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Src
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN15826 | ZM 306416 | 690206-97-4 | ZM-306416 is an inhibitor of VEGFR (Flk-1 or KDR) and Flt with IC50 of 100 nM and 2 μM. It also shows inhibition activity against Src and Abl with IC50 values of 0.33μM and 1.3μM, respectively. |
| CSN16229 | WH-4-023 | 837422-57-8 | WH-4-023 is an inhibitor of Lck and Src with IC50 of 2 nM, 6 nM, respectively. |
| CSN17744 | WEHI-345 analog | 1354825-62-9 | WEHI-345 analog is a Src inhibitor |
| CSN20579 | Repotrectinib | 1802220-02-5 | TPX-0005 is a potent ALKROS1TRK inhibitor with IC50 of 53 nM 101 nM 126 nM and 108 nM for SRC WT ALK ALK G1202R and ALK L1196M respectively |
| CSN18504 | TG 100572 | 867334-05-2 | TG 100572 is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 272105 nM for VEGFR1VEGFR2FGFR1SrcFyn kianse respectively |
| CSN18503 | TG 100572 Hydrochloride | 867331-64-4 | TG 100572 HCl is a multi-targeted kinase inhibitor that inhibits select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM for VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively. |
| CSN17735 | T338C Src-IN-2 | 1351927-00-8 | T338C Src-IN-2 is a potent mutant c-Src T338C kinase inhibitor with IC50 of 317 nM and also inhibits T338CV323A and T338CV323S with IC50 of 57 nM19 nM |
| CSN17734 | T338C Src-IN-1 | 1351926-90-3 | T338C Src-IN-1 is a potent mutant-Src T338C inhibitor and exhibits the most potent inhibition of T338C IC50111 nM relative to WT c-Src10-fold increase |
| CSN18218 | SU6656 | 330161-87-0 | SU 6656 is an inhibitor of Src kinases and can target Src Yes Lyn and Fyn with IC50 of 280 nM 20 nM 130 nM 170 nM respectively |
| CSN17355 | Src Inhibitor 1 | 179248-59-0 | Src inhibitor 1 is an inhibitor of Src and Lck with IC50 of 44 nM and 88nM |
| CSN23720 | RK-24466 | 213743-31-8 | RK-24466 is an inhibitor of Lck 64-509 and LckCD isoforms with IC50s of 2 nM |
| CSN11759 | PP2 | 172889-27-9 | PP2 is a ATP-competitive inhibitor of the Src family of protein tyrosine kinases. The IC50s for p56lck, p59fynT, Hck, Src are 4 nM, 5 nM, 5 nM, 100 nM, respectively. |
| CSN11758 | PP1 | 172889-26-8 | PP1 is a selective inhibitor of Src and LckFyn with IC50 of 5 nM, 6 nM, respectively. |
| CSN21067 | Ponatinib hydrochloride | 1114544-31-8 | Ponatinib is a multi-targeted kinase inhibitor with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src respectively. |
| CSN23025 | PD0166285 dihydrochloride | 212391-63-4 | PD 166285 inhibited Src nonreceptor tyrosine kinase, fibroblast growth factor receptor-1, epidermal growth factor receptor and platelet-derived growth factor receptor beta subunit (PDGFR-beta), tyrosine kinases with half-maximal inhibitory potencies (IC50 values) of 8.4 +/- 2.3 nM (n = 6), 39.3 +/- 2.8 nM (n = 16), 87.5 +/- 13.7 nM (n = 6) and 98.3 +/- 7.9 nM (n = 16), respectively. |
| CSN16663 | NVP-BHG712 | 940310-85-0 | NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition and also shows activity against c-Raf c-Src and c-Abl with IC50 of 0395 M 1266 M and 1667 M respectively |
| CSN12108 | Tolimidone | 41964-07-2 | MLR-1023 is a chemical compound which inhibits acid secretion in animal models and also acts as a bronchodilator in histamine-challenged animals. |
| CSN17507 | MCB-613 | 1162656-22-5 | MCB-613 is a stimulator of steroid receptor coactivator SRC |
| CSN16563 | Lck Inhibitor | 847950-09-8 | Lck inhibitor is a class of compounds that are potent inhibitors of Lck with an IC50 value of 7 nM. |
| CSN18620 | Lck inhibitor 2 | 944795-06-6 | Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively. |
