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Smo

Smo

Cat. No. Product Name CAS No. Information
CSN19210 SAG HCl   2095432-58-7 Smoothened agonist hydrochloride is a cell-permeable Smoothened (Smo) agonist with EC50 of 3 nM in Shh-LIGHT2 cells.
CSN20315 Smo Inhibitor C24 1567963-99-8 Smo inhibitor C24 is a tetrahydropyrido43-dpyrimidine derivative that represent a set of Smo inhibitors that could potentially be utilized to treat medulloblastoma and other Hh pathway related malignancies
CSN16966 SAG 912545-86-9 SAG is a potent Smo receptor agonist and activates the Hedgehog signaling pathway with Kd of 59 nM
CSN15983 Purmorphamine   483367-10-8 Purmorphamine is an activator of Smoothened and blocks BODIPY-cyclopamine binding to Smo with IC50 of appr 15 M and also is an inducer of osteoblast differentiation with EC50 of 1 M
CSN15911 PF-5274857 1373615-35-0 PF-5274857 is a potent and selective Smoothened Smo antagonist inhibits Hedgehog Hh signaling with IC50 and Ki of 58 nM and 46 nM respectively and can penetrate the bloodbrain barrier
CSN13874 PF-04449913 1095173-27-5 PF-04449913 is a potent and orally bioavailable smoothened inhibitor PF-04449913 binds to human SMO amino acids 181-787 with an IC50 of 4 nM
CSN18669 MK-4101 935273-79-3 MK-4101 inhibits the hedgehog pathway with anti-tumor activity via the inhibition of proliferation and induction of apoptosis
CSN16217 LY2940680 1258861-20-9 LY2940680 can bind to the Smo receptor and inhibit hedgehog signaling
CSN19814 LEQ506 1204975-42-7 LEQ506 is an orally bioavailable small-molecule Smoothened Smo antagonist with potential antineoplastic activity
CSN16234 LDE225   956697-53-3 LDE225 is an antagonist of Smoothened that can inhibit hedgehog signaling with IC50 of 2.5 nM.
CSN17578 LDE225 Diphosphate 1218778-77-8 LDE225 diphosphate is a potent and selective Smo antagonist with IC50 of 13 nM and 25 nM for mouse and human Smo in binding assay respectively
CSN15980 Jervine   469-59-0 Jervine is hedgehog signaling inhibitor with IC50 of 500 nM-700 nM that disrupts the interaction with smoothened
CSN10720 Cyclopamine   4449-51-8 Cyclopamine is a specific Hedgehog Hh signaling pathway antagonist of Smoothened Smo with IC50 of 46 nM in TM3Hh12 cells
CSN17174 BMS-833923   1059734-66-5 BMS-833923 is an inhibitor of Smoothened with potential antineoplastic activity It can also inhibit BODIPY cyclopamine binding to SMO with IC50 of 21 nM
CSN22854 IHR 1 548779-60-8
CSN23031 PF 04449913 Maleate 2030410-25-2
CSN22839 GSA 10 300833-95-8
CSN23037 PF 5274857 HCl 1613439-62-5
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