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Sodium Channel

Sodium Channel

Cat. No. Product Name CAS No. Information
CSN25305 Tenapanor 1234423-95-0 Tenapanor is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kidney, with IC50 values of 5 and 10 nM against human and rat NHE3, respectively.
CSN22177 Sodium Channel Inhibitor 2 653573-60-5 Sodium Channel inhibitor 2 is a sodium channel blocker extracted from patent WO 2004011439 A2 compound 3c
CSN23212 Zoniporide 2HCl 241799-10-0 Selective NHE1 inhibitor
CSN11872 Rufinamide   106308-44-5 Rufinamide, an antiepileptic agent, is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS).
CSN24189 Rimeporide 187870-78-6 Rimeporide is a potent and selective NHE1 inhibitor.
CSN12584 Riluzole   1744-22-5 Riluzole is an antagonist of glutamate that used as an anticonvulsant. It can prolong the survival of patients with amyotrophic lateral sclerosis.
CSN12787 Ranolazine 2HCl 95635-56-6 Ranolazine 2HCl is a calcium uptake inhibitor via the sodium/calcium channal, used to treat chronic angina.
CSN11774 Procaine   59-46-1 Procaine, a benzoic acid derivative, is an anesthetic drug through targeting multiple proteins.
CSN12795 Phenytoin 57-41-0 Phenytoin is an inactive voltage-gated sodium channel stabilizer.
CSN18533 PH-064 892546-37-1 PH-064 is a sodium channel inhibitor. It is also a selective Gαq inhibitor. It traps Gαq in the empty pocket conformation by permitting GDP exit but interdicting GTP entry.
CSN21395 PF-06869206 2227425-05-8 PF-06869206 is an orally bioavailable selective inhibitor of the sodium-phosphate cotransporter NaPi2a SLC34A1 with an IC50 of 380 nM
CSN26169 PF-06305591 1449473-97-5 PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with IC50 of 15 nM. It shows excellent preclinical in vitro ADME and safety profile.
CSN26313 PF-01247324 875051-72-2 PF-01247324 is a selective Nav1.8 channel blocker with an IC50 of 196 nM.
CSN22144 PF-04531083 1079400-07-9 PF 04531083 is a selective NaV18 blocker and used for the research of neuropathicinflammatory pain
CSN21275 NHE3-IN-1 632355-68-1 NHE3-IN-1 is a sodiumproton exchanger type 3 NHE-3 inhibitor extracted from patent WO 2011019784 A1
CSN26179 N-Me-aminopyrimidinone 9 1356834-62-2 N-Me-aminopyrimidinone 9 is an improved Nav1.7 antagonist with minimal off-target hERG liability, and improved rat PK properties.
CSN21733 Micinicate 39537-99-0 Micinicate, a local anesthetic, can reversibly block transient Na+ inward current as well as the steady-state K+ outward current.
CSN25458 Licarbazepine 29331-92-8 Licarbazepine, also known as BIA-2-005; GP-47779; LIC-477; LIC-477D; TRI-477, is a voltage-gated sodium channel blocker with anticonvulsant and mood-stabilizing effects that is related to oxcarbazepine. It is an active metabolite of oxcarbazepine. In addition, an isomer of licarbazepine, eslicarbazepine ((S)-(+)-licarbazepine), is an active metabolite of eslicarbazepine acetate. Oxcarbazepine and eslicarbazepine acetate are inactive on their own, and behave instead as prodrugs to licarbazepine and eslicarbazepine, respectively, to produce their therapeutic effects.
CSN12998 Lamotrigine   84057-84-1 Lamotrigine is a member of the sodium channel blocking class of antiepileptic drugs which can block L-, N-, and P-type calcium channels and has weak 5-HT3 receptor inhibition.
CSN24781 GNE-131 1629063-81-5 GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7, with an IC50 of 3 nM.
CSN19828 Funapide 1259933-16-8 Funapide is an analgesic agent which may be useful for the treatment of a variety of chronic pain conditions.
CSN21301 FR183998 239440-20-1 FR183998 free base is a potent NaH-exchange inhibitor, with IC50s of 0.3 nM, 3.1 nM and 6.5 nM by measurement of pHi change in rat lymphocytes, rat and human platelets, respectively.
CSN21637 ETH2120 81686-22-8 ETH2120 is a Na+ ionophore suitable for the assay of sodium activity in blood.
CSN20530 Eniporide 176644-21-6 Eniporide is an inhibitor of NaH exchange that prevents ischemic Na overload
CSN25462 EIPA 1154-25-2 EIPA (L593754) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na+/H+-exchanger (NHE) and macropinocytosis.
CSN25620 DSP-2230 1233231-30-5 DSP-2230 is a selective Nav1.7/Nav1.8 blocker.
CSN21438 Disopyramide   3737-09-5 Disopyramide can block sodium channel it is a class IA antiarrhythmic drug
CSN51363 CRMP2-Ubc9-NaV1.7 inhibitor 194 2241651-99-8 CRMP2-Ubc9-NaV1.7 inhibitor 194 is a CRMP2-Ubc9-NaV1.7 inhibitor.
CSN13878 CNV1014802 934240-30-9 CNV1014802 is a blocker of Nav1.7 sodium channel.
CSN15719 CNV1014802 HCl 934240-31-0 CNV1014802 HCl is a blocker of Nav1.7 sodium channel with analgesic effects.
CSN20559 Cariporide   159138-80-4 Cariporide is a selective inhibitor of NaH exchanger isoform 1 NHE1 with IC50 value of 005 M with cardioprotective and antiarrhythmic effects
CSN16283 Carbamazepine   298-46-4 Carbamazepine is a blocker of sodium channel with IC50 of 131 M in rat brain synaptosomes. It is an anticonvulsant drug.
CSN11492 Camostat Mesilate 59721-29-8 Camostat mesylate is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trypsin, prostasin and matriptase.
CSN22716 BIX NHE1 Inhibitor 1204329-34-9 BIX NHE1 Inhibitor is a potent and selective NHE1 inhibitor with IC50 of 31 nM.
CSN23800 Benzamil HCl 161804-20-2 Benzamil hydrochloride is a specific blocker of sodium channel (ENaC).
CSN20028 AMG8379 1642112-31-9 AMG8379 is a potent and selective small molecule sulfonamide antagonist of the voltage-gated sodium channel NaV17
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