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Potassium Channel

Potassium Channel

Cat. No. Product Name CAS No. Information
CSN20024 XE991 122955-42-4 XE991 is a potent and selective blocker of KV7 KCNQ voltage-gated potassium channels which blocks KV7273 KCNQ23 M-currents IC50 06 - 098 M and KV71 KCNQ1 homomeric channels IC50 075 M but is less potent against KV71minK channels IC50 111 M
CSN20025 XE991 2HCl 122955-13-9 XE991 dihydrochloride is a potent and selective blocker of KV7 KCNQ voltage-gated potassium channels which blocks KV7273 KCNQ23 M-currents IC50 06 - 098 M and KV71 KCNQ1 homomeric channels IC50 075 M but is less potent against KV71minK channels IC50 111 M
CSN12971 Vernakalant 794466-70-9 Vernakalant is an investigational mixed ion channel blocker that can terminate acute atrial fibrillation AF in humans at 2 to 5 mgkg and may be more atrial-selective than available agents used in treatment of antiarrhythmic
CSN12970 Vernakalant HCl 748810-28-8 Vernakalant HCl prolongs repolarization by blocking atrial potassium channels its a class III antiarrhythmics
CSN12701 TRAM-34 289905-88-0 TRAM-34 is a highly selective blocker of intermediate conductance Ca2-activated K channels KCa31 Kd 20 nM
CSN12105 Tolbutamide   64-77-7 Tolbutamide is a potassium channel blocker sulfonylurea oral hypoglycemic drug
CSN12056 Terfenadine 50679-08-8 Terfenadine is a potent open-channel blocker of hERG with a mean IC50 of 204 nM.
CSN16112 TAK-438   1260141-27-2 TAK-438, a potassium proton pump inhibitor, can reversibly inhibit HK ATPase with IC50 of 17 nM and does not affect NaK ATPase. It also controls gastric acid secretion.
CSN18522 TAK-438 Free Base   881681-00-1 TAK-438 is a blocker of potassium-competitive proton pump that reversibly inhibits HK ATPase with IC50 of 17 nM at pH 65 while do not affect on NaK ATPase activity It has been used to treatment of erosive esophagitis and gastroduodenal ulcer
CSN11584 Repaglinide   135062-02-1 Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes.
CSN10033 PAP-1 870653-45-5 PAP-1 is a selective inhibitor of Kv1.3, voltage-gated K channel, it potently inhibits human T effector memory cell proliferation with EC50 of 2 nM and delayed hypersensitivity.
CSN18234 NS-6180   353262-04-1 NS-6180 is a channel blocker of KCa3.1 (IC50 9 nM for rat and 14 nM for human). It can prevent T-cell activation and inflammation.
CSN12824 NS-1643   448895-37-2 NS-1643 is a potent human ether-a-go-go related gene hERG KV111 channel activator with EC50 of 105 M
CSN12339 NS-1619   153587-01-0 NS-1619 is a selective large conductance Ca2-activated K-channel activator
CSN11558 Nigericin Sodium   28643-80-3 Nigericin sodium is an antibiotic from Streptomyces hygroscopicus that works by acting as an H K and Pb2 ionophore
CSN12869 Nicorandil   65141-46-0 Nicorandil is a potassium channel activator and stimulates guanylate cyclase to increase formation of cyclic GMP cGMP
CSN12478 Nateglinide   105816-04-4 Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM).
CSN21324 Naminidil 220641-11-2 Naminidil is a cyanoguanidine KATP opener
CSN18626 ML365 947914-18-3 ML365 is a selective small molecule inhibitor of TASK1 KCNK3 with IC50 of 4 nM thallium influx fluorescent assay and 16 nM automated electrophysiology assay
CSN17790 ML277 1401242-74-7 ML277 is a potent and selective Kv71 KCNQ1 potassium channel activator with EC50 of 270 nM
CSN13712 ML133 HCl 1222781-70-5 ML133 hydrochloride selectively inhibit Kir21 with IC50 of 18 M at pH74 and 290 nM at pH85 and has no effect on Kir11 and weak activity for Kir41 and Kir71
CSN18790 Mitiglinide Calcium Hydrate 207844-01-7 Mitiglinide calcium is a drug for the treatment of type 2 diabetes and it is a highly selective KATP channel antagonist.
CSN12556 Mitiglinide Calcium   145525-41-3 Mitiglinide calcium is a blood glucose-lowering drugs, stimulating insulin secretion by closing the ATP-sensitive K channels in pancreatic beta-cells.
