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Potassium Channel
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN20024 | XE991 | 122955-42-4 | XE991 is a potent and selective blocker of KV7 KCNQ voltage-gated potassium channels which blocks KV7273 KCNQ23 M-currents IC50 06 - 098 M and KV71 KCNQ1 homomeric channels IC50 075 M but is less potent against KV71minK channels IC50 111 M |
| CSN20025 | XE991 2HCl | 122955-13-9 | XE991 dihydrochloride is a potent and selective blocker of KV7 KCNQ voltage-gated potassium channels which blocks KV7273 KCNQ23 M-currents IC50 06 - 098 M and KV71 KCNQ1 homomeric channels IC50 075 M but is less potent against KV71minK channels IC50 111 M |
| CSN12971 | Vernakalant | 794466-70-9 | Vernakalant is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation AF in humans at 2 to 5 mgkg and may be more atrial-selective than available agents used in treatment of antiarrhythmic |
| CSN12970 | Vernakalant HCl | 748810-28-8 | Vernakalant HCl prolongs repolarization by blocking atrial potassium channels its a class III antiarrhythmics |
| CSN12701 | TRAM-34 | 289905-88-0 | TRAM-34 is a highly selective blocker of intermediate conductance Ca2-activated K channels KCa31 Kd 20 nM |
| CSN12105 | Tolbutamide | 64-77-7 | Tolbutamide is a potassium channel blocker sulfonylurea oral hypoglycemic drug |
| CSN12056 | Terfenadine | 50679-08-8 | Terfenadine is a potent open-channel blocker of hERG with a mean IC50 of 204 nM. |
| CSN16112 | TAK-438 | 1260141-27-2 | TAK-438, a potassium proton pump inhibitor, can reversibly inhibit HK ATPase with IC50 of 17 nM and does not affect NaK ATPase. It also controls gastric acid secretion. |
| CSN18522 | TAK-438 Free Base | 881681-00-1 | TAK-438 is a blocker of potassium-competitive proton pump that reversibly inhibits HK ATPase with IC50 of 17 nM at pH 65 while do not affect on NaK ATPase activity It has been used to treatment of erosive esophagitis and gastroduodenal ulcer |
| CSN11584 | Repaglinide | 135062-02-1 | Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes. |
| CSN10033 | PAP-1 | 870653-45-5 | PAP-1 is a selective inhibitor of Kv1.3, voltage-gated K channel, it potently inhibits human T effector memory cell proliferation with EC50 of 2 nM and delayed hypersensitivity. |
| CSN18234 | NS-6180 | 353262-04-1 | NS-6180 is a channel blocker of KCa3.1 (IC50 9 nM for rat and 14 nM for human). It can prevent T-cell activation and inflammation. |
| CSN12824 | NS-1643 | 448895-37-2 | NS-1643 is a potent human ether-a-go-go related gene hERG KV111 channel activator with EC50 of 105 M |
| CSN12339 | NS-1619 | 153587-01-0 | NS-1619 is a selective large conductance Ca2-activated K-channel activator |
| CSN11558 | Nigericin Sodium | 28643-80-3 | Nigericin sodium is an antibiotic from Streptomyces hygroscopicus that works by acting as an H K and Pb2 ionophore |
| CSN12869 | Nicorandil | 65141-46-0 | Nicorandil is a potassium channel activator and stimulates guanylate cyclase to increase formation of cyclic GMP cGMP |
| CSN12478 | Nateglinide | 105816-04-4 | Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). |
| CSN21324 | Naminidil | 220641-11-2 | Naminidil is a cyanoguanidine KATP opener |
| CSN18626 | ML365 | 947914-18-3 | ML365 is a selective small molecule inhibitor of TASK1 KCNK3 with IC50 of 4 nM thallium influx fluorescent assay and 16 nM automated electrophysiology assay |
| CSN17790 | ML277 | 1401242-74-7 | ML277 is a potent and selective Kv71 KCNQ1 potassium channel activator with EC50 of 270 nM |
| CSN13712 | ML133 HCl | 1222781-70-5 | ML133 hydrochloride selectively inhibit Kir21 with IC50 of 18 M at pH74 and 290 nM at pH85 and has no effect on Kir11 and weak activity for Kir41 and Kir71 |
| CSN18790 | Mitiglinide Calcium Hydrate | 207844-01-7 | Mitiglinide calcium is a drug for the treatment of type 2 diabetes and it is a highly selective KATP channel antagonist. |
| CSN12556 | Mitiglinide Calcium | 145525-41-3 | Mitiglinide calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K channels in pancreatic beta-cells. |
| CSN10129 | Minoxidil Sulfate | 83701-22-8 | Minoxidil sulfate is a K channel agonist and a strong vascular smooth muscle relaxant It has been shown to relax norepinephrine contraction and is reported to be a vasodilator Minoxidil sulfate has been used to better understand the blood-brain tumor barrier in syngeneic and allogeneic rat studies and has demonstrated to increase tumor permeability |
| CSN11450 | Minoxidil | 38304-91-5 | Minoxidil is an antihypertensive vasodilator medication |
