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STAT

STAT

Cat. No. Product Name CAS No. Information
CSN19902 Vitexicarpin 479-91-4 Vitexicarpin, a natural product isolated and purified from the fruits of Vitex trifolia L. var. simplicifolia Cham., can significantly reduce vascular inflammation, through inhibition of ROS-NF-B pathway in vascular endothelial cells, and may become a potential leading drug in the therapy of prostate carcinoma.
CSN10157 Stattic   19983-44-9 Stattic a nonpeptidic small molecule potently inhibits STAT3 activation and nuclear translocation with IC50 of 51 M in cell-free assays highly selectivity over STAT1
CSN27227 STAT3-IN-1   2059952-75-7 STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor apoptosis .
CSN19226 STA-21 111540-00-2 STA-21 is a selective STAT3 inhibitor.
CSN10165 Scutellarin   27740-01-8 Scutellarin is an active flavonoid that shows anti-tumor activity and anti-proteasome action. It can be isolated from the root of Scutellaria baicalensis Georgi.
CSN11557 Nifuroxazide   965-52-6 Nifuroxazide suppresses the transcription activity of STAT1 STAT3 IC50 3 M in cells and STAT5 It is a nitrofuran-based antidiarrheal agent that can prevent urinary tract infections
CSN18451 Napabucasin 83280-65-3 Napabucasin is a first-in-class cancer stemness inhibitor that targets STAT3
CSN22827 Galiellalactone 133613-71-5 Galiellalactone is a STAT3 inhibitor that irreversibly binds STAT3 and inhibits binding to DNA.
CSN12576 Diosgenin   512-04-9 Diosgenin, a natural product isolated and purified from the rhizomes of Dioscorea zingiberensis C.H.Wright, is an important natural source of steroidal hormones, and has favorable effects in the improvement of diabetes and regulation of lipid metabolism.
CSN16361 Cryptotanshinone   35825-57-1 Cryptotanshinone is a potent STAT3 inhibitor (IC50 =4.6 μM) and inhibits STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells. Cryptotanshinone showed inhibitory effect on PL(pro) with IC50 value of 0.8μM and slight inhibitory effect on 3CLpro with IC50 value of 226.7μM.
CSN14698 Brevilin A 16503-32-5 Brevilin A, a natural product isolated and purified from the herbs of Centipeda minima, is a strong impetus for the development of selective JAK-STAT inhibitors and therapeutic drugs in order to improve survival of patients with hyperactivated JAKs and STATs, and has antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM).
CSN17200 BP-1-102 1334493-07-0 BP-1-102 is an orally available small-molecule inhibitor of transcription factor STAT3
CSN12785 Balsalazide 80573-04-2 Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
CSN15925 Balsalazide Disodium Dihydrate   150399-21-6 Balsalazide Disodium is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.
CSN13071 Artesunate   88495-63-0 Artesunate is a part of the artemisinin group of agents with an IC50 of 5 M for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and EXP1 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro.
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