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Inhibitors & Agonists

PROTACs

Bromodomain BET/PROTACVHL/PROTACFKBP/PROTACTRIM/PROTACCDK/PROTACALK/PROTACERR/PROTACPTK2/PROTACRaf/PROTACSirtuin/PROTACCRBN/PROTAC

Functionalized E3 Ligand

Functionalized E3 Ligand (Thalidomide)Functionalized E3 Ligand (VH032)Functionalized E3 Ligand (Pomalidomide)Functionalized E3 Ligand (other)Functionalized E3 Ligand (for VHL)

Linker

PROTAC Linker

Functionalized Warhead Ligand

Bromodomain BET/Warhead LigandBcr-Abl/Warhead LigandSirtuin/Warhead LigandFKBP/Warhead Ligand

E3 Ligand Plus Linker

E3 Ligand Plus Linker (Pomalidomide)E3 Ligand Plus Linker (VH032)E3 Ligand Plus Linker (Thalidomide)E3 Ligand Plus Linker (Lenalidomide)E3 Ligand Plus Linker (other)

Anti-infection

AntibacterialAntifungalAntiparasiticCMVFilovirusHBVHCVHIVHIV IntegraseHIV ProteaseHRVHSVInfluenza VirusNNRTINRTIOrthopoxvirusReverse TranscriptaseRSVSARS-CoVCCRDengue VirusH37RvHHVLpxCNeuraminidaseNS2B-NS3 ProteasePrionSQLEAntiviral

Apoptosis

Apoptosis InducerBcl-2Caspasec-Mycc-RETDAPKIAPMDM2p53PD-1/PD-L1PERKPKDSurvivinThymidylate SynthaseTNF-alpha

Autophagy

AutophagyCXCRLRRK2ULKSPHK

Cell Cycle

APCAurora KinaseCasein KinaseCDKChkc-MycCRISPR/Cas9CRM1DHFRDNA/RNA SynthesisDUBDYRKeIFG-quadruplexHaspin KinaseHSPIRE1KinesinLIMKMicrotubule/TubulinMps1Nucleoside Antimetabolite/Analogp97PAKPD-1/PD-L1PERKPLKPPARPTENRAD51RhoROCKWee1BUBHSFMad2p21E1/E2/E3 EnzymeFOXM1

Cytoskeleton

AktBcr-AblDynaminFAKGap Junction ProteinHSPIntegrinKinesinMicrotubule/TubulinMps1MyosinPAKWntβ-cateninSelectinArp2/3 ComplexPKC

DNA Damage

ATM/ATRDNA/RNA SynthesisDNA Alkylator/CrosslinkerDNA-PKHDACMTH1PARPSirtuinTelomeraseTopoisomerase

Endocrinology/Hormones

5 alpha ReductaseACEAndrogen ReceptorAromataseERRGlucocorticoid ReceptorGPCR
Opioid ReceptorProgesterone ReceptorReninTPOTRHRThyroid Hormone Receptor

Epigenetics

AMPKAurora KinaseCECR2DNA MethyltransferaseEpigenetic Reader DomainHDACHIFHistone AcetyltransferaseHistone DemethylaseHistone MethyltransferaseJAKmicroRNAPADPARPPimPKCSirtuin

GPCR/G Protein

Adenosine ReceptorAdiponectin ReceptorAdrenergic ReceptorAngiotensin ReceptorBombesin ReceptorBradykinin ReceptorcAMPCannabinoid ReceptorCaSRCCRCGRP ReceptorCholecystokinin ReceptorCRTH2CXCRDopamine ReceptorEndothelin ReceptorGHSRGlucagon ReceptorGlucocorticoid ReceptorGNRH ReceptorGuanylate CyclaseHedgehogHistamine ReceptorImidazoline ReceptorLPA ReceptorLTRmGluRMotilin ReceptorMT ReceptorNeurotensin ReceptorNK ReceptorNMUROpioid ReceptorOX ReceptorOXTRP2Y ReceptorPAFRPARPKAProstaglandin ReceptorRasRGSSGLTSigma ReceptorSSTRTSH ReceptorUrotensin ReceptorVasopressin ReceptorHDRGPR88LHCGRMelanocortin ReceptorRAPGEF4SPHK5-HT ReceptorAChRACTH ReceptorApelin ReceptorCRF ReceptorGPCRLPL ReceptorNeuropeptide Y Receptor

Immunology/Inflammation

CCRComplement SystemCOXCRTH2CXCRFLAPHistamine ReceptorIFNARIL ReceptorIRAKLTRMALT1NADPH OxidaseNLRNOSNrf2PD-1/PD-L1PGE SynthaseROSSIKSTINGThrombopoietin ReceptorTLRCalcineurinComplement ReceptorILIRF3MIFS100A9TSPOcGASImmunology & Inflammation RelatedLTA4HMYD88

JAK/STAT Signaling

EGFRJAKPimSTAT

MAPK/ERK Pathway

ERKJNKKLFMEKMLKMNKp38 MAPKRafRSKCot/tpl2MAP3K12MAP4K4

LIF/Stat3

LIF

Membrane Transporter/Ion Channel

AMPARBCRPCFTRChloride ChannelCRAC ChannelCRM1EAAT2HCN ChannelMATMCTNa+/Ca2+ ExchangerNKCCP2X ReceptorP-gpPotassium ChannelProton PumpSodium Channel