| CSN20022 | Linopirdine | 105431-72-9 | Linopirdine is a blocker of KV7 KCNQ voltage-gated potassium channels which blocks KV71 73 KCNQ2 3 M-currents IC50 4 - 7 M and KV71 KCNQ1 homomeric channels IC50 89 M and is a putative cognition-enhancing drug |
| CSN20023 | Linopirdine 2HCl | 113168-57-3 | Linopirdine dihydrochloride is a blocker of KV7 KCNQ voltage-gated potassium channels which blocks KV71 73 KCNQ2 3 M-currents IC50 4 - 7 M and KV71 KCNQ1 homomeric channels IC50 89 M and is a putative cognition-enhancing drug |
| CSN20179 | Isopimaric Acid | 5835-26-7 | Isopimaric acid a natural product isolated and purifed from the herbs of Daemonorops draco Blume potently opens large conductance Ca-activated K channels and also possibly has an antagonistic interaction with reserpine which may render the antibiotics inactive |
| CSN19691 | BMS-919373 | 1272353-82-8 | IKur inhibitor C25 is a selective IKur inhibitor for the potential treatment of atrial fibrillation |
| CSN21276 | H100 | 643727-55-3 | H100 is a Cl- transport inhibitor with partial effects against both the NaK2Cl cotransporter and the Band 3 anion exchanger but no effect against KCl cotransporter in human erythrocytes |
| CSN11101 | Glipizide | 29094-61-9 | Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. |
| CSN16794 | Glimepiride | 93479-97-1 | Glimepiride is a sulfonylurea which inhibit KATP with IC50 of 30 nM in pancreatic -cells with fewer cardiac actions It is used in the treatment of type 2 diabetes mellitus |
| CSN10055 | Glibenclamide | 10238-21-8 | Glibenclamide is a sulfonylurea compound that modulates insulin production |
| CSN18763 | Flupirtine Maleate | 75507-68-5 | Flupirtine maleate is a non-opioid analgesic of KV7 potassium channels Flupirtine also inderectly antagonizes NMDA receptor and GABAa receptors It exhibits the relaxantion of muscles and neuroprotective |
| CSN13087 | E-4031 2HCl | 113559-13-0 | E-4031 is a benzenesulfonamide antiarrhythmic agent which blocks the ATP-sensitive potassium channel |
| CSN10860 | Doxapram | 309-29-5 | Doxapram inhibits TASK-1 TASK-3 TASK-1TASK-3 heterodimeric channel function with EC50 of 410 nM 37 M 9 M respectively |
| CSN16013 | Doxapram HCl H2O | 7081-53-0 | Doxapram hydrochloride a respiratory stimulant exhibits inhibition of TASK-1 EC50 410 nM TASK-3 EC50 37 nM and TASK-1TASK-3 heterodimeric EC50 9 nM channel function It is widely used in central nervous system excitability and directly stimulate the medullary respiratory or vascular movement center |
| CSN12647 | Diazoxide | 364-98-7 | Diazoxide is an ATP-sensitive potassium channel activator which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. and can be used to treat hyperinsulinism. |
| CSN10772 | Dequalinium Chloride | 522-51-0 | Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 M, and also a selective blocker of apamin-sensitive K channels with IC50 of 1.1 M. |
| CSN13101 | Chlorzoxazone | 95-25-0 | Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. |
| CSN17990 | BMS-191095 | 166095-21-2 | BMS-191095 is an activators of mitochondrial ATP-sensitive potassium mitoKATP channels |
| CSN10370 | Azimilide | 149908-53-2 | Azimilide is a class III antiarrhythmic compound inhibits IKs and IKr in guinea-pig cardiac myocytes and IKs minK channels expressed in Xenopus oocytes |
| CSN17898 | Azimilide 2HCl | 149888-94-8 | Azimilide dihydrochloride a class III antiarrhythmic compound blocks the Kv71 and Kv111 patassium channels It also inhibits NaCa2 exchanger in vitro |
| CSN12596 | Amiodarone HCl | 19774-82-4 | Amiodarone HCl is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 191 M |
| CSN19508 | Amifampridine | 54-96-6 | Amifampridine is a quaternary ammonium compound that blocks presynaptic potassium channels, subsequently prolongs the action potential and increases presynaptic calcium concentrations, it was approved by the US FDA for the treatment of adults with LEMS. |
| CSN22235 | Almokalant | 123955-10-2 | Almokalant is a class III antiarrhythmic drug acts as a potassium channel blocker and inhibits a specific component Ikr of the time-dependent delayed rectifier K current |
| CSN21132 | Almitrine Mesylate | 29608-49-9 | Almitrine mesylate is an agonist of peripheral chemoreceptor and inhibits selectively the Ca2-dependent K channel. It can improve chronic obstructive pulmonary disease and nocturnal oxygen desaturation. |
| CSN10068 | Ajmaline | 4360-12-7 | Ajmaline, a natural alkaloid isolated and purified from the roots of Rauvolfia verticillata, is a class Ia antiarrhythmic agent. |
| CSN22765 | CLP 257 | 1181081-71-9 | |
| CSN23809 | Cloperastine Fendizoate | 85187-37-7 |
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