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Potassium Channel
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN25285 | VU0810464 | 2126040-21-7 | VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator,with EC50 of 720 nM for GIRK1/4 channels. |
| CSN27561 | VU0134992 hydrochloride | 1052515-91-9 | VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 µM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 µM) at -120 mV. |
| CSN25451 | Tetraethylammonium chloride | 56-34-8 | Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties. |
| CSN23324 | Tannic Acid | 5424-20-4 | Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM. |
| CSN16469 | Sophocarpine | 6483-15-4 | Sophocarpine is a naturally-occuring HERG K channel blocker with IC50 ranging in 100-300 M found from plant Sophora flavescens |
| CSN11584 | Repaglinide | 135062-02-1 | Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes. |
| CSN16137 | Quinine | 130-95-0 | Quinine is a medication used to treat malaria and babesiosis, isolated from the bark of a cinchona tree. |
| CSN23838 | Pinacidil H2O | 85371-64-8 | Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator. |
| CSN18234 | NS-6180 | 353262-04-1 | NS-6180 is a channel blocker of KCa3.1 (IC50 9 nM for rat and 14 nM for human). It can prevent T-cell activation and inflammation. |
| CSN12478 | Nateglinide | 105816-04-4 | Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). |
| CSN27562 | ML418 | 1928763-08-9 | ML418 is the first potent, selective and CNS penetrating blocker of Kir7.1 potassium channel (IC50, 310 nM), which also potently inhibits Kir6.2/SUR1, and exhibits superior selectivity over other Kir channels. |
| CSN18790 | Mitiglinide Calcium Hydrate | 207844-01-7 | Mitiglinide calcium is a drug for the treatment of type 2 diabetes and it is a highly selective KATP channel antagonist. |
| CSN12556 | Mitiglinide Calcium | 145525-41-3 | Mitiglinide calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K channels in pancreatic beta-cells. |
| CSN21733 | Micinicate | 39537-99-0 | Micinicate, a local anesthetic, can reversibly block transient Na+ inward current as well as the steady-state K+ outward current. |
| CSN21708 | Levcromakalim | 94535-50-9 | Levcromakalim is an activator of ATP-sensitive K+ channel (KATP). |
| CSN25242 | ICA 110381 | 325457-99-6 | ICA 110381 is a KV7.2/7.3 activator with EC50 of 0.38 μM. |
| CSN24161 | GSK369796 2HCl | 1010411-21-8 | GSK369796 2HCl is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC50 of 7.5 μM. |
| CSN11101 | Glipizide | 29094-61-9 | Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. |
| CSN22064 | GAL-021 | 1380341-99-0 | GAL-021 a new intravenous Potassium Channel KCa1.1 blocker. |
| CSN12647 | Diazoxide | 364-98-7 | Diazoxide is an ATP-sensitive potassium channel activator which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. and can be used to treat hyperinsulinism. |
| CSN10772 | Dequalinium Chloride | 522-51-0 | Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 M, and also a selective blocker of apamin-sensitive K channels with IC50 of 1.1 M. |
| CSN26156 | CyPPA | 73029-73-9 | CyPPA is a selective activator of both KCa2.3 and KCa2.2 with EC50 values of 5.6μM and 14μM, respectively. |
| CSN23548 | Cloperastine HCl | 14984-68-0 | Cloperastine hydrochloride inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM. |
| CSN23809 | Cloperastine Fendizoate | 85187-37-7 | Cloperastine fendizoate inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM. |
| CSN19508 | Amifampridine | 54-96-6 | Amifampridine is a quaternary ammonium compound that blocks presynaptic potassium channels, subsequently prolongs the action potential and increases presynaptic calcium concentrations, it was approved by the US FDA for the treatment of adults with LEMS. |
| CSN24263 | AM 92016 hydrochloride | 133229-11-5 | AM 92016 is a KV channel blocker. |
| CSN25452 | 1-EBIO | 10045-45-1 | Activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes. |
| CSN25278 | A2793 | 88349-90-0 | A2793 is an inhibitor of TRESK (IC50 value of 6.8 μM for mTRESK). |
| CSN25279 | A2764 2HCl | 861038-72-4 | A2764 dihydrochloride is a selective inhibitor of TRESK (KCNK18) with an IC50 value of 11.8 μM. A2764 can inhibit TRESK in native cells, leading to cell depolarization and increased excitability. |
| CSN27560 | 2,2,2-Trichloroethanol | 115-20-8 | 2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4). |
| CSN27563 | (±)-Naringenin | 67604-48-2 | (±)-Naringenin is a naturally-occurring flavonoid. (±)-Naringenin displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes. |
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