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Potassium Channel

Potassium Channel

Cat. No. Product Name CAS No. Information
CSN20024 XE991 122955-42-4 XE991 is a potent and selective blocker of KV7 KCNQ voltage-gated potassium channels which blocks KV7273 KCNQ23 M-currents IC50 06 - 098 M and KV71 KCNQ1 homomeric channels IC50 075 M but is less potent against KV71minK channels IC50 111 M
CSN20025 XE991 2HCl 122955-13-9 XE991 2HCl is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM).
CSN12971 Vernakalant 794466-70-9 Vernakalant is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation AF in humans at 2 to 5 mgkg and may be more atrial-selective than available agents used in treatment of antiarrhythmic
CSN12970 Vernakalant HCl 748810-28-8 Vernakalant HCl prolongs repolarization by blocking atrial potassium channels its a class III antiarrhythmics
CSN12701 TRAM-34 289905-88-0 TRAM-34 is a highly selective blocker of intermediate conductance Ca2-activated K channels KCa31 Kd 20 nM
CSN12105 Tolbutamide   64-77-7 Tolbutamide is a potassium channel blocker sulfonylurea oral hypoglycemic drug
CSN20596 TKDC 425666-42-8 TKDC is an inhibitor of TREKs a subfamily of K2P two-pore domain potassium channels
CSN12056 Terfenadine 50679-08-8 Terfenadine is a potent open-channel blocker of hERG with a mean IC50 of 204 nM.
CSN16112 TAK-438   1260141-27-2 TAK-438, a potassium proton pump inhibitor, can reversibly inhibit HK ATPase with IC50 of 17 nM and does not affect NaK ATPase. It also controls gastric acid secretion.
CSN16469 Sophocarpine   6483-15-4 Sophocarpine is a naturally-occuring HERG K channel blocker with IC50 ranging in 100-300 M found from plant Sophora flavescens
CSN11584 Repaglinide   135062-02-1 Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes.
CSN16137 Quinine   130-95-0 Quinine is a medication used to treat malaria and babesiosis, isolated from the bark of a cinchona tree.
CSN21820 Quinidine HCl H2O 6151-40-2 Quinidine HCl H2O is a class IA antiarrhythmic and a blocker of potassium channel.
CSN21725 Peptide 401 32908-73-9 Peptide 401 is a blocker of voltage-sensitive K+ channels with convulsant activity.
CSN10033 PAP-1 870653-45-5 PAP-1 is a selective inhibitor of Kv1.3, voltage-gated K channel, it potently inhibits human T effector memory cell proliferation with EC50 of 2 nM and delayed hypersensitivity.
CSN18234 NS-6180   353262-04-1 NS-6180 is a channel blocker of KCa3.1 (IC50 9 nM for rat and 14 nM for human). It can prevent T-cell activation and inflammation.
CSN12824 NS-1643   448895-37-2 NS-1643 is a potent human ether-a-go-go related gene hERG KV111 channel activator with EC50 of 105 M
CSN11558 Nigericin Sodium   28643-80-3 Nigericin sodium is an antibiotic from Streptomyces hygroscopicus that works by acting as an H K and Pb2 ionophore
CSN12869 Nicorandil   65141-46-0 Nicorandil is a potassium channel activator and stimulates guanylate cyclase to increase formation of cyclic GMP cGMP
CSN12478 Nateglinide   105816-04-4 Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).
CSN18626 ML365 947914-18-3 ML365 is a selective small molecule inhibitor of TASK1 KCNK3 with IC50 of 4 nM thallium influx fluorescent assay and 16 nM automated electrophysiology assay
CSN13712 ML133 HCl 1222781-70-5 ML133 HCl selectively inhibit Kir2.1 with IC50 of 1.8 μM at pH7.4 and 290 nM at pH8.5 and has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1.
CSN18790 Mitiglinide Calcium Hydrate 207844-01-7 Mitiglinide calcium is a drug for the treatment of type 2 diabetes and it is a highly selective KATP channel antagonist.
CSN12556 Mitiglinide Calcium   145525-41-3 Mitiglinide calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K channels in pancreatic beta-cells.
