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SRPK

SRPK

Cat. No. Product Name CAS No. Information
CSN19078 WNK463 2012607-27-9 WNK463 is a potant With-No-Lysine WNK kinase inhibitor with IC50s of 5169 nM for WNK1234
CSN23723 WNK-IN-11 2123489-30-3 WNK-IN-11 is a potent selective and orally active inhibitor of WNK1 kinase with IC50 of 6 nM
CSN22078 TMPA 1258275-73-8 TMPA is an antagonist of nuclear receptor Nur77 and LKB1 interaction.
CSN23884 STK16-IN-1 1223001-53-3 STK16-IN-1 is a serine/threonine protein kinase 16 (STK16) inhibitor with IC50 of 295 nM.
CSN13762 SRPIN340 218156-96-8 SRPIN340 is an inhibitor of serinearginine-rich protein kinase SRPK1 with IC50 of 089 M
CSN23673 SPHINX31 1818389-84-2 SPHINX31 is a potent and selective inhibitor of serine/arginine-rich protein kinase 1 (SRPK1), with an IC50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1). SPHINX31 is a potential topical therapeutic for neovascular eye disease[1].
CSN23063 rac-CCT 250863 1364269-06-6 rac-CCT-250863 is a potent Nek2 inhibitor. exhibiting selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.
CSN20434 PROTAC TBK1 C3i 2052306-13-3 PROTAC TBK1 C3i is a potent hit TBK1 DC50 12 nM Dmax 96 with excellent selectivity against a related kinase IKK which was further used as a chemical tool to assess TBK1 as a target in mutant K-Ras cancer cells
CSN17627 AR-13324 HCl 1253952-02-1 Netarsudil primarily targets cells in the conventional outflow tract, efficiently decreasing IOP in both human and non-human primate eyes.
CSN23000 NCL 00017509 1507367-00-1 NCL 00017509 is a potent and reversible NIMA related kinase 2 (Nek2) inhibitor with IC50 of 56 nM.
CSN23710 ML-9 105637-50-1 ML 9 a is myosin light chain kinase (MLCK) inhibitor. ML-9 enhances the anticancer activity of docetaxel, suggesting its potential application as an adjuvant to existing anticancer chemotherapy. The complex effect of ML-9 on autophagy and indentified ML-9 as an attractive tool for targeting autophagy in cancer therapy through dual inhibition of both the Akt pathway and the autophagy.
CSN17686 MK2-IN-1 1314118-92-7 MK2-IN-1 is a potent and selecitve MAPKAPK2 MK2 inhibitor IC50011 M with a non-ATP competitive binding mode
CSN17687 MK2-IN-1 HCl   1314118-94-9 MK2-IN-1 HCl is a non-ATP competitive inhibitor of MAPKAPK2 (MK2) with IC50 of 0.11 μM.
CSN19765 KY 05009 1228280-29-2 Inhibitor of Traf2- and Nck-Interacting Kinase TNIK Ki value 100 nM in ATP competitive assay that attenuates TGF-1-mediated Wnt and Smad signaling and epithelial-to-mesenchymal transition EMT in human lung adenocarcinoma A549 cells Additionally KY05009 inhibits TGF-1-induced phosphorylation of JNK12 FAK Src and paxillin
CSN18951 ILK-IN-2 2070015-22-2 ILK-IN-2 is a ILK inhibitor
CSN17699 ILK-IN-1 1333146-24-9 ILK-IN-1 is an ILK inhibitor with IC50 of 06 M
CSN24084 GSK8612 2361659-62-1 GSK8612 is a potent and highly selective Tank-binding Kinase-1 (TBK1) inhibitor with pIC50 of 6.8 for recombinant TBK1.
CSN15402 Cycloheterophyllin 36545-53-6 Cycloheterophyllin, a natural product isolated and purified from the herbs of Artocarpus heterophyllus, exerts a concentration-dependent inhibition of neutrophil cytosolic protein kinase C (PKC) and rat brain PKC by the O2- generation in rat neutrophils, but has no effect on porcine heart protein kinase A (PKA).
CSN20021 Bryostatin 1 83314-01-6 Bryostatin 1 is a Protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM).
CSN12528 4μ8C   14003-96-4 48C is a potent and selective IRE1 Rnase inhibitor with IC50 of 76 nM.
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