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Ros1
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN20579 | Repotrectinib | 1802220-02-5 | TPX-0005 is a potent ALKROS1TRK inhibitor with IC50 of 53 nM 101 nM 126 nM and 108 nM for SRC WT ALK ALK G1202R and ALK L1196M respectively |
| CSN27197 | Taletrectinib | 1505515-69-4 | Taletrectinib is a new-generation selective ROS1/Trk Receptor inhibitor with IC50 values of 0.207nM, 0.622nM, 2.28nM and 0.98nM for ROS1, Trk Receptor A, B and C, respectively. It induces dramatic growth inhibition of both wild type and G2032R mutant ROS1-rearranged cancers or NTRK-rearranged cancers in vitro and in vivo. |
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