Welcome to CSNpharm! For Research Use Only!
Home +1-708-781-1677

Raf

Raf

Cat. No. Product Name CAS No. Information
CSN12243 ZM336372 208260-29-1 ZM336372 is an inhibitor of c-Raf with IC50 of 70 nM
CSN22915 XRK3F2   N/A XRK3F2 is a p62-ZZdomain inhibitor which can blunt MM-induced Runx2 suppression and induce new bone formation and remodeling
CSN12742 Vemurafenib 918504-65-1 Vemurafenib is a potent inhibitor of B-Raf V600E with IC50 of 31 nM in cell-free assay, and is 10-fold selective for B-Raf V600E over wild-type B-Raf in enzymatic assays while the cellular selectivity can exceed 100-fold.
CSN15889 TAK-632 1228591-30-7 TAK-632 is a selective pan-RAF kinase inhibitor with IC50 values of 2414 nM for BRAF V600Ec-RAF with 60 fold selectivity over VEGFR
CSN12366 Sorafenib Tosylate   475207-59-1 Sorafenib tosylate is a potent inhibitor of Raf-1 with IC50 values of 6 nM 22 nM and 90 nM for Raf-1 B-Raf and VEGFR2 respectively Sorafenib tosylate suppresses both wild-type and V599E mutant BRAF activity in vitro
CSN10381 Sorafenib   284461-73-0 Sorafenib is a multikinase inhibitor of Raf-1 B-Raf and VEGFR-2 with IC50 of 6 nM 22 nM and 90 nM in cell-free assays respectively
CSN16576 SB-590885 405554-55-4 SB-590885 is a potent B-Raf inhibitor with Ki of 016 nM 11-fold greater selectivity for B-Raf over c-Raf no inhibition to other human kinases
CSN18623 Ro 5126766 946128-88-7 Ro 5126766 is a unique and allosteric MEKRAF signaling inhibitor with IC50 values of 82 19 56 and 160nM for BRAFsupV600Esup mutant BRAF CRAF and MEK1 respectively
CSN18848 RAF709 1628838-42-5 RAF709 is an inhibitor of c-Raf and b-Raf with IC50 of 05 nM and 18 nM respectively
CSN17783 PLX8394 1393466-87-9 PLX8394 is an inhibitor of B-Raf V600E with IC50 of 5 nM
CSN17782 PLX7904 1393465-84-3 PLX7904 is a Raf inhibitor inhibits the growth of two melanoma cell lines A375 and COLO829 and human colorectal cancer cell line COLO205 that expressed BRAFV600E with IC50 values of 017 M 053 M and 016 M respectively
CSN12391 PLX4720 918505-84-7 PLX 4720 is a potent and selective inhibitor of B-RafV600E IC5013 nM and c-Raf-1Y340DY341D IC5067 nM whth a 10-fold selectivity for B-RafV600E than wild-type B-Raf
CSN21057 Paclitaxtide N/A Paclitaxtide is in phase III clinical trials for the treatment of breast cancer and non small cell lung cancer NSCLC
CSN13788 MLN2480 1096708-71-2 MLN 2480 is a selective inhibitor of pan-Raf kinase with antitumor activity
CSN15738 LY3009120     1454682-72-4 LY3009120 is a small molecule that has been shown to be a pan-RAF inhibitor of all isoforms inhibiting BRAFV600E BRAFWT and CRAFWT with IC50 values of 58 91 and 15 nM and blocking proliferation in both BRAF and RAS mutant cells
CSN21371 LXH254 1800398-38-2 LXH254 is an ATP-competitive inhibitor of Raf with anti-proliferative activity Phase I
CSN12290 L-779450 303727-31-3 L-779450 is a potent ATP-competitive Raf kinase inhibitor IC50 10 nM that displays 7 30 and 70-fold selectivity over p38 GSK3 and Lck respectively
CSN16951 HG6-64-1 1315329-43-1 HG6-64-1 is a potent and selective B-Raf and mutant B-Raf inhibitor
