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Ser/Thr Protease

Ser/Thr Protease

Cat. No. Product Name CAS No. Information
CSN23680 ZK824190 2254001-81-3 ZK824859 is a selective urokinase plasminogen activator uPA inhibitor and a promising treatment for multiple sclerosis
CSN23689 ZK824859 2271122-53-1 ZK824859 is a new structural class uPA inhibitor with potential effect on treating multiple sclerosis.
CSN21157 UK-371804 256477-09-5 UK-371804 is a potent and selective urokinase-type plasmogen activator uPA inhibitor with excellent enzyme potency Ki10 nM and selectivity profile 4000-fold versus tPA and 2700-fold versus plasmin
CSN23329 UK-371804 HCl 256476-36-5 UK-371804 HCl is a potent and selective urokinase-type plasmogen activator uPA inhibitor with excellent enzyme potency Ki10 nM and selectivity profile 4000-fold versus tPA and 2700-fold versus plasmin
CSN26335 N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride 4272-74-6 TLCK hydrochloride inhibits serine proteinases with trypsin-like activity.
CSN26457 SRI 31215 TFA 1832686-44-8 SRI31215 2TFA is a small molecule that acts as a triplex inhibitor of matriptase, hepsin and HGFA and mimics the activity of HAI-1/2. SRI31215 2TFA blocks signaling between cancer cells and fibroblasts and inhibits the tumor-promoting activity of cancer-associated fibroblasts.
CSN26760 Patamostat 114568-26-2 Patamostat (E-3123) is a potent protease inhibitor. Patamostat potently inhibits trypsin, plasmin and thrombin with IC50s of 39 nM, 950 nM and 1.9 μM, respectively. E-3123 may possess suppressing effects on pathogenesis and development of acute pancreatitis[1][2].
CSN23618 6-Bromo-2-hydroxy-3-methoxybenzaldehyde   20035-41-0 NSC95682 is a derivative of bromobenzaldehyde which can inhibit inositol-requiring enzyme 1 IRE-1 with IC50 of 008 M
CSN11508 Nafamostat mesylate   82956-11-4 Nafamostat mesylate is a synthetic inhibitor of serine protease with anticoagulant activity.
CSN18442 Nafamostat 81525-10-2 Nafamostat is a broad spectrum serine protease inhibitor kallikrein inhibitor and inhibits blood coagulation It is also a possible complement inhibitor
CSN18437 Nafamostat hydrochloride 80251-32-7 Nafamostat HCl is a broad spectrum serine protease inhibitor, kallikrein inhibitor, and inhibits blood coagulation. It is also a possible complement inhibitor.
CSN24265 LSP-249 1801253-04-2 LSP-249 is a plasma kallikrein inhibitor for treatment of angioedema.
CSN26395 K-252c 85753-43-1 K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase, with IC50 values of 8, 8 and 10 μM respectively[1][2][3].
CSN33248 Hepln-13 64369-13-7 Hepln-13 is a potent and orally active Hepsin inhibitor with an IC50 of 0.33 µM.
CSN21080 GSK-872 1346546-69-7 GSK872 is an inhibitor of RIPK3 with IC50 of 18 nM and kinase activity IC50 13 nM It also exhibits supression of necrosis induced by toll-like receptor 3
CSN21179 GCN2-IN-1 1448693-69-3 GCN2-IN-1 is a potent general control nonderepressible 2 kinase GCN2 inhibitor with IC50s of 03 M in the enzyme and cell assay
CSN11071 Gabexate mesylate   56974-61-9 Gabexate mesylate could inhibit trypsin plasmin plasma kallikrein and thrombin with IC50s of 94 M 30 M 41 M and 110 M It has certain anticoagulant effect
CSN27644 FOY 251 71079-09-9 FOY-251 is a metabolite of Camostat that acts as a pollen protease inhibitor for prevention and control of allergies.
CSN22162 FK-448 Free base 85858-76-0 FK-448 Free base is an effective and specific inhibitor of chymotrypsin with an IC50 of 720 nM
CSN13551 Demethylwedelolactone 6468-55-9 Demethylwedelolactone, a natural product isolated and purified from the herbs of Eclipta prostrata, has trypsin inhibitory effect. Demethylwedelolactone exerts anti-invasive growth effect on breast cancer cells.
CSN25456 Benzamidine hydrochloride 1670-14-0 Benzamidine hydrochloride is an reversible competitive inhibitor of trypsin-like serine proteases, with Kis of 97 µM, 21 µM, 20 µM and 110 µM for uPA, trypsin, tryptase and factor Xa, respectively.
CSN22063 Avoralstat 918407-35-9 Avoralstat is an oral plasma kallikrein (PKK) inhibitor and is used for the treatment of hereditary angioedema.
CSN23538 2-Aminopurine   452-06-2 7H-Purin-2-amine isomer of adenine is an inhibitor of protein kinase R PKR with antimetabolite effect
CSN24042 3,4-Dichloroisocoumarin 51050-59-0 3,4 Dichloroisocoumarin is a potent, irreversible inhibitor of serine proteases. It reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. 3,4 Dichloroisocoumarin also inhibits granzymes A, B, and H, cathepsin G, neutrophil elastase, proteinase and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. 3,4 Dichloroisocoumarin inhibits activation of neutral sphingomyelinase and daunorubicin-triggered apoptosis as well as apoptosis induced by camptothecin in HL-60 cells. 3,4 Dichloroisocoumarin inhibits migration of eosinophils through basement membrane components in vitro. 3,4 Dichloroisocoumarin does not affect thiol proteases and metalloproteases. 3,4 Dichloroisocoumarin does not exhibit any activity towards β-lactamases. 3,4 Dichloroisocoumarin is an inhibitor of Chymotrypsin and Trypsin.
CSN29445 Milvexian 1802425-99-5
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