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Secretase

Secretase

Cat. No. Product Name CAS No. Information
CSN11079 Z-Ile-Leu-aldehyde 161710-10-7 Z-Ile-Leu-aldehyde is a potent gamma-secretase inhibitor and a Notch signaling inhibitor.
CSN16909 Semagacestat 425386-60-3 Semagacestat is an inhibitor of γ-secretase. It inhibits Aβ42, Aβ38, Aβ40 and the Notch signaling with IC50 of 10 nM, 12 nM, 12.1 nM and 14.1 nM.
CSN24823 IN00076730 1454700-89-0 Selective BACE1 inhibitor
CSN21372 PF-06751979 1818339-66-0 PF-06751979 is a potent brain penetrant -site amyloid precursor protein cleaving enzyme 1 BACE1 inhibitor with an IC50 of 73 nM in BACE1 binding assay
CSN24064 NGP555 1304630-27-0 NGP555 is a γ-secretase modulator.
CSN26758 NB-360 1262857-73-7 NB-360 is a potent and brain penetrable BACE-1 inhibitor. NB-360 shows a superior pharmacological profile and robust reduction of amyloid-β and neuroinflammation in APP transgenic mice. NB-360 can completely block the progression of Aβ deposition in the brains of APP transgenic mice, a model for amyloid pathology. NB-360 stopped accumulation of activated inflammatory cells in the brains of APP transgenic mice. Upon chronic treatment of APP transgenic mice, patches of grey hairs appeared.
CSN25317 LY 2886721 HCl 1262036-49-6 LY 2886721 hydrochloride is the first oral inhibitor of human β-secretase (BACE-1) with the potential to treat Alzheimer's Disease.
CSN18608 gamma-Secretase Modulators 937812-80-1 gamma-Secretase modulators is an Amyloid- production inhibitor, useful for Alzheimers disease.
CSN13122 YO-01027 209984-56-5 Dibenzazepine is a dipeptidic -secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively.
CSN13896 DAPT     208255-80-5 DAPT is an inhibitor of -secretase and it can reduce the expression of A40 and A42 with IC50 values of 115 nM and 200 nM.
CSN23874 Compound E 209986-17-4 Compound E is an inhibitor of γ-Secretase.
CSN29546 BMS-906024 1401066-79-2 BMS-906024 is a highly potent, selective inhibitor of γ-secretase mediated signaling of Notch1/2/3/4 receptors with IC50 of 1.6/0.7/3.4/2.9 nM, respectively.
CSN26212 Begacestat 769169-27-9 Begacestat (GSI-953) is a selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase (IC50Aβ40=15 nM) for the treatment of Alzheimer's disease[1].
CSN22229 BACE1-IN-1 1310347-50-2 BACE1-IN-1 is a potent and highly brain penetrant BACE1 inhibitor with IC50s of 32 and 47 nM for human BACE1 and BACE2 respectively
CSN18659 Lanabecestat 1383982-64-6 AZD3293 is an oral beta-secretase 1 cleaving enzyme (BACE) inhibitor.
CSN51573 (R)-5-Fluoro-N-(4-fluoro-3-(3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl)phenyl)picolinamide 2,2,2-trifluoroacetate 2095432-65-6
CSN40189 Kushenol C 99119-73-0
CSN37942 Aloeresin D 105317-67-7
CSN41080 Sulindac sulfide 49627-27-2
CSN33952 BACE-IN-1 1254166-60-3
CSN42189 SCH 900229 1100361-36-1
CSN43103 BACE1-IN-2 1352416-78-4
CSN43102 BACE1-IN-4 2361157-92-6
CSN43106 (1α,1'S,4β)-Lanabecestat 1384082-96-5
CSN43100 BACE-1 inhibitor 1 1262858-14-9
CSN43101 AM-6494 1874232-80-0
CSN43105 N-(3-((4AS,5R,7aS)-2-amino-5-methyl-4a,5-dihydro-4H-furo[3,4-d][1,3]thiazin-7a(7H)-yl)-4-fluorophenyl)-5-(difluoromethyl)pyrazine-2-carboxamide 1388651-30-6
CSN62128 Cassiaside 13709-03-0
CSN67397 GSM-1 884600-68-4
CSN69353 β-Secretase Inhibitor I 1818239-19-8
CSN70728 JNJ-67569762 2380313-26-6
CSN70614 FRM-024 2085780-87-4
CSN83935 AMG-8718 1215868-94-2
CSN84768 COX-2-IN-22 2447589-08-2
CSN84909 BACE1/2-IN-1 2671036-34-1
CSN85251 AChE/BChE/BACE-1-IN-1 1321361-13-0
CSN85427 BACE1-IN-12 2479315-19-8
CSN85546 AChE/BChE/BACE-1-IN-2 1877000-20-8
CSN106037 1-Methylguanidine xhydrochloride 22661-87-6
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