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Raf

Raf

Cat. No. Product Name CAS No. Information
CSN12243 ZM336372 208260-29-1 ZM336372 is an inhibitor of c-Raf with IC50 of 70 nM
CSN22915 XRK3F2   2375193-43-2 XRK3F2 is a p62-ZZdomain inhibitor which can blunt MM-induced Runx2 suppression and induce new bone formation and remodeling
CSN12366 Sorafenib Tosylate   475207-59-1 Sorafenib tosylate is a potent inhibitor of Raf-1 with IC50 values of 6 nM 22 nM and 90 nM for Raf-1 B-Raf and VEGFR2 respectively Sorafenib tosylate suppresses both wild-type and V599E mutant BRAF activity in vitro
CSN10381 Sorafenib   284461-73-0 Sorafenib is a multikinase inhibitor of Raf-1 B-Raf and VEGFR-2 with IC50 of 6 nM 22 nM and 90 nM in cell-free assays respectively
CSN16576 SB-590885 405554-55-4 SB-590885 is a potent B-Raf inhibitor with Ki of 016 nM 11-fold greater selectivity for B-Raf over c-Raf no inhibition to other human kinases
CSN12290 L-779450 303727-31-3 L-779450 is a potent ATP-competitive Raf kinase inhibitor IC50 10 nM that displays 7 30 and 70-fold selectivity over p38 GSK3 and Lck respectively
CSN18123 GW5074 220904-83-6 GW5074 is an inhibitor of c-Raf1 kinase with IC50 of 9 nM
CSN24269 Belvarafenib 1446113-23-0 Belvarafenib is a pan-RAF inhibitor, with IC50 values of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFV600E and C-RAF, respectively.
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