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Potassium Channel

Potassium Channel

Cat. No. Product Name CAS No. Information
CSN25578 VU590 2HCl 1783987-83-6 VU590 dihydrochloride has been reported to inhibit the renal, outer medullary potassium channel (KIR1.1) with IC50 of 294 nM, and also able to inhibit the inward rectifying potassium channel KIR7.1.
CSN25562 VU590 313505-85-0 VU590 dihydrochloride has been reported to inhibit the renal, outer medullary potassium channel (KIR1.1) with IC50 of 294 nM, and also able to inhibit the inward rectifying potassium channel KIR7.1.
CSN23185 VU 0463271 1391737-01-1 VU0463271 is a potent KCC2 antagonist, with an IC50 of 61 nM.
CSN27561 VU0134992 hydrochloride 1052515-91-9 VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 µM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 µM) at -120 mV.
CSN25451 Tetraethylammonium chloride 56-34-8 Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties.
CSN23324 Tannic Acid 5424-20-4 Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM.
CSN16112 TAK-438   1260141-27-2 TAK-438, a potassium proton pump inhibitor, can reversibly inhibit HK ATPase with IC50 of 17 nM and does not affect NaK ATPase. It also controls gastric acid secretion.
CSN16469 Sophocarpine   6483-15-4 Sophocarpine is a naturally-occuring HERG K channel blocker with IC50 ranging in 100-300 M found from plant Sophora flavescens
CSN27571 Ropivacaine mesylate 854056-07-8 Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup>. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane.
CSN11584 Repaglinide   135062-02-1 Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes.
CSN16137 Quinine   130-95-0 Quinine is a medication used to treat malaria and babesiosis, isolated from the bark of a cinchona tree.
CSN21820 Quinidine HCl H2O 6151-40-2 Quinidine HCl H2O is a class IA antiarrhythmic and a blocker of potassium channel.
CSN23838 Pinacidil H2O 85371-64-8 Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator.
CSN21725 Peptide 401 32908-73-9 Peptide 401 is a blocker of voltage-sensitive K+ channels with convulsant activity. 
CSN10033 PAP-1 870653-45-5 PAP-1 is a selective inhibitor of Kv1.3, voltage-gated K channel, it potently inhibits human T effector memory cell proliferation with EC50 of 2 nM and delayed hypersensitivity.
CSN25559 NS 5806 426834-69-7 NS5806, a KV4.3 channel activator, increases peak current amplitude of the potassium channel Kv4.3 with EC50 of 5.3 uM. NS5806 also slows Kv4.3 and Kv4.2 current dacay in channel complexes containing KChIP2.
CSN25560 NS19504 327062-46-4 NS19504 is a selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) with EC50 of 11 μM.
CSN18234 NS-6180   353262-04-1 NS-6180 is a channel blocker of KCa3.1 (IC50 9 nM for rat and 14 nM for human). It can prevent T-cell activation and inflammation.
CSN12478 Nateglinide   105816-04-4 Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).
CSN27562 ML418 1928763-08-9 ML418 is the first potent, selective and CNS penetrating blocker of Kir7.1 potassium channel (IC50, 310 nM), which also potently inhibits Kir6.2/SUR1, and exhibits superior selectivity over other Kir channels.
CSN25420 ML335 825658-06-8 ML335 is a selective activator of both TREK-1 and TREK-2.
CSN25288 ML 297 1443246-62-5 ML 297 is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM.
CSN18790 Mitiglinide Calcium Hydrate 207844-01-7 Mitiglinide calcium is a drug for the treatment of type 2 diabetes and it is a highly selective KATP channel antagonist.
CSN21733 Micinicate 39537-99-0 Micinicate, a local anesthetic, can reversibly block transient Na+ inward current as well as the steady-state K+ outward current.
CSN21708 Levcromakalim 94535-50-9 Levcromakalim is an activator of ATP-sensitive K+ channel (KATP).
CSN25450 JNJ 303 878489-28-2 JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. JNJ 303 does not have any effects on other cardiac channels at concentrations of 3.3 μM for INa, Ica, Ito, and IKr. JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP).
CSN24792 IK1 inhibitor PA-6 500715-03-7 IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia[1][2][3].
CSN25242 ICA 110381 325457-99-6 ICA 110381 is a KV7.2/7.3 activator with EC50 of 0.38 μM.
CSN24161 GSK369796 2HCl   1010411-21-8 GSK369796 2HCl is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC50 of 7.5 μM.
CSN11101 Glipizide   29094-61-9 Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes.
CSN22064 GAL-021 1380341-99-0 GAL-021 a new intravenous Potassium Channel KCa1.1 blocker.
CSN12647 Diazoxide   364-98-7 Diazoxide is an ATP-sensitive potassium channel activator which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. and can be used to treat hyperinsulinism.
CSN10772 Dequalinium Chloride 522-51-0 Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 M, and also a selective blocker of apamin-sensitive K channels with IC50 of 1.1 M.
CSN15660 Daurisoline 70553-76-3 Daurisoline, a natural product isolated and purified from the roots of Menispermum dauricu with antiarrhythmic effects, exerts a blocking effect on hERG at concentrations below 30 uM, but does not affect the expression and function of the hERG channel.
CSN26156 CyPPA 73029-73-9 CyPPA is a selective activator of both KCa2.3 and KCa2.2 with EC50 values of 5.6μM and 14μM, respectively.
CSN24262 CLP-290   1181083-81-7 CLP-290 is a highly selective KCC2 modulator and prodrug of CLP-257.
CSN23548 Cloperastine HCl 14984-68-0 Cloperastine hydrochloride inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM.
CSN23809 Cloperastine Fendizoate 85187-37-7 Cloperastine fendizoate inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM.
CSN23891 AUT1 1311136-84-1 AUT1 is a Kv3 potassium channel modulator with pEC50 values of 5.33 and 5.31 for human recombinant Kv3.1b and Kv3.2a, respectively.
CSN21493 Apamin 24345-16-2 Apamin, an 18 amino acid peptide toxin found in bee venom, is a potent blocker of small conductance Ca2+-activated K+ (SK, KCa2) channels.
CSN19508 Amifampridine   54-96-6 Amifampridine is a quaternary ammonium compound that blocks presynaptic potassium channels, subsequently prolongs the action potential and increases presynaptic calcium concentrations, it was approved by the US FDA for the treatment of adults with LEMS.
CSN24263 AM 92016 hydrochloride 133229-11-5 AM 92016 is a KV channel blocker.
CSN21132 Almitrine Mesylate   29608-49-9 Almitrine mesylate is an agonist of peripheral chemoreceptor and inhibits selectively the Ca2-dependent K channel. It can improve chronic obstructive pulmonary disease and nocturnal oxygen desaturation.
CSN25452 1-EBIO 10045-45-1 Activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes.
CSN25278 A2793 88349-90-0 A2793 is an inhibitor of TRESK (IC50 value of 6.8 μM for mTRESK).
CSN25279 A2764 2HCl 861038-72-4 A2764 dihydrochloride is a selective inhibitor of TRESK (KCNK18) with an IC50 value of 11.8 μM. A2764 can inhibit TRESK in native cells, leading to cell depolarization and increased excitability.
CSN27560 2,2,2-Trichloroethanol 115-20-8 2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4).
CSN27563 (±)-Naringenin 67604-48-2 (±)-Naringenin is a naturally-occurring flavonoid. (±)-Naringenin displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
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