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PPAR

PPAR

Cat. No. Product Name CAS No. Information
CSN12217 Pirinixic acid 50892-23-4 Wy-14643 is an agonist of PPAR with EC50 of 0.63 M that can decrease the inflammatory response. It has other functions including lipid metabolism, cell proliferation, differentiation, adipogenesis etc..
CSN26416 Tesaglitazar 251565-85-2 Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively, and approximately 0.2 μM for both rat and human PPARγ. Tesaglitazar induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats[1].
CSN23126 SR1664 1338259-05-4 SR1664 is a potent and selective PPARγ inhibitor with potential antidiabetic activity. SR1664 binds to PPARγ and potently inhibits Cdk5-mediated PPARγ phosphorylation (IC50 = 80 nM; Ki = 28.67 nM) without exhibiting PPARγ agonist activity.
CSN23127 Mifobate 76541-72-5 SR 202 is a selective PPARγ antagonist which attenuates troglitazone-induced PPARγ transcriptional activity with IC50 value of 140μM. It inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo and improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo.
CSN32930 Seladelpar lysine 928821-40-3 Seladelpar lysine is a selective PPAR-δ agonist.
CSN20554 Seladelpar   851528-79-5 Seladelpar is selectively exhibits activation of peroxisome proliferator-activated receptor (PPAR) which may has therapeutic activity against dyslipidemia, metabolic syndrome, type 2 diabetes, and non-alcoholic steatohepatitis.
CSN22093 Saroglitazar magnesium 1639792-20-3 Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ in HepG2 cells, respectively.
CSN12570 Rosiglitazone maleate   155141-29-0 Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor- (PPAR) with Kd of 40 nM and it also acts as a modulator of TRP channels.
CSN12570 Rosiglitazone maleate   155141-29-0 Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor- (PPAR) with Kd of 40 nM and it also acts as a modulator of TRP channels.
CSN33127 Sodium (E)-2-(4-((3-(4-fluorophenyl)-3-(4-(3-morpholinoprop-1-yn-1-yl)phenyl)allyl)oxy)-2-methylphenoxy)acetate 1604815-32-8 REN-001 is a PPARdelta agonist.
CSN10029 Pioglitazone   111025-46-8 Pioglitazone is an agonist of peroxisome proliferator-activated receptor gamma (PPAR, EC50 500-600 nM) over PPAR. It also a thiazolidinedione (TZD) anti-diabetic.
CSN12489 Pioglitazone hydrochloride   112529-15-4 Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes.
CSN12489 Pioglitazone hydrochloride   112529-15-4 Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes.
CSN25412 Oroxin A 57396-78-8 Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE), activates peroxisome proliferator-activated receptor γ (PPARγ) by docking into the PPARγ protein ligand-binding domain. Oroxin A exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence.
CSN25571 MA-0204 2095128-17-7 MA-0204 is a potent, highly selective and orally available peroxisome proliferator activated receptor δ (PPARδ) modulator with EC50s of 0.4 nM, 7.9 nM and 10 nM for human, mouse and rat PPARδ, respectively. It is potential for Duchene Muscular Dystrophy treatment.
CSN23900 LJ570 2252488-69-8 LJ570 is the first PPARα/γ dual agonist with EC50 values of 1.05 and 0.12 μM, respectively.
CSN33142 Leriglitazone 146062-44-4 Leriglitazone is a peroxisome proliferator activated receptor (PPAR) gamma agonist.
CSN21901 Imiglitazar 250601-04-8 Imiglitazar is a potent and dual human PPARα and PPARγ1 agonist with EC50 values of 67 and 31 nM, respectively.
CSN11131 GW9662   22978-25-2 GW9662 selectively antagonizes PPAR with IC50 of 3.3 nM. It can inhibit the growth of mammary cancer cells.
CSN11130 GW1929 196808-24-9 GW1929 is a synthetic peroxisome proliferator-activated receptor- (PPAR) agonist with IC50 of 6.2 nM and 13 nM for human and mouse PPAR, respectively.
