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PKC
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN16722 | Zoledronic Acid Monohydrate | 165800-06-6 | Zoledronic acid is an activator of protein kinase C with apoptotic effects on multiple myeloma cell lines. |
| CSN23775 | VTX-27 | 1321924-70-2 | VTX-27 is an inhibitor of protein kinase C θ (PKC θ) and PKC δ with Kis of 0.08 nM and 16 nM, respectively. |
| CSN23871 | UCN-01 | 112953-11-4 | UCN-01 is a selective inhibitor of protein kinase C. |
| CSN21991 | TPPB | 497259-23-1 | TPPB is a cell-permeable benzolactam-derived protein kinase C (PKC) activator with Ki of 11.9 nM. |
| CSN18071 | TAS-301 | 193620-69-8 | TAS-301 is an inhibitor of smooth muscle cell migration and proliferation, inhibits intimal thickening after balloon injury to rat carotid arteries. |
| CSN11980 | Staurosporine | 62996-74-1 | Staurosporine is a prototypical potent ATP-competitive multikinase inhibitor with IC50 of 0.7, 7, 8.5, 6, 20 nM for PKC, PKA,PKG, p60v-src tyrosine protein kinase, CaM kinase II, respectively. |
| CSN17145 | Sotrastaurin | 425637-18-9 | Sotrastaurin is a potent and selective pan-PKC inhibitor, mostly for PKCθ with Ki of 0.22 nM and inactive to PKCζ. |
| CSN23069 | Ro 32-0432 | 151342-35-7 | Ro 32-0432 is a selective and orally active inhibitor of protein kinase C prevents T-cell activation. It displays slight selectivity for conventional PKC isoforms over Ca2+ and atypical PKC isoforms; binding affinities for rat isoforms are 9, 28, 31, 37 and 108 nM for PKC's α, βΙ, βΙΙ, γ and ε respectively. Ro 32-0432 is orally available and prevents T cell chronic inflammation in vivo. ). |
| CSN11854 | Ro 31-8220 Mesylate | 138489-18-6 | Ro 31-8220 mesylate is a pan-PKC inhibitor with IC50 of 5 nM, 24 nM, 14 nM, 27 nM, and 24 nM for PKC-, PKC-I, PKC-II, PKC-, and PKC-, respectively. |
| CSN17625 | Ro 31-8220 | 125314-64-9 | Ro 31-8220 is a pan-PKC inhibitor with IC50 of 5 nM 24 nM 14 nM 27 nM and 24 nM for PKC- PKC-I PKC-II PKC- and PKC- respectively |
| CSN23052 | Prostratin | 60857-08-1 | Prostratin is a PKC and NF-κB activator. |
| CSN23246 | Ro 32-0432 HCl | 1781828-85-0 | Potent, orally active PKC inhibitor |
| CSN24744 | PKCθ inhibitor | 736048-65-0 | PKθ inhibitor is a selective PKC-θ inhibitor with IC50 value of 12nM. |
| CSN15884 | PKC412 | 120685-11-2 | PKC412 is a broad spectrum protein kinase inhibitor and inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. |
| CSN17423 | PKC-IN-1 | 1046787-18-1 | PKC-IN-1 is a poent PKC beta II inhibitor with Ki of 149 nM |
| CSN11701 | Phorbol 12-Myristate 13-Acetate | 16561-29-8 | Phorbol 12-myristate 13-acetate is a PKC-activating phorbol ester, increases the intracellular Ca2 concentration (Ca2i) in a dose-dependent manner, with an EC50 of 11.7 nM. |
| CSN13863 | Phellopterin | 2543-94-4 | Phellopterin, a natural product isolated and purified from the roots of Saposhnikovia divaricata, is a partial agonist of the central benzodiazepine receptors in vitro, shows cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM, and reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium. |
| CSN18434 | NSC 305787 | 785718-37-8 | NSC305787 is a small molecule inhibitor of PKC with IC50 of 83 M 94 M 55 M for PKC phosphorylation of recombinant ezrin of moesin and of radixin |
| CSN18323 | NSC 305787 HCl | 53868-26-1 | NSC305787 HCl is a small molecule inhibitor of PKC, with IC50 of 8.3 μM, 9.4 μM, 55 μM for PKCΙ phosphorylation of recombinant ezrin, of moesin, and of radixin. |
| CSN11485 | Myricitrin | 17912-87-7 | Myricitrin a flavonoid compound isolated from the root bark of Myrica cerifera which exerts antinociceptive effects |
| CSN12991 | LY333531 HCl | 169939-93-9 | LY333531 is a -specific protein kinase C inhibitor. It competitively and reversibly inhibits PKC1 and PKC2 with IC50 values of 4.7 and 5.9 nM respectively. |
| CSN20625 | LXS196 | 1874276-76-2 | LXS196 is a potent and orally active protein kinase C PKC inhibitor used for the treatment of uveal melanoma |
| CSN14537 | Isojacareubin | 50597-93-8 | Isojacareubin, a natural product isolated and purified from the roots of Garcinia fusca Pierre., is a potent inhibitor of protein kinase C (PKC), suppresses hepatocellular carcinoma metastasis and induces apoptosis in vitro and in vivo, thus, it as a promising lead compound for the development of antihepatoma agents, and displays potent activity against H. |
