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Secretase
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN11079 | Z-Ile-Leu-aldehyde | 161710-10-7 | Z-Ile-Leu-aldehyde is a potent gamma-secretase inhibitor and a Notch signaling inhibitor. |
| CSN16909 | Semagacestat | 425386-60-3 | Semagacestat is an inhibitor of γ-secretase. It inhibits Aβ42, Aβ38, Aβ40 and the Notch signaling with IC50 of 10 nM, 12 nM, 12.1 nM and 14.1 nM. |
| CSN24823 | IN00076730 | 1454700-89-0 | Selective BACE1 inhibitor |
| CSN21372 | PF-06751979 | 1818339-66-0 | PF-06751979 is a potent brain penetrant -site amyloid precursor protein cleaving enzyme 1 BACE1 inhibitor with an IC50 of 73 nM in BACE1 binding assay |
| CSN24064 | NGP555 | 1304630-27-0 | NGP555 is a γ-secretase modulator. |
| CSN26758 | NB-360 | 1262857-73-7 | NB-360 is a potent and brain penetrable BACE-1 inhibitor. NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice, a model for amyloid pathology. NB-360 stopped accumulation of activated inflammatory cells in the brains of APP transgenic mice. Upon chronic treatment of APP transgenic mice, patches of grey hairs appeared. |
| CSN25317 | LY 2886721 hydrochloride | 1262036-49-6 | LY 2886721 hydrochloride is the first oral inhibitor of human β-secretase (BACE-1) with the potential to treat Alzheimer's Disease. |
| CSN18608 | gamma-Secretase Modulators | 937812-80-1 | gamma-Secretase modulators is an Amyloid- production inhibitor, useful for Alzheimers disease. |
| CSN13122 | YO-01027 | 209984-56-5 | Dibenzazepine is a dipeptidic -secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively. |
| CSN13896 | DAPT | 208255-80-5 | DAPT is an inhibitor of -secretase and it can reduce the expression of A40 and A42 with IC50 values of 115 nM and 200 nM. |
| CSN23874 | Compound E | 209986-17-4 | Compound E is an inhibitor of γ-Secretase. |
| CSN29546 | BMS-906024 | 1401066-79-2 | BMS-906024 is a highly potent, selective inhibitor of γ-secretase mediated signaling of Notch1/2/3/4 receptors with IC50 of 1.6/0.7/3.4/2.9 nM, respectively. |
| CSN26212 | Begacestat | 769169-27-9 | Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50Aβ40=15 nM) for the treatment of Alzheimer's disease[1]. |
| CSN22229 | BACE1-IN-1 | 1310347-50-2 | BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2 respectively |
| CSN18659 | Lanabecestat | 1383982-64-6 | AZD3293 is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor. |
| CSN51573 | (R)-5-Fluoro-N-(4-fluoro-3-(3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl)phenyl)picolinamide 2,2,2-trifluoroacetate | 2095432-65-6 | |
| CSN40189 | Kushenol C | 99119-73-0 | |
| CSN37942 | Aloeresin D | 105317-67-7 | |
| CSN41080 | Sulindac sulfide | 49627-27-2 | |
| CSN33952 | BACE-IN-1 | 1254166-60-3 | |
| CSN42189 | (4S,4aS,10bS)-10b-((4-Chlorophenyl)sulfonyl)-7,10-difluoro-4-(2-(methylsulfonyl)ethyl)-1,4a,5,10b-tetrahydro-2H,4H-pyrano[3,4-c]chromene | 1100361-36-1 | |
| CSN43103 | BACE1-IN-2 | 1352416-78-4 | |
| CSN43102 | BACE1-IN-4 | 2361157-92-6 | |
| CSN43106 | (1α,1'S,4β)-Lanabecestat | 1384082-96-5 | |
| CSN43100 | BACE-1 inhibitor 1 | 1262858-14-9 | |
| CSN43101 | AM-6494 | 1874232-80-0 | |
| CSN43105 | Elenbecestat | 1388651-30-6 | |
| CSN62128 | Cassiaside | 13709-03-0 | |
| CSN67397 | GSM-1 | 884600-68-4 | |
| CSN69353 | β-Secretase Inhibitor I | 1818239-19-8 | |
| CSN70728 | JNJ-67569762 | 2380313-26-6 | |
| CSN70614 | FRM-024 | 2085780-87-4 | |
| CSN83935 | AMG-8718 | 1215868-94-2 | |
| CSN84768 | COX-2-IN-22 | 2447589-08-2 | |
| CSN84909 | BACE1/2-IN-1 | 2671036-34-1 | |
| CSN85251 | AChE/BChE/BACE-1-IN-1 | 1321361-13-0 | |
| CSN85427 | BACE1-IN-12 | 2479315-19-8 | |
| CSN85546 | AChE/BChE/BACE-1-IN-2 | 1877000-20-8 | |
| CSN106037 | 1-Methylguanidine xhydrochloride | 22661-87-6 |
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