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PPAR
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN12217 | Wy-14643 | 50892-23-4 | Wy-14643 is an agonist of PPAR with EC50 of 0.63 M that can decrease the inflammatory response. It has other functions including lipid metabolism, cell proliferation, differentiation, adipogenesis etc.. |
| CSN20285 | Suksdorfin | 53023-17-9 | Suksdorfin promotes adipocyte differentiation and improves abnormalities in glucose metabolism via PPAR activation |
| CSN23127 | SR 202 | 76541-72-5 | SR 202 is a selective PPARγ antagonist which attenuates troglitazone-induced PPARγ transcriptional activity with IC50 value of 140μM. It inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo and improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo. |
| CSN12570 | Rosiglitazone Maleate | 155141-29-0 | Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor- (PPAR) with Kd of 40 nM and it also acts as a modulator of TRP channels. |
| CSN12570 | Rosiglitazone Maleate | 155141-29-0 | Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor- (PPAR) with Kd of 40 nM and it also acts as a modulator of TRP channels. |
| CSN10029 | Pioglitazone | 111025-46-8 | Pioglitazone is an agonist of peroxisome proliferator-activated receptor gamma (PPAR, EC50 500-600 nM) over PPAR. It also a thiazolidinedione (TZD) anti-diabetic. |
| CSN12489 | Pioglitazone HCl | 112529-15-4 | Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes. |
| CSN12489 | Pioglitazone HCl | 112529-15-4 | Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes. |
| CSN25412 | Oroxin A | 57396-78-8 | Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE), activates peroxisome proliferator-activated receptor γ (PPARγ) by docking into the PPARγ protein ligand-binding domain. Oroxin A exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence. |
| CSN13703 | MK-886 | 118414-82-7 | MK886 is an inhibitor of 5-lipoxygenase activating protein FLAP PPAR and the biosynthesis of leukotriene LT |
| CSN20225 | MHY553 | 6265-56-1 | MHY553 a PPAR agonist alleviates hepatic steatosis by increasing fatty acid oxidation and decreasing inflammation during aging |
| CSN21901 | Imiglitazar | 250601-04-8 | Imiglitazar is a potent and dual human PPARα and PPARγ1 agonist with EC50 values of 67 and 31 nM, respectively. |
| CSN27564 | Gypenoside XLIX | 94987-08-3 | Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells. |
| CSN11131 | GW9662 | 22978-25-2 | GW9662 selectively antagonizes PPAR with IC50 of 3.3 nM. It can inhibit the growth of mammary cancer cells. |
| CSN11130 | GW1929 | 196808-24-9 | GW1929 is a synthetic peroxisome proliferator-activated receptor- (PPAR) agonist with IC50 of 6.2 nM and 13 nM for human and mouse PPAR, respectively. |
| CSN11100 | Glabridin | 59870-68-7 | Glabridin has many biological functions such as regulating the synthesis and activity of iNOS under high-glucose levels, significantly inhibiting free radicals generated during metabolism in the body, and protecting against oxidation-sensitive biomacromolecules (LDL, LDL, DNA) and cell walls. It is a natural product isolated and purified from the roots of Glycyrrhiza glabra L. with whitening and anti-aging activity. |
| CSN18750 | Fenofibric Acid | 42017-89-0 | Fenofibric acid is an agonist of PPAR that can regulate lipid level. It also exhibits inhibition of COX-2. |
| CSN25193 | Cinnamyl alcohol | 104-54-1 | Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon. |
| CSN22759 | Ciglitazone | 74772-77-3 | Ciglitazone is a selective agonist at PPARγ (peroxisome proliferator-activated receptor γ) with an EC50 of 3 μM in vitro. |
| CSN18278 | CDDO-Im | 443104-02-7 | CDDO-Im is a synthetic triterpenoid more potent than its parent compound CDDO both in vitro and in vivo and a PPAR agonist. |
| CSN10449 | Bilobetin | 521-32-4 | Bilobetin, a natural product isolated and purified from the leaves of Ginkgo biloba L., whose treatment ameliorates hyperlipidaemia, lipotoxicity and insulin resistance in rats by stimulating PPAR-mediated lipid catabolism. |
| CSN10380 | Bavachinin | 19879-30-2 | Bavachinin is an agonist of PPAR with EC50s of 4.0 M, 8.1 M, and 0.74 M for ,, and respectively. It is a natural flavanone with anti-angiogenic effect. |
| CSN18081 | Balaglitazone | 199113-98-9 | Balaglitazone is a partial agonist of PPAR-. |
| CSN22706 | BADGE | 1675-54-3 | BADGE is a PPARγ antagonist. |
| CSN20493 | Astaxanthin | 472-61-7 | Astaxanthin is a carotenoid pigment found primarily in marine organisms including Haematococcus Pluvialis, shrimp and salmon. It is a potent lipid-soluble antioxidant. |
| CSN22075 | MBX 102 | 24136-23-0 | Arhalofenate is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ ans is used for the treatment of type 2 diabetes. |
| CSN20181 | AMG-131 | 315224-26-1 | AMG-131 is a hypoglycemic agent It is a potent PPAR partial agonist that displays robust glucose-lowering activity in rodent models of diabetes while exhibiting a reduced side-effects profile compared to marketed TZDs |
| CSN16319 | Alpinetin | 36052-37-6 | Alpinetin can act as an inhibitor of UCK2 and shows antioxidant, anticancer and antithrombotic properties. Alpinetin is mainly found in ginger plants. |
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