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Pim
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN22892 | TP-3654 | 1361951-15-6 | TP-3654 is a selective Pim kinase inhibitor with Ki values of 5nM 239nM and 42nM for Pim-1 Pim-2 and Pim-3 respectively as well as with an average EC50 of 67nM for cellular PIM-1 inhibition in the PIM-1BAD overexpression system and with moderate potency to FLT3 |
| CSN16821 | TCS-PIM-1-4a | 327033-36-3 | TCS-PIM-1-4a is a Pim inhibitor that blocks mTORC1 activity via activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines with IC50 values ranging from 08 to 40 M |
| CSN16592 | TCS PIM-1 1 | 491871-58-0 | TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM displays good selectivity over Pim-2 and MEK1MEK2 IC50s 20000 nM |
| CSN15804 | (Z)-SMI-4a | 438190-29-5 | SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM modestly potent to Pim-2 does not significantly inhibit any other serinethreonine- or tyrosine-kinases |
| CSN20347 | SMI-16a | 587852-28-6 | SMI-16a the PIM12 Kinase inhibitor VI controls the biological activity of PIM12 This small molecular inhibitor is primarily used for Phosphorylation Dephosphorylation applications |
| CSN17161 | SGI-1776 | 1025065-69-3 | SGI-1776 free base is an ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay 50- and 10-fold selective versus Pim2 and Pim3 also potent to Flt3 and haspin |
| CSN17458 | Pim1/AKK1-IN-1 | 1093222-27-5 | Pim1 AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM53 nM75 nM380 nM for Pim1AKK1MST2LKB1 respectively and also inhibits MPSK1 and TNIK |
| CSN20612 | pan-PIM Inhibitor CS11 | 2139294-71-4 | pan-PIM inhibitor CS11 is a pan-PIM kinase inhibitor which inhibits PIM1 and PIM2 with IC50 of 1 nM and 6 nM respectively |
| CSN17786 | M-110 | 1395048-49-3 | M-110 is a highly selective inhibitor of PIM kinases and inhibits the proliferation of prostate cancer cell lines with IC50s of 06 to 09 M with no activity on normal human peripheral blood mononuclear cells up to 40 M |
| CSN16602 | Hispidulin | 1447-88-7 | Hispidulin, a natural product isolated and purified from the herbs of Ambrosia artemisiifolia Linn., is a Pim-1 inhibitor with an IC50 of 2.71 M. |
| CSN17835 | GDC-0339 | 1428569-85-0 | GDC-0339 is a Pim kinase inhibitor with IC50 of 436 nM for BaF3 PIM1 |
| CSN26540 | CK2/PIM1-IN-1 | 292640-28-9 | for CK2 and PIM1, respectively. CK2/PIM1-IN-1 is developed for the research of proliferative disorders such as cancer, as well as other kinase-associated conditions including inflammation, pain, vascular disorders, pathogenic infections and certain immunological disorders[1]. |
| CSN16136 | CX-6258 | 1202916-90-2 | CX-6258 is a selective and potent Pim inhibitor with IC50 values of 5nM 25nM and 16nM for Pim-1 Pim-2 and Pim-3 measured by SAR assay respectively |
| CSN19180 | CX-6258 hydrochloride | 1353859-00-3 | CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively. |
| CSN17740 | CX-6258 hydrochloride hydrate | 1353858-99-7 | CX-6258 HCl hydrate is the HCl hydrate form of CX-6258. CX-6258 is a selective and potent Pim inhibitor with IC50 values of 5nM, 25nM and 16nM for Pim-1, Pim-2 and Pim-3 (measured by SAR assay), respectively. |
| CSN15816 | AZD1208 | 1204144-28-4 | AZD1208 is an orally bioavailable highly selective PIM kinases inhibitor with single nanomolar potency against all three PIM kinases IC50 of 04 nM 5 nM and 19 nM for Pim1 Pim2 and Pim3 in cell-free assays respectively and is used for treating AML |
| CSN19008 | (1S,3R,5R)-PIM447 dihydrochloride | 2096989-57-8 | (1S,3R,5R)-PIM447 2HCl an PIM inhibitor with IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3. |
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