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Ser/Thr Protease
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN23680 | ZK824190 | 2254001-81-3 | ZK824859 is a selective urokinase plasminogen activator uPA inhibitor and a promising treatment for multiple sclerosis |
| CSN23689 | ZK824859 | 2271122-53-1 | ZK824859 is a new structural class uPA inhibitor with potential effect on treating multiple sclerosis. |
| CSN21157 | UK-371804 | 256477-09-5 | UK-371804 is a potent and selective urokinase-type plasmogen activator uPA inhibitor with excellent enzyme potency Ki10 nM and selectivity profile 4000-fold versus tPA and 2700-fold versus plasmin |
| CSN23329 | UK-371804 HCl | 256476-36-5 | UK-371804 HCl is a potent and selective urokinase-type plasmogen activator uPA inhibitor with excellent enzyme potency Ki10 nM and selectivity profile 4000-fold versus tPA and 2700-fold versus plasmin |
| CSN26335 | N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride | 4272-74-6 | TLCK hydrochloride inhibits serine proteinases with trypsin-like activity. |
| CSN26457 | SRI 31215 TFA | 1832686-44-8 | SRI31215 2TFA is a small molecule that acts as a triplex inhibitor of matriptase, hepsin and HGFA and mimics the activity of HAI-1/2. SRI31215 2TFA blocks signaling between cancer cells and fibroblasts and inhibits the tumor-promoting activity of cancer-associated fibroblasts. |
| CSN26760 | Patamostat | 114568-26-2 | Patamostat (E-3123) is a potent protease inhibitor. Patamostat potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. E-3123 may possess suppressing effects on pathogenesis and development of acute pancreatitis[1][2]. |
| CSN23618 | 6-Bromo-2-hydroxy-3-methoxybenzaldehyde | 20035-41-0 | NSC95682 is a derivative of bromobenzaldehyde which can inhibit inositol-requiring enzyme 1 IRE-1 with IC50 of 008 M |
| CSN11508 | Nafamostat mesylate | 82956-11-4 | Nafamostat mesylate is a synthetic inhibitor of serine protease with anticoagulant activity. |
| CSN18442 | Nafamostat | 81525-10-2 | Nafamostat is a broad spectrum serine protease inhibitor kallikrein inhibitor and inhibits blood coagulation It is also a possible complement inhibitor |
| CSN18437 | Nafamostat hydrochloride | 80251-32-7 | Nafamostat HCl is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation. It is also a possible complement inhibitor. |
| CSN24265 | LSP-249 | 1801253-04-2 | LSP-249 is a plasma kallikrein inhibitor for treatment of angioedema. |
| CSN26395 | K-252c | 85753-43-1 | K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase, with IC50 values of 8, 8 and 10 μM respectively[1][2][3]. |
| CSN33248 | Hepln-13 | 64369-13-7 | Hepln-13 is a potent and orally active Hepsin inhibitor with an IC50 of 0.33 µM. |
| CSN21080 | GSK-872 | 1346546-69-7 | GSK872 is an inhibitor of RIPK3 with IC50 of 18 nM and kinase activity IC50 13 nM It also exhibits supression of necrosis induced by toll-like receptor 3 |
| CSN21179 | GCN2-IN-1 | 1448693-69-3 | GCN2-IN-1 is a potent general control nonderepressible 2 kinase GCN2 inhibitor with IC50s of 03 M in the enzyme and cell assay |
| CSN11071 | Gabexate mesylate | 56974-61-9 | Gabexate mesylate could inhibit trypsin plasmin plasma kallikrein and thrombin with IC50s of 94 M 30 M 41 M and 110 M It has certain anticoagulant effect |
| CSN27644 | FOY 251 | 71079-09-9 | FOY-251 is a metabolite of Camostat that acts as a pollen protease inhibitor for prevention and control of allergies. |
| CSN22162 | FK-448 Free base | 85858-76-0 | FK-448 Free base is an effective and specific inhibitor of chymotrypsin with an IC50 of 720 nM |
| CSN13551 | Demethylwedelolactone | 6468-55-9 | Demethylwedelolactone, a natural product isolated and purified from the herbs of Eclipta prostrata, has trypsin inhibitory effect. Demethylwedelolactone exerts anti-invasive growth effect on breast cancer cells. |
| CSN25456 | Benzamidine hydrochloride | 1670-14-0 | Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectively. |
| CSN22063 | Avoralstat | 918407-35-9 | Avoralstat is an oral plasma kallikrein (PKK) inhibitor and is used for the treatment of hereditary angioedema. |
| CSN23538 | 2-Aminopurine | 452-06-2 | 7H-Purin-2-amine isomer of adenine is an inhibitor of protein kinase R PKR with antimetabolite effect |
| CSN24042 | 3,4-Dichloroisocoumarin | 51050-59-0 | 3,4 Dichloroisocoumarin is a potent, irreversible inhibitor of serine proteases. It reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. 3,4 Dichloroisocoumarin also inhibits granzymes A, B, and H, cathepsin G, neutrophil elastase, proteinase and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. 3,4 Dichloroisocoumarin inhibits activation of neutral sphingomyelinase and daunorubicin-triggered apoptosis as well as apoptosis induced by camptothecin in HL-60 cells. 3,4 Dichloroisocoumarin inhibits migration of eosinophils through basement membrane components in vitro. 3,4 Dichloroisocoumarin does not affect thiol proteases and metalloproteases. 3,4 Dichloroisocoumarin does not exhibit any activity towards β-lactamases. 3,4 Dichloroisocoumarin is an inhibitor of Chymotrypsin and Trypsin. |
| CSN29445 | Milvexian | 1802425-99-5 | |
| CSN95489 | Cyclotheonamide A | 129033-04-1 | |
| CSN51570 | 1-(4-Chlorophenyl)guanidine hydrochloride | 14279-91-5 |
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