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STING

STING

Cat. No. Product Name CAS No. Information
CSN23755 STING ligand-1 2365039-41-2 STING ligand-1 is a lead STING ligand with IC50 of 68 nM for HAQ STING
CSN24506 STING agonist-3 2138299-29-1 STING agonist-3 is a selective small-molecule STING agonist which has durable anti-tumor effect and tremendous potential to improve treatment of cancer.
CSN18399 STING Agonist-1 702662-50-8 STING agonist-1 is a human-specific STING agonist that elicits antiviral activity against emerging Alphaviruses.
CSN29565 SN-011 2249435-90-1 SN-011 is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING-​mediated disease. SN-011 is a demethyl analogue of DUN99845.
CSN16863 ML RR-S2 CDA 1638241-89-0 ML RR-S2 CDA is a highly active cyclic-di-nucleotide immune stimulators that activate DCs via the cytoplamtic receptor STING (Stimulator of Interferon Genes).
CSN19006 ML RR-S2 CDA Ammonium 1638750-96-5 ML RR-S2 CDA ammonium is an inducer of STING (stimulator of interferon genes). ML RR-S2 CDA has enhanced binding affinity to STING and activate all known human STING alleles.
CSN23676 H-151 941987-60-6 H-151 is a irreversible inhibitor of STING that can inhibit the type I interferon (IFN) response and reduce the phosphorylation of TBK1 and palmitoylation of human STING in vitro.
CSN29564 DUN99845 727699-84-5 DUN99845 was reported as a STING inhbiitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING-​mediated disease.
CSN24296 diABZI STING agonist-1 3HCl 2138299-34-8 diABZI STING agonist-1 is a selective STING receptor agonist with EC50 value of 130nM.
CSN23276 diABZI STING agonist-1 2138498-18-5 diABZI STING agonist-1 is a selective stimulator of interferon genes STING receptor agonist with EC50s of 130 186 nM for human and mouse respectively
CSN18324 c-Di-AMP 54447-84-6 Cyclic-di-AMP is a second messenger molecule produced in bacteria but not in mammals and can induce a strong immune response in vitro and in vivo.
CSN27873 ChX710 2438721-44-7 ChX710 can boost cellular response to cytosolic DNA via STING. It efficiently primed cellular response to transfected plasmid DNA as assessed by potent synergistic effects on IFN-β secretion and ISG expression levels.
CSN18467 cGAMP 849214-04-6 cGAMP, an endogenous second messenger, can induce the formation of cytokines and promote innate immune response. It also acts as an activator of STING with antitumor activity.
CSN23535 C-178 329198-87-0 C-178 is a STING inhibitor that can block palmitoylation PMA-induced clustering of STING
CSN22907 C-176   314054-00-7 C-176 is a STING inhibitor with anti-inflammatory effect. It blocks the palmitoylation of STING by covalently targeting the transmembrane cysteine residue 91.
CSN26922 2',3'-cGAMP 1441190-66-4 2',3'-cGAMP (2'-3'-cyclic GMP-AMP) is a endogenous cGAMP in mammalian cells. 2',3'-cGAMP binds to STING with a high affinity and is a potent inducer of interferon-β (IFNβ). 2',3'-cGAMP is produced in mammalian cells in response to DNA in the cytoplasm[1].
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