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PIKfyve

PIKfyve

Cat. No. Product Name CAS No. Information
CSN15968 YM-201636 371942-69-7 YM-201636 is a selective PIKfyve inhibitor with IC50 of 33 nM
CSN27620 Vacuolin-1 351986-85-1 Vacuolin-1 is cell-permeable inhibitor of lysosomal exocytosis and can block the Ca2+-dependent exocytosis of lysosomes and prevents the release of lysosomal content without affecting the process of resealing. Vacuolin-1 is also PIKfyve inhibitor that inhibits late-stage autophagy by impairing lysosomal maturation.
CSN16251 Psoralidin 18642-23-4 Psoralidin, a natural furanocoumarin, is isolated from Psoralea corylifolia L. with anticancer and chemopreventive properties, inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation.
CSN16316 APY0201 1232221-74-7 APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor (IC505.2 nM) that interrupts the conversion of phosphatidylinositol 3-phosphate (PtdIns3P) to PtdIns(3,5)P2. It is a unique small molecular IL-1223 production inhibitor.
CSN16991 Apilimod mesylate 870087-36-8 Apilimod mesylate is a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma, and can block filoviral entry and infection. It can also down-regulates both IL-12 p35 and IL-12IL-23 p40 at the transcriptional level, and inhibits the production of both IL-12 and IL-23 cytokines.
CSN10321 Apilimod 541550-19-0 Apilimod is a PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma, and can block filoviral entry and infection. It can also down-regulates both IL-12 p35 and IL-12IL-23 p40 at the transcriptional level, and inhibits the production of both IL-12 and IL-23 cytokines.
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