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Sesquiterpenoids

Sesquiterpenoids

Cat. No. Product Name CAS No. Information
CSN13998 Xanthatin 26791-73-1 Xanthatin, a natural product isolated and purified from the fruits of Xanthium sibiricum with cytotoxic, antibacterial and antifungal activities, can inhibit murine melanoma B16-F10 cell proliferation possibly associated with activation of Wnt-catenin pathway and its activity against melanoma tumor might also be relevant to inhibition of angiogenesis.
CSN15519 Vibralactone D 1251748-32-9 Vibralactones D is a natural product isolated and purified from cultures of the basidiomycete Boreostereum vibrans, showing weak inhibitory activities against isozymes of 11beta-hydroxysteroid dehydrogenases (HSD) with IC(50) values of 85.7 mM (human HSD1), 295.2 mM (mouse HSD1), and 87.1 mM (human HSD2).
CSN13958 Tussilagone 104012-37-5 Tussilagone, a natural product isolated and purified from the flower of Tussilago farfara, has potential treatment of neuro-inflammatory diseases through the inhibition of overproduction of nitric oxide and prostaglandin E(2) .
CSN14470 Torilolone 13018-09-2 Torilolone, a natural product isolated and purified from the herbs of Cnidium monnieri, show hepatoprotective effects on tacrine-induced cytotoxicity in human liver-derived Hep G2 cells,the EC50 value is 20.6 - 1.86.
CSN13977 Spathulenol 6750-60-3 Spathulenol, a natural product isolated and purified from the herbs of Salvia sclarea, has immunoinhibitory effect and shows the capacity to inhibit proliferation in the lymphocytes and to induce apoptosis in these cells possibly through a caspase-3 independent pathway.
CSN15498 Shizukaol D 142279-42-3 Shizukaol D, a natural product isolated and purified from the herbs of Chloranthus japonicus, exerts a growth inhibition effect on liver cancer cells in a dose- and time-dependent manner by modulating wnt signalling pathway, and induces mitochondrial dysfunction by depolarizing the mitochondrial membrane and suppressing energy production, which may result in AMPK activation, suggests that shizukaol D may be used to treat metabolic syndrome.
CSN14937 Scabertopin 185213-52-9 Scabertopin, a natural product isolated and purified from the herbs of Elephantopus scaber Linn., exhibits significant antitumor effect in vitro in a concentration-dependent manner.
CSN14454 Santamarine 4290-13-5 Santamarine, a natural product isolated and purified from the root of Dolomiaea souliei (Franch.) Shih, with significant anticancer activity, can inhibit L1210 cells because of its cytotoxic,cytostatic and blocking mitosis and reducing uptake of thymidine, and shows anti-bactericidal activity against clinical strains of Mycobacterium tuberculosis.
CSN14948 Pterosin B 34175-96-7 Pterosin B is a natural product isolated and purified from the aerial parts of Pteris semipinnata, is a salt-inducible kinase 3 (Sik3) pathway inhibitor, preventing chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3.
CSN14948 Pterosin B 34175-96-7 Pterosin B is a natural product isolated and purified from the aerial parts of Pteris semipinnata, is a salt-inducible kinase 3 (Sik3) pathway inhibitor, preventing chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3.
CSN14938 Piptocarphin A 76248-63-0 Piptocarphin A, a natural product isolated and purified from the herbs of Vernonia volkameriifolia, shows strong cytotoxic activity against mouse lymphoid tumor cell line P388 with the IC(50) value of 0.77 mM .
CSN11462 Mollugin 55481-88-4 Mollugin, a natural product isolated and purified from the roots of Rubia cordifolia L., may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway.
CSN14455 Macrocarpal B 142698-60-0 Macrocarpal B is a natural product isolated and purified from the branch of Eucalyptus globulus with antibacterial and antifouling activities.
CSN14694 Lipiferolide 41059-80-7 Lipiferolide, a natural product isolated and purified from the herbs of Liriodendron tulipifera with antiplasmodial activity, is an inhibitor of farnesyl protein transferase, inhibits the FPTase activity in a dose-dependent manner, and shows cell growth inhibitory activity against several tumor cells, and possesses cytotoxic activity against KB cells.
CSN13549 Linderene 26146-27-0 Linderene is a natural product isolated and purified from the roots of Lindera aggregata (Sims) Kosterm.
CSN19969 Linderane 13476-25-0 Linderane, a natural product isolated and purified from the roots of Lindera aggregata( Sims) Kosterm, is an inactivator of CYP2C9.
CSN14473 Leucomisine 17946-87-1 Leucomisine is a natural product isolated and purified from Artemisia leucodes.
