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PPAR

PPAR

Cat. No. Product Name CAS No. Information
CSN12217 Wy-14643 50892-23-4 Wy-14643 is an agonist of PPAR with EC50 of 0.63 M that can decrease the inflammatory response. It has other functions including lipid metabolism, cell proliferation, differentiation, adipogenesis etc..
CSN20285 Suksdorfin 53023-17-9 Suksdorfin promotes adipocyte differentiation and improves abnormalities in glucose metabolism via PPAR activation
CSN23127 SR 202 76541-72-5 SR 202 is a selective PPARγ antagonist which attenuates troglitazone-induced PPARγ transcriptional activity with IC50 value of 140μM. It inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo and improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo.
CSN23086 S26948 353280-43-0 Selective PPARγ agonist; antidiabetic agent
CSN20554 Seladelpar   851528-79-5 Seladelpar is selectively exhibits activation of peroxisome proliferator-activated receptor (PPAR) which may has therapeutic activity against dyslipidemia, metabolic syndrome, type 2 diabetes, and non-alcoholic steatohepatitis.
CSN22093 Saroglitazar Magnesium 1639792-20-3 Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ in HepG2 cells, respectively.
CSN12570 Rosiglitazone Maleate   155141-29-0 Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor- (PPAR) with Kd of 40 nM and it also acts as a modulator of TRP channels.
CSN12512 Rosiglitazone     122320-73-4 Rosiglitazone is a selective agonist of PPAR with EC50 of 60 nM and has no effect on PPAR and PPAR It is an insulin sensitizing and potent antihyperglycemic agent
CSN22489 Pparδ Agonist 942594-93-6 PPAR agonist is a PPAR agonist extracted from patent US20180071304 compound example 10
CSN22490 Pparδ Agonist 1 1902161-12-9 Ppar agonist 1 is a PPAR- agonist with an EC50 of 506 nM used in the research of PPAR-delta related diseases such as mitochondrial diseases muscular diseases vascular diseases demyelinating diseases and metabolic diseases
CSN10029 Pioglitazone   111025-46-8 Pioglitazone is an agonist of peroxisome proliferator-activated receptor gamma (PPAR, EC50 500-600 nM) over PPAR. It also a thiazolidinedione (TZD) anti-diabetic.
CSN12489 Pioglitazone HCl   112529-15-4 Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes.
CSN18946 Pemafibrate Racemate 848258-31-1 Pemafibrate racemate is a selective PPAR modulator SPPARM
CSN23900 LJ570 2252488-69-8 LJ570 is the first PPARα/γ dual agonist with EC50 values of 1.05 and 0.12 μM, respectively.
CSN20539 IVA-337     927961-18-0 IVA-337 is a agonist of peroxisome proliferator-activated receptors PPAR which is widely used in the study of lung fibrosis and pulmonary hypertension
CSN21901 Imiglitazar 250601-04-8 Imiglitazar is a potent and dual human PPARα and PPARγ1 agonist with EC50 values of 67 and 31 nM, respectively.
CSN11131 GW9662 22978-25-2 GW9662 selectively antagonizes PPAR with IC50 of 3.3 nM. It can inhibit the growth of mammary cancer cells.
CSN11130 GW1929 196808-24-9 GW1929 is a synthetic peroxisome proliferator-activated receptor- (PPAR) agonist with IC50 of 6.2 nM and 13 nM for human and mouse PPAR, respectively.
CSN13142 GW0742   317318-84-6 GW0742 is an agonist of PPAR with EC50 of 11 nM It can protect right heart from hypertrophy and enhance lipid metabolism in heart. It also works as an antagonist of vitamin D receptor.
CSN22426 GW 6471 880635-03-0 GW 6471 is a potent PPAR antagonist
CSN15822 GSK3787   188591-46-0 GSK3787 selectively and irreversibly antagonizes PPAR with pIC50 of 66 with no significant effect on hPPAR or hPPAR
CSN15777 GSK0660 1014691-61-2 GSK0660 is a selective antagonist of PPAR and exhibits inverse agonist effects when used alone
CSN11100 Glabridin   59870-68-7 Glabridin has many biological functions such as regulating the synthesis and activity of iNOS under high-glucose levels, significantly inhibiting free radicals generated during metabolism in the body, and protecting against oxidation-sensitive biomacromolecules (LDL, LDL, DNA) and cell walls. It is a natural product isolated and purified from the roots of Glycyrrhiza glabra L. with whitening and anti-aging activity.
CSN16260 Gemfibrozil   25812-30-0 Gemfibrozil is an agonist of PPAR It can act as a hyperlipidemic agent that elevates plasma HDL and lowers triglycerides
CSN22403 Fonadelpar 515138-06-4 Fonadelpar is a PPAR agonist, used in the research of neuroparalytic keratopathy.
CSN15096 Ficusin A 173429-83-9 Ficusin A is a natural product isolated and purified from the seeds of Psoralea corylifolia Linn.
