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Potassium Channel

Potassium Channel

Cat. No. Product Name CAS No. Information
CSN25285 VU0810464 2126040-21-7 VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator,with EC50 of 720 nM for GIRK1/4 channels.
CSN27561 VU0134992 hydrochloride 1052515-91-9 VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 µM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 µM) at -120 mV.
CSN25451 Tetraethylammonium chloride 56-34-8 Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties.
CSN23324 Tannic Acid 5424-20-4 Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM.
CSN16469 Sophocarpine   6483-15-4 Sophocarpine is a naturally-occuring HERG K channel blocker with IC50 ranging in 100-300 M found from plant Sophora flavescens
CSN11584 Repaglinide   135062-02-1 Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes.
CSN16137 Quinine   130-95-0 Quinine is a medication used to treat malaria and babesiosis, isolated from the bark of a cinchona tree.
CSN23838 Pinacidil H2O 85371-64-8 Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator.
CSN18234 NS-6180   353262-04-1 NS-6180 is a channel blocker of KCa3.1 (IC50 9 nM for rat and 14 nM for human). It can prevent T-cell activation and inflammation.
CSN12478 Nateglinide   105816-04-4 Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).
CSN27562 ML418 1928763-08-9 ML418 is the first potent, selective and CNS penetrating blocker of Kir7.1 potassium channel (IC50, 310 nM), which also potently inhibits Kir6.2/SUR1, and exhibits superior selectivity over other Kir channels.
CSN12556 Mitiglinide Calcium   145525-41-3 Mitiglinide calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K channels in pancreatic beta-cells.
CSN21708 Levcromakalim 94535-50-9 Levcromakalim is an activator of ATP-sensitive K+ channel (KATP).
CSN25242 ICA 110381 325457-99-6 ICA 110381 is a KV7.2/7.3 activator with EC50 of 0.38 μM.
CSN24161 GSK369796 2HCl   1010411-21-8 GSK369796 2HCl is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC50 of 7.5 μM.
CSN11101 Glipizide   29094-61-9 Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes.
CSN12647 Diazoxide   364-98-7 Diazoxide is an ATP-sensitive potassium channel activator which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. and can be used to treat hyperinsulinism.
CSN10772 Dequalinium Chloride 522-51-0 Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 M, and also a selective blocker of apamin-sensitive K channels with IC50 of 1.1 M.
CSN26156 CyPPA 73029-73-9 CyPPA is a selective activator of both KCa2.3 and KCa2.2 with EC50 values of 5.6μM and 14μM, respectively.
CSN23548 Cloperastine HCl 14984-68-0 Cloperastine hydrochloride inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM.
CSN23809 Cloperastine Fendizoate 85187-37-7 Cloperastine fendizoate inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM.
CSN19508 Amifampridine   54-96-6 Amifampridine is a quaternary ammonium compound that blocks presynaptic potassium channels, subsequently prolongs the action potential and increases presynaptic calcium concentrations, it was approved by the US FDA for the treatment of adults with LEMS.
CSN24263 AM 92016 hydrochloride 133229-11-5 AM 92016 is a KV channel blocker.
CSN25452 1-EBIO 10045-45-1 Activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes.
CSN25278 A2793 88349-90-0 A2793 is an inhibitor of TRESK (IC50 value of 6.8 μM for mTRESK).
CSN25279 A2764 2HCl 861038-72-4 A2764 dihydrochloride is a selective inhibitor of TRESK (KCNK18) with an IC50 value of 11.8 μM. A2764 can inhibit TRESK in native cells, leading to cell depolarization and increased excitability.
CSN27560 2,2,2-Trichloroethanol 115-20-8 2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4).
CSN27563 (±)-Naringenin 67604-48-2 (±)-Naringenin is a naturally-occurring flavonoid. (±)-Naringenin displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes.
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