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The papain-like protease (PLP) is an IFN antagonist that constitutes a domain of the replicase polyprotein and, therefore, may be active at an early stage of the replication cycle to antagonize an upstream step of IFN induction. Additionally, unlike accessory proteins, which can vary greatly between CoV species, maintenance of PLP catalytic activity is critical to viral replication and is therefore conserved across all CoVs. The coronavirus PLP proteins are multifunctional and encode a catalytic triad domain that catalyzes site-specific peptide cleavage of the viral polyprotein and the removal of both ubiquitin and IFN stimulated gene (ISG) 15 post-translational modifications. PLP protease activity catalyzes the processing of the replicase polyprotein at cleavage sites between nsp1/nsp2, nsp2/nsp3, and nsp3/nsp4.

PLP

Cat. No. Product Name CAS No. Information
CSN19410 Tanshinone IIA   568-72-9 Tanshinone IIA is a naturally occuring cardioprotective agent which can inhibit NF-κB and AP-1 DNA binding and display antioxidant and anti-inflammatory properties. Tanshinone IIA showed inhibitory effect on PL(pro) with IC50 value of 1.6μM and less inhibitory effect on 3CLpro with IC50 value of 89.1μM.
CSN12435 Tanshinone I 568-73-0 Tanshinone I, an active principle isolated from the roots of Salvia miltiorrhiza (Danshen), is an inhibitor of type IIA human recombinant sPLA2 and rabbit recombinant cPLA2 with IC50s of 11 μM and 82 μM, respectively, is structurally similar to tanshinone IIA and may possess similar cytotoxic effects on tumor cells. Tanshinone I showed inhibitory effect on PL(pro) with IC50 value of 8.8μM and less inhibitory effect on 3CLpro with IC50 value of 38.7μM.
CSN13714 6-Thioguanine   154-42-7 6-Thioguanine belongs to the thiopurine family of drugs that also include mercaptopurine and azathioprine, which are examples of antimetabolites, and is a purine analogue of the nucleobase guanine. It was found to inhibit SARS-CoV PLpro.
CSN12836 6-Mercaptopurine Monohydrate   6112-76-1 6-Mercaptopurine Monohydrate inhibits the de novo purine synthesis through incorporation of thiopurine methyltransferase metabolites into DNA and RNA, it is a widely used antileukemic agent and immunosuppressive drug. 6-mercaptopurine was found to inhibit SARS-CoV PLpro.
CSN16373 6-Mercaptopurine   50-44-2 6-Mercaptopurine inhibits the de novo purine synthesis through interference with DNA and RNA synthesis, it's an immunosuppressive and antileukemic drug. 6-mercaptopurine was found to inhibit SARS-CoV PLpro.
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