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Inhibitors & Agonists

Functionalized Warhead Ligand

Bromodomain BET/Warhead LigandBcr-Abl/Warhead LigandSirtuin/Warhead LigandFKBP/Warhead Ligand

E3 Ligand Plus Linker

E3 Ligand Plus Linker (Pomalidomide)E3 Ligand Plus Linker (VH032)E3 Ligand Plus Linker (Thalidomide)E3 Ligand Plus Linker (Lenalidomide)E3 Ligand Plus Linker (other)

PROTACs

Bromodomain BET/PROTACVHL/PROTACFKBP/PROTACTRIM/PROTACCDK/PROTACALK/PROTACERR/PROTACPTK2/PROTACRaf/PROTACSirtuin/PROTACCRBN/PROTAC

Functionalized E3 Ligand

Functionalized E3 Ligand (Thalidomide)Functionalized E3 Ligand (VH032)Functionalized E3 Ligand (Pomalidomide)Functionalized E3 Ligand (other)Functionalized E3 Ligand (for VHL)

Linker

PROTAC Linker

Anti-infection

AntibacterialAntifungalAntiparasiticCMVFilovirusHBVHCVHIVHIV IntegraseHIV ProteaseHRVHSVInfluenza VirusNNRTINRTIOrthopoxvirusReverse TranscriptaseRSVSARS-CoVCCRDengue VirusHHVLpxCNeuraminidaseNS2B-NS3 ProteaseSQLEAntiviral

Apoptosis

Apoptosis InducerBcl-2Caspasec-Mycc-RETDAPKIAPMDM2p53PD-1/PD-L1PERKPKDSurvivinThymidylate SynthaseTNF-alpha

Autophagy

AutophagyCXCRLRRK2ULK

Cell Cycle

APCAurora KinaseCasein KinaseCDKChkc-MycCRISPR/Cas9CRM1DHFRDNA/RNA SynthesisDUBDYRKeIFG-quadruplexHaspin KinaseHSPIRE1KinesinLIMKMicrotubule/TubulinMps1Nucleoside Antimetabolite/Analogp97PAKPD-1/PD-L1PERKPLKPPARPTENRAD51RhoROCKWee1BUBHSFp21E1/E2/E3 Enzyme

Cytoskeleton

AktBcr-AblDynaminFAKGap Junction ProteinHSPIntegrinKinesinMicrotubule/TubulinMps1MyosinPAKWntβ-cateninSelectinArp2/3 ComplexPKC

DNA Damage

ATM/ATRDNA/RNA SynthesisDNA Alkylator/CrosslinkerDNA-PKHDACMTH1PARPSirtuinTelomeraseTopoisomerase

Endocrinology/Hormones

5 alpha Reductase