Welcome to CSNpharm! For Research Use Only!
Home +1-708-781-1677

PI3K

PI3K

Cat. No. Product Name CAS No. Information
CSN15908 XL765 Analogue 1349796-36-6 XL765 analogue is a dual inhibitor of mTORPI3K, mostly for p110 with IC50 of 9 nM, and also inhibits DNA-PK and mTOR.
CSN16985 XL147   934526-89-3 XL147 is a potent, orally bioavailable inhibitor of the class I PI3K family of lipid kinases with IC50 values of 39 nM383 nM36 nM23 nM for PI3K, respectively and less potent to PI3K.
CSN12670 XL147 Analogue 956958-53-5 XL147 analogue is a selective and reversible class I PI3K inhibitor for PI3K with IC50 of 39 nM36 nM23 nM in cell-free assays, less potent to PI3K.
CSN13854 VS-5584 1246560-33-7 VS-5584 is a potent and selective dual PI3KmTOR inhibitor for mTOR PI3K with IC50 of 34 nM and 26-21 nM
CSN21430 VPS34 inhibitor 1   1383716-46-8 Vps34-IN1 is a potent inhibitor of the class III phosphoinositide 3-kinase (PI3K) vacuolar protein sorting 34 (Vsp34) with IC50 of 15 nM.
CSN16944 Voxtalisib 934493-76-2 Voxtalisib is a potent and highly selective inhibitor of class I PI3Ks with IC50 of 39110943 nM for PI3K, also inhibits mTOR with IC50 of 160-910 nM.
CSN19738 Seletalisib 1362850-20-1 Seletalisib is a potent and selective PI3 kinase inhibitor, which may be useful for the treatment of immune-inflammatory diseases, such as psoriasis amd primary Sjogrens syndrome.
CSN15741 RP-5264 1532533-67-7 RP-5264 is an orally available, next generation PI3Kdelta inhibitor, inhibits PI3K activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 and 24.3 nM respectively.
CSN16214 PKI-587   1197160-78-3 PKI-587 is a highly potent dual PI3K/mTOR kinase inhibitor with IC50 of 0.4 nM, 5.4 nM and 1.6 nM for PI3Kα, PI3Kγ and mTOR, respectively.
CSN20258 PI3Kδ Inhibitor C52 1911564-39-0 PI3K inhibitor C52 is a potent, selective, and efficacious PI3K inhibitor with improved Caco-2 permeability, reduced Caco-2 efflux, reduced hERG PC activity, and increased selectivity profile while maintaining potency in the CD69 hWB assay, and is very potent in PKPD assays and highly efficacious in a mouse collagen-induced arthritis model.
CSN13561 PI3Kγ Inhibitor 1 1172118-03-4 PI3K inhibitor 1 is a potent PI3K inhibitor
CSN13877 PI-3065 955977-50-1 PI-3065 is a selective p110 inhibitor with IC50 of 15 nM, 70-fold selectivity over other PI3K family members.
CSN12265 PI-103 371935-74-9 PI-103 is a potent inhibitor with low IC50 values against recombinant PI3K isoforms p110alpha IC50 2 nM p110beta IC50 3 nM p110delta IC50 3 nM and p110gamma IC50 15 nM less potent to mTORDNA-PK with IC50 of 30 nM23 nM
CSN13906 PI-103 HCl 371935-79-4 PI-103 HCl is a potent PI3K/Akt and mTOR inhibitor with IC50 values of 2 nM for recombinant PI3K isoform p110α and 30 nM for mTOR.
CSN17655 PF-4989216 1276553-09-3 PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM 142 nM 65 nM 1 nM and 110 nM for p110 p110 p110 p110 and VPS34 respectively
CSN16085 PF-04691502 1013101-36-4 PF-04691502 is an ATP-competitive PI3K mTOR dual inhibitor with Ki of 18 nM21 nM16 nM19 nM and 16 nM little activity against either Vps34 AKT PDK1 p70S6K MEK ERK p38 or JNK
CSN17801 ON 146040 1404231-34-0 ON 146040 is the first dual PI3K and BCR-ABL inhibitor that targets the STAT3 and STAT5 pathways and inhibits PI3K isoforms with IC50 of 1420 nM
CSN13693 NVP-BKM120 HCl 1312445-63-8 NVP-BKM120 HclBKM120 is a selective PI3K inhibitor of p110 with IC50 of 52 nM166 nM116 nM262 nM respectively Reduced potency against VPS34 mTOR DNAPK with little activity to PI4K
CSN17646 MLN1117 1268454-23-4 MLN1117 is a selective p110 inhibitor with IC50 of 15 nM.
CSN11346 LY294002     154447-36-6 LY294002 is the first synthetic molecule known to inhibit p110α, p110β and p110δ with IC50 of 0.5 μM, 0.57 μM, 0.97 μM.
CSN20673 Leniolisib 1354690-24-6 Leniolisib is a potent and selective PI3K inhibitor currently in used for the treatment of immunodeficiency disorders.
CSN12216 KY 12420 19545-26-7 KY 12420 is the first described PI3K inhibitor with IC50 of 3 nM in a cell-free assay, with little selectivity within the PI3K family. It also blocks autophagosome formation and potently inhibits DNA-PKATM with IC50 of 16 nM and 150 nM in cell-free assays.
CSN16586 KU-0060648 881375-00-4 KU-0060648 is a dual inhibitor of DNA-PK and PI3K PI3K PI3K with IC50 of 86 nM and 4 nM 05 nM 01 nM respectively and with less inhibition of PI3K with IC50 of 059 M
