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RIP Kinase

RIP Kinase

Cat. No. Product Name CAS No. Information
CSN17743 WEHI-345 1354825-58-3 WEHI-345 is a potent and selective inhibitor of RIPK2, with IC50 of 0.13 M.
CSN26751 RIPK3-IN-1 2361139-70-8 RIPK3-IN-1 is a RIPK3 type II DFG-out inhibitor with an IC50 of 9.1 nM. RIPK3-IN-1 inhibits RIPK1 and RIPK2 with IC50s of 5.5 and >10 μM. RIPK3-IN-1 is also a c-Met kinase inhibitor with an IC50 of 1.1 μM[1].
CSN26118 RIPA-56 1956370-21-0 RIPA-56 is a RIP1 inhibitor with EC50 value of 28nM. It efficiently reduced TNFα-induced mortality and multi-organ damage.
CSN19068 RIP2 Kinase Inhibitor 2 1581270-11-2 RIP2 kinase inhibitor 2 is a receptor interacting protein-2 (RIP2) kinase inhibitor.
CSN19069 RIP2 Kinase Inhibitor 1 1423186-80-4 RIP2 kinase inhibitor 1 is a receptor interacting protein-2 (RIP2) kinase inhibitor.
CSN28473 PROTAC RIPK degrader-6 2089205-64-9 PROTAC RIPK degrader-6 (example 1) is a PROTAC targeting RIP Kinase degradation wherein the RIP2 kinase inhibitor is linked via a linker to a cereblon binder.
CSN28460 PROTAC RIPK degrader-2 1801547-16-9 PROTAC RIPK degrader-2 is a nonpeptidic PROTAC which potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.
CSN11637 Necrostatin 1   4311-88-0 Necrostatin-1 is an inhibitor of RIP1 and can decrease TNF--induced necroptosis with EC50 of 490 nM.
CSN33247 Nec-34 375835-43-1 Nec-34 can synergize with Nec-1s to inhibit RIPK1 in vitro and in vivo.
CSN23683 HS1371 2158197-70-5 HS1371 is an ATP-competitive and novel kinase inhibitor of RIP3-mediated necroptosis which can directly bind to RIP3.
CSN17724 GSK583   1346547-00-9 GSK583 is a selective inhibitor of RIP2 Kinase and IC50 value is 5 nM.
CSN25567 GSK3145095 1622849-43-7 GSK3145095 is a potent and orally active RIPK1 inhibitor with IC50 of 5 nM and potential antineoplastic and immunomodulatory activities.
CSN25270 GSK2983559 1579965-12-0 GSK2983559 free acid is a small-molecule inhibitor of RIP2 kinase. GSK2983559 free acid potently binds to RIP2 kinase with good kinase specificity and has excellent activity in blocking many proinflammatory cytokine responses in vivo .
CSN19682 GSK2982772 1622848-92-3 GSK2982772 is an inhibitor of receptor interacting protein 1 (RIP1) with IC50 of 16 nM and it is used for the treatment of inflammatory diseases.
CSN23895 GSK'547 2226735-55-1 GSK'547 is a highly selective and potent inhibitor of RIP1 with improved pharmacokinetics.
CSN33246 nec-34i 2212541-00-7
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