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CAS No.: 2305154-31-6

JCN037 Catalog No. CSN26106

Synonyms: JGK037

JCN037 is a potent EGFR inhibitor with IC50 values of 2.49 nM, 3.95 nM and 4.48 nM for EGFR, p-wtEGFR and pEGFRvⅢ, respectively. It displayed potent activity against EGFR amplified/mutant patient-derived cell cultures, significant BBB penetration (2:1 brain-to-plasma ratio), and superior efficacy in an EGFR-driven orthotopic glioblastoma xenograft model.

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CAS No. 2305154-31-6 Storage
Formula C16H11BrFN3O2 Shipping Blue ice
M.W. 376.18 Synonyms JGK037

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