CSN14461 Isofuranodiene 57566-47-9 Isofuranodiene, a natural product isolated and purified from the herbs of Chloranthus spicatus, has anticancer activity, by inhibiting the proliferation and inducing apoptosis in cancer cells, protects GalN/LPS-induced liver injury in SD rats, it may be a potential functional food ingredient for the prevention and treatment of liver diseases and can induce apoptosis in colon cancer cells in a time and concentration-dependent manner suggesting a potential role as models for the development of chemopreventive agents.
CSN14701 Isodeoxyelephantopin 38927-54-7 Isodeoxyelephantopin, a natural product isolated and purified from the herbs of Elephantopus scaber Linn., exerts antitumor effects on several cancer cells by inducing apoptosis, cell cycle arrest, and inhibiting proliferation, and enhances apoptosis and inhibit invasion and osteoclastogenesis by inhibiting NF-kappaB activation and NF-kappaB-regulated gene expression.
CSN14073 Ilicic Acid 4586-68-9 Ilicic acid is a natural product isolated and purified from the bark of Laggera pterodonta with anti-hyperglycemic and anti-inflammatory activities.
CSN13571 Humulene Epoxide II 19888-34-7 Humulene epoxide II, a natural product isolated and purified from the rhizomes of Zingiber officinale Roscoe, has mildly phytotoxic and antifungal activities.
CSN16838 Guaiol 489-86-1 Guaiol, a natural product isolated and purified from the roots of Ferula ferulaeoides with insecticidal activity, shows significant inhibition of aphids at a concentration of 70 mg/L and good contact activities against the 4th instar larvae of Mythimna separate and 3rd instar larvae of Plutella xylostella, with LD50 values of 0.07 and 8.9 mg/larva, as well as fumigation activity against the 4th instar larvae of M.
CSN16452 Germacrone 6902-91-6 Germacrone, a natural product isolated and purified from the rhizoma of Curcuma wenyujin with anti-tumor activity, can inhibit the proliferation of breast cancer cell lines by inducing cell cycle arrest and apoptosis through mitochondria-mediated caspase pathway, and may be a potent chemopreventive drug candidate for liver cancer via regulating the expression of proteins related to G2/M cell cycle and apoptosis, and p53 and oxidative damage may play important roles in the inhibition of human hepatoma cells growth by germacrone.
CSN16274 Fraxinellone 28808-62-0 Fraxinellone, a natural product isolated and purified from the root barks of Dictamnus dasycarpus Turcz. with neuroprotective, vasorelaxing, insecticidal, and antimicrobial activities, is a selective blocker of voltage-dependent Ca2 channel, while dictamine relaxed the rat aorta by suppressing the Ca2 influx through both voltage-dependent and receptor-operated Ca2 channels, and can dramatically induce apoptosis of activated peripheral CD4() T cells in vivo, consequently resulting in less CD4() T-cell activation and infiltration to the liver.
CSN14475 Eupatoriopicrin 6856-01-5 Eupatoriopicrin is a natural product isolated and purified from Eupatorium cannabinum L..
CSN13554 Eupalinolide B 877822-41-8 Eupalinolide A is a natural product isolated and purified from the herbs of Eupatorium lindleyanum DC.
CSN13554 Eupalinolide B 877822-41-8 Eupalinolide A is a natural product isolated and purified from the herbs of Eupatorium lindleyanum DC.
CSN13999 Epiglobulol 88728-58-9 Epiglobulol is a natural product isolated and purified from the leaves of Callicarpa japonica Thunb..
CSN14468 Deoxyelephantopin 29307-03-7 Deoxyelephantopin is a natural product isolated and purified from the herbs of Elephantopus scaber Linn. with hepatoprotective and antitumor activity, by inhibiting metastatic, inducing apoptosis, modulating oxidative stress , STAT3p53p21 signaling, MAPK pathway, PI3kAktmTOR pathway, caspase cascades, and ROS .
CSN14137 Curzerenone 20493-56-5 Curzerenone, a natural product isolated and purified from the rhizome of Curcuma zedoaria, has slightly effective against E. coli (IZ 10.8 0.52. Curzerenone and holds great promise for use in chemopreventive and chemotherapeutic strategies.
CSN16370 Curcumol   4871-97-0 Curcumol is a sesquiterpene originally isolated from curcuma rhizomes showing anticancer activities both in vitro and in vivo.
CSN14136 Cryptomeridiol 4666-84-6 Cryptomeridiol, a natural product isolated and purified from the herbs of Blumea balsamifera DC, exhibits a significant and concentration-dependent inhibitory effect on platelet-activating factor receptor binding, and has low activity against A.
