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Raf

Raf

Cat. No. Product Name CAS No. Information
CSN12243 ZM336372 208260-29-1 ZM336372 is an inhibitor of c-Raf with IC50 of 70 nM
CSN22915 XRK3F2   2375193-43-2 XRK3F2 is a p62-ZZdomain inhibitor which can blunt MM-induced Runx2 suppression and induce new bone formation and remodeling
CSN12366 Sorafenib Tosylate   475207-59-1 Sorafenib tosylate is a potent inhibitor of Raf-1 with IC50 values of 6 nM 22 nM and 90 nM for Raf-1 B-Raf and VEGFR2 respectively Sorafenib tosylate suppresses both wild-type and V599E mutant BRAF activity in vitro
CSN10381 Sorafenib   284461-73-0 Sorafenib is a multikinase inhibitor of Raf-1 B-Raf and VEGFR-2 with IC50 of 6 nM 22 nM and 90 nM in cell-free assays respectively
CSN16576 SB-590885 405554-55-4 SB-590885 is a potent B-Raf inhibitor with Ki of 016 nM 11-fold greater selectivity for B-Raf over c-Raf no inhibition to other human kinases
CSN18623 Ro 5126766 946128-88-7 Ro 5126766 is a unique and allosteric MEKRAF signaling inhibitor with IC50 values of 82 19 56 and 160nM for BRAFsupV600Esup mutant BRAF CRAF and MEK1 respectively
CSN12290 L-779450 303727-31-3 L-779450 is a potent ATP-competitive Raf kinase inhibitor IC50 10 nM that displays 7 30 and 70-fold selectivity over p38 GSK3 and Lck respectively
CSN18123 GW5074 220904-83-6 GW5074 is an inhibitor of c-Raf1 kinase with IC50 of 9 nM
CSN12428 GDC-0879 905281-76-7 GDC-0879 is a potent and selective B-Raf inhibitor with IC50 of 013 nM with activity against c-Raf as well displaying no inhibition known to other protein kinases
CSN15883 CEP-32496 1188910-76-0 CEP-32496 is an inhibitor of BRAF V600E (IC50 14 nM), WT (IC50 34 nM) and c-Raf (IC50 39 nM). It also exhibits certain inhibitory activity against Abl-1, c-Kit, Ret, PDGFR and VEGFR2.
CSN24269 Belvarafenib 1446113-23-0 Belvarafenib is a pan-RAF inhibitor, with IC50 values of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFV600E and C-RAF, respectively.
CSN15686 B-Raf Inhibitor 1 2HCl 1191385-19-9 B-Raf inhibitor 1 is a potent and selective B-Raf inhibitor with cell IC50s of 031 M and 2 nM for A375 proliferation and A375 p-ERK respectively
CSN22609 AZ304   942507-42-8 AZ304 is an inhibitor of BRAF and can target many kinases The IC50s for wild type BRAF V600E mutant BRAF and wild type CRAF are 79 nM 38 nM and 68 nM respectively It can also inhibit p38 IC50 6 nM and CSF1R IC50 35 nM
CSN13566 AZ 628 878739-06-1 AZ 628 is a pan-Raf inhibitor for BRAF BRAFV600E and c-Raf-1 with IC50 of 105 nM 34 nM and 29 nM also inhibits VEGFR2 DDR2 Lyn Flt1 FMS etc
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