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STAT
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN19902 | Casticin | 479-91-4 | Vitexicarpin, a natural product isolated and purified from the fruits of Vitex trifolia L. var. simplicifolia Cham., can significantly reduce vascular inflammation, through inhibition of ROS-NF-B pathway in vascular endothelial cells, and may become a potential leading drug in the therapy of prostate carcinoma. |
| CSN20470 | STX-0119 | 851095-32-4 | STX-0119 is a potent STAT3 inhibitor STX-0119 is an efficient therapeutic to overcome TMZ resistance in recurrent GBM tumors and could be the next promising compound leading to survival prolongation |
| CSN20442 | STAT5-IN-1 | 285986-31-4 | STAT5 inhibitor suppresses STAT5 via interaction of its SH2 domain with IC50 of 47 M |
| CSN27573 | 1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(4-(4-cyanophenoxy)phenyl)urea | 1313019-65-6 | STAT3-IN-7 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3. STAT3-IN-7 induces cell apoptosis through SHP-1 dependent STAT3 inactivation. STAT3-IN-7 does not inhibit kinase activity and has anticancer effects. |
| CSN27227 | STAT3-IN-1 | 2059952-75-7 | STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor apoptosis . |
| CSN32601 | 1-Acetyl-5-hydroxyanthracene-9,10-dione | 63972-38-3 | STAT3 Inhibitors, Signal Transduction Modulators |
| CSN19288 | Stafib-1 | 1688703-26-5 | Stafib-2 selectively inhibits tyrosine phosphorylation of STAT5b in human leukaemia cells and induces apoptosis in a STAT5-dependent manner |
| CSN19226 | Ochromycinone | 111540-00-2 | STA-21 is a selective STAT3 inhibitor. |
| CSN22560 | SH5-07 | 1456632-41-9 | SH5-07 is an inhibitor of STAT3 with IC50 of 3906 M with antitumor effects and it can suppresse human glioma and breast cancer |
| CSN28525 | SD-36 | 2429877-44-9 | SD-36 is a PROTAC Degrader of STAT3 Protein. SD-36 potently induces the degradation of STAT3 protein in vitro and in vivo and demonstrates high selectivity over other STAT members. Induced degradation of STAT3 results in a strong suppression of its transcription network in leukemia and lymphoma cells. SD-36 inhibits the growth of a subset of acute myeloid leukemia and anaplastic large-cell lymphoma cell lines by inducing cell-cycle arrest and/or apoptosis. SD-36 achieves complete and long-lasting tumor regression in multiple xenograft mouse models at well-tolerated dose schedules. |
| CSN10165 | Scutellarin | 27740-01-8 | Scutellarin is an active flavonoid that shows anti-tumor activity and anti-proteasome action. It can be isolated from the root of Scutellaria baicalensis Georgi. |
| CSN20515 | inS3-54A18 | 328998-53-4 | inS3-54-A18 is an inhibitor of STAT3 that suppresses tumor growth metastasis and the expression of STAT3 target genes |
| CSN19012 | HO-3867 | 1172133-28-6 | HO-3867 selectively inhibits the phosphorylation and transcription of STAT3 It is an analog of curcumin |
| CSN22552 | HJC0152 hydrochloride | 1420290-99-8 | HJC0152 inhibits STAT3 promoter activity in MDA-MB-231 cells in a dose-dependent manner. |
| CSN22827 | Galiellalactone | 133613-71-5 | Galiellalactone is a STAT3 inhibitor that irreversibly binds STAT3 and inhibits binding to DNA. |
| CSN16361 | Cryptotanshinone | 35825-57-1 | Cryptotanshinone is a potent STAT3 inhibitor (IC50 =4.6 μM) and inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells. Cryptotanshinone showed inhibitory effect on PL(pro) with IC50 value of 0.8μM and slight inhibitory effect on 3CLpro with IC50 value of 226.7μM. |
| CSN20212 | C188-9 | 432001-19-9 | C188-9 is a STAT3 inhibitor and has no effects on non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) in mice. |
| CSN14698 | Brevilin A | 16503-32-5 | Brevilin A, a natural product isolated and purified from the herbs of Centipeda minima, is a strong impetus for the development of selective JAK-STAT inhibitors and therapeutic drugs in order to improve survival of patients with hyperactivated JAKs and STATs, and has antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM). |
| CSN12785 | Balsalazide | 80573-04-2 | Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease. |
| CSN15925 | Balsalazide sodium hydrate | 150399-21-6 | Balsalazide Disodium is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease. |
| CSN13598 | AS1517499 | 919486-40-1 | AS-1517499 is a potent STAT6 inhibitor with IC50 of 21 nM. |
| CSN32598 | Tetramethylcurcumin | 52328-97-9 | Apoptosis Inducers, STAT3 Inhibitors, Signal Transduction Modulators |
| CSN13724 | AG490 | 133550-30-8 | AG-490 is a broad-spectrum inhibitor that has several targets including EGFR (IC50 2 M), ErbB2 (IC50 13.5 M), STAT3 and JAK2. |
| CSN156393 | N-(1',2-Dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide | 432001-19-9 | |
| CSN40263 | Oleoylcarnitine | 38677-66-6 | |
| CSN39779 | STAT3-IN-3 | 2361304-26-7 | |
| CSN35028 | STAT5-IN-2 | 2111834-61-6 | |
| CSN42294 | 4-Bromo-2-(3-(4-chlorophenyl)acryloyl)-7-(methylamino)cyclohepta-2,4,6-trienone | 723746-47-2 | |
| CSN62721 | Stafib-2 | 2097938-74-2 | |
| CSN67704 | YM-341619 | 643082-52-4 | |
| CSN67451 | Stafia-1-dipivaloyloxymethyl ester | 2582755-72-2 | |
| CSN75532 | MM-206 | 1809581-87-0 | |
| CSN83112 | IST5-002 | 13484-66-7 | |
| CSN86021 | (S)-PM-43I | 1637532-77-4 |
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