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PPAR
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN12217 | Wy-14643 | 50892-23-4 | Wy-14643 is an agonist of PPAR with EC50 of 0.63 M that can decrease the inflammatory response. It has other functions including lipid metabolism, cell proliferation, differentiation, adipogenesis etc.. |
| CSN20285 | Suksdorfin | 53023-17-9 | Suksdorfin promotes adipocyte differentiation and improves abnormalities in glucose metabolism via PPAR activation |
| CSN23127 | SR 202 | 76541-72-5 | SR 202 is a selective PPARγ antagonist which attenuates troglitazone-induced PPARγ transcriptional activity with IC50 value of 140μM. It inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo and improves insulin sensitivity in diabetic ob/ob mice and increases HDL levels in rats in vivo. |
| CSN23086 | S26948 | 353280-43-0 | Selective PPARγ agonist; antidiabetic agent |
| CSN20554 | Seladelpar | 851528-79-5 | Seladelpar is selectively exhibits activation of peroxisome proliferator-activated receptor (PPAR) which may has therapeutic activity against dyslipidemia, metabolic syndrome, type 2 diabetes, and non-alcoholic steatohepatitis. |
| CSN22093 | Saroglitazar Magnesium | 1639792-20-3 | Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist with EC50 values of 0.65 pM and 3 nM for PPARα and PPARγ in HepG2 cells, respectively. |
| CSN12570 | Rosiglitazone Maleate | 155141-29-0 | Rosiglitazone maleate is the maleate form of rosiglitazone which is a high-affinity selective agonist of the peroxisome proliferator-activated receptor- (PPAR) with Kd of 40 nM and it also acts as a modulator of TRP channels. |
| CSN22489 | Pparδ Agonist | 942594-93-6 | PPAR agonist is a PPAR agonist extracted from patent US20180071304 compound example 10 |
| CSN22490 | Pparδ Agonist 1 | 1902161-12-9 | Ppar agonist 1 is a PPAR- agonist with an EC50 of 506 nM used in the research of PPAR-delta related diseases such as mitochondrial diseases muscular diseases vascular diseases demyelinating diseases and metabolic diseases |
| CSN10029 | Pioglitazone | 111025-46-8 | Pioglitazone is an agonist of peroxisome proliferator-activated receptor gamma (PPAR, EC50 500-600 nM) over PPAR. It also a thiazolidinedione (TZD) anti-diabetic. |
| CSN12489 | Pioglitazone HCl | 112529-15-4 | Pioglitazone HCl is a selective agonist of PPARγ with EC50 of 0.93 μM which is used to treat diabetes. |
| CSN18946 | Pemafibrate Racemate | 848258-31-1 | Pemafibrate racemate is a selective PPAR modulator SPPARM |
| CSN25412 | Oroxin A | 57396-78-8 | Oroxin A is the major component of an ethanol-water Oroxylum indicum (L.) Kurz (Bignoniaceae) seed extract (OISE), activates peroxisome proliferator-activated receptor γ (PPARγ) by docking into the PPARγ protein ligand-binding domain. Oroxin A exhibits an inhibitory activity against α-glucosidase and an antioxidant capacity. Oroxin A exerts anti-breast cancer effects by inducing ER stress-mediated senescence. |
| CSN13703 | MK-886 | 118414-82-7 | MK886 is an inhibitor of 5-lipoxygenase activating protein FLAP PPAR and the biosynthesis of leukotriene LT |
| CSN23900 | LJ570 | 2252488-69-8 | LJ570 is the first PPARα/γ dual agonist with EC50 values of 1.05 and 0.12 μM, respectively. |
| CSN21901 | Imiglitazar | 250601-04-8 | Imiglitazar is a potent and dual human PPARα and PPARγ1 agonist with EC50 values of 67 and 31 nM, respectively. |
| CSN27564 | Gypenoside XLIX | 94987-08-3 | Gypenoside XLIX, a dammarane-type glycoside, is a prominent component of G. pentaphyllum. Gypenoside XLIX is a selective peroxisome proliferator-activated receptor (PPAR)-alpha activator and inhibits cytokine-induced vascular cell adhesion molecule-1 (VCAM-1) overexpression and hyperactivity in human endothelial cells. |
| CSN11131 | GW9662 | 22978-25-2 | GW9662 selectively antagonizes PPAR with IC50 of 3.3 nM. It can inhibit the growth of mammary cancer cells. |
| CSN26116 | GW7647 | 265129-71-3 | GW7647 is a potent human PPARα agonist with EC50 value of 6nM. |
| CSN11130 | GW1929 | 196808-24-9 | GW1929 is a synthetic peroxisome proliferator-activated receptor- (PPAR) agonist with IC50 of 6.2 nM and 13 nM for human and mouse PPAR, respectively. |
| CSN13142 | GW0742 | 317318-84-6 | GW0742 is an agonist of PPAR with EC50 of 11 nM It can protect right heart from hypertrophy and enhance lipid metabolism in heart. It also works as an antagonist of vitamin D receptor. |
| CSN22426 | GW 6471 | 880635-03-0 | GW 6471 is a potent PPAR antagonist |
| CSN15822 | GSK3787 | 188591-46-0 | GSK3787 selectively and irreversibly antagonizes PPAR with pIC50 of 66 with no significant effect on hPPAR or hPPAR |
| CSN15777 | GSK0660 | 1014691-61-2 | GSK0660 is a selective antagonist of PPAR and exhibits inverse agonist effects when used alone |