CSN10129 Minoxidil Sulfate 83701-22-8 Minoxidil sulfate is a K channel agonist and a strong vascular smooth muscle relaxant It has been shown to relax norepinephrine contraction and is reported to be a vasodilator Minoxidil sulfate has been used to better understand the blood-brain tumor barrier in syngeneic and allogeneic rat studies and has demonstrated to increase tumor permeability
CSN11450 Minoxidil   38304-91-5 Minoxidil is an antihypertensive vasodilator medication
CSN20022 Linopirdine 105431-72-9 Linopirdine is a blocker of KV7 KCNQ voltage-gated potassium channels which blocks KV71 73 KCNQ2 3 M-currents IC50 4 - 7 M and KV71 KCNQ1 homomeric channels IC50 89 M and is a putative cognition-enhancing drug
CSN20023 Linopirdine 2HCl 113168-57-3 Linopirdine dihydrochloride is a blocker of KV7 KCNQ voltage-gated potassium channels which blocks KV71 73 KCNQ2 3 M-currents IC50 4 - 7 M and KV71 KCNQ1 homomeric channels IC50 89 M and is a putative cognition-enhancing drug
CSN20179 Isopimaric Acid 5835-26-7 Isopimaric acid a natural product isolated and purifed from the herbs of Daemonorops draco Blume potently opens large conductance Ca-activated K channels and also possibly has an antagonistic interaction with reserpine which may render the antibiotics inactive
CSN19691 BMS-919373 1272353-82-8 IKur inhibitor C25 is a selective IKur inhibitor for the potential treatment of atrial fibrillation
CSN21276 H100 643727-55-3 H100 is a Cl- transport inhibitor with partial effects against both the NaK2Cl cotransporter and the Band 3 anion exchanger but no effect against KCl cotransporter in human erythrocytes
CSN24161 GSK369796 2HCl 1010411-21-8 GSK369796 2HCl is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC50 of 7.5 μM.
CSN11101 Glipizide   29094-61-9 Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes.
CSN16794 Glimepiride   93479-97-1 Glimepiride is a sulfonylurea which inhibit KATP with IC50 of 30 nM in pancreatic -cells with fewer cardiac actions It is used in the treatment of type 2 diabetes mellitus
CSN10055 Glibenclamide   10238-21-8 Glibenclamide is a sulfonylurea compound that modulates insulin production
CSN24317 GI 530159 69563-88-8 GI 530159 is a selective and mechano-sensitive K2P channel opener, exhibits selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels.
CSN18763 Flupirtine Maleate   75507-68-5 Flupirtine maleate is a non-opioid analgesic of KV7 potassium channels Flupirtine also inderectly antagonizes NMDA receptor and GABAa receptors It exhibits the relaxantion of muscles and neuroprotective
CSN13087 E-4031 2HCl 113559-13-0 E-4031 is a benzenesulfonamide antiarrhythmic agent which blocks the ATP-sensitive potassium channel
CSN12647 Diazoxide   364-98-7 Diazoxide is an ATP-sensitive potassium channel activator which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. and can be used to treat hyperinsulinism.
CSN10772 Dequalinium Chloride 522-51-0 Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 M, and also a selective blocker of apamin-sensitive K channels with IC50 of 1.1 M.
CSN13101 Chlorzoxazone   95-25-0 Chlorzoxazone, a potassium channel activator, is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort.
CSN17990 BMS-191095 166095-21-2 BMS-191095 is an activators of mitochondrial ATP-sensitive potassium mitoKATP channels
CSN10370 Azimilide 149908-53-2 Azimilide is a class III antiarrhythmic compound inhibits IKs and IKr in guinea-pig cardiac myocytes and IKs minK channels expressed in Xenopus oocytes
CSN17898 Azimilide 2HCl 149888-94-8 Azimilide dihydrochloride a class III antiarrhythmic compound blocks the Kv71 and Kv111 patassium channels It also inhibits NaCa2 exchanger in vitro
CSN12596 Amiodarone HCl   19774-82-4 Amiodarone HCl is an antiarrhythmic drug for inhibition of ATP-sensitive potassium channel with IC50 of 191 M
CSN19508 Amifampridine   54-96-6 Amifampridine is a quaternary ammonium compound that blocks presynaptic potassium channels, subsequently prolongs the action potential and increases presynaptic calcium concentrations, it was approved by the US FDA for the treatment of adults with LEMS.
CSN22235 Almokalant 123955-10-2 Almokalant is a class III antiarrhythmic drug acts as a potassium channel blocker and inhibits a specific component Ikr of the time-dependent delayed rectifier K current
CSN21132 Almitrine Mesylate   29608-49-9 Almitrine mesylate is an agonist of peripheral chemoreceptor and inhibits selectively the Ca2-dependent K channel. It can improve chronic obstructive pulmonary disease and nocturnal oxygen desaturation.
CSN10068 Ajmaline   4360-12-7 Ajmaline, a natural alkaloid isolated and purified from the roots of Rauvolfia verticillata, is a class Ia antiarrhythmic agent.
CSN22765 CLP 257 1181081-71-9
CSN23809 Cloperastine Fendizoate 85187-37-7
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