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ROCK

ROCK

Cat. No. Product Name CAS No. Information
CSN19251 ZINC00881524 557782-81-7 ZINC00881524 is an inhibitor of ROCK
CSN13431 Y-33075 2HCl 173897-44-4 Y-39983 HCl is a selective rho-associated protein kinase(ROCK) inhibitor with an IC50 of 3.6 nM.
CSN18082 Y-33075 199433-58-4 Y-33075 is potent and selective p160 ROCK inhibitor with an Ki value of 014 M 200 fold selectivity for p160ROCK than PKC cAMP-dependent protein kianse and Mypsin light-chain kinase
CSN12226 Y-27632 146986-50-7 Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II respectively
CSN13895 Y-27632 2HCl   129830-38-2 Y-27632 2HCl is a selective ROCK1 (p160ROCK) inhibitor with Ki of 140 nM, exhibits > 200-fold selectivity over other kinases, including PKC, cAMP-dependent protein kinase, MLCK and PAK.
CSN26523 Verosudil 1414854-42-4 Verosudil, also known as AR-12286, is a potent and selective Rho kinase inhibitor. AR-12286 was well tolerated and provided statistically significant reduction in IOP (intraocular pressure) in patients with XFS (exfoliation syndrome) and OHT (ocular hypertension) or XFG (exfoliative glaucoma). This drug may represent an additional therapeutic paradigm for the treatment of XFG.
CSN12292 Thiazovivin     1226056-71-8 Thiazovivin is a ROCK inhibitor with IC50 of 05 M in a cell-free assay promotes hESC survival after single-cell dissociation
CSN17184 SR-3677 1072959-67-1 SR-3677 is a potent and selective ROCK-II inhibitor with an IC50 of 3 nM in enzyme and cell based assays and its IC50 for ROCK-I is 56 12 nM
CSN18583 SAR407899   923359-38-0 SAR407899 is a potent ATP-competitive ROCK inhibitor woth Ki value of 36 nM41 nM for human ROCKRat ROCK respectively
CSN16099 SAR407899 HCl 923262-96-8 SAR407899 HCl is a potent, ATP-competitive ROCK inhibitor woth Ki value of 36 nM/41 nM for human ROCK/Rat ROCK respectively.
CSN22498 ROCK2-IN-2 1995065-79-6 ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of 1 M.
CSN15904 RKI-1447 1342278-01-6 RKI-1447 is a potent small molecule inhibitor of ROCK1 and ROCK2 with IC50 of 145 nM and 62 nM respectively and has anti-invasive and antitumor activities
CSN17539 LX7101 1192189-69-7 LX7101 is a potent inhibitor of LIMK and ROCK2 with IC50 values of 24 16 and 10 nM for LIMK1 LIMK2 and ROCK2 respectively and also inhibits PKA with an IC50 less than 1 nM
CSN16953 K-115 223645-67-8 K-115, an isoquinolinesulfonamide compound, is a highly selective and potent (IC50 31 nM) Rho-kinase inhibitor, and used for treating POAG or ocular hypertension.
CSN16952 K-115 HCl 2H2O   887375-67-9 K-115 HCl is potent ROCK inhibitor with IC50 of 51 nM and 19 nM for ROCK1 and ROCK2, respectively, used for the treatment of glaucoma and ocular hypertension.
CSN17105 Hydroxyfasudil 105628-72-6 Hydroxyfasudil metabolite of Fasudil is a potent Rho-kinase inhibitor and vasodilator
CSN15927 Hydroxyfasudil HCl 155558-32-0 Hydroxyfasudil HCl, metabolite of fasudil, is a potent Rho-kinase inhibitor and vasodilator.
CSN16493 H-1152 451462-58-1 H-1152 an isoquinolinesulfonamide derivative is a more specific stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 16 nM but poor inhibitor of other serinethreonine kinases
CSN16045 H-1152 2HCl 871543-07-6 H-1152 2HCl, an isoquinolinesulfonamide derivative, is a more specific, stronger and membrane-permeable inhibitor of Rho-kinase with a Ki value of 1.6 nM, but poor inhibitor of other serine/threonine kinases.
CSN16231 GSK429286A 864082-47-3 GSK429286A selectively inhibits ROCK1 and ROCK2 with the IC50 value of 14 nM and 63 nM, respectively.
CSN18470 GSK269962 850664-21-0 GSK269962A is a potent ROCK inhibitor IC50 values are 16 and 4 nM for recombinant human ROCK1 and ROCK2 respectively and displays greater than 30-fold selectivity for ROCK against a panel of serinethreonine kinases
CSN19208 GSK269962 HCl 2095432-71-4 GSK269962 HCl is a selective ROCK (Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
CSN22832 Glycyl-H 1152 2HCl 913844-45-8 Glycyl-H 1152 2HCl is a selective Rho-kinase (ROCK) inhibitor with IC50 of 0.0118 μM for ROCKII.
CSN10984 Fasudil HCl   105628-07-7 Fasudil HCl is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.
CSN10983 Fasudil 103745-39-7 Fasudil HCl is a potent inhibitor of ROCK-II, PKA, PKG, PKC, and MLCK with Ki of 0.33 μM, 1.6 μM, 1.6 μM, 3.3 μM and 36 μM, respectively.
CSN26558 CRT0066854 HCl 2250019-91-9 CRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC50 values of 132 nM, 639 nM, and 620 nM, respectively[1].
CSN17653 Chroman 1 1273579-40-0 Chroman 1 is a highly potent and selective ROCK II inhibitor
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