CSN22845 GW1929 hydrochloride 1217466-21-1 GW 1929 HCl is a highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist with pEC50 of 8.05 for human PPARγ.
CSN11100 Glabridin   59870-68-7 Glabridin has many biological functions such as regulating the synthesis and activity of iNOS under high-glucose levels, significantly inhibiting free radicals generated during metabolism in the body, and protecting against oxidation-sensitive biomacromolecules (LDL, LDL, DNA) and cell walls. It is a natural product isolated and purified from the roots of Glycyrrhiza glabra L. with whitening and anti-aging activity.
CSN22403 Fonadelpar 515138-06-4 Fonadelpar is a PPAR agonist, used in the research of neuroparalytic keratopathy.
CSN15096 Ficusin A 173429-83-9 Ficusin A is a natural product isolated and purified from the seeds of Psoralea corylifolia Linn.
CSN17195 FH535 108409-83-2 FH535 is a compound that suppresses both Wntbeta-catenin and peroxisome proliferator-activated receptor (PPAR) signaling.
CSN18750 Fenofibric acid   42017-89-0 Fenofibric acid is an agonist of PPAR that can regulate lipid level. It also exhibits inhibition of COX-2.
CSN22800 Edaglitazone 213411-83-7 Edaglitazone is a potent and selective PPARγ agonist with EC50 of 35.61 nM.
CSN27742 Diflapolin 724453-98-9 Diflapolin is a dual inhibitor of both FLAP and sEH. It inhibited 5-LOX product formation in intact human monocytes and neutrophils with IC50 = 30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC50 = 20 nM).
CSN26559 CUDA 479413-68-8 CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC50s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively[1]. CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease[2].
CSN22773 CP-775146 702680-17-9 CP 775146 is a selective, high affinity PPARα agonist with Ki of 24.5 nM.
CSN25193 Cinnamyl Alcohol 104-54-1 Cinnamyl alcohol is a naturally occurring compound that is found within cinnamon.
CSN22759 Ciglitazone 74772-77-3 Ciglitazone is a selective agonist at PPARγ (peroxisome proliferator-activated receptor γ) with an EC50 of 3 μM in vitro.
CSN18278 CDDO-Im 443104-02-7 CDDO-Im is a synthetic triterpenoid more potent than its parent compound CDDO both in vitro and in vivo and a PPAR agonist.
CSN10449 Bilobetin 521-32-4 Bilobetin, a natural product isolated and purified from the leaves of Ginkgo biloba L., whose treatment ameliorates hyperlipidaemia, lipotoxicity and insulin resistance in rats by stimulating PPAR-mediated lipid catabolism.
CSN10380 Bavachinin 19879-30-2 Bavachinin is an agonist of PPAR with EC50s of 4.0 M, 8.1 M, and 0.74 M for ,, and respectively. It is a natural flavanone with anti-angiogenic effect.
CSN18081 Balaglitazone 199113-98-9 Balaglitazone is a partial agonist of PPAR-.
CSN21934 AVE-8134 304025-09-0 AVE-8134 is a potent PPARα agonist with EC50 of 100 and 3000 nM for human and rodent PPARα receptor, respectively.
CSN20493 Astaxanthin   472-61-7 Astaxanthin is a carotenoid pigment found primarily in marine organisms including Haematococcus Pluvialis, shrimp and salmon. It is a potent lipid-soluble antioxidant.
CSN22075 Arhalofenate 24136-23-0 Arhalofenate is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ ans is used for the treatment of type 2 diabetes.
CSN16319 Alpinetin 36052-37-6 Alpinetin can act as an inhibitor of UCK2 and shows antioxidant, anticancer and antithrombotic properties. Alpinetin is mainly found in ginger plants.
CSN10234 Aleglitazar 475479-34-6 Aleglitazar is a dual PPAR- agonist with IC50 of 2.8 nM4.6 nM.
CSN51362 SR 16832 2088135-12-8
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