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Potassium Channel
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN20024 | XE991 | 122955-42-4 | XE991 is a potent and selective blocker of KV7 KCNQ voltage-gated potassium channels which blocks KV7273 KCNQ23 M-currents IC50 06 - 098 M and KV71 KCNQ1 homomeric channels IC50 075 M but is less potent against KV71minK channels IC50 111 M |
| CSN20025 | XE991 2HCl | 122955-13-9 | XE991 2HCl is a potent and selective blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.2+7.3 (KCNQ2+3) / M-currents (IC50 = 0.6 - 0.98 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 0.75 μM) but is less potent against KV7.1/minK channels (IC50 = 11.1 μM). |
| CSN12971 | Vernakalant | 794466-70-9 | Vernakalant is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation AF in humans at 2 to 5 mgkg and may be more atrial-selective than available agents used in treatment of antiarrhythmic |
| CSN12970 | Vernakalant HCl | 748810-28-8 | Vernakalant HCl prolongs repolarization by blocking atrial potassium channels its a class III antiarrhythmics |
| CSN12701 | TRAM-34 | 289905-88-0 | TRAM-34 is a highly selective blocker of intermediate conductance Ca2-activated K channels KCa31 Kd 20 nM |
| CSN12105 | Tolbutamide | 64-77-7 | Tolbutamide is a potassium channel blocker sulfonylurea oral hypoglycemic drug |
| CSN20596 | TKDC | 425666-42-8 | TKDC is an inhibitor of TREKs a subfamily of K2P two-pore domain potassium channels |
| CSN12056 | Terfenadine | 50679-08-8 | Terfenadine is a potent open-channel blocker of hERG with a mean IC50 of 204 nM. |
| CSN16112 | TAK-438 | 1260141-27-2 | TAK-438, a potassium proton pump inhibitor, can reversibly inhibit HK ATPase with IC50 of 17 nM and does not affect NaK ATPase. It also controls gastric acid secretion. |
| CSN16469 | Sophocarpine | 6483-15-4 | Sophocarpine is a naturally-occuring HERG K channel blocker with IC50 ranging in 100-300 M found from plant Sophora flavescens |
| CSN11584 | Repaglinide | 135062-02-1 | Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes. |
| CSN16137 | Quinine | 130-95-0 | Quinine is a medication used to treat malaria and babesiosis, isolated from the bark of a cinchona tree. |
| CSN21820 | Quinidine HCl H2O | 6151-40-2 | Quinidine HCl H2O is a class IA antiarrhythmic and a blocker of potassium channel. |
| CSN21725 | Peptide 401 | 32908-73-9 | Peptide 401 is a blocker of voltage-sensitive K+ channels with convulsant activity. |
| CSN10033 | PAP-1 | 870653-45-5 | PAP-1 is a selective inhibitor of Kv1.3, voltage-gated K channel, it potently inhibits human T effector memory cell proliferation with EC50 of 2 nM and delayed hypersensitivity. |
| CSN18234 | NS-6180 | 353262-04-1 | NS-6180 is a channel blocker of KCa3.1 (IC50 9 nM for rat and 14 nM for human). It can prevent T-cell activation and inflammation. |
| CSN12824 | NS-1643 | 448895-37-2 | NS-1643 is a potent human ether-a-go-go related gene hERG KV111 channel activator with EC50 of 105 M |
| CSN11558 | Nigericin Sodium | 28643-80-3 | Nigericin sodium is an antibiotic from Streptomyces hygroscopicus that works by acting as an H K and Pb2 ionophore |
| CSN12869 | Nicorandil | 65141-46-0 | Nicorandil is a potassium channel activator and stimulates guanylate cyclase to increase formation of cyclic GMP cGMP |
| CSN12478 | Nateglinide | 105816-04-4 | Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). |
| CSN18626 | ML365 | 947914-18-3 | ML365 is a selective small molecule inhibitor of TASK1 KCNK3 with IC50 of 4 nM thallium influx fluorescent assay and 16 nM automated electrophysiology assay |
| CSN13712 | ML133 HCl | 1222781-70-5 | ML133 HCl selectively inhibit Kir2.1 with IC50 of 1.8 μM at pH7.4 and 290 nM at pH8.5 and has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1. |
| CSN18790 | Mitiglinide Calcium Hydrate | 207844-01-7 | Mitiglinide calcium is a drug for the treatment of type 2 diabetes and it is a highly selective KATP channel antagonist. |
| CSN12556 | Mitiglinide Calcium | 145525-41-3 | Mitiglinide calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K channels in pancreatic beta-cells. |
| CSN10129 | Minoxidil Sulfate | 83701-22-8 | Minoxidil sulfate is a K channel agonist and a strong vascular smooth muscle relaxant It has been shown to relax norepinephrine contraction and is reported to be a vasodilator Minoxidil sulfate has been used to better understand the blood-brain tumor barrier in syngeneic and allogeneic rat studies and has demonstrated to increase tumor permeability |
