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Potassium Channel
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN25578 | VU590 2HCl | 1783987-83-6 | VU590 dihydrochloride has been reported to inhibit the renal, outer medullary potassium channel (KIR1.1) with IC50 of 294 nM, and also able to inhibit the inward rectifying potassium channel KIR7.1. |
| CSN25562 | VU590 | 313505-85-0 | VU590 dihydrochloride has been reported to inhibit the renal, outer medullary potassium channel (KIR1.1) with IC50 of 294 nM, and also able to inhibit the inward rectifying potassium channel KIR7.1. |
| CSN23185 | VU 0463271 | 1391737-01-1 | VU0463271 is a potent KCC2 antagonist, with an IC50 of 61 nM. |
| CSN27561 | VU0134992 hydrochloride | 1052515-91-9 | VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 µM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 µM) at -120 mV. |
| CSN25451 | Tetraethylammonium chloride | 56-34-8 | Tetraethylammonium chloride is a non-selective potassium channel blocker. Tetraethylammonium chloride is a good substrate for organic cation transporter (OCTN1). Tetraethylammonium chloride antitumor properties. |
| CSN23324 | Tannic Acid | 5424-20-4 | Tannic acid is a novel hERG channel blocker with IC50 of 3.4 μM. |
| CSN16112 | TAK-438 | 1260141-27-2 | TAK-438, a potassium proton pump inhibitor, can reversibly inhibit HK ATPase with IC50 of 17 nM and does not affect NaK ATPase. It also controls gastric acid secretion. |
| CSN16469 | Sophocarpine | 6483-15-4 | Sophocarpine is a naturally-occuring HERG K channel blocker with IC50 ranging in 100-300 M found from plant Sophora flavescens |
| CSN27571 | Ropivacaine mesylate | 854056-07-8 | Ropivacaine mesylate is a long-acting amide local anaesthetic agent for a spinal block and effectively blocks neuropathic pain. Ropivacaine blocks impulse conduction via reversible inhibition of sodium ion influx in nerve fibressup>. Ropivacaine is also an inhibitor of K2P (two-pore domain potassium channel) TREK-1 with an IC50 of 402.7 μM in COS-7 cell's membrane. |
| CSN11584 | Repaglinide | 135062-02-1 | Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes. |
| CSN16137 | Quinine | 130-95-0 | Quinine is a medication used to treat malaria and babesiosis, isolated from the bark of a cinchona tree. |
| CSN21820 | Quinidine HCl H2O | 6151-40-2 | Quinidine HCl H2O is a class IA antiarrhythmic and a blocker of potassium channel. |
| CSN23838 | Pinacidil H2O | 85371-64-8 | Pinacidil monohydrate, an antihypertensive drug, is a potassium channel activator. |
| CSN21725 | Peptide 401 | 32908-73-9 | Peptide 401 is a blocker of voltage-sensitive K+ channels with convulsant activity. |
| CSN10033 | PAP-1 | 870653-45-5 | PAP-1 is a selective inhibitor of Kv1.3, voltage-gated K channel, it potently inhibits human T effector memory cell proliferation with EC50 of 2 nM and delayed hypersensitivity. |
| CSN25559 | NS 5806 | 426834-69-7 | NS5806, a KV4.3 channel activator, increases peak current amplitude of the potassium channel Kv4.3 with EC50 of 5.3 uM. NS5806 also slows Kv4.3 and Kv4.2 current dacay in channel complexes containing KChIP2. |
| CSN25560 | NS19504 | 327062-46-4 | NS19504 is a selective activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1) with EC50 of 11 μM. |
| CSN18234 | NS-6180 | 353262-04-1 | NS-6180 is a channel blocker of KCa3.1 (IC50 9 nM for rat and 14 nM for human). It can prevent T-cell activation and inflammation. |
| CSN12478 | Nateglinide | 105816-04-4 | Nateglinide is an insulin secretagog agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). |
| CSN27562 | ML418 | 1928763-08-9 | ML418 is the first potent, selective and CNS penetrating blocker of Kir7.1 potassium channel (IC50, 310 nM), which also potently inhibits Kir6.2/SUR1, and exhibits superior selectivity over other Kir channels. |
| CSN25420 | ML335 | 825658-06-8 | ML335 is a selective activator of both TREK-1 and TREK-2. |
| CSN25288 | ML 297 | 1443246-62-5 | ML 297 is a potent and selective GIRK1/2 activator, with an EC50 of 0.16 μM. |
| CSN18790 | Mitiglinide Calcium Hydrate | 207844-01-7 | Mitiglinide calcium is a drug for the treatment of type 2 diabetes and it is a highly selective KATP channel antagonist. |
| CSN21733 | Micinicate | 39537-99-0 | Micinicate, a local anesthetic, can reversibly block transient Na+ inward current as well as the steady-state K+ outward current. |
| CSN21708 | Levcromakalim | 94535-50-9 | Levcromakalim is an activator of ATP-sensitive K+ channel (KATP). |
