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Inhibitors & Agonists

PROTACs

Bromodomain BET/PROTACVHL/PROTACFKBP/PROTACTRIM/PROTACCDK/PROTACALK/PROTACPTK2/PROTACRaf/PROTACSirtuin/PROTACCRBN/PROTACMultikinase/PROTACp38/PROTACK-Ras (G12C)/PROTACERα/PROTACCdc20/PROTACBcl-2/PROTACMcl-1/PROTACFAK/PROTACSGK3/PROTACBTK/PROTACRIP Kinase/PROTACFLT3-ITD/PROTACRAR/PROTAC

Functionalized E3 Ligand

Functionalized E3 Ligand (Thalidomide)Functionalized E3 Ligand (VH032)Functionalized E3 Ligand (Pomalidomide)Functionalized E3 Ligand (other)Functionalized E3 Ligand (for VHL)

Linker

PROTAC Linker

Functionalized Warhead Ligand

Bromodomain BET/Warhead LigandBcr-Abl/Warhead LigandSirtuin/Warhead LigandFKBP/Warhead Ligand

E3 Ligand Plus Linker

E3 Ligand Plus Linker (Pomalidomide)E3 Ligand Plus Linker (VH032)E3 Ligand Plus Linker (Thalidomide)E3 Ligand Plus Linker (Lenalidomide)E3 Ligand Plus Linker (other)

Anti-infection

AntibacterialAntifungalAntiparasiticCMVFilovirusHBVHCVHIVHIV IntegraseHIV ProteaseHRVHSVInfluenza VirusNNRTINRTIOrthopoxvirusReverse TranscriptaseRSVSARS-CoVCCRDengue VirusHHVLpxCNeuraminidaseNS2B-NS3 ProteasePrionSQLEAntiviralβ-lactamaseFCoV3CLproM2 proton channelAntiprotozoalViral MTasePLPGraRPeroxiredoxin

Apoptosis

Apoptosis InducerBcl-2Caspasec-Mycc-RETDAPKIAPMDM2p53PD-1/PD-L1PERKPKDSurvivinThymidylate SynthaseTNF-alphaG0/G1 switch protein 2MDM2/PROTACMcl-1 (stapled peptide)Bim (stapled peptide)Bcl-2 (stapled peptide)p53/MDM2 (stapled peptide)NecroptosisC/EBPMcl-1/PROTACBcl-2/PROTAC

Autophagy

AutophagyCXCRLRRK2ULKSPHKPPTmitoNEETTFEBLC3

Cell Cycle

APCAurora KinaseCasein KinaseCDKChkc-MycCRISPR/Cas9CRM1DHFRDNA/RNA SynthesisDUBDYRKeIFG-quadruplexHaspin KinaseHSPIRE1KinesinLIMKMicrotubule/TubulinMps1Nucleoside Antimetabolite/Analogp97PAKPD-1/PD-L1PERKPLKPPARPTENRAD51RhoROCKWee1BUBHSFMad2p21E1/E2/E3 EnzymeFOXM1MKLPCdc25TACCDOCKClathrinMARPLats kinaseHGFCdc20/PROTACMRE11

Cytoskeleton

AktBcr-AblDynaminFAKGap Junction ProteinHSPIntegrinKinesinMicrotubule/TubulinMps1MyosinPAKWntβ-cateninSelectinArp2/3 ComplexPKCSpastinGap JunctionMLCKTACCFAK/PROTAC

DNA Damage

ATM/ATRDNA/RNA SynthesisDNA Alkylator/CrosslinkerDNA-PKHDACMTH1PARPSirtuinTelomeraseTopoisomeraseOGGATAD5MRE11WRN

Endocrinology/Hormones

5 Alpha ReductaseACEAndrogen Receptor
AromataseERRGlucocorticoid ReceptorGPCROpioid ReceptorProgesterone ReceptorReninTPOTRHRThyroid Hormone ReceptorPTGR

Epigenetics

AMPKAurora KinaseCECR2DNA MethyltransferaseEpigenetic Reader DomainHDACHIFHistone AcetyltransferaseHistone DemethylaseHistone MethyltransferaseJAKMicroRNAPADPARPPimPKCSirtuinTETMBD-containing proteinEZH2 (stapled peptide)HESFTOSir2p

