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Pim

Pim

Cat. No. Product Name CAS No. Information
CSN22892 TP-3654 1361951-15-6 TP-3654 is a selective Pim kinase inhibitor with Ki values of 5nM 239nM and 42nM for Pim-1 Pim-2 and Pim-3 respectively as well as with an average EC50 of 67nM for cellular PIM-1 inhibition in the PIM-1BAD overexpression system and with moderate potency to FLT3
CSN16821 TCS-PIM-1-4a 327033-36-3 TCS-PIM-1-4a is a Pim inhibitor that blocks mTORC1 activity via activation of AMPK and kills a wide range of both myeloid and lymphoid cell lines with IC50 values ranging from 08 to 40 M
CSN16592 TCS PIM-1 1   491871-58-0 TCS PIM-1 1 is a potent and selective ATP-competitive Pim-1 kianse inhibitor with IC50 of 50 nM displays good selectivity over Pim-2 and MEK1MEK2 IC50s 20000 nM
CSN15804 SMI-4a   438190-29-5 SMI-4a is a potent inhibitor of Pim1 with IC50 of 17 nM modestly potent to Pim-2 does not significantly inhibit any other serinethreonine- or tyrosine-kinases
CSN20347 SMI-16a 587852-28-6 SMI-16a the PIM12 Kinase inhibitor VI controls the biological activity of PIM12 This small molecular inhibitor is primarily used for Phosphorylation Dephosphorylation applications
CSN17161 SGI-1776   1025065-69-3 SGI-1776 free base is an ATP competitive inhibitor of Pim1 with IC50 of 7 nM in a cell-free assay 50- and 10-fold selective versus Pim2 and Pim3 also potent to Flt3 and haspin
CSN17458 Pim1 AKK1-IN-1 1093222-27-5 Pim1 AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM53 nM75 nM380 nM for Pim1AKK1MST2LKB1 respectively and also inhibits MPSK1 and TNIK
CSN19123 PIM-447 1210608-43-7 PIM-447 is pan-PIM kinase inhibitor including Moloney Murine Leukemia PIM1 2 and 3 Kinase
CSN19124 PIM-447 2HCl 1820565-69-2 PIM-447 2HCl is pan-PIM kinase inhibitor, including Moloney Murine Leukemia (PIM)1, 2, and 3 Kinase.
CSN20612 pan-PIM Inhibitor CS11 2139294-71-4 pan-PIM inhibitor CS11 is a pan-PIM kinase inhibitor which inhibits PIM1 and PIM2 with IC50 of 1 nM and 6 nM respectively
CSN17786 M-110 1395048-49-3 M-110 is a highly selective inhibitor of PIM kinases and inhibits the proliferation of prostate cancer cell lines with IC50s of 06 to 09 M with no activity on normal human peripheral blood mononuclear cells up to 40 M
CSN20019 GNE-955 1527523-39-2 GNE-955 is a pan-Pim inhibitor with bioavailability bioavailability and a potential hematologiconcology use
CSN17835 GDC-0339 1428569-85-0 GDC-0339 is a Pim kinase inhibitor with IC50 of 436 nM for BaF3 PIM1
CSN16136 CX-6258 1202916-90-2 CX-6258 is a selective and potent Pim inhibitor with IC50 values of 5nM 25nM and 16nM for Pim-1 Pim-2 and Pim-3 measured by SAR assay respectively
CSN19180 CX-6258 HCl 1353859-00-3 CX-6258 HCl is a potent, orally efficacious pan-Pim kinase inhibitor with IC50 of 5 nM, 25 nM and 16 nM for Pim1, Pim2, and Pim3, respectively.
CSN17740 CX-6258 HCl H2O 1353858-99-7 CX-6258 HCl hydrate is the HCl hydrate form of CX-6258. CX-6258 is a selective and potent Pim inhibitor with IC50 values of 5nM, 25nM and 16nM for Pim-1, Pim-2 and Pim-3 (measured by SAR assay), respectively.
CSN15816 AZD1208   1204144-28-4 AZD1208 is an orally bioavailable highly selective PIM kinases inhibitor with single nanomolar potency against all three PIM kinases IC50 of 04 nM 5 nM and 19 nM for Pim1 Pim2 and Pim3 in cell-free assays respectively and is used for treating AML
CSN19008 (1S,3R,5R)-PIM447 2HCl N/A (1S,3R,5R)-PIM447 2HCl an PIM inhibitor with IC50 values of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3.
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