CSN18750 Fenofibric Acid   42017-89-0 Fenofibric acid is an agonist of PPAR that can regulate lipid level. It also exhibits inhibition of COX-2.
CSN12680 Fenofibrate   49562-28-9 Fenofibrate is an agonist of PPAR EC50 30 M and an inhibitor of CYP2C19 IC50 02 M and CYP2B6 IC50 07 M Fenofibrate is a fibric acid derivative and used to treat hypercholesterolemia and hypertriglyceridemia
CSN13948 Eupatilin   22368-21-4 Eupatilin is an activiator of PPAR It is a lipohilic flavonoid extracted from artemisia species with antioxidant anti-tumor and anti-inflammatory activities
CSN16153 Elafibranor 923978-27-2 Elafibranor is an agonist of PPAR and PPAR with EC50 values of 45 nM and 175 nM respectively Elafibranor also attenuates nonalcoholic steatohepatitis without fibrosis worsening
CSN17750 DG172 2HCl 1361504-77-9 DG172 2HCl is a PPARβ/δ-selective ligand showing high binding affinity (IC50 = 27 nM) and potent inverse agonistic properties.
CSN13070 Clofibric Acid   882-09-7 Clofibric acid is an agonist of PPAR and can act as a hypolipidemic agent
CSN18278 CDDO-Im 443104-02-7 CDDO-Im is a synthetic triterpenoid more potent than its parent compound CDDO both in vitro and in vivo and a PPAR agonist.
CSN10556 Catalposide 6736-85-2 Catalposide, a natural product isolated and purified from the herb of Catalpa ovata G.Don, is hypolipidemic by activation of PPAR via a ligand-mediated mechanism that modulates the expression of in lipid metabolism genes in hepatocytes, and may be an effective agent for the treatment of diseases characterized by mucosal inflammation.
CSN10449 Bilobetin 521-32-4 Bilobetin, a natural product isolated and purified from the leaves of Ginkgo biloba L., whose treatment ameliorates hyperlipidaemia, lipotoxicity and insulin resistance in rats by stimulating PPAR-mediated lipid catabolism.
CSN10380 Bavachinin 19879-30-2 Bavachinin is an agonist of PPAR with EC50s of 4.0 M, 8.1 M, and 0.74 M for ,, and respectively. It is a natural flavanone with anti-angiogenic effect.
CSN18081 Balaglitazone 199113-98-9 Balaglitazone is a partial agonist of PPAR-.
CSN22706 BADGE 1675-54-3 BADGE is a PPARγ antagonist.
CSN21934 AVE-8134 304025-09-0 AVE-8134 is a potent PPARα agonist with EC50 of 100 and 3000 nM for human and rodent PPARα receptor, respectively.
CSN20493 Astaxanthin   472-61-7 Astaxanthin is a carotenoid pigment found primarily in marine organisms including Haematococcus Pluvialis, shrimp and salmon. It is a potent lipid-soluble antioxidant.
CSN14141 Arjunolic Acid 465-00-9 Arjunolic acid a natural peroxisome proliferator-activated receptor alpha agonist isolated and purified from the fruits of Terminalia chebula Retz can protect against cisplatin-induced testicular injury by attenuating oxidative stress parameters along with downregulation of iNOS TNF- and p38-MAPK testicular expressions
CSN22075 MBX 102 24136-23-0 Arhalofenate is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ ans is used for the treatment of type 2 diabetes.
CSN14120 Angeloylgomisin H 66056-22-2 Angeloylgomisin H, a natural product isolated and purified from the fruits of Schizandra chinensis, shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ugmL against MCF7, HEK293 and CAL27 cell lines and may present significant myocardial protective activity.
CSN20181 AMG-131 315224-26-1 AMG-131 is a hypoglycemic agent It is a potent PPAR partial agonist that displays robust glucose-lowering activity in rodent models of diabetes while exhibiting a reduced side-effects profile compared to marketed TZDs
CSN16319 Alpinetin 36052-37-6 Alpinetin can act as an inhibitor of UCK2 and shows antioxidant, anticancer and antithrombotic properties. Alpinetin is mainly found in ginger plants.
CSN10234 Aleglitazar 475479-34-6 Aleglitazar is a dual PPAR- agonist with IC50 of 2.8 nM4.6 nM.
CSN10195 Abietic Acid 514-10-3 Abietic acid is a PPAR dual activator to inhibit UVB-induced MMP-1 expression and age-related inflammation by suppressing NF-B and the MAPKAP-1 pathway, its a natural product isolated and purified from the herbs of Pinus massoniana which can be used not only for anti-inflammation but also for regulating lipid metabolism and atherosclerosis.
CSN12767 4-(4-Hydroxyphenyl)-2-Butanone   5471-51-2 4-4-Hydroxyphenyl-2-butanone is the primary aroma compound of red raspberries and shows PPAR- agonistic activity
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