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Ras

Ras

Cat. No. Product Name CAS No. Information
CSN16326 ZCL278 587841-73-4 ZCL278 is a modulator of Cdc42 through directly binding to Cdc42 with Kd of 114 M
CSN17256 RBC8 361185-42-4 RBC8 is an inhibitor of GTPases RalA and RalB with IC50 of 35 M in cell assay
CSN28451 PROTAC K-Ras Degrader-1 2378258-52-5 PROTAC K-Ras Degrader-1 (Compound 518) is a PROTAC targeting on K-Ras and exhibits ≥70% degradation efficacy in SW1573 cells.
CSN16515 NSC 23766 3HCl 1177865-17-6 NSC23766 is identified to fit into a surface groove of Rac1 known to be critical for GEF specification.
CSN19268 NSC 23766 733767-34-5 NSC 23766 is a specific inhibitor of the binding and activation of RAC GTPase with IC50 of 50 M and does not inhibit the closely related targets Cdc42 or RhoA
CSN25249 MRTX849 2326521-71-3 MRTX849 is a potent, selective and covalent K-Ras (G12C) inhibitor that exhibits favorable drug-like properties, selectively modifies mutant cysteine 12 in GDP-bound K-Ras (G12C), and inhibits KRAS-dependent signaling.
CSN25213 MRTX1257   2206736-04-9 MRTX1257 is a selective, covalent K-Ras G12C inhibitor with oral activity in animal models of cancer.
CSN16332 ML141   71203-35-5 ML141 is a reversible and selective inhibitor of Cdc42 GTPase with IC50 of 200 nM
CSN18462 MDK-3017 84783-01-7 MDK-3017 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.
CSN19755 MBQ-167 2097938-73-1 MBQ-167 is a dual Rac and Cdc42 inhibitor potential to be developed as an anticancer drug
CSN27182 LC-2 2502156-03-6 LC-2 is the first PROTAC capable of degrading endogenous KRAS(G12C). It covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRASG12C cell lines.
CSN13741 K-Ras(G12C) Inhibitor 12 1469337-95-8 K-Ras(G12C) inhibitor 12 belongs to a series of small molecules, which irreversibly bind to a common oncogenic mutant K-Ras(G12C) and blocks K-Ras(G12C) interactions.
CSN17973 K-Ras G12C-IN-3 1629268-19-4 K-Ras G12C-IN-3 is an irreversible inhibitor of mutant K-ras G12C
CSN17972 K-Ras G12C-IN-2 1629267-75-9 K-Ras G12C-IN-2 is an irreversible inhibitor of mutant K-ras G12C
CSN17971 K-Ras G12C-IN-1 1629265-17-3 K-Ras G12C-IN-1 is an irreversible inhibitor of mutant K-ras G12C
CSN16411 EHT 1864 754240-09-0 EHT 1864 2HCl is an inhibitor of Rac1 (Kd = 40 nM), Rac1b (Kd = 50 nM), Rac2 (Kd = 60 nM) and Rac3 (Kd = 250 nM).
CSN17155 EHop-016 1380432-32-5 EHop-016 is an inhibitor of Rac1 with IC50 of 11 M in MDA-MB-435 cells
CSN27757 DUN09716 300809-71-6 DUN09716 is a potent KRAS inhibitor with Kd value of 92μM that blocks the formation of GTP-KRAS and downstream activation of KRAS.
CSN25306 CID 1067700   314042-01-8 CID-1067700 is a potent and competitive inhibitor of Ras-related GTPases inhibitor, and competitively inhibits Ras-related in brain 7 (Rab7) with a Ki of 13 nM.
CSN16977 CASIN 425399-05-9 CASIN is an inhibitor of GTPase Cdc42 with IC50 of 2 M that can generat a rejuvenated phenotype of HSCs
CSN17244 BQU57 1637739-82-2 BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth similar to depletion of Ral by siRNA
CSN25336 BI-2852 2375482-51-0 BI-2852 is a KRAS(G12C) inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based drug design with nanomolar affinity, with IC50 of 450 nM.
CSN10366 Azathioprine   446-86-6 Azathioprine can inhibit GTP-binding protein Rac1 activation and purine synthesis. Azathioprine is used to treat organ transplantation and autoimmune diseases.
CSN18987 ARS-853 1629268-00-3 ARS-853 is an inhibitor of KRAS G12C with IC50 of 25 M
CSN21239 ARS-1630 1698055-86-5 ARS-1630 is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1
CSN21101 ARS-1620 1698055-85-4 ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics
CSN33094 ARS-1323-Alkyne 2436544-27-1 ARS-1323-alkyne is a KRASG12C occupancy probe. It is a chemical probe that enables measurement of live-cell KRASG12C covalent inhibition kinetics.
CSN21238 ARS-1323 1698024-73-5 ARS-1323 is a novel inhibitor of mutant K-ras G12C extracted from patent WO 2015054572 A1
CSN24158 AMG 510 2296729-00-3 AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor, which locks KRAS G12C in an inactive GDP-bound state. AMG-510 selectively targets the KRAS p.G12C mutant and shows anti-tumor activity.
CSN24274 AMG-510 racemate 2252403-56-6 AMG-510 is a covalent inhibitor of K-RAS(G12C) with antineoplastic activity.
CSN17885 6H05 1469338-01-9 6H05 is a selective and allosteric inhibitor of oncogenic mutant K-Ras G12C
CSN24205 1A-116   1430208-73-3 1A-116 is a specific Rac1 inhibitor.
CSN51381 RM-018 2641993-55-5
CSN51432 KRAS G12D inhibitor 1 2621928-43-4
CSN51431 KRAS G12D inhibitor 5 2621928-53-6
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