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PLK

PLK

Cat. No. Product Name CAS No. Information
CSN23160 TC-S 7005 1082739-92-1 TC-S 7005 is a Polo-like kinases (Plks) inhibitor with IC50s of 4 nM, 24 nM and 214 nM for Plk2, Plk3, and Plk1, respectively[1].
CSN18210 Poloxin 321688-88-4 Poloxin is a non-ATP competitive Polo-like Kinase 1 PLK1 inhibitor that targets the polo-box domain
CSN18009 Poloxime 17302-61-3 Poloxime is an analogue of thymoquinone which bind to the phosphoserinephosphothreonine recognition site of the polo-box domain of polo-like kinase 1
CSN16519 HMN-214 173529-46-9 HMN-214 is a potent PLK1 inhibitor an average IC50 of 012 M and a prodrug of HMN-176 which alters the cellular spatial orientation of Plk1
CSN19103 HMN-176 173529-10-7 HMN-176 is the active derivative of HMN-214 which can alter the cellular spatial orientation of Plk1
CSN12710 GW843682X 660868-91-7 GW843682X is a selective PLK1 and PLK3 inhibitor with IC50s of 22 nM PLK1 and 91 nM PLK3 and displays 100-fold selectivity over 30 other kinases tested including cdk1 and cdk2
CSN22785 Cyclapolin 9 40533-25-3 Cyclapolin 9 is a selective, ATP-competitive polo-like kinase 1 (PLK1) inhibitor with IC50 of 500 nM.
CSN12712 Volasertib 755038-65-4 BI6727 is an ATP-competitive kinase inhibitor from the dihydropteridinone class of compounds.
CSN12461 BI-2536 755038-02-9 BI-2536 is a potent Plk1 inhibitor with IC50 of 083 nM BI2536 shows 4- and 11-fold greater selectivity against Plk2 and Plk3 and also is a BRD4 inhibitor IC50 25 nM
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