Biological Activity

• Description(-)-Epicatechin gallate (ECG) inhibits cyclooxygenase-1 (COX-1) with an IC50 of 7.5 μM. (-)-Epicatechin-3-O-gallate (ECG), a component of Rhei Rhizoma, the absolute bioavailability values (F) were 1.02, 1.47 and 3.30% at doses of 12.5, 25.0, and 50.0 mg/kg, respectively. And oral administration of ECG, ECG plasma levels revealed curves characterized by peaks at 0.065, 0.063 and 0.085 h.(-)-Epicatechin gallate(ECG) (25 μg ml−1) suppresses the secretion of coagulase and α-toxin by clinical isolates of S. aureus(Staphylococcus aureus ).
• Clinical Study

• NCT Number	Condition or disease	Phase	Recruitment Status	Estimated Study Completion Date	Locations
  NCT00611650	Lung Cancer P... more >>recancerous Condition Tobacco Use Disorder Collapse <<	Phase 2	Terminated(Slow recruitment)	-	Canada, British Columbia ... more >> British Columbia Cancer Agency - Vancouver Cancer Centre Vancouver, British Columbia, Canada, V5Z 4E6 Collapse <<
  NCT00253643	Precancerous Condition ... more >> Prostate Cancer Collapse <<	Not Applicable	Completed	-	United States, Oregon ... more >> Kaiser Permanente Center for Health Research Portland, Oregon, United States, 97227 OHSU Knight Cancer Institute Portland, Oregon, United States, 97239-3098 Veterans Affairs Medical Center - Portland Portland, Oregon, United States, 97239 Collapse <<
  NCT00253643	-	-	Completed	-	-

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• References

• [1] Malik S, Suchal K, Bhatia J, Gamad N, Dinda AK, Gupta YK, Arya DS. Molecular mechanisms underlying attenuation of cisplatin-induced acute kidney injury by epicatechin gallate. Lab Invest. 2016 Aug;96(8):853-61.

  [2] Shiota S, Shimizu M, et al. Marked reduction in the minimum inhibitory concentration (MIC) of beta-lactams in methicillin-resistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis). Biol Pharm Bull. 1999 Dec;22(12):1388-90.