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Sirtuin
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN25238 | UBCS039 | 358721-70-7 | UBCS039 is a specific Sirtuin 6 activator which showed robust activating effects on Sirt6-dependent H3K18ac deacetylation of both full-length histone proteins and complete HeLa nucleosomes. |
| CSN12331 | Triacetylresveratrol | 42206-94-0 | Triacetylresveratrol is a prodrug of resveratrol with multiple targets including sirt, COX, IKK and LOX, etc.. |
| CSN20494 | Thiomyristoyl | 1429749-41-6 | Thiomyristoyl is an inhibitor of Sirt2 and Sirt1 with IC50 of 28 nM 98 M |
| CSN15828 | SRT1720 HCl | 2060259-60-9 | The maximum activation ratio of SRT1720 versus the closest sirtuin homologues, SIRT2 (EC1.5 = 37 μM) and SIRT3 (EC1.5 > 300 μM) is up to 781%. |
| CSN15867 | Tenovin-6 | 1011557-82-6 | Tenovin-6 is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 IC5021 M and SIRT2 IC50 10 M inhibitor as well as p53 activator |
| CSN17390 | Tenovin 6 HCl | 1011301-29-3 | Tenovin 6 HCl is the water soluble analog of Tenovin-1 and acts as a potent SIRT1 (IC50=21 μM) and SIRT2 (IC50= 10 μM) inhibitor as well as p53 activator. |
| CSN26139 | SRTCX1003 | 1203480-93-6 | SRTCX1003 is a Sirtuin 1 activator. It enhanced deacetylation of cellular p65 protein, which resulted in the suppression of TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner. |
| CSN18940 | SRT3025 HCl | 2070015-26-6 | SRT3025 HCl is an orally available sirtuin modulator. |
| CSN19241 | SRT2183 | 1001908-89-9 | SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1 |
| CSN17459 | SRT2104 | 1093403-33-8 | SRT2104 is an activator of SIRT1 which is involved in the regulation of energy homeostasis |
| CSN12823 | SRT1720 | 925434-55-5 | SRT1720 is a selective activator of human SIRT1 EC15 016 M versus the closest sirtuin homologues SIRT2 and SIRT3 SIRT2 EC15 37 MSIRT3 EC15 300 M |
| CSN24314 | SRT1720 2HCl | 1001645-58-4 | SRT1720 2HCl is a selective SIRT1 activator. |
| CSN25631 | SRT1460 | 925432-73-1 | SRT1460 is a SIRT1 activator with EC50 value of 2.9μM in an in vitro fluorescence polarization assay. |
| CSN12889 | Splitomicin | 5690-03-9 | Splitomicin is a selective NAD-dependent histone deacetylase Sir2p inhibitor with IC50 of 60 M showing a higher activity in a cell-based assay |
| CSN20027 | Sirtuin Inhibitor C18 | 1392810-44-4 | Sirtuin inhibitor C18 is a histone deacetylase class III inhibitor of sirtuin 1 and 2 exerting antiproliferative activity against cancer cell lines |
| CSN12523 | Sirtinol | 410536-97-9 | Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 M and 38 M in cell-free assays respectively |
| CSN19216 | SirReal2 | 709002-46-0 | SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM |
| CSN18937 | Salermide | 1105698-15-4 | Salermide a reverse amide can act as an inhibitor of sirt especially of sirt2 with the property of inducing apoptosis of tumor cells |
| CSN22311 | Sirt2-PROTAC-1 | 2098487-75-1 | PROTAC Sirt2 Degrader-12 is a PROTAC selectively targeting on Sirt2, consist an isotype-selective Sirt2 inhibitor SirReal as a warhead linked to cereblon ligand thalidomide. |
| CSN25457 | OSS_128167 | 887686-02-4 | OSS_128167 is a potent selective sirtuin 6 (SIRT6) inhibitor with IC50s of 89 μM, 1578 μM and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-HBV activity that inhibits HBV transcription and replication. OSS_128167 has anti-cancer, anti-inflammation and anti-viral effects. |
| CSN16796 | Nicotinamide | 98-92-0 | Nicotinamide can act as an inhibitor of sirtuins and it is the active component of NAD and NADP |
| CSN23883 | MDL-801 | 2275619-55-9 | MDL-801 is an activator of SIRT6 deacetylation with EC50 of 5.7 µM. |
| CSN15959 | Inauhzin | 309271-94-1 | Inauhzin is a small molecule that effectively reactivates p53 by inhibiting SIRT1 activity and promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress IC503 M in A549 cell |
| CSN18677 | Fisetin | 528-48-3 | Fisetin is an active flavonol that can be used in the synthesis of pharmaceutical with anti-inflammatory and antiproliferative activities |
| CSN15833 | EX-527 S-Enantiomer | 848193-68-0 | EX-527 S-enantiomer is a potent and selective SIRT1 inhibitor with IC50 of 123 nM showing no inhibition on SIRT3 and SIRT3 |
| CSN15817 | EX-527 R-Enantiomer | 848193-69-1 | EX-527 R-enantiomer is the R-enantiomer of EX-527 EX-527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM EX-527 has much lower potency against SIRT2 IC50 196 M or SIRT3 IC50 487 M |
| CSN10146 | EX-527 | 49843-98-3 | EX-527 is a potent and selective SIRT1 inhibitor with IC50 of 38 nM, exhibits 200-fold selectivity against SIRT2 and SIRT3. |
| CSN10815 | Dihydrocoumarin | 119-84-6 | Dihydrocoumarin, a natural product isolated and purified from the leaves of Southern sweet-grass., is widespread used as a flavoring agent in beverages, gelatins, puddings, candy, and other food items. It is also as a fragrance in perfumes, creams, and cosmetics. |
| CSN21950 | CAY10602 | 374922-43-7 | CAY10602 is a SIRT1 activator. |
| CSN16491 | AK-7 | 420831-40-9 | AK-7 is a selective and brain-permeable SIRT2 inhibitor and is neuroprotective in Huntington disease mouse models |
| CSN21121 | AK-1 | 330461-64-8 | AK-1 is a cell permeable benzylsulfonamide that inhibits SIRT2 activity IC50 125 M through enzymatic assay by targeting the SIRT2 nicotinamide binding site but may also target SIRT1 and SIRT3 IC50 40 M with much less potency |
| CSN19942 | Agrimol B | 55576-66-4 | Agrimol B is a natural product isolated and purified from the herbs of Agrimonia pilosa Ledeb. |
| CSN13831 | AGK2 | 304896-28-4 | AGK2 is a potent and selective SIRT2 inhibitor with IC50 of 35 M that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels |
| CSN20654 | 3-TYP | 120241-79-4 | 3-TYP is a selective inhibitor of SIRT3 |
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