GPCR/G Protein

Adenosine ReceptorAdiponectin ReceptorAdrenergic ReceptorAngiotensin ReceptorBombesin ReceptorBradykinin ReceptorcAMPCannabinoid ReceptorCaSRCCRCGRP ReceptorCholecystokinin ReceptorCRTH2CXCRDopamine ReceptorEndothelin ReceptorGHSRGlucagon ReceptorGlucocorticoid ReceptorGNRH ReceptorGuanylate CyclaseHedgehogHistamine ReceptorImidazoline ReceptorLPA ReceptorLTRmGluRMotilin ReceptorMT ReceptorNeurotensin ReceptorNK ReceptorNMUROpioid ReceptorOX ReceptorOXTRP2Y ReceptorPAFRPARPKAProstaglandin ReceptorRasRGSSGLTSigma ReceptorSSTRTSH ReceptorUrotensin ReceptorVasopressin ReceptorHDRGPR88LHCGRMelanocortin ReceptorSPHK5-HT ReceptorAChRApelin ReceptorCRF ReceptorGPCRLPL ReceptorNeuropeptide Y ReceptorEpacG proteinEndorphinSOS1/KRAS (stapled peptide)Rab (stapled peptide)SOS

Immunology/Inflammation

CCRComplement SystemCOXCRTH2CXCRFLAPHistamine ReceptorIFNARIL ReceptorIRAKLTRMALT1NADPH OxidaseNLRNOSNrf2PD-1/PD-L1PGE SynthaseROSSIKSTINGThrombopoietin ReceptorTLRCalcineurinComplement ReceptorILIRF3MIFS100A9TSPOcGASImmunology & Inflammation RelatedLTA4HMyD88macrophage/microgliaNFATFPRCYPACD80Scavenger receptorNOTCD28-B7EndorphinLanC-like proteinPG SynthaseXBP1S100βComplement C3

JAK/STAT Signaling

EGFRJAKPimSTAT

LIF/Stat3

LIF

MAPK/ERK Pathway

ERKJNKKLFMEKMLKMNKp38 MAPKRafRSKCot/tpl2MAP3K12MAP4K4AP-1

Membrane Transporter/Ion Channel

AMPARBCRPCFTRChloride ChannelCRAC ChannelCRM1EAAT2HCN ChannelMATMCTNa+/Ca2+ ExchangerNKCCP2X ReceptorP-gpPotassium ChannelProton PumpSodium ChannelTRPVURAT1VDACGABA ReceptorIBATOctSGLTAChRATPaseCalcium ChannelEAAT1GlyT1Na+/K+ ATPaseNBCNMDARTRP ChannelSLCGlutamate transporterUCP
ENTGABA transporterGlycine transporterKainate receptorABC TransporterANTAKK1Efflux pumpClathrinPiezoOCTNAQP

Metabolic Enzyme

15-PGDHACCACEAdenosine DeaminaseAdenosine KinaseAhRALDHAldose ReductaseAminopeptidaseATP Citrate LyaseCarbonic AnhydraseCathepsinCETPCOMTCPADecarboxylaseDehydrogenaseDGATDHFRElastaseEnolaseFAAHFABPFactor XaFASFerroptosisFXRGlucokinaseGLUT1GSNORGSTHexokinaseHIFHIV IntegraseHMGCRHSPHydroxylaseIDHIDOLipaseLipoxygenaseLXRMAOMineralocorticoid ReceptorNAENAMPTNeprilysinP450PAI-1PDEPDHKPGC-1αPhospholipaseProcollagen C ProteinaseRAR/RXRReninRORSCDSGKThioredoxinThrombinTransferaseVD/VDRXanthine OxidaseCYP51GlucosidaseGlutaminase CGlyoxalaseKetohexokinaseLDLMitochondrial Electron Transport ChainMitochondrial MetabolismMPCPGAM1PKM2Pyruvate KinaseTGHTransketolaseαKGD3-PGDHACATACMSDAdenosylhomocysteinaseArginaseATP synthaseFumarate hydrataseSteroid SulfataseGalactosidasesHydrolaseACSD-amino acid oxidaseP448SrxAO5 Alpha ReductaseCarboxylesteraseCPSIGLUTQRsEHGPxG0/G1 switch protein 2GMPSCYPAPvdQ acylaseBDKCreatine kinaseNPPVDR (stapled peptide)NQOXBP1AKRHMG-CoA synthaseRBPFTOD6DOGTADP-ribosyltransferaseERAPLRH-1PASKPME-NMTPDE-NMTPEPCKCardiolipin PeroxidaseAconitate hydrataseAsparagine synthetaseSGK3/PROTACRAR/PROTACOPA1

