(E)-3PO | 18550-98-6 |CSNpharm

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You are here : Home / Others / Others-Others / (E)-3PO

CAS No.: 18550-98-6

(E)-3PO Catalog No. CSN13880

Synonyms: (E)-3-PO

(E)-3PO is a small-molecule inhibitor of the PFKFB3 isozyme, 3PO markedly attenuates the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50, 1.4-24 M) which target PFKFB3 isozyme. 3PO inhibits recombinant PFKFB3 activity, suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD, and NADH in vitro.

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Biological Activity

Description(E)-3PO is a small-molecule inhibitor of the PFKFB3 isozyme, 3PO markedly attenuates the proliferation of several human malignant hematopoietic and adenocarcinoma cell lines (IC50, 1.4-24 μM) which target: PFKFB3 isozyme. 3PO inhibits recombinant PFKFB3 activity, suppresses glucose uptake, and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+, and NADH in vitro.
References

[1] Schoors S, De Bock K, et al. Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab. 2014 Jan 7;19(1):37-48.
[2] Clem B, Telang S, et al. Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth. Mol Cancer Ther. 2008 Jan;7(1):110-20.

Protocol

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- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.7567 mL
- 23.7833 mL
- 47.5667 mL
- 5 mM
- 0.9513 mL
- 4.7567 mL
- 9.5133 mL
- 10 mM
- 0.4757 mL
- 2.3783 mL
- 4.7567 mL

Technical Information

CAS No.	18550-98-6		Storage	Powder -20°C 3 years In solvent -80°C 12 months
Formula	C13H10N2O		Shipping	Blue ice
M.W.	210.23		Synonyms	(E)-3-PO

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