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STAT

STAT

Cat. No. Product Name CAS No. Information
CSN19902 Vitexicarpin 479-91-4 Vitexicarpin, a natural product isolated and purified from the fruits of Vitex trifolia L. var. simplicifolia Cham., can significantly reduce vascular inflammation, through inhibition of ROS-NF-B pathway in vascular endothelial cells, and may become a potential leading drug in the therapy of prostate carcinoma.
CSN20470 STX-0119 851095-32-4 STX-0119 is a potent STAT3 inhibitor STX-0119 is an efficient therapeutic to overcome TMZ resistance in recurrent GBM tumors and could be the next promising compound leading to survival prolongation
CSN10157 Stattic   19983-44-9 Stattic a nonpeptidic small molecule potently inhibits STAT3 activation and nuclear translocation with IC50 of 51 M in cell-free assays highly selectivity over STAT1
CSN20442 STAT5 Inhibitor 285986-31-4 STAT5 inhibitor suppresses STAT5 via interaction of its SH2 domain with IC50 of 47 M
CSN19288 Stafib-2 1688703-26-5 Stafib-2 selectively inhibits tyrosine phosphorylation of STAT5b in human leukaemia cells and induces apoptosis in a STAT5-dependent manner
CSN19226 STA-21 111540-00-2 STA-21 is a selective STAT3 inhibitor.
CSN22560 SH5-07 1456632-41-9 SH5-07 is an inhibitor of STAT3 with IC50 of 3906 M with antitumor effects and it can suppresse human glioma and breast cancer
CSN17881 SH-4-54 1456632-40-8 SH-4-54 is a potent small molecule nonphosphorylated STAT3 inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5 respectively
CSN10165 Scutellarin   27740-01-8 Scutellarin is an active flavonoid that shows anti-tumor activity and anti-proteasome action. It can be isolated from the root of Scutellaria baicalensis Georgi.
CSN19875 Saikosaponin D 20874-52-6 Saikosaponin D, a natural product isolated and purified from the herb of Bupleurum chinense DC., is a SERCA inhibitor by inhibiting NF-κB and STAT3 signaling to protect against acetaminophen-induced hepatotoxicity and a potent inhibitor on acute hepatic injury by CCl4 and a potent cytotoxicity agent for human hepatocellular carcinoma cells, and has the antiproliferative effect in A549 cells that may be the induction of p53 and activity of the Fas/FasL apoptotic system.
CSN15990 S3I-201 501919-59-1 S3I-201 shows potent inhibition of STAT3 DNA-binding activity with IC50 of 86 M and low activity towards STAT1 and STAT5
CSN11557 Nifuroxazide   965-52-6 Nifuroxazide suppresses the transcription activity of STAT1 STAT3 IC50 3 M in cells and STAT5 It is a nitrofuran-based antidiarrheal agent that can prevent urinary tract infections
CSN16410 Niclosamide Monohydrate 73360-56-2 Niclosamide is used for the treatment of most tapeworm infections by inhibiting DNA replication.
CSN18451 Napabucasin 83280-65-3 Napabucasin is a first-in-class cancer stemness inhibitor that targets STAT3
CSN20515 inS3-54-A18 328998-53-4 inS3-54-A18 is an inhibitor of STAT3 that suppresses tumor growth metastasis and the expression of STAT3 target genes
CSN19012 HO-3867 1172133-28-6 HO-3867 selectively inhibits the phosphorylation and transcription of STAT3 It is an analog of curcumin
CSN22552 HJC0152 1420290-99-8 HJC0152 inhibits STAT3 promoter activity in MDA-MB-231 cells in a dose-dependent manner.
CSN22827 Galiellalactone 133613-71-5 Galiellalactone is a STAT3 inhibitor that irreversibly binds STAT3 and inhibits binding to DNA.
CSN12576 Diosgenin   512-04-9 Diosgenin, a natural product isolated and purified from the rhizomes of Dioscorea zingiberensis C.H.Wright, is an important natural source of steroidal hormones, and has favorable effects in the improvement of diabetes and regulation of lipid metabolism.
CSN16361 Cryptotanshinone   35825-57-1 Cryptotanshinone is a potent STAT3 inhibitor (IC50 =4.6 μM) and inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells. Cryptotanshinone showed inhibitory effect on PL(pro) with IC50 value of 0.8μM and slight inhibitory effect on 3CLpro with IC50 value of 226.7μM.
CSN14607 Corylifol A 775351-88-7 Corylifol A is a phenolic compounds isolated from Psoralea corylifolia and inhibits IL-6-induced STAT3 activation and phosphorylation IC5008 M
CSN23522 Colivelin 867021-83-8 Colivelin is a peptide and activator of STAT3 with neuroprotective effects
CSN20212 C188-9 432001-19-9 C188-9 is a STAT3 inhibitor and has no effects on non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) in mice.
CSN14698 Brevilin A 16503-32-5 Brevilin A, a natural product isolated and purified from the herbs of Centipeda minima, is a strong impetus for the development of selective JAK-STAT inhibitors and therapeutic drugs in order to improve survival of patients with hyperactivated JAKs and STATs, and has antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM).
CSN17200 BP-1-102 1334493-07-0 BP-1-102 is an orally available small-molecule inhibitor of transcription factor STAT3
CSN12785 Balsalazide 80573-04-2 Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
CSN15925 Balsalazide Disodium Dihydrate   150399-21-6 Balsalazide Disodium is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
CSN13598 AS-1517499 919486-40-1 AS-1517499 is a potent STAT6 inhibitor with IC50 of 21 nM.
CSN13071 Artesunate   88495-63-0 Artesunate is a part of the artemisinin group of agents with an IC50 of 5 M for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and EXP1 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro.
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