14 nM, and also inhibits assembly of NLRP3 inflammasomes induced by Nigericin.
CSN16634 GS-9973   1229208-44-9 GS-9973 is a Syk inhibitor with IC50 value of 7.7 nM which is used for the treatment of autoimmune and oncology indications.
CSN15818 Fostamatinib 901119-35-5 Fostamatinib, a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.
CSN18411 BAY 61-3606 732983-37-8 BAY 61-3606 is a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (Ki 7.5 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src.
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