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PPAR
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN12217 | Pirinixic acid | 50892-23-4 | Wy-14643 is an agonist of PPAR with EC50 of 0.63 M that can decrease the inflammatory response. It has other functions including lipid metabolism, cell proliferation, differentiation, adipogenesis etc.. |
| CSN26416 | Tesaglitazar | 251565-85-2 | Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively, and approximately 0.2 μM for both rat and human PPARγ. Tesaglitazar induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats[1]. |
| CSN23126 | SR1664 | 1338259-05-4 | SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC50 = 80 nM; Ki = 28.67 nM) without exhibiting PPARγ agonist activity. |
| CSN23127 | Mifobate | 76541-72-5 | SR 202 is a selective PPARγ antagonist which attenuates troglitazone-induced PPARγ transcriptional activity with IC50 value of 140μM. It inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo and improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo. |
| CSN32930 | Seladelpar lysine | 928821-40-3 | Seladelpar lysine is a selective PPAR-δ agonist. |
| CSN20554 | Seladelpar | 851528-79-5 | Seladelpar is selectively exhibits activation of peroxisome proliferator-activated receptor (PPAR) which may has therapeutic activity against dyslipidemia, metabolic syndrome, type 2 diabetes, and non-alcoholic steatohepatitis. |
| CSN22093 | Saroglitazar magnesium | 1639792-20-3 | Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ in HepG2 cells, respectively. |
| CSN12570 | Rosiglitazone maleate | 155141-29-0 | Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor- (PPAR) with Kd of 40 nM and it also acts as a modulator of TRP channels. |
| CSN12570 | Rosiglitazone maleate | 155141-29-0 | Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor- (PPAR) with Kd of 40 nM and it also acts as a modulator of TRP channels. |
| CSN33127 | Sodium (E)-2-(4-((3-(4-fluorophenyl)-3-(4-(3-morpholinoprop-1-yn-1-yl)phenyl)allyl)oxy)-2-methylphenoxy)acetate | 1604815-32-8 | REN-001 is a PPARdelta agonist. |
| CSN10029 | Pioglitazone | 111025-46-8 | Pioglitazone is an agonist of peroxisome proliferator-activated receptor gamma (PPAR, EC50 500-600 nM) over PPAR. It also a thiazolidinedione (TZD) anti-diabetic. |
| CSN12489 | Pioglitazone hydrochloride | 112529-15-4 | Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes. |
| CSN12489 | Pioglitazone hydrochloride | 112529-15-4 | Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes. |
| CSN25412 | Oroxin A | 57396-78-8 | Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE), activates peroxisome proliferator-activated receptor γ (PPARγ) by docking into the PPARγ protein ligand-binding domain. Oroxin A exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence. |
| CSN25571 | MA-0204 | 2095128-17-7 | MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. It is potential for Duchene Muscular Dystrophy treatment. |
| CSN23900 | LJ570 | 2252488-69-8 | LJ570 is the first PPARα/γ dual agonist with EC50 values of 1.05 and 0.12 μM, respectively. |
| CSN33142 | Leriglitazone | 146062-44-4 | Leriglitazone is a peroxisome proliferator activated receptor (PPAR) gamma agonist. |
| CSN21901 | Imiglitazar | 250601-04-8 | Imiglitazar is a potent and dual human PPARα and PPARγ1 agonist with EC50 values of 67 and 31 nM, respectively. |
| CSN11131 | GW9662 | 22978-25-2 | GW9662 selectively antagonizes PPAR with IC50 of 3.3 nM. It can inhibit the growth of mammary cancer cells. |
| CSN11130 | GW1929 | 196808-24-9 | GW1929 is a synthetic peroxisome proliferator-activated receptor- (PPAR) agonist with IC50 of 6.2 nM and 13 nM for human and mouse PPAR, respectively. |
