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Ras
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN16326 | ZCL278 | 587841-73-4 | ZCL278 is a modulator of Cdc42 through directly binding to Cdc42 with Kd of 114 M |
| CSN27257 | SAH-SOS1A | 1652561-87-9 | SAH-SOS1A is a KRAS-targeting stapled peptide with EC50 values of 106, 109, 154, 140, 155 and 175nM for K-Ras, K-Ras (G12D), K-Ras (G12V), K-Ras (G12C), K-Ras (G12S) and K-Ras (Q61H), respectively. It disrupts the SOS1/KRAS protein interaction and directly inhibit nucleotide association to wild-type and mutant KRAS proteins. |
| CSN17256 | RBC8 | 361185-42-4 | RBC8 is an inhibitor of GTPases RalA and RalB with IC50 of 35 M in cell assay |
| CSN28451 | PROTAC K-Ras Degrader-1 | 2378258-52-5 | PROTAC K-Ras Degrader-1 (Compound 518) is a PROTAC targeting on K-Ras and exhibits ≥70% degradation efficacy in SW1573 cells. |
| CSN16515 | NSC 23766 trihydrochloride | 1177865-17-6 | NSC23766 is identified to fit into a surface groove of Rac1 known to be critical for GEF specification. |
| CSN19268 | NSC 23766 | 733767-34-5 | NSC 23766 is a specific inhibitor of the binding and activation of RAC GTPase with IC50 of 50 M and does not inhibit the closely related targets Cdc42 or RhoA |
| CSN25249 | Adagrasib | 2326521-71-3 | MRTX849 is a potent, selective and covalent K-Ras (G12C) inhibitor that exhibits favorable drug-like properties, selectively modifies mutant cysteine 12 in GDP-bound K-Ras (G12C), and inhibits KRAS-dependent signaling. |
| CSN25213 | MRTX-1257 | 2206736-04-9 | MRTX1257 is a selective, covalent K-Ras G12C inhibitor with oral activity in animal models of cancer. |
| CSN16332 | ML141 | 71203-35-5 | ML141 is a reversible and selective inhibitor of Cdc42 GTPase with IC50 of 200 nM |
| CSN18462 | K-Ras-IN-1 | 84783-01-7 | MDK-3017 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure. |
| CSN19755 | MBQ-167 | 2097938-73-1 | MBQ-167 is a dual Rac and Cdc42 inhibitor potential to be developed as an anticancer drug |
| CSN27182 | LC-2 | 2502156-03-6 | LC-2 is the first PROTAC capable of degrading endogenous KRAS(G12C). It covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRASG12C cell lines. |
| CSN13741 | K-Ras(G12C) inhibitor 12 | 1469337-95-8 | K-Ras(G12C) inhibitor 12 belongs to a series of small molecules, which irreversibly bind to a common oncogenic mutant K-Ras(G12C) and blocks K-Ras(G12C) interactions. |
| CSN17973 | K-Ras G12C-IN-3 | 1629268-19-4 | K-Ras G12C-IN-3 is an irreversible inhibitor of mutant K-ras G12C |
| CSN17972 | K-Ras G12C-IN-2 | 1629267-75-9 | K-Ras G12C-IN-2 is an irreversible inhibitor of mutant K-ras G12C |
| CSN17971 | K-Ras G12C-IN-1 | 1629265-17-3 | K-Ras G12C-IN-1 is an irreversible inhibitor of mutant K-ras G12C |
| CSN16411 | EHT 1864 | 754240-09-0 | EHT 1864 2HCl is an inhibitor of Rac1 (Kd = 40 nM), Rac1b (Kd = 50 nM), Rac2 (Kd = 60 nM) and Rac3 (Kd = 250 nM). |
| CSN17155 | EHop-016 | 1380432-32-5 | EHop-016 is an inhibitor of Rac1 with IC50 of 11 M in MDA-MB-435 cells |
| CSN27757 | KRAS inhibitor-9 | 300809-71-6 | DUN09716 is a potent KRAS inhibitor with Kd value of 92μM that blocks the formation of GTP-KRAS and downstream activation of KRAS. |
| CSN25306 | CID-1067700 | 314042-01-8 | CID-1067700 is a potent and competitive inhibitor of Ras-related GTPases inhibitor, and competitively inhibits Ras-related in brain 7 (Rab7) with a Ki of 13 nM. |
| CSN19709 | CCG-203971 | 1443437-74-8 | CCG-203971 is a small-molecule inhibitor of the RhoMRTFSRF pathway with the IC50 value of 0.64 M for SRE.L. It inhibits Rho-mediated gene transcription. |
| CSN16977 | CASIN | 425399-05-9 | CASIN is an inhibitor of GTPase Cdc42 with IC50 of 2 M that can generat a rejuvenated phenotype of HSCs |
| CSN17244 | BQU57 | 1637739-82-2 | BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth similar to depletion of Ral by siRNA |
| CSN25336 | BI-2852 | 2375482-51-0 | BI-2852 is a KRAS(G12C) inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based drug design with nanomolar affinity, with IC50 of 450 nM. |
| CSN10366 | Azathioprine | 446-86-6 | Azathioprine can inhibit GTP-binding protein Rac1 activation and purine synthesis. Azathioprine is used to treat organ transplantation and autoimmune diseases. |
| CSN18987 | ARS-853 | 1629268-00-3 | ARS-853 is an inhibitor of KRAS G12C with IC50 of 25 M |
| CSN21239 | ARS-1630 | 1698055-86-5 | ARS-1630 is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1 |
| CSN21101 | ARS-1620 | 1698055-85-4 | ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics |
| CSN33094 | ARS-1323-alkyne | 2436544-27-1 | ARS-1323-alkyne is a KRASG12C occupancy probe. It is a chemical probe that enables measurement of live-cell KRASG12C covalent inhibition kinetics. |
| CSN21238 | ARS-1323 | 1698024-73-5 | ARS-1323 is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1 |
| CSN24158 | Sotorasib | 2296729-00-3 | AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor, which locks KRAS G12C in an inactive GDP-bound state. AMG-510 selectively targets the KRAS p.G12C mutant and shows anti-tumor activity. |
| CSN24274 | Sotorasib racemate | 2252403-56-6 | AMG-510 is a covalent inhibitor of K-RAS(G12C) with antineoplastic activity. |
| CSN18970 | 6H05 (TFA) | 2061344-88-3 | 6H05 trifluoroacetate is a selective and allosteric inhibitor of oncogenic mutant K-Ras G12C |
| CSN17885 | 6H05 | 1469338-01-9 | 6H05 is a selective and allosteric inhibitor of oncogenic mutant K-Ras G12C |
| CSN24205 | 1A-116 | 1430208-73-3 | 1A-116 is a specific Rac1 inhibitor. |
| CSN51381 | RM-018 | 2641993-55-5 | |
| CSN51386 | ASP2453 | 2241719-73-1 | |
| CSN51387 | XY-02-082 | 2080446-99-5 | |
| CSN51432 | KRAS G12D inhibitor 1 | 2621928-43-4 | |
| CSN51431 | KRAS G12D inhibitor 5 | 2621928-53-6 | |
| CSN77265 | GDC-6036 | 2417987-45-0 |
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