CSN21128 IPI-3063 1425043-73-7 IPI-3063 is a potent and selective PI3K p110 inhibitor with an IC50 of 2.51.2 nM.
CSN12474 GSK2126458   1086062-66-9 GSK2126458 is a highly selective and potent inhibitor of PI3K with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2 , respectively.
CSN17123 GNE-477 1032754-81-6 GNE-477 is a potent and efficacious dual PI3KmTOR inhibitor with IC50 of 4 nM for PI3K Ki of 21 nM for mTOR
CSN17784 GNE-317 1394076-92-6 GNE-317 is a potent PI3KmTOR inhibitor that can cross the bloodbrain barrier and shows potent suppression of the PI3K pathway in the brain of mice with intact BBB
CSN15869 GDC-0980 1032754-93-0 GDC-0980 is a potent, class I PI3K inhibitor for PI3K with IC50 of 5 nM27 nM7 nM14 nM in cell-free assays
CSN12429 GDC-0941 957054-30-7 GDC-0941 is a potent inhibitor of PI3K with IC50 of 3 nM, with modest selectivity against p110(11-fold) and p110(25-fold).
CSN16999 GDC-0032 1282512-48-4 GDC-0032 is a potent, next-generation isoform-sparing PI3K inhibitor targeting PI3K with IC50 of 0.29 nM0.12 nM0.97nM, 10 fold selective over PI3K.
CSN17639 Duvelisib R-Enantiomer 1261590-48-0 Duvelisib R-enantiomer is a selective PI3K inhibitor with Ki and IC50 of 23 pM243 pM and 1 nM50 nM
CSN13707 Duvelisib   1201438-56-3 Duvelisib is a selective PI3K inhibitor with Ki and IC50 of 23 pM243 pM and 1 nM50 nM, highly selective for PI3K than other protein kinases.
CSN15117 Dehydroglyasperin C 199331-35-6 Dehydroglyasperin C a natural product isolated and purified from the roots of Glycyrrhiza uralensis Fisch suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K
CSN15881 CZC-24832 1159824-67-5 CZC-24832 is the first selective PI3K inhibitor with IC50 of 27 nM, with 10-fold selectivity over PI3K and 100-fold selectivity over PI3K and PI3K.
CSN17841 CAL-130 1431697-74-3 CAL-130 is a phosphoinositide 3-kinase PI3K inhibitor It is reported that combined inhibition of PI3K as therapy for T cell acute lymphoblastic leukemia T-ALL
CSN17842 CAL-130 HCl 1431697-78-7 CAL-130 Hydrochloride is a phosphoinositide 3-kinase PI3K inhibitor It is reported that combined inhibition of PI3K as therapy for T cell acute lymphoblastic leukemia T-ALL
CSN12930 CAL-101   870281-82-6 CAL-101 is a selective p110 inhibitor with IC50 of 2.5 nM, shown to have 40- to 300-fold greater selectivity for p110 than p110, and 400- to 4000-fold selectivity to p110 than C2, hVPS34, DNA-PK and mTOR.
CSN13168 BKM-120   944396-07-0 BKM120 is a selective PI3K inhibitor of p110 with IC50 of 52 nM166 nM116 nM262 nM in cell-free assays respectively
CSN17405 BEZ235 Tosylate 1028385-32-1 BEZ235 tosylate is a dual PI3K and mTOR kinase inhibitor with IC50 values of 4, 75, 7, 5 nM for PI3K, , , , respectively.
CSN12260 BEZ235   915019-65-7 BEZ235 is a dual ATP-competitive PI3K and mTOR inhibitor for p110 and mTOR(p70S6K) with IC50 of 4 nM 5 nM 7 nM 75 nM 6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell.
CSN17605 BEBT-908 1235449-52-1 BEBT-908 is a PI3K inhibitor with an IC50 0.1 M, and also inhibits HDAC (0.1 M IC50 1 M) .
CSN16946 AZD8835 1620576-64-8 AZD8835 ia a mixed inhibitor of PI3K and PI3K with IC50 of 62 nM and 57 nM respectively also with selectivity against PI3K IC50431 nM and PI3K IC5090 nM
CSN13098 AS-605240 648450-29-7 AS-605240 selectively inhibits PI3K with IC50 of 8 nM over 30-fold and 75-fold selective for PI3K than PI3K and PI3K in cell-free assays respectively
CSN19171 AS-604850   648449-76-7 AS-604850 is a selective, ATP-competitive PI3K inhibitor with IC50 of 250 nM, showing over 80-fold selectivity for PI3K than PI3K, and being 18-fold selective for PI3K than PI3K.
CSN16052 AS-252424 900515-16-4 AS-252424 is a potent PI3K inhibitor with IC50 of 30 nM in a cell-free assay with 30-fold selectivity for PI3K than PI3K and low inhibitory activity towards PI3K
CSN13709 Alpelisib     1217486-61-7 Alpelisib is a potent and selective PI3Kα inhibitor with IC50 of 5 nM, liitle or no effect on PI3Kβ/γ/δ.
CSN16673 A66 1166227-08-2 A66 is a potent and specific p110 inhibitor with IC50 of 32 nM 100 fold selectivity for p110 over other class-I PI3K isoforms
CSN19389 3-Methyladenine   5142-23-4 3-Methyladenine is a selective PI3K inhibitor for Vps34 and PI3K with IC50 of 25 M and 60 M.
CSN17198 GSK2269557 1254036-71-9
CSN24176 ME-401 1595129-71-7
<< PREV 1 2 3 4 NEXT >>