Neuronal Signaling

AChEAdenosine KinaseAdrenergic ReceptorAMPARAmyloid-βCaMKCGRP ReceptorCOMTCOXDATDopamine ReceptorFAAHGABA ReceptorGlyT1Histamine ReceptorImidazoline ReceptorMAOmGluRMT ReceptorNK ReceptorNMDAROpioid ReceptorOX ReceptorP2X ReceptorP-gpSecretaseSSRIsSubstance PCholineCholinesteraseEnkephalinaseGlucosylceramide SynthaseNETPSD-95RAGESERT5-HT ReceptorAChRProprotein convertasesQCCHTGABA transporterGlycine transporterKainate receptorEndorphinS100β

PI3K/Akt/mTOR

AktAMPKATM/ATRDNA-PKGSK-3MELKmTORPDK-1PI3KPI4KPIKfyvePTENRSKFOXOPHLPPPDK

Protease

Caspase
Cysteine ProteaseDPP4GlutaminaseHIV ProteaseMMPProteasomeSecretaseSer/Thr ProteaseNEPPEAspartic ProteaseTyrosinaseDPP2Dipeptidase 1

Protein Tyrosine Kinase/RTK

Ack1ALKBcr-AblBMX KinaseBTKc-FMSc-Kitc-Met/HGFRc-RETDDR1/DDR2 ReceptorDYRKEGFREphrin ReceptorFAKFGFRFLT3HER2IGF-1RInsulin ReceptorITKPDGFRPKAPTKPyk2Ros1SrcSykTAM ReceptorTie-2Trk ReceptorVEGFRBRKMERTKFGFTecErbBBTK/PROTACFLT3-ITD/PROTAC

Stem Cells/Wnt

Casein KinaseERKGliGSK-3HedgehogJAKMSTNotchPKAPORCNROCKSecretasesFRP-1SmoSTATWntYAPβ-cateninBMI-1TGF-beta ReceptorCREBβ-catenin (stapled peptide)Notch (stapled peptide)PKA/AKAP (stapled peptide)MARPLIN28LRH-1

TGF-beta/Smad

TGF-beta ReceptorSmadTGF-betaMARP

Ubiquitin

APCDUBNAEp97ProteasomeE1/E2/E3 EnzymeSUMOFBXO

Phosphatase

NF-κB

HDACIKKMALT1NF-κBNrf2PPARRIP KinaseTAK1LUBACRIP Kinase/PROTAC

Biochemical Reagent

Intermediate and OthersBiochemical Assay ReagentDye ReagentCationic & Neutral Lipids

Stapled Peptide

Mcl-1 (stapled peptide)β-catenin (stapled peptide)EZH2 (stapled peptide)SOS1/KRAS (stapled peptide)Notch (stapled peptide)PKA/AKAP (stapled peptide)Beclin 1 (stapled peptide)Bim (stapled peptide)Bcl-2 (stapled peptide)p53/MDM2 (stapled peptide)RAP1/TRF2 (stapled peptide)Rab (stapled peptide)VDR (stapled peptide)β-arrestin/β-adaptin (stapled peptide)

Others

PhosphataseSRPKDiureticDUE-BE2FECEFANCJFAPFer/FerTFPP synthaseFucosyltransferaseGalectin-3GBF1GCaseHIPK2HPPDInsecticideLAT1MLKLMPOMPTPMTTPMuscle RelaxantNMDNO SynthesisNur77Osteoclasts/Bone/OsteogenesisPAX2PBRPCA1PCSK9PDX1PFKFB3PhosphorylasePIN1PKGPlateletPME-1Protein SynthesisRev-ErbASAPSQSSREBPSweetenerTgaseTIR1UGT1A1UreaseVaninVAP-1VDAXORAnti-ulcerCancer Stem CellsCD73CerKChelating AgentCholine KinaseCARITPKALegumainOthers-OthersOxPhosVitaminE-NTPDaseGMPSTTRATAD5PANKGRKVPS4BTNIKRUNXHRGP20-HETECardiac transcription factorAIMP2-DX2PAM complexIMP1