| CSN25450 | JNJ 303 | 878489-28-2 | JNJ 303 is a potent IKs blocker with an IC50 value of 64 nM. JNJ 303 does not have any effects on other cardiac channels at concentrations of 3.3 μM for INa, Ica, Ito, and IKr. JNJ 303 induces QT-prolongations and causes unprovoked torsades de pointes (TdP). |
| CSN24792 | IK1 inhibitor PA-6 | 500715-03-7 | IK1 inhibitor PA-6 (PA-6), a pentamidine analogue, is a selective and potent IK1 (KIR2.x ion-channel-carried inward rectifier current) inhibitor, with IC50 values of 12-15 nM for human and mouse KIR2.x currents. IK1 inhibitor PA-6 (PA-6) elevates KIR2.1 protein expression and induces intracellular KIR2.1 accumulation. IK1 inhibitor PA-6 (PA-6) has the potential to treat atrial fibrillation and arrhythmia[1][2][3]. |
| CSN25242 | ICA 110381 | 325457-99-6 | ICA 110381 is a KV7.2/7.3 activator with EC50 of 0.38 μM. |
| CSN24161 | GSK369796 2HCl | 1010411-21-8 | GSK369796 2HCl is an affordable and effective antimalarial and inhibits hERG potassium ion channel repolarization with an IC50 of 7.5 μM. |
| CSN11101 | Glipizide | 29094-61-9 | Glipizide is used to treat high blood sugar levels caused by a type of diabetes mellitus called type 2 diabetes. |
| CSN22064 | GAL-021 | 1380341-99-0 | GAL-021 a new intravenous Potassium Channel KCa1.1 blocker. |
| CSN12647 | Diazoxide | 364-98-7 | Diazoxide is an ATP-sensitive potassium channel activator which causes local relaxation in smooth muscle by increasing membrane permeability to potassium ions. and can be used to treat hyperinsulinism. |
| CSN10772 | Dequalinium Chloride | 522-51-0 | Dequalinium Chloride is a PKC inhibitor with IC50 of 7-18 M, and also a selective blocker of apamin-sensitive K channels with IC50 of 1.1 M. |
| CSN15660 | Daurisoline | 70553-76-3 | Daurisoline, a natural product isolated and purified from the roots of Menispermum dauricu with antiarrhythmic effects, exerts a blocking effect on hERG at concentrations below 30 uM, but does not affect the expression and function of the hERG channel. |
| CSN26156 | CyPPA | 73029-73-9 | CyPPA is a selective activator of both KCa2.3 and KCa2.2 with EC50 values of 5.6μM and 14μM, respectively. |
| CSN24262 | CLP-290 | 1181083-81-7 | CLP-290 is a highly selective KCC2 modulator and prodrug of CLP-257. |
| CSN23548 | Cloperastine HCl | 14984-68-0 | Cloperastine hydrochloride inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM. |
| CSN23809 | Cloperastine Fendizoate | 85187-37-7 | Cloperastine fendizoate inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM. |
| CSN23891 | AUT1 | 1311136-84-1 | AUT1 is a Kv3 potassium channel modulator with pEC50 values of 5.33 and 5.31 for human recombinant Kv3.1b and Kv3.2a, respectively. |
| CSN21493 | Apamin | 24345-16-2 | Apamin, an 18 amino acid peptide toxin found in bee venom, is a potent blocker of small conductance Ca2+-activated K+ (SK, KCa2) channels. |
| CSN19508 | Amifampridine | 54-96-6 | Amifampridine is a quaternary ammonium compound that blocks presynaptic potassium channels, subsequently prolongs the action potential and increases presynaptic calcium concentrations, it was approved by the US FDA for the treatment of adults with LEMS. |
| CSN24263 | AM 92016 hydrochloride | 133229-11-5 | AM 92016 is a KV channel blocker. |
| CSN21132 | Almitrine Mesylate | 29608-49-9 | Almitrine mesylate is an agonist of peripheral chemoreceptor and inhibits selectively the Ca2-dependent K channel. It can improve chronic obstructive pulmonary disease and nocturnal oxygen desaturation. |
| CSN25452 | 1-EBIO | 10045-45-1 | Activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. Induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Promotes embryonic stem cell (ESC) differentiation into cardiomyocytes. |
| CSN25278 | A2793 | 88349-90-0 | A2793 is an inhibitor of TRESK (IC50 value of 6.8 μM for mTRESK). |
| CSN25279 | A2764 2HCl | 861038-72-4 | A2764 dihydrochloride is a selective inhibitor of TRESK (KCNK18) with an IC50 value of 11.8 μM. A2764 can inhibit TRESK in native cells, leading to cell depolarization and increased excitability. |
| CSN27560 | 2,2,2-Trichloroethanol | 115-20-8 | 2,2,2-Trichloroethanol, the active form of the sedative hypnotic drug chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4). |
| CSN27563 | (±)-Naringenin | 67604-48-2 | (±)-Naringenin is a naturally-occurring flavonoid. (±)-Naringenin displays vasorelaxant effect on endothelium-denuded vessels via the activation of BKCa channels in myocytes. |
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