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Ras

Ras

Cat. No. Product Name CAS No. Information
CSN16630 Schisantherin A 58546-56-8 Schisantherin A is a natural product isolated and purified from the herbs of Chelidonium majus with anti-microbial, anti-oxidant and anti-inflammatory properties, and is a specific inhibitor of Rac1b.
CSN16625 Sanguinarine 2447-54-3 Sanguinarine is a benzophenanthridine alkaloid which has anti-microbial, anti-oxidant and anti-inflammatory properties. It is a specific inhibitor of Rac1b, and with potential antitumor activity.
CSN27257 SAH-SOS1A 1652561-87-9 SAH-SOS1A is a KRAS-targeting stapled peptide with EC50 values of 106, 109, 154, 140, 155 and 175nM for K-Ras, K-Ras (G12D), K-Ras (G12V), K-Ras (G12C), K-Ras (G12S) and K-Ras (Q61H), respectively. It disrupts the SOS1/KRAS protein interaction and directly inhibit nucleotide association to wild-type and mutant KRAS proteins.
CSN16332 ML141   71203-35-5 ML141 is a reversible and selective inhibitor of Cdc42 GTPase with IC50 of 200 nM
CSN18462 MDK-3017 84783-01-7 MDK-3017 is a K-Ras inhibitor, by binding to K-Ras in a hydrophobic pocket that is occupied by Tyr-71 in the apo-Ras crystal structure.
CSN27182 LC-2 2502156-03-6 LC-2 is the first PROTAC capable of degrading endogenous KRAS(G12C). It covalently binds KRASG12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRASG12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRASG12C cell lines.
CSN17973 K-Ras G12C-IN-3 1629268-19-4 K-Ras G12C-IN-3 is an irreversible inhibitor of mutant K-ras G12C
CSN17971 K-Ras G12C-IN-1 1629265-17-3 K-Ras G12C-IN-1 is an irreversible inhibitor of mutant K-ras G12C
CSN16411 EHT 1864 754240-09-0 EHT 1864 2HCl is an inhibitor of Rac1 (Kd = 40 nM), Rac1b (Kd = 50 nM), Rac2 (Kd = 60 nM) and Rac3 (Kd = 250 nM).
CSN17155 EHop-016 1380432-32-5 EHop-016 is an inhibitor of Rac1 with IC50 of 11 M in MDA-MB-435 cells
CSN25306 CID 1067700   314042-01-8 CID-1067700 is a potent and competitive inhibitor of Ras-related GTPases inhibitor, and competitively inhibits Ras-related in brain 7 (Rab7) with a Ki of 13 nM.
CSN16977 CASIN 425399-05-9 CASIN is an inhibitor of GTPase Cdc42 with IC50 of 2 M that can generat a rejuvenated phenotype of HSCs
CSN25336 BI-2852 2375482-51-0 BI-2852 is a KRAS(G12C) inhibitor for the switch I/II pocket (SI/II-pocket) by structure-based drug design with nanomolar affinity, with IC50 of 450 nM.
CSN10366 Azathioprine   446-86-6 Azathioprine can inhibit GTP-binding protein Rac1 activation and purine synthesis. Azathioprine is used to treat organ transplantation and autoimmune diseases.
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