CSN10129 Minoxidil Sulfate 83701-22-8 Minoxidil sulfate is a K channel agonist and a strong vascular smooth muscle relaxant It has been shown to relax norepinephrine contraction and is reported to be a vasodilator Minoxidil sulfate has been used to better understand the blood-brain tumor barrier in syngeneic and allogeneic rat studies and has demonstrated to increase tumor permeability
CSN21733 Micinicate 39537-99-0 Micinicate, a local anesthetic, can reversibly block transient Na+ inward current as well as the steady-state K+ outward current.
CSN20023 Linopirdine 2HCl 113168-57-3 Linopirdine 2HCl is a blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC50 = 4 - 7 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 μM), and is a putative cognition-enhancing drug.
CSN21708 Levcromakalim 94535-50-9 Levcromakalim is an activator of ATP-sensitive K+ channel (KATP).
CSN20179 Isopimaric Acid 5835-26-7 Isopimaric acid a natural product isolated and purifed from the herbs of Daemonorops draco Blume potently opens large conductance Ca-activated K channels and also possibly has an antagonistic interaction with reserpine which may render the antibiotics inactive
CSN24161 GSK369796 2HCl 1010411-21-8 GSK369796 2HCl is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC50 of 7.5 μM.
CSN11101 Glipizide   29094-61-9 Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes.
CSN10055 Glibenclamide   10238-21-8 Glibenclamide is a sulfonylurea compound that modulates insulin production
CSN24317 GI 530159 69563-88-8 GI 530159 is a selective and mechano-sensitive K2P channel opener, exhibits selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels.
CSN22064 GAL-021 1380341-99-0 GAL-021 a new intravenous Potassium Channel KCa1.1 blocker.
CSN18763 Flupirtine Maleate   75507-68-5 Flupirtine maleate is a non-opioid analgesic of KV7 potassium channels Flupirtine also inderectly antagonizes NMDA receptor and GABAa receptors It exhibits the relaxantion of muscles and neuroprotective
CSN13087 E-4031 2HCl 113559-13-0 E-4031 is a benzenesulfonamide antiarrhythmic agent which blocks the ATP-sensitive potassium channel
CSN12647 Diazoxide   364-98-7 Diazoxide is an ATP-sensitive potassium channel activator which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. and can be used to treat hyperinsulinism.
CSN10772 Dequalinium Chloride 522-51-0 Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 M, and also a selective blocker of apamin-sensitive K channels with IC50 of 1.1 M.
CSN24262 CLP-290 1181083-81-7 CLP-290 is a highly selective KCC2 modulator and prodrug of CLP-257.
CSN13101 Chlorzoxazone   95-25-0 Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort.
CSN10370 Azimilide 149908-53-2 Azimilide is a class III antiarrhythmic compound inhibits IKs and IKr in guinea-pig cardiac myocytes and IKs minK channels expressed in Xenopus oocytes
CSN23891 AUT1 1311136-84-1 AUT1 is a Kv3 potassium channel modulator with pEC50 values of 5.33 and 5.31 for human recombinant Kv3.1b and Kv3.2a, respectively.
CSN21493 Apamin 24345-16-2 Apamin, an 18 amino acid peptide toxin found in bee venom, is a potent blocker of small conductance Ca2+-activated K+ (SK, KCa2) channels.
CSN12596 Amiodarone HCl   19774-82-4 Amiodarone HCl is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 191 M
CSN19508 Amifampridine   54-96-6 Amifampridine is a quaternary ammonium compound that blocks presynaptic potassium channels, subsequently prolongs the action potential and increases presynaptic calcium concentrations, it was approved by the US FDA for the treatment of adults with LEMS.
CSN22235 Almokalant 123955-10-2 Almokalant is a class III antiarrhythmic drug acts as a potassium channel blocker and inhibits a specific component Ikr of the time-dependent delayed rectifier K current
CSN21132 Almitrine Mesylate   29608-49-9 Almitrine mesylate is an agonist of peripheral chemoreceptor and inhibits selectively the Ca2-dependent K channel. It can improve chronic obstructive pulmonary disease and nocturnal oxygen desaturation.
CSN10068 Ajmaline   4360-12-7 Ajmaline, a natural alkaloid isolated and purified from the roots of Rauvolfia verticillata, is a class Ia antiarrhythmic agent.
CSN15660 Daurisoline 70553-76-3
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