CSN18123 GW5074 220904-83-6 GW5074 is an inhibitor of c-Raf1 kinase with IC50 of 9 nM
CSN12428 GDC-0879 905281-76-7 GDC-0879 is a potent and selective B-Raf inhibitor with IC50 of 013 nM with activity against c-Raf as well displaying no inhibition known to other protein kinases
CSN16321 Encorafenib 1269440-17-6 Encorafenib is a potent and selective B-RafsupV600Esup inhibitor with no significant activity observed against a panel of 100 kinases IC50900nM
CSN15748 Dabrafenib Mesylate 1195768-06-9 Dabrafenib mesylate is an inhibitor of raf kinase with IC50 values of 0.6 nM and 5.0 nM for B-Raf V600E and c-Raf, respectively.
CSN13802 Dabrafenib 1195765-45-7 Dabrafenib is a potent, selective and efficacious inhibitor of B-RafsupV600Esup with ICsub50sub value of 0.7 nM, and less potent to B-Raf and C-Raf with ICsub50sub values of 5.2 nM and 6.3 nM, respectively.
CSN15883 CEP-32496 1188910-76-0 CEP-32496 is an inhibitor of BRAF V600E (IC50 14 nM), WT (IC50 34 nM) and c-Raf (IC50 39 nM). It also exhibits certain inhibitory activity against Abl-1, c-Kit, Ret, PDGFR and VEGFR2.
CSN17126 CEP-32496 HCl 1227678-26-3 CEP-32496 hydrochloride is a highly potent inhibitor of BRAF (V600EWT) and c-Raf with Kd of 14 nM36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFR and VEGFR2, respectively, displaying insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2.
CSN21971 CCT196969 1163719-56-9 CCT196969 is active against melanoma and colorectal cancer cell lines that are mutant for BRAF but not cancer cells that are wild-type for BRAF and NRAS CCT196969 induces caspase 3 and PARP cleavage thus induces apoptosis CCT196969 does not drive paradoxical pathway activation and inhibit MEKERK in BRAF and NRAS mutant melanoma
CSN12390 BRAF Inhibitor 918505-61-0 BRAF inhibitor is a potent BRAF inhibitor
CSN13581 B-Raf Inhibitor 1315330-11-0 B-Raf inhibitor a pyrazine and pyrrolo23-bpyridine derivative is useful in the treatment of cancer and proliferative diseases
CSN16200 B-Raf Inhibitor 1 1093100-40-3 B-Raf inhibitor 1 is an inhibitor of B-Raf with IC50s ranging from 031 M to 2 nM in cells assay
CSN15686 B-Raf Inhibitor 1 2HCl 1191385-19-9 B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 031 M and 2 nM for A375 proliferation and A375 p-ERK respectively
CSN16988 B-Raf IN 1 950736-05-7 B-Raf IN 1 is a highlt potent and selective B-Raf inhibitor with IC50 of 24 nM equipotent against c-Raf IC50 25 nM
CSN22609 AZ304   942507-42-8 AZ304 is an inhibitor of BRAF and can target many kinases The IC50s for wild type BRAF V600E mutant BRAF and wild type CRAF are 79 nM 38 nM and 68 nM respectively It can also inhibit p38 IC50 6 nM and CSF1R IC50 35 nM
CSN13566 AZ 628 878739-06-1 AZ 628 is a pan-Raf inhibitor for BRAF BRAFV600E and c-Raf-1 with IC50 of 105 nM 34 nM and 29 nM also inhibits VEGFR2 DDR2 Lyn Flt1 FMS etc
CSN22979 ML 786 2HCl 1237536-18-3
CSN21043 N-(3-Methoxybenzyl)oleamide N/A
CSN23267 VU 0469650 HCl N/A
CSN23257 5-Oxocyclopent-1-enecarboxylic acid N/A
<< PREV 1 2 NEXT >>