| CSN21733 | Micinicate | 39537-99-0 | Micinicate, a local anesthetic, can reversibly block transient Na+ inward current as well as the steady-state K+ outward current. |
| CSN20023 | Linopirdine 2HCl | 113168-57-3 | Linopirdine 2HCl is a blocker of KV7 (KCNQ) voltage-gated potassium channels which blocks KV7.1 + 7.3 (KCNQ2 + 3) / M-currents (IC50 = 4 - 7 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 μM), and is a putative cognition-enhancing drug. |
| CSN21708 | Levcromakalim | 94535-50-9 | Levcromakalim is an activator of ATP-sensitive K+ channel (KATP). |
| CSN20179 | Isopimaric Acid | 5835-26-7 | Isopimaric acid a natural product isolated and purifed from the herbs of Daemonorops draco Blume potently opens large conductance Ca-activated K channels and also possibly has an antagonistic interaction with reserpine which may render the antibiotics inactive |
| CSN24161 | GSK369796 2HCl | 1010411-21-8 | GSK369796 2HCl is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC50 of 7.5 μM. |
| CSN11101 | Glipizide | 29094-61-9 | Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. |
| CSN10055 | Glibenclamide | 10238-21-8 | Glibenclamide is a sulfonylurea compound that modulates insulin production |
| CSN24317 | GI 530159 | 69563-88-8 | GI 530159 is a selective and mechano-sensitive K2P channel opener, exhibits selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels. |
| CSN22064 | GAL-021 | 1380341-99-0 | GAL-021 a new intravenous Potassium Channel KCa1.1 blocker. |
| CSN18763 | Flupirtine Maleate | 75507-68-5 | Flupirtine maleate is a non-opioid analgesic of KV7 potassium channels Flupirtine also inderectly antagonizes NMDA receptor and GABAa receptors It exhibits the relaxantion of muscles and neuroprotective |
| CSN13087 | E-4031 2HCl | 113559-13-0 | E-4031 is a benzenesulfonamide antiarrhythmic agent which blocks the ATP-sensitive potassium channel |
| CSN12647 | Diazoxide | 364-98-7 | Diazoxide is an ATP-sensitive potassium channel activator which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. and can be used to treat hyperinsulinism. |
| CSN10772 | Dequalinium Chloride | 522-51-0 | Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 M, and also a selective blocker of apamin-sensitive K channels with IC50 of 1.1 M. |
| CSN24262 | CLP-290 | 1181083-81-7 | CLP-290 is a highly selective KCC2 modulator and prodrug of CLP-257. |
| CSN13101 | Chlorzoxazone | 95-25-0 | Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. |
| CSN10370 | Azimilide | 149908-53-2 | Azimilide is a class III antiarrhythmic compound inhibits IKs and IKr in guinea-pig cardiac myocytes and IKs minK channels expressed in Xenopus oocytes |
| CSN23891 | AUT1 | 1311136-84-1 | AUT1 is a Kv3 potassium channel modulator with pEC50 values of 5.33 and 5.31 for human recombinant Kv3.1b and Kv3.2a, respectively. |
| CSN21493 | Apamin | 24345-16-2 | Apamin, an 18 amino acid peptide toxin found in bee venom, is a potent blocker of small conductance Ca2+-activated K+ (SK, KCa2) channels. |
| CSN12596 | Amiodarone HCl | 19774-82-4 | Amiodarone HCl is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 191 M |
| CSN19508 | Amifampridine | 54-96-6 | Amifampridine is a quaternary ammonium compound that blocks presynaptic potassium channels, subsequently prolongs the action potential and increases presynaptic calcium concentrations, it was approved by the US FDA for the treatment of adults with LEMS. |
| CSN22235 | Almokalant | 123955-10-2 | Almokalant is a class III antiarrhythmic drug acts as a potassium channel blocker and inhibits a specific component Ikr of the time-dependent delayed rectifier K current |
| CSN21132 | Almitrine Mesylate | 29608-49-9 | Almitrine mesylate is an agonist of peripheral chemoreceptor and inhibits selectively the Ca2-dependent K channel. It can improve chronic obstructive pulmonary disease and nocturnal oxygen desaturation. |
| CSN10068 | Ajmaline | 4360-12-7 | Ajmaline, a natural alkaloid isolated and purified from the roots of Rauvolfia verticillata, is a class Ia antiarrhythmic agent. |
| CSN15660 | Daurisoline | 70553-76-3 |
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