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Sirtuin
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN25238 | UBCS039 | 358721-70-7 | UBCS039 is a specific Sirtuin 6 activator which showed robust activating effects on Sirt6-dependent H3K18ac deacetylation of both full-length histone proteins and complete HeLa nucleosomes. |
| CSN12331 | Triacetylresveratrol | 42206-94-0 | Triacetylresveratrol is a prodrug of resveratrol with multiple targets including sirt, COX, IKK and LOX, etc.. |
| CSN32918 | Omzotirome | 1092551-88-6 | TRC-150094 is a NAD-Dependent Protein Deacetylase Sirtuin-1 (SIRT1) activator. |
| CSN20494 | Thiomyristoyl | 1429749-41-6 | Thiomyristoyl is an inhibitor of Sirt2 and Sirt1 with IC50 of 28 nM 98 M |
| CSN15828 | SRT 1720 Hydrochloride | 2060259-60-9 | The maximum activation ratio of SRT1720 versus the closest sirtuin homologues, SIRT2 (EC1.5 = 37 μM) and SIRT3 (EC1.5 > 300 μM) is up to 781%. |
| CSN15867 | Tenovin-6 | 1011557-82-6 | Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 IC5021 M and SIRT2 IC50 10 M inhibitor as well as p53 activator |
| CSN17390 | Tenovin-6 Hydrochloride | 1011301-29-3 | Tenovin 6 HCl is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 (IC50=21 μM) and SIRT2 (IC50= 10 μM) inhibitor as well as p53 activator. |
| CSN26766 | SRT3657 | 1383551-17-4 | SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect[1]. |
| CSN18940 | Sirtuin modulator 1 | 2070015-26-6 | SRT3025 HCl is an orally available sirtuin modulator. |
| CSN19241 | SRT 2183 | 1001908-89-9 | SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1 |
| CSN17459 | SRT 2104 | 1093403-33-8 | SRT2104 is an activator of SIRT1 which is involved in the regulation of energy homeostasis |
| CSN12823 | SRT 1720 | 925434-55-5 | SRT1720 is a selective activator of human SIRT1 EC15 016 M versus the closest sirtuin homologues SIRT2 and SIRT3 SIRT2 EC15 37 MSIRT3 EC15 300 M |
| CSN24314 | SRT1720 HCl | 1001645-58-4 | SRT1720 2HCl is a selective SIRT1 activator. |
| CSN25631 | SRT 1460 | 925432-73-1 | SRT1460 is a SIRT1 activator with EC50 value of 2.9μM in an in vitro fluorescence polarization assay. |
| CSN12889 | Splitomicin | 5690-03-9 | Splitomicin is a selective NAD-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 M showing a higher activity in a cell-based assay |
| CSN20027 | Sirtuin Inhibitor C18 | 1392810-44-4 | Sirtuin inhibitor C18 is a histone deacetylase class III inhibitor of sirtuin 1 and 2 exerting antiproliferative activity against cancer cell lines |
| CSN12523 | Sirtinol | 410536-97-9 | Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 M and 38 M in cell-free assays respectively |
| CSN28412 | SIRT5 inhibitor 1 | 2166487-21-2 | SIRT5 inhibitor 1 is "drug-like" and potent SIRT5 inhibitor with IC50 value of 0.11μM. |
| CSN26762 | SIRT1-IN-1 | 352554-02-0 | SIRT1-IN-1 is a selective SIRT1 inhibitor with an IC50 of 0.205 μM. SIRT1-IN-1 inhibits SIRT2 with an IC50 of 11.5 μM[1]. SIRT1-IN-1, a indole, is a cytomegalovirus (CMV) inhibitors and has antiviral activity[2]. |
| CSN19216 | SirReal2 | 709002-46-0 | SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM |
| CSN18937 | Salermide | 1105698-15-4 | Salermide a reverse amide can act as an inhibitor of sirt especially of sirt2 with the property of inducing apoptosis of tumor cells |
| CSN22311 | PROTAC Sirt2 Degrader-1 | 2098487-75-1 | PROTAC Sirt2 Degrader-12 is a PROTAC selectively targeting on Sirt2, consist an isotype-selective Sirt2 inhibitor SirReal as a warhead linked to cereblon ligand thalidomide. |
| CSN25457 | OSS_128167 | 887686-02-4 | OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects. |
| CSN26763 | Nicotinamide riboside malate | 2415659-01-5 | Nicotinamide riboside malate, an orally active NAD+ precursor, increases NAD+ levels and activates SIRT1 and SIRT3. Nicotinamide riboside malate is a source of vitamin B3 (niacin) and enhances oxidative metabolism, protection against high fat diet-induced metabolic abnormalities[1]. Nicotinamide riboside malate reduces cognitive deterioration in a transgenic mouse model of Alzheimer’s disease[2]. |
| CSN29498 | Nicotinamide riboside | 1341-23-7 | Nicotinamide riboside increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. |
| CSN16796 | Nicotinamide | 98-92-0 | Nicotinamide can act as an inhibitor of sirtuins and it is the active component of NAD and NADP |
| CSN16506 | Isoliquiritigenin | 961-29-5 | Isoliquiritigenin is a licorice chalconoid, a type of natural phenols, and a sirtuin-activating compound. |
| CSN15959 | Inauhzin | 309271-94-1 | Inauhzin is a small molecule that effectively reactivates p53 by inhibiting SIRT1 activity and promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress IC503 M in A549 cell |
| CSN15833 | (S)-Selisistat | 848193-68-0 | EX-527 S-enantiomer is a potent and selective SIRT1 inhibitor with IC50 of 123 nM showing no inhibition on SIRT3 and SIRT3 |
| CSN15817 | (R)-Selisistat | 848193-69-1 | EX-527 R-enantiomer is the R-enantiomer of EX-527 EX-527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM EX-527 has much lower potency against SIRT2 IC50 196 M or SIRT3 IC50 487 M |
| CSN10146 | Selisistat | 49843-98-3 | EX-527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits 200-fold selectivity against SIRT2 and SIRT3. |
| CSN10815 | Dihydrocoumarin | 119-84-6 | Dihydrocoumarin, a natural product isolated and purified from the leaves of Southern sweet-grass., is widespread used as a flavoring agent in beverages, gelatins, puddings, candy, and other food items. It is also as a fragrance in perfumes, creams, and cosmetics. |
| CSN21950 | CAY10602 | 374922-43-7 | CAY10602 is a SIRT1 activator. |
| CSN26404 | Cambinol | 14513-15-6 | Cambinol is a SIRT1 and SIRT2 inhibitor with IC50 values of 56 and 59 μM, respectively. |
| CSN16491 | AK-7 | 420831-40-9 | AK-7 is a selective and brain-permeable SIRT2 inhibitor and is neuroprotective in Huntington disease mouse models |
| CSN21121 | AK-1 | 330461-64-8 | AK-1 is a cell permeable benzylsulfonamide that inhibits SIRT2 activity IC50 125 M through enzymatic assay by targeting the SIRT2 nicotinamide binding site but may also target SIRT1 and SIRT3 IC50 40 M with much less potency |
| CSN19942 | Agrimol B | 55576-66-4 | Agrimol B is a natural product isolated and purified from the herbs of Agrimonia pilosa Ledeb. |
| CSN13831 | AGK2 | 304896-28-4 | AGK2 is a potent and selective SIRT2 inhibitor with IC50 of 35 M that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels |
| CSN20654 | 3-TYP | 120241-79-4 | 3-TYP is a selective inhibitor of SIRT3 |
| CSN28859 | E1231 | 1031195-19-3 |
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