| CSN11100 | Glabridin | 59870-68-7 | Glabridin has many biological functions such as regulating the synthesis and activity of iNOS under high-glucose levels, significantly inhibiting free radicals generated during metabolism in the body, and protecting against oxidation-sensitive biomacromolecules (LDL, LDL, DNA) and cell walls. It is a natural product isolated and purified from the roots of Glycyrrhiza glabra L. with whitening and anti-aging activity. |
| CSN16260 | Gemfibrozil | 25812-30-0 | Gemfibrozil is an agonist of PPAR It can act as a hyperlipidemic agent that elevates plasma HDL and lowers triglycerides |
| CSN22403 | Fonadelpar | 515138-06-4 | Fonadelpar is a PPAR agonist, used in the research of neuroparalytic keratopathy. |
| CSN15096 | Ficusin A | 173429-83-9 | Ficusin A is a natural product isolated and purified from the seeds of Psoralea corylifolia Linn. |
| CSN18750 | Fenofibric Acid | 42017-89-0 | Fenofibric acid is an agonist of PPAR that can regulate lipid level. It also exhibits inhibition of COX-2. |
| CSN13948 | Eupatilin | 22368-21-4 | Eupatilin is an activiator of PPAR It is a lipohilic flavonoid extracted from artemisia species with antioxidant anti-tumor and anti-inflammatory activities |
| CSN16153 | Elafibranor | 923978-27-2 | Elafibranor is an agonist of PPAR and PPAR with EC50 values of 45 nM and 175 nM respectively Elafibranor also attenuates nonalcoholic steatohepatitis without fibrosis worsening |
| CSN17750 | DG172 2HCl | 1361504-77-9 | DG172 2HCl is a PPARβ/δ-selective ligand showing high binding affinity (IC50 = 27 nM) and potent inverse agonistic properties. |
| CSN13070 | Clofibric Acid | 882-09-7 | Clofibric acid is an agonist of PPAR and can act as a hypolipidemic agent |
| CSN18278 | CDDO-Im | 443104-02-7 | CDDO-Im is a synthetic triterpenoid more potent than its parent compound CDDO both in vitro and in vivo and a PPAR agonist. |
| CSN10556 | Catalposide | 6736-85-2 | Catalposide, a natural product isolated and purified from the herb of Catalpa ovata G.Don, is hypolipidemic by activation of PPAR via a ligand-mediated mechanism that modulates the expression of in lipid metabolism genes in hepatocytes, and may be an effective agent for the treatment of diseases characterized by mucosal inflammation. |
| CSN10449 | Bilobetin | 521-32-4 | Bilobetin, a natural product isolated and purified from the leaves of Ginkgo biloba L., whose treatment ameliorates hyperlipidaemia, lipotoxicity and insulin resistance in rats by stimulating PPAR-mediated lipid catabolism. |
| CSN10380 | Bavachinin | 19879-30-2 | Bavachinin is an agonist of PPAR with EC50s of 4.0 M, 8.1 M, and 0.74 M for ,, and respectively. It is a natural flavanone with anti-angiogenic effect. |
| CSN18081 | Balaglitazone | 199113-98-9 | Balaglitazone is a partial agonist of PPAR-. |
| CSN22706 | BADGE | 1675-54-3 | BADGE is a PPARγ antagonist. |
| CSN21934 | AVE-8134 | 304025-09-0 | AVE-8134 is a potent PPARα agonist with EC50 of 100 and 3000 nM for human and rodent PPARα receptor, respectively. |
| CSN20493 | Astaxanthin | 472-61-7 | Astaxanthin is a carotenoid pigment found primarily in marine organisms including Haematococcus Pluvialis, shrimp and salmon. It is a potent lipid-soluble antioxidant. |
| CSN14141 | Arjunolic Acid | 465-00-9 | Arjunolic acid a natural peroxisome proliferator-activated receptor alpha agonist isolated and purified from the fruits of Terminalia chebula Retz can protect against cisplatin-induced testicular injury by attenuating oxidative stress parameters along with downregulation of iNOS TNF- and p38-MAPK testicular expressions |
| CSN22075 | MBX 102 | 24136-23-0 | Arhalofenate is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ ans is used for the treatment of type 2 diabetes. |
| CSN14120 | Angeloylgomisin H | 66056-22-2 | Angeloylgomisin H, a natural product isolated and purified from the fruits of Schizandra chinensis, shows moderate cytotoxic activities with IC50 values ranging from 100 to 200 ugmL against MCF7, HEK293 and CAL27 cell lines and may present significant myocardial protective activity. |
| CSN20181 | AMG-131 | 315224-26-1 | AMG-131 is a hypoglycemic agent It is a potent PPAR partial agonist that displays robust glucose-lowering activity in rodent models of diabetes while exhibiting a reduced side-effects profile compared to marketed TZDs |
| CSN16319 | Alpinetin | 36052-37-6 | Alpinetin can act as an inhibitor of UCK2 and shows antioxidant, anticancer and antithrombotic properties. Alpinetin is mainly found in ginger plants. |
| CSN10234 | Aleglitazar | 475479-34-6 | Aleglitazar is a dual PPAR- agonist with IC50 of 2.8 nM4.6 nM. |
| CSN10195 | Abietic Acid | 514-10-3 | Abietic acid is a PPAR dual activator to inhibit UVB-induced MMP-1 expression and age-related inflammation by suppressing NF-B and the MAPKAP-1 pathway, its a natural product isolated and purified from the herbs of Pinus massoniana which can be used not only for anti-inflammation but also for regulating lipid metabolism and atherosclerosis. |
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