Proto-oncogene tyrosine-protein kinase | Protein Tyrosine Kinase/RTK| CSNpharm

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Cat. No.	Product Name	CAS No.	Information
CSN16229	WH-4-023	837422-57-8	WH-4-023 is an inhibitor of Lck and Src with IC50 of 2 nM, 6 nM, respectively.
CSN17744	WEHI-345 Analog	1354825-62-9	WEHI-345 analog is a Src inhibitor
CSN13096	TG 100801	867331-82-6	TG 100801 is the prodrug of TG 100572 which is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src family kinases with IC50 values of 272105 nM of VEGFR1VEGFR2FGFR1SrcFyn kianse respectively
CSN18504	TG 100572	867334-05-2	TG 100572 is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 272105 nM for VEGFR1VEGFR2FGFR1SrcFyn kianse respectively
CSN18503	TG 100572 HCl	867331-64-4	TG 100572 HCl is a multi-targeted kinase inhibitor that inhibits select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM for VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively.
CSN17735	T338C Src-IN-2	1351927-00-8	T338C Src-IN-2 is a potent mutant c-Src T338C kinase inhibitor with IC50 of 317 nM and also inhibits T338CV323A and T338CV323S with IC50 of 57 nM19 nM
CSN17734	T338C Src-IN-1	1351926-90-3	T338C Src-IN-1 is a potent mutant-Src T338C inhibitor and exhibits the most potent inhibition of T338C IC50111 nM relative to WT c-Src10-fold increase
CSN18218	SU6656	330161-87-0	SU 6656 is an inhibitor of Src kinases and can target Src Yes Lyn and Fyn with IC50 of 280 nM 20 nM 130 nM 170 nM respectively
CSN17355	Src Inhibitor 1	179248-59-0	Src inhibitor 1 is an inhibitor of Src and Lck with IC50 of 44 nM and 88nM
CSN12259	Saracatinib	379231-04-6	Saracatinib is Src inhibitor with IC50 of 27 nM
CSN23720	RK 24466	213743-31-8	RK-24466 is an inhibitor of Lck 64-509 and LckCD isoforms with IC50s of 2 nM
CSN11759	PP2	172889-27-9	PP2 is a ATP-competitive inhibitor of the Src family of protein tyrosine kinases. The IC50s for p56lck, p59fynT, Hck, Src are 4 nM, 5 nM, 5 nM, 100 nM, respectively.
CSN11758	PP1	172889-26-8	PP1 is a selective inhibitor of Src and LckFyn with IC50 of 5 nM, 6 nM, respectively.
CSN21067	Ponatinib HCl	1114544-31-8	Ponatinib is a multi-targeted kinase inhibitor with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src respectively.
CSN12857	PD173955	260415-63-2	PD173955 is an src family-selective tyrosine kinase inhibitor with IC50 of 22 nM for Src Yes and Abl kinase and is less potent for FGFR and no activity on InsR and PKC
CSN23025	PD 166285 2HCl	212391-63-4	PD 166285 inhibited Src nonreceptor tyrosine kinase, fibroblast growth factor receptor-1, epidermal growth factor receptor and platelet-derived growth factor receptor beta subunit (PDGFR-beta), tyrosine kinases with half-maximal inhibitory potencies (IC50 values) of 8.4 +/- 2.3 nM (n = 6), 39.3 +/- 2.8 nM (n = 16), 87.5 +/- 13.7 nM (n = 6) and 98.3 +/- 7.9 nM (n = 16), respectively.
CSN12108	MLR-1023	41964-07-2	MLR-1023 is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals.
CSN17507	MCB-613	1162656-22-5	MCB-613 is a stimulator of steroid receptor coactivator SRC
CSN16563	Lck Inhibitor	847950-09-8	Lck inhibitor is a class of compounds that are potent inhibitors of Lck with an IC50 value of 7 nM.
CSN18620	Lck Inhibitor 2	944795-06-6	Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively.
CSN18935	KX2-391 Mesylate	1080645-95-9	KX2-391 mesylate is an inhibitor of Src that targets the peptide substrate site of Src with GI50 of 9-60 nM in cancer cell lines
CSN16540	KX2-391	897016-82-9	KX2-391 is an inhibitor of Src with IC50 of 9 nM-60 nM in cancer cells It is the first clinical and peptidomimetic class Src inhibitor
CSN16378	KX2-391 2HCl	1038395-65-1	KX2-391 2HCl is the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.
CSN13760	KX1-004	518058-84-9	KX1-004 is a potent small molecule inhibitor of Src-PTK as a potential protective drug for NIHL
CSN19857	KB SRC 4	1380088-03-8	KB SRC 4 is a potent and selective c-Src inhibitor Ki 44 nM and does not inhibit c-Abl at concentrations up to 125 M
CSN25623	Hck-IN-1	1473404-51-1	Hck Blocker compound B9 is a Nef-dependent Hck blocker with IC50 value of 2.8μM for Nef-Hck complex but >20μM for Hck alone. It binds directly to Nef via a pocket formed by the Nef dimerization interface and disrupts Nef dimerization in cells.
CSN16269	CTX-0294885	1439934-41-4	CTX-0294885 is a bisanilino pyrimidine and exhibits inhibitory activity against a broad range of kinases in vitro, further developed into a Sepharose-supported kinase capture reagent.
CSN11935	Bosutinib	380843-75-4	Bosutinib is an inhibitor of Src and Abl with IC50 of 12 nM and 1 nM
CSN18293	AZM475271	476159-98-5	AZM475271 is a potent and selective Src kinase inhibitor with IC50 of 5 nM showing no inhibitory activity on Flt3 KDR Tie-2
CSN17121	AMG-47a	882663-88-9	AMG-47a is a Lck inhibitor that can decrease T cell proliferation with anti-inflammatory activity.
CSN24193	A-420983	330789-03-2	A-420983 is a potent lck inhibitor, exhibiting oral efficacy in animal models of delayed-type hypersensitivity and organ transplant rejection.
CSN18243	A 419259	364042-47-7	A 419259 is an apoptosis inducing agent that inhibits Src family kinases c-Src and also induces apoptosis in CML cell ines and blocks Stat5 and Erk activation
CSN17856	A 419259 3HCl	1435934-25-0	A 419259 3HCl is a broad-spectrum pyrrolo-pyrimidine inhibitor, designed to enhance selectivity towards the Src family with IC50 of 9 nM, < 3 nM and < 3 nM for Src, Lck and Lyn, respectively.
CSN21118	7-Hydroxy-4-chromone	59887-89-7	7-Hydroxychromone is a Src kinase inhibitor with an IC50 of 300 M
CSN13856	1-Naphthyl PP1	221243-82-9	1-Naphthyl PP1 is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl IC50 values are 10 06 06 18 and 22 M for v-Src c-Fyn c-Abl CDK2 and CAMK II respectively
CSN15753	1-Naphthyl PP1 HCl	956025-47-1	1-Naphthyl PP1 HCl is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively).

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