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Secretase

Secretase

Cat. No. Product Name CAS No. Information
CSN11079 Z-Ile-Leu-aldehyde 161710-10-7 Z-Ile-Leu-aldehyde is a potent gamma-secretase inhibitor and a Notch signaling inhibitor.
CSN18740 Verubecestat 1286770-55-5 Verubecestat is a BACE1 inhibitor MK-8931 binds significantly to -secretase
CSN16909 Semagacestat 425386-60-3 Semagacestat is an inhibitor of γ-secretase. It inhibits Aβ42, Aβ38, Aβ40 and the Notch signaling with IC50 of 10 nM, 12 nM, 12.1 nM and 14.1 nM.
CSN16034 RO4929097 847925-91-1 RO4929097 is an inhibitor of secretase the IC50s of A40 and notch are 14 nM and 5 nM respectively
CSN17660 PF-3084014 1290543-63-3 PF-3084014 is a reversible inhibitor of -secretase with IC50 of 62 nM
CSN21372 PF-06751979 1818339-66-0 PF-06751979 is a potent brain penetrant -site amyloid precursor protein cleaving enzyme 1 BACE1 inhibitor with an IC50 of 73 nM in BACE1 binding assay
CSN19274 LY411575 Isomer 3 2070009-28-6 LY411575 isomer 3 is an isomer of LY411575 which is a potent -secretase inhibitor with IC50 of 0078 nM0082 nM membranecell-based also inhibits Notch clevage with withIC50 of 039 nM
CSN19271 LY411575 Isomer 2 2070009-70-8 LY411575 isomer 2 is an isomer of LY411575 which is a potent -secretase inhibitor with IC50 of 0078 nM0082 nM membranecell-based also inhibits Notch clevage with with IC50 of 039 nM
CSN17132 LY411575 209984-57-6 LY411575 is an inhibitor of -secretase with IC50 of 0078 nM and it can also inhibit Notch clevage IC50 039 nM
CSN17134 LY2886721 1262036-50-9 LY2886721 is an BACE inhibitor used for the treatment of Alzheimers Disease
CSN12810 LY2811376 1194044-20-6 LY2811376 is the first orally available non-peptidic -secretase BACE1 inhibitor with IC50 of 239 nM-249 nM that acts to decrease A secretion with EC50 of 300 nM and demonstrates to have 10-fold selectivity towards BACE1 over BACE2 and more than 50-fold inhibition over other aspartic proteases including cathepsin D pepsin or renin
CSN18101 LY411575 Isomer 1 209984-58-7 LY-411575 isomer 1 is an isomer of LY411575 which is a potent -secretase inhibitor with IC50 of 0078 nM0082 nM membranecell-based also inhibits Notch clevage with with IC50 of 039 nM
CSN17284 L-685,458 292632-98-5 L-685458 is an inhibitor of amyloid -protein precursor gamma-secretase activity with Ki of 17 nM
CSN18608 gamma-Secretase Modulators 937812-80-1 gamma-Secretase modulators is an Amyloid- production inhibitor, useful for Alzheimers disease.
CSN17843 gamma-Secretase Modulator 3 1431697-84-5 gamma-Secretase modulator 3 is a gamma-secretase modulator
CSN17461 gamma-Secretase Modulator 2 1093978-89-2 gamma-Secretase modulator 2 is a potent and selective -secretase modulator for treatment of Alzheimers disease
CSN17513 gamma-Secretase Modulator 1 1172637-87-4 gamma-Secretase modulator 1 is a gamma-secretase modulator useful for Alzheimers disease
CSN19004 Epiberberine Chloride 889665-86-5 Epiberberine chloride a natural alkaloid is a BACE1 inhibitor which also exhibits inhibition activity on CYP2D6 and aldose reductase alpha-adrenoceptors acetylcholinesterase AChE butyrylcholinesterase and b-site amyloid precursor protein cleaving enzyme 1
CSN17015 E-2012 870843-42-8 E 2012 is a potent -secretase modulator
CSN13122 YO-01027 209984-56-5 Dibenzazepine is a dipeptidic -secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively.
CSN13896 DAPT     208255-80-5 DAPT is an inhibitor of -secretase and it can reduce the expression of A40 and A42 with IC50 values of 115 nM and 200 nM.
CSN16335 CHF5074 749269-83-8 CHF5074 is a -secretase modulator reduces A42 and A40 secretion with an IC50 of 36 and 184 M respectively
CSN19065 BMS-299897 290315-45-6 BMS 299897 is an orally active potent -secretase inhibitor IC50 12 nM
CSN22229 BACE1-IN-1 1310347-50-2 BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2 respectively
CSN19061 AZD3839 1227163-84-9 AZD3839 is an inhibitor of BACE1 with IC50 of 236 uM
CSN18659 AZD3293 1383982-64-6 AZD3293 is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor.
CSN12379 Avagacestat 1146699-66-2 Avagacestat is an inhibitor of -secretase A40 and A42 with IC50s of 03 nM and 027 nM respectively
CSN20327 27-Deoxyactein 264624-38-6 27-Deoxyactein a natural product isolated and purified from Actaea racemosa has shown stimulation of osteoblast function and inhibits bone resorbing mediators in the treatment of osteoporosis It is a derivative of actein a gamma secretase modulators derived from botanicals It can also protect the pancreatic -cells against MG-induced cell death
CSN22538 β-Secretase Inhibitor IV 797035-11-1 -Secretase Inhibitor IV is a potent cell-active BACE-1 inhibitor with IC50s of 156 and 163nM under BACE-1 concentrations of 2 nM and 100 pM respectively
CSN19237 Verubecestat Trifluoroacetate 2095432-65-6
CSN23769 LY900009 209984-68-9
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