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Secretase

Secretase

Cat. No. Product Name CAS No. Information
CSN18740 Verubecestat 1286770-55-5 Verubecestat is a BACE1 inhibitor MK-8931 binds significantly to -secretase
CSN16909 Semagacestat 425386-60-3 Semagacestat is an inhibitor of γ-secretase. It inhibits Aβ42, Aβ38, Aβ40 and the Notch signaling with IC50 of 10 nM, 12 nM, 12.1 nM and 14.1 nM.
CSN17660 PF-3084014 1290543-63-3 PF-3084014 is a reversible inhibitor of -secretase with IC50 of 62 nM
CSN17132 LY411575 209984-57-6 LY411575 is an inhibitor of -secretase with IC50 of 0078 nM and it can also inhibit Notch clevage IC50 039 nM
CSN17284 L-685,458 292632-98-5 L-685458 is an inhibitor of amyloid -protein precursor gamma-secretase activity with Ki of 17 nM
CSN13122 YO-01027 209984-56-5 Dibenzazepine is a dipeptidic -secretase inhibitor with IC50 of 2.6 nM and 2.9 nM in cell-free assays for APPL and Notch cleavage, respectively.
CSN13896 DAPT     208255-80-5 DAPT is an inhibitor of -secretase and it can reduce the expression of A40 and A42 with IC50 values of 115 nM and 200 nM.
CSN23874 Compound E 209986-17-4 Compound E is an inhibitor of γ-Secretase.
CSN19065 BMS-299897 290315-45-6 BMS 299897 is an orally active potent -secretase inhibitor IC50 12 nM
CSN22538 β-Secretase Inhibitor IV 797035-11-1 -Secretase Inhibitor IV is a potent cell-active BACE-1 inhibitor with IC50s of 156 and 163nM under BACE-1 concentrations of 2 nM and 100 pM respectively
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