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ROCK
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN19251 | ZINC00881524 | 557782-81-7 | ZINC00881524 is an inhibitor of ROCK |
| CSN13431 | Y-33075 dihydrochloride | 173897-44-4 | Y-39983 HCl is a selective rho-associated protein kinase(ROCK) inhibitor with an IC50 of 3.6 nM. |
| CSN18082 | Y-33075 | 199433-58-4 | Y-33075 is potent and selective p160 ROCK inhibitor with an Ki value of 014 M 200 fold selectivity for p160ROCK than PKC cAMP-dependent protein kianse and Mypsin light-chain kinase |
| CSN12226 | Y-27632 | 146986-50-7 | Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II respectively |
| CSN13895 | Y-27632 dihydrochloride | 129830-38-2 | Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits > 200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK. |
| CSN26523 | Verosudil | 1414854-42-4 | Verosudil, also known as AR-12286, is a potent and selective Rho kinase inhibitor. AR-12286 was well tolerated and provided statistically significant reduction in IOP (intraocular pressure) in patients with XFS (exfoliation syndrome) and OHT (ocular hypertension) or XFG (exfoliative glaucoma). This drug may represent an additional therapeutic paradigm for the treatment of XFG. |
| CSN12292 | Thiazovivin | 1226056-71-8 | Thiazovivin is a ROCK inhibitor with IC50 of 05 M in a cell-free assay promotes hESC survival after single-cell dissociation |
| CSN17184 | SR-3677 | 1072959-67-1 | SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of 3 nM in enzyme and cell based assays and its IC50 for ROCK-I is 56 12 nM |
| CSN16967 | Belumosudil | 911417-87-3 | SLx-2119 is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM which is over 200 fold selecivity over ROCK1 IC50 24 M |
| CSN18583 | SAR407899 | 923359-38-0 | SAR407899 is a potent ATP-competitive ROCK inhibitor woth Ki value of 36 nM41 nM for human ROCKRat ROCK respectively |
| CSN16099 | SAR407899 hydrochloride | 923262-96-8 | SAR407899 HCl is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively. |
| CSN22498 | ROCK2-IN-2 | 1995065-79-6 | ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of 1 M. |
| CSN18502 | BAY-549 | 867017-68-3 | ROCK inhibitor is a highly potent inhibitor of human ROCK-1 and ROCK-2 isoenzymes with IC50 values of 0.6 and 1.1 nM, respectively. |
| CSN15904 | RKI-1447 | 1342278-01-6 | RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2 with IC50 of 145 nM and 62 nM respectively and has anti-invasive and antitumor activities |
| CSN19802 | RKI-1313 | 1342276-76-9 | RKI-1313 is a negative control for RKI-1447 GLXC-05200 which is a potent inhibitor of the Rho-associated ROCK kinases with anti-invasive and antitumor activities in breast cancer |
| CSN17627 | Netarsudil (AR-13324) 2HCl | 1253952-02-1 | Netarsudil primarily targets cells in the conventional outflow tract, efficiently decreasing IOP in both human and non-human primate eyes. |
| CSN29547 | (S)-4-(3-Amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate | 1254032-66-0 | Netarsudil (AR-13324) is a potent, selective ROCK inhibitor with Ki of 4.2 nM for ROCK2. |
| CSN17539 | LX7101 | 1192189-69-7 | LX7101 is a potent inhibitor of LIMK and ROCK2 with IC50 values of 24 16 and 10 nM for LIMK1 LIMK2 and ROCK2 respectively and also inhibits PKA with an IC50 less than 1 nM |
| CSN16953 | Ripasudil free base | 223645-67-8 | K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 31 nM) Rho-kinase inhibitor, and used for treating POAG or ocular hypertension. |
| CSN16952 | Ripasudil | 887375-67-9 | K-115 HCl is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension. |
| CSN17105 | Hydroxyfasudil | 105628-72-6 | Hydroxyfasudil metabolite of Fasudil is a potent Rho-kinase inhibitor and vasodilator |
| CSN15927 | Hydroxyfasudil hydrochloride | 155558-32-0 | Hydroxyfasudil HCl, metabolite of fasudil, is a potent Rho-kinase inhibitor and vasodilator. |
| CSN16493 | H-1152 | 451462-58-1 | H-1152 an isoquinolinesulfonamide derivative is a more specific stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 16 nM but poor inhibitor of other serinethreonine kinases |
| CSN16045 | H-1152 dihydrochloride | 871543-07-6 | H-1152 2HCl, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases. |
| CSN16231 | GSK429286A | 864082-47-3 | GSK429286A selectively inhibits ROCK1 and ROCK2 with the IC50 value of 14 nM and 63 nM, respectively. |
| CSN18470 | GSK269962A | 850664-21-0 | GSK269962A is a potent ROCK inhibitor IC50 values are 16 and 4 nM for recombinant human ROCK1 and ROCK2 respectively and displays greater than 30-fold selectivity for ROCK against a panel of serinethreonine kinases |
| CSN19208 | GSK269962A hydrochloride | 2095432-71-4 | GSK269962 HCl is a selective ROCK (Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively. |
| CSN25217 | GSK-25 | 874119-56-9 | GSK-25 is a ROCK1 inhibitor with IC50 value of 6nM. It showed oral bioavailability (49% in rat and 19% in monkey), good half-life (1.8 h in rat and 2.2 h in monkey) and gave a robust 25 mmHg reduction mean arterial pressure in spontaneously hypertensive rats at a single dose of 30 mg/kg. |
| CSN22832 | Glycyl H-1152 hydrochloride | 913844-45-8 | Glycyl-H 1152 2HCl is a selective Rho-kinase (ROCK) inhibitor with IC50 of 0.0118 μM for ROCKII. |
| CSN10984 | Fasudil Hydrochloride | 105628-07-7 | Fasudil HCl is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. |
| CSN10983 | Fasudil | 103745-39-7 | Fasudil HCl is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively. |
| CSN26558 | CRT0066854 hydrochloride | 2250019-91-9 | CRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively[1]. |
| CSN17653 | Chroman 1 | 1273579-40-0 | Chroman 1 is a highly potent and selective ROCK II inhibitor |
| CSN42722 | Belumosudil mesylate | 2109704-99-4 | Belumosudil is a small molecule and selective inhibitor of ROCK2 with IC50 of 105 nM, which is over 200 fold selecivity over ROCK1 (IC50 =24 μM). |
| CSN17830 | AR-13324 Mesylate | 2166548-12-3 | AR-13324 mesylate is a small-molecule inhibitor of Rho kinase and a norepinephrine transporter which inhibits kinases ROCK1 and ROCK2 with a Ki of 1 nM each disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM respectively and blocked the profibrotic effects of TGF-2 in HTM cells |
| CSN18948 | AR-13324 Mesylate Analog | N/A | AR-13324 mesylate analog is a small-molecule inhibitor of Rho kinase and a norepinephrine transporter and reduces intraocular pressure IOP in normotensive monkey eyes |
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