| CSN16020 | Ingenol Mebutate | 75567-37-2 | Ingenol mebutate is a substance found in the sap of the plant Euphorbia peplus and an inducer of cell death. |
| CSN11206 | Ingenol | 30220-46-3 | Ingenol is a diterpenoid with unique architecture and has derivatives possessing important anticancer activity. |
| CSN11182 | Hypocrellin A | 77029-83-5 | Hypocrellin A is a natural product isolated and purified from the Hypocrella bambusae, with light-induced antitumor, antifungal and antiviral activities, showing photodynamic activity towards microorganisms. |
| CSN16527 | Go6983 | 133053-19-7 | Go6983 is a pan-PKC inhibitor against for PKC PKC PKC and PKC with IC50 of 7 nM 7 nM 6 nM and 10 nM respectively and less potent to PKC and inactive to PKC |
| CSN10464 | Bisindolylmaleimide I | 133052-90-1 | GF109203X is a potent PKC inhibitor with IC50 of 20 nM, 17 nM, 16 nM, and 20 nM for PKC, PKCI, PKCII, and PKC in cell-free assays, respectively, showing more than 3000-fold selectivity for PKC as compared to EGFR, PDGFR and insulin receptor. |
| CSN16571 | Go6976 | 136194-77-9 | G6976 is a pan inhibitor of Casup2sup-dependent PKC isozymes, PKC and PKC1, with IC50 values of 2.3nM and 6.2nM, respectively, but has no effect on Casup2sup-independent PKC isozymes PKC, and . |
| CSN22823 | FR 236924 | 28399-31-7 | FR 236924 is a selective PKCε activator. |
| CSN12444 | Enzastaurin | 170364-57-5 | Enzastaurin is a potent PKC selective inhibitor with IC50 of 6 nM 6- to 20-fold selectivity against PKC PKC and PKC |
| CSN21985 | Decursinol angelate | 130848-06-5 | Decursinol angelate (DA) blocks PGE2-induced activation of the EP2 receptor signaling pathway, including the activation of PKA and the phosphorylation of CREB. |
| CSN15402 | Cycloheterophyllin | 36545-53-6 | Cycloheterophyllin, a natural product isolated and purified from the herbs of Artocarpus heterophyllus, exerts a concentration-dependent inhibition of neutrophil cytosolic protein kinase C (PKC) and rat brain PKC by the O2- generation in rat neutrophils, but has no effect on porcine heart protein kinase A (PKA). |
| CSN10607 | Chelerythrine Chloride | 3895-92-9 | Chelerythrine Chloride is a potent, cell-permeable inhibitor of protein kinase C (IC50 = 660 nM) and competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. |
| CSN19868 | Chelerythrine | 34316-15-9 | Chelerythrine a natural product isolated and purified from the herbs of Chelidonium majus with potent antimanic antiproliferatvie and antitumor effect can inhibit telomerase activity and is a well-known protein kinase C inhibitor |
| CSN17986 | CGP-60474 | 164658-13-3 | CGP60474 is a promising inhibitor of PKC with a high degree of selectivity versus other serinethreonine and tyrosine kinases and show competitive kinetics relative to ATP |
| CSN22738 | Calphostin C | 121263-19-2 | Calphostin C is a potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain with IC50 of 50 nM. |
| CSN20021 | Bryostatin 1 | 83314-01-6 | Bryostatin 1 is a Protein kinase C (PKC) activator that binds with high affinity (Ki = 1.35 nM). |
| CSN25331 | Bisindolylmaleimide IV | 119139-23-0 | Bisindolylmaleimide IV is an inhibitor of protein kinase C. |
| CSN24270 | Bisindolylmaleimide X HCl | 145317-11-9 | Bisindolylmaleimide is a potent PKC inhibitor and also a potent nAChR antagonist. |
| CSN22715 | Bisindolylmaleimide II | 137592-45-1 | Bisindolylmaleimide II is a potent, ATP-competitive protein kinase C (PKC) inhibitor with IC50 of 0.01 μM, and also a potent nAChR antagonist. |
| CSN11220 | Acteoside | 61276-17-3 | Acteoside, is a natural product isolated and purified from the herbs of Cistanche deserticola Y.C. Ma with known antioxidant activity. It is a protein kinase C inhibitor (IC50 25 M). |
| CSN14800 | 20-Deoxyingenol 3-Angelate | 75567-38-3 | 20-Deoxyingenol 3-angelate a natural product isolated and purified from the aerial parts of Euphorbia peplus L can induce significant platelet aggregation accompanied by induction of phosphorylation of PKC substrates in platelets it is a protein kinase C PKC activator and is known as promoters of tumors of mouse skin |
| CSN12210 | α-Tocopherol | 59-02-9 | -Tocopherol is a type of vitamin E and an antagonist of PKC. |
| CSN16839 | (-)-Indolactam V | 90365-57-4 | (-)-Indolactam V is a protein kinase C activator, which strongly directs human ES cell-derived definitive endoderm into pancreatic endoderm. |
| CSN23664 | C-1 HCl | 141543-63-7 |
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