| CSN18935 | Tirbanibulin Mesylate | 1080645-95-9 | KX2-391 mesylate is an inhibitor of Src that targets the peptide substrate site of Src with GI50 of 9-60 nM in cancer cell lines |
| CSN16540 | Tirbanibulin | 897016-82-9 | KX2-391 is an inhibitor of Src with IC50 of 9 nM-60 nM in cancer cells It is the first clinical and peptidomimetic class Src inhibitor |
| CSN16378 | Tirbanibulin dihydrochloride | 1038395-65-1 | KX2-391 2HCl is the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. |
| CSN11250 | Kenpaullone | 142273-20-9 | Kenpaullone is an ATP-competitive inhibitor of CDK1cyclin B (IC50 0.4 M), CDK2cyclin A (IC50 0.68 M), CDK5p25 (IC50 0.85 M), lymphocyte kinase (IC50 0.47 M) , and GSK-3 (C50 0.23 M). |
| CSN19857 | KB SRC 4 | 1380088-03-8 | KB SRC 4 is a potent and selective c-Src inhibitor Ki 44 nM and does not inhibit c-Abl at concentrations up to 125 M |
| CSN25623 | Hck-IN-1 | 1473404-51-1 | Hck Blocker compound B9 is a Nef-dependent Hck blocker with IC50 value of 2.8μM for Nef-Hck complex but >20μM for Hck alone. It binds directly to Nef via a pocket formed by the Nef dimerization interface and disrupts Nef dimerization in cells. |
| CSN27682 | DGY-06-116 | 2556836-50-9 | DGY-06-116 is an irreversible covalent and selective Src inhibitor. |
| CSN16497 | Dasatinib | 302962-49-8 | Dasatinib is a potent and dual Abl/ Src inhibitor IC50 of < 1 nM/0.8 nM respectively and also inhibits c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM. |
| CSN16269 | CTX-0294885 | 1439934-41-4 | CTX-0294885 is a bisanilino pyrimidine and exhibits inhibitory activity against a broad range of kinases in vitro, further developed into a Sepharose-supported kinase capture reagent. CTX-0294885 is a broad spectrum kinase inhibitor that inhibited FAK, FLT3, JAK2, JAK3, Src, Aurora kinase A, and VEGF receptor 3 (IC50s = 4, 1, 3, 28, 2, 18, and 3 nM, respectively) in an initial screen. |
| CSN27592 | CH6953755 | 2055918-71-1 | CH6953755 is a selective inhibitor of YES1 kinase with IC50 of 1.8 nM. |
| CSN18293 | AZM475271 | 476159-98-5 | AZM475271 is a potent and selective Src kinase inhibitor with IC50 of 5 nM showing no inhibitory activity on Flt3 KDR Tie-2 |
| CSN17121 | AMG-47a | 882663-88-9 | AMG-47a is a Lck inhibitor that can decrease T cell proliferation with anti-inflammatory activity. |
| CSN18243 | A 419259 | 364042-47-7 | A 419259 is an apoptosis inducing agent that inhibits Src family kinases c-Src and also induces apoptosis in CML cell ines and blocks Stat5 and Erk activation |
| CSN17856 | A 419259 trihydrochloride | 1435934-25-0 | A 419259 3HCl is a broad-spectrum pyrrolo-pyrimidine inhibitor, designed to enhance selectivity towards the Src family with IC50 of 9 nM, < 3 nM and < 3 nM for Src, Lck and Lyn, respectively. |
| CSN21118 | 7-Hydroxy-4H-chromen-4-one | 59887-89-7 | 7-Hydroxychromone is a Src kinase inhibitor with an IC50 of 300 M |
| CSN13856 | 1-Naphthyl PP1 | 221243-82-9 | 1-Naphthyl PP1 is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl IC50 values are 10 06 06 18 and 22 M for v-Src c-Fyn c-Abl CDK2 and CAMK II respectively |
| CSN15753 | 1-Naphthyl PP1 hydrochloride | 956025-47-1 | 1-Naphthyl PP1 HCl is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). |
| CSN26939 | HG-7-85-01 | 1258391-13-7 | |
| CSN28978 | 4-Chloro-5-(1H-indol-3-yl)oxazole | 120191-51-7 | |
| CSN39056 | SM1-71 | 2088179-99-9 | |
| CSN35548 | Dasatinib metabolite M6 | 910297-53-9 | |
| CSN43294 | eCF506 | 1914078-41-3 | |
| CSN42896 | AZD0424 | 692054-06-1 | |
| CSN79705 | N-(3-fluorobenzyl)-2-(5-(4-morpholinophenyl)pyridin-2-yl)acetamide | 897016-26-1 | |
| CSN83349 | Bosutinib hydrate | 918639-08-4 |
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