| CSN22845 | GW1929 hydrochloride | 1217466-21-1 | GW 1929 HCl is a highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist with pEC50 of 8.05 for human PPARγ. |
| CSN11100 | Glabridin | 59870-68-7 | Glabridin has many biological functions such as regulating the synthesis and activity of iNOS under high-glucose levels, significantly inhibiting free radicals generated during metabolism in the body, and protecting against oxidation-sensitive biomacromolecules (LDL, LDL, DNA) and cell walls. It is a natural product isolated and purified from the roots of Glycyrrhiza glabra L. with whitening and anti-aging activity. |
| CSN22403 | Fonadelpar | 515138-06-4 | Fonadelpar is a PPAR agonist, used in the research of neuroparalytic keratopathy. |
| CSN15096 | Ficusin A | 173429-83-9 | Ficusin A is a natural product isolated and purified from the seeds of Psoralea corylifolia Linn. |
| CSN17195 | FH535 | 108409-83-2 | FH535 is a compound that suppresses both Wntbeta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling. |
| CSN18750 | Fenofibric acid | 42017-89-0 | Fenofibric acid is an agonist of PPAR that can regulate lipid level. It also exhibits inhibition of COX-2. |
| CSN22800 | Edaglitazone | 213411-83-7 | Edaglitazone is a potent and selective PPARγ agonist with EC50 of 35.61 nM. |
| CSN27742 | Diflapolin | 724453-98-9 | Diflapolin is a dual inhibitor of both FLAP and sEH. It inhibited 5-LOX product formation in intact human monocytes and neutrophils with IC50 = 30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC50 = 20 nM). |
| CSN26559 | CUDA | 479413-68-8 | CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively[1]. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease[2]. |
| CSN22773 | CP-775146 | 702680-17-9 | CP 775146 is a selective, high affinity PPARα agonist with Ki of 24.5 nM. |
| CSN25193 | Cinnamyl Alcohol | 104-54-1 | Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon. |
| CSN22759 | Ciglitazone | 74772-77-3 | Ciglitazone is a selective agonist at PPARγ (peroxisome proliferator-activated receptor γ) with an EC50 of 3 μM in vitro. |
| CSN18278 | CDDO-Im | 443104-02-7 | CDDO-Im is a synthetic triterpenoid more potent than its parent compound CDDO both in vitro and in vivo and a PPAR agonist. |
| CSN10449 | Bilobetin | 521-32-4 | Bilobetin, a natural product isolated and purified from the leaves of Ginkgo biloba L., whose treatment ameliorates hyperlipidaemia, lipotoxicity and insulin resistance in rats by stimulating PPAR-mediated lipid catabolism. |
| CSN10380 | Bavachinin | 19879-30-2 | Bavachinin is an agonist of PPAR with EC50s of 4.0 M, 8.1 M, and 0.74 M for ,, and respectively. It is a natural flavanone with anti-angiogenic effect. |
| CSN18081 | Balaglitazone | 199113-98-9 | Balaglitazone is a partial agonist of PPAR-. |
| CSN21934 | AVE-8134 | 304025-09-0 | AVE-8134 is a potent PPARα agonist with EC50 of 100 and 3000 nM for human and rodent PPARα receptor, respectively. |
| CSN20493 | Astaxanthin | 472-61-7 | Astaxanthin is a carotenoid pigment found primarily in marine organisms including Haematococcus Pluvialis, shrimp and salmon. It is a potent lipid-soluble antioxidant. |
| CSN22075 | Arhalofenate | 24136-23-0 | Arhalofenate is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ ans is used for the treatment of type 2 diabetes. |
| CSN16319 | Alpinetin | 36052-37-6 | Alpinetin can act as an inhibitor of UCK2 and shows antioxidant, anticancer and antithrombotic properties. Alpinetin is mainly found in ginger plants. |
| CSN10234 | Aleglitazar | 475479-34-6 | Aleglitazar is a dual PPAR- agonist with IC50 of 2.8 nM4.6 nM. |
| CSN51362 | SR 16832 | 2088135-12-8 |
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