CSN14466 Corchoionoside C 185414-25-9 Corchoionoside C, a natural product isolated and purified from the herbs of Polygonum hydropiper with antifungal, anti-allergic and anti-histaminic effects, inhibits the histamine release from rat peritoneal exudate cells induced by antigen-antibody reaction.
CSN14463 Clovanediol 2649-64-1 Clovanediol is a natural product isolated and purified from the herbs of Psidium guajava.
CSN16181 Carabrone 1748-81-8 Carabrone, a natural product isolated and purified from the herbs of Carpesium abrotanoides, exhibit antifungal activities in vitro or in vivo.
CSN14698 Brevilin A 16503-32-5 Brevilin A, a natural product isolated and purified from the herbs of Centipeda minima, is a strong impetus for the development of selective JAK-STAT inhibitors and therapeutic drugs in order to improve survival of patients with hyperactivated JAKs and STATs, and has antigiardial activity (IC50 = 16.1 μM) and was similarly active in vitro against Entamoeba histolytica (IC50 between 4.5 and 9 μM) and against Plasmodium falciparum (IC50 = 9.42 μM).
CSN14074 beta-Costic Acid 3650-43-9 beta-Costic acid, a natural product isolated and purified from the herb of Dittrichia graveolens, is used against the acari Varroa destructor as parasite of the honey bee.
CSN14708 Bakkenolide B 18455-98-6 Bakkenolide B, a natural product isolated and purified from the leaves of Peatasites japonicus, has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma.
CSN13607 Atractylone 6989-21-5 Atractylone, a natural product isolated and purified from the roots of Atractylodes macrocephala, has inhibitory effects on mast cell-mediated allergic reactions, it regulates the degranulation of mast cell, proves its potential in the treatment of mast cell-mediated allergic reactions.
CSN16456 Atractylenolide III 73030-71-4 Atractylenolide III, a natural product isolated and purified from the rhizome of Atractylodes macrocephala Koidz., may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury, and is a potential candidate for treatment of human lung carcinoma by inducing the release of cytochrome c, upregulating the expression of bax and translocating apoptosis-inducing factor.
CSN13071 Artesunate   88495-63-0 Artesunate is a part of the artemisinin group of agents with an IC50 of 5 M for small cell lung carcinoma cell line H69. It is a potential inhibitor of STAT-3 and EXP1 and exhibits selective cytotoxicity of cancer cells over normal cells in vitro.
CSN15189 9-Oxo-10,11-Dehydroageraphorone 79491-71-7 9-Oxo-10,11-dehydroageraphorone, a natural product isolated and purified from the herbs of Eupatorium adenophorum with acaricidal activity, induces hepatotoxicity and cholestasis in rats, effectively inhibits the proliferation of HeLa cells by arresting the cell cycle transition from S to G2/M phase, did not continue to complete the cell cycle activity and induces apoptosis by improving the gene expression level of apoptotic proteases such as caspase-10 in HeLa cells.
CSN14706 8α-(2-Methylacryloyloxy)hirsutinolide 13-O-Acetate 67667-71-4 8-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate is a natural product isolated and purified from the herbs of Vernonia cinerea showing inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.
CSN13389 4(15),5,10(14)-Germacratrien-1-Ol 81968-62-9 4(15),5,10(14)-Germacratrien-1-ol is a natural product isolated and purified from the roots of Acorus calamus L..
CSN14462 3,6-Caryolanediol 155485-76-0 3,6-Caryolanediol is a natural product isolated and purified from the herbs of Sindora sumatrana..
CSN13027 3,4-Dihydro-2,2-Dimethyl-2H-Naphtho[1,2-B]pyran 16274-33-2 3,4-Dihydro-2,2-dimethyl-2H-naphtho1,2-bpyran is a natural product isolated and purified from the herbs of Catalpa ovata.
CSN15203 1alpha-Hydroxytorilin 887147-75-3 1alpha-Hydroxytorilin, a natural product isolated and purified from the fruits of Torilis japonica, exhibits cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.
CSN13248 1-Hydroxy-2-Prenylnaphthalene 16274-34-3 1-Hydroxy-2-prenylnaphthalene is a natural product isolated and purified from the herbs of Catalpa ovata.
CSN13290 1,10:4,5-Diepoxy-7(11)-Germacren-8-One 32179-18-3 1,104,5-Diepoxy-7(11)-germacren-8-one is a natural product isolated and purified from the herbs of Isodon adenantha.
CSN11893 β-Santalol 11031-45-1 -Santalol is a compound of sandalwood oil showing antiinflammatory property by suppressing of lipopolysaccharide-stimulated cytokinechemokine production in skin cells and anti-viral effect against influenza viral replication in vitro.
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