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STAT

STAT

Cat. No. Product Name CAS No. Information
CSN19902 Casticin 479-91-4 Vitexicarpin, a natural product isolated and purified from the fruits of Vitex trifolia L. var. simplicifolia Cham., can significantly reduce vascular inflammation, through inhibition of ROS-NF-B pathway in vascular endothelial cells, and may become a potential leading drug in the therapy of prostate carcinoma.
CSN20470 STX-0119 851095-32-4 STX-0119 is a potent STAT3 inhibitor STX-0119 is an efficient therapeutic to overcome TMZ resistance in recurrent GBM tumors and could be the next promising compound leading to survival prolongation
CSN20442 STAT5-IN-1 285986-31-4 STAT5 inhibitor suppresses STAT5 via interaction of its SH2 domain with IC50 of 47 M
CSN27573 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea 1313019-65-6 STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3. STAT3-IN-7 induces cell apoptosis through SHP-1 dependent STAT3 inactivation. STAT3-IN-7 does not inhibit kinase activity and has anticancer effects.
CSN27227 STAT3-IN-1   2059952-75-7 STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor apoptosis .
CSN32601 1-Acetyl-5-hydroxyanthracene-9,10-dione 63972-38-3 STAT3 Inhibitors, Signal Transduction Modulators
CSN19288 Stafib-1 1688703-26-5 Stafib-2 selectively inhibits tyrosine phosphorylation of STAT5b in human leukaemia cells and induces apoptosis in a STAT5-dependent manner
CSN19226 Ochromycinone 111540-00-2 STA-21 is a selective STAT3 inhibitor.
CSN22560 SH5-07 1456632-41-9 SH5-07 is an inhibitor of STAT3 with IC50 of 3906 M with antitumor effects and it can suppresse human glioma and breast cancer
CSN28525 SD-36 2429877-44-9 SD-36 is a PROTAC Degrader of STAT3 Protein. SD-36 potently induces the degradation of STAT3 protein in vitro and in vivo and demonstrates high selectivity over other STAT members. Induced degradation of STAT3 results in a strong suppression of its transcription network in leukemia and lymphoma cells. SD-36 inhibits the growth of a subset of acute myeloid leukemia and anaplastic large-cell lymphoma cell lines by inducing cell-cycle arrest and/or apoptosis. SD-36 achieves complete and long-lasting tumor regression in multiple xenograft mouse models at well-tolerated dose schedules.
CSN10165 Scutellarin   27740-01-8 Scutellarin is an active flavonoid that shows anti-tumor activity and anti-proteasome action. It can be isolated from the root of Scutellaria baicalensis Georgi.
CSN20515 inS3-54A18 328998-53-4 inS3-54-A18 is an inhibitor of STAT3 that suppresses tumor growth metastasis and the expression of STAT3 target genes
CSN19012 HO-3867 1172133-28-6 HO-3867 selectively inhibits the phosphorylation and transcription of STAT3 It is an analog of curcumin
CSN22552 HJC0152 hydrochloride 1420290-99-8 HJC0152 inhibits STAT3 promoter activity in MDA-MB-231 cells in a dose-dependent manner.
CSN22827 Galiellalactone 133613-71-5 Galiellalactone is a STAT3 inhibitor that irreversibly binds STAT3 and inhibits binding to DNA.
CSN16361 Cryptotanshinone   35825-57-1 Cryptotanshinone is a potent STAT3 inhibitor (IC50 =4.6 μM) and inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells. Cryptotanshinone showed inhibitory effect on PL(pro) with IC50 value of 0.8μM and slight inhibitory effect on 3CLpro with IC50 value of 226.7μM.
CSN20212 C188-9 432001-19-9 C188-9 is a STAT3 inhibitor and has no effects on non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) in mice.
CSN14698 Brevilin A 16503-32-5 Brevilin A, a natural product isolated and purified from the herbs of Centipeda minima, is a strong impetus for the development of selective JAK-STAT inhibitors and therapeutic drugs in order to improve survival of patients with hyperactivated JAKs and STATs, and has antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM).
CSN12785 Balsalazide 80573-04-2 Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
CSN15925 Balsalazide sodium hydrate   150399-21-6 Balsalazide Disodium is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
CSN13598 AS1517499 919486-40-1 AS-1517499 is a potent STAT6 inhibitor with IC50 of 21 nM.
CSN32598 Tetramethylcurcumin 52328-97-9 Apoptosis Inducers, STAT3 Inhibitors, Signal Transduction Modulators
CSN13724 AG490   133550-30-8 AG-490 is a broad-spectrum inhibitor that has several targets including EGFR (IC50 2 M), ErbB2 (IC50 13.5 M), STAT3 and JAK2.
CSN40263 Oleoylcarnitine 38677-66-6
CSN39779 STAT3-IN-3 2361304-26-7
CSN35028 STAT5-IN-2 2111834-61-6
CSN42294 4-Bromo-2-(3-(4-chlorophenyl)acryloyl)-7-(methylamino)cyclohepta-2,4,6-trienone 723746-47-2
CSN62721 Stafib-2 2097938-74-2
CSN67704 YM-341619 643082-52-4
CSN67451 Stafia-1-dipivaloyloxymethyl ester 2582755-72-2
CSN75532 MM-206 1809581-87-0
CSN83112 IST5-002 13484-66-7
CSN86021 (S)-PM-43I 1637532-77-4
CSN51563 (R)-2-Amino-3-(prop-2-yn-1-ylthio)propanoic acid 3262-64-4
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