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PLK
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN23160 | TC-S 7005 | 1082739-92-1 | TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively[1]. |
| CSN18210 | Poloxin | 321688-88-4 | Poloxin is a non-ATP competitive Polo-like Kinase 1 PLK1 inhibitor that targets the polo-box domain |
| CSN18009 | Poloxime | 17302-61-3 | Poloxime is an analogue of thymoquinone which bind to the phosphoserinephosphothreonine recognition site of the polo-box domain of polo-like kinase 1 |
| CSN16519 | HMN-214 | 173529-46-9 | HMN-214 is a potent PLK1 inhibitor an average IC50 of 012 M and a prodrug of HMN-176 which alters the cellular spatial orientation of Plk1 |
| CSN19103 | HMN-176 | 173529-10-7 | HMN-176 is the active derivative of HMN-214 which can alter the cellular spatial orientation of Plk1 |
| CSN12710 | GW843682X | 660868-91-7 | GW843682X is a selective PLK1 and PLK3 inhibitor with IC50s of 22 nM PLK1 and 91 nM PLK3 and displays 100-fold selectivity over 30 other kinases tested including cdk1 and cdk2 |
| CSN22785 | Cyclapolin 9 | 40533-25-3 | Cyclapolin 9 is a selective, ATP-competitive polo-like kinase 1 (PLK1) inhibitor with IC50 of 500 nM. |
| CSN12712 | Volasertib | 755038-65-4 | BI6727 is an ATP-competitive kinase inhibitor from the dihydropteridinone class of compounds. |
| CSN12461 | BI-2536 | 755038-02-9 | BI-2536 is a potent Plk1 inhibitor with IC50 of 083 nM BI2536 shows 4- and 11-fold greater selectivity against Plk2 and Plk3 and also is a BRD4 inhibitor IC50 25 nM |
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