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PI3K
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN15908 | XL765 Analogue | 1349796-36-6 | XL765 analogue is a dual inhibitor of mTORPI3K, mostly for p110 with IC50 of 9 nM, and also inhibits DNA-PK and mTOR. |
| CSN16985 | XL147 | 934526-89-3 | XL147 is a potent, orally bioavailable inhibitor of the class I PI3K family of lipid kinases with IC50 values of 39 nM383 nM36 nM23 nM for PI3K, respectively and less potent to PI3K. |
| CSN12670 | XL147 Analogue | 956958-53-5 | XL147 analogue is a selective and reversible class I PI3K inhibitor for PI3K with IC50 of 39 nM36 nM23 nM in cell-free assays, less potent to PI3K. |
| CSN13854 | VS-5584 | 1246560-33-7 | VS-5584 is a potent and selective dual PI3KmTOR inhibitor for mTOR PI3K with IC50 of 34 nM and 26-21 nM |
| CSN21430 | VPS34 inhibitor 1 | 1383716-46-8 | Vps34-IN1 is a potent inhibitor of the class III phosphoinositide 3-kinase (PI3K) vacuolar protein sorting 34 (Vsp34) with IC50 of 15 nM. |
| CSN16944 | Voxtalisib | 934493-76-2 | Voxtalisib is a potent and highly selective inhibitor of class I PI3Ks with IC50 of 39110943 nM for PI3K, also inhibits mTOR with IC50 of 160-910 nM. |
| CSN19738 | Seletalisib | 1362850-20-1 | Seletalisib is a potent and selective PI3 kinase inhibitor, which may be useful for the treatment of immune-inflammatory diseases, such as psoriasis amd primary Sjogrens syndrome. |
| CSN15741 | RP-5264 | 1532533-67-7 | RP-5264 is an orally available, next generation PI3Kdelta inhibitor, inhibits PI3K activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 and 24.3 nM respectively. |
| CSN16214 | PKI-587 | 1197160-78-3 | PKI-587 is a highly potent dual PI3K/mTOR kinase inhibitor with IC50 of 0.4 nM, 5.4 nM and 1.6 nM for PI3Kα, PI3Kγ and mTOR, respectively. |
| CSN20258 | PI3Kδ Inhibitor C52 | 1911564-39-0 | PI3K inhibitor C52 is a potent, selective, and efficacious PI3K inhibitor with improved Caco-2 permeability, reduced Caco-2 efflux, reduced hERG PC activity, and increased selectivity profile while maintaining potency in the CD69 hWB assay, and is very potent in PKPD assays and highly efficacious in a mouse collagen-induced arthritis model. |
| CSN13561 | PI3Kγ Inhibitor 1 | 1172118-03-4 | PI3K inhibitor 1 is a potent PI3K inhibitor |
| CSN13877 | PI-3065 | 955977-50-1 | PI-3065 is a selective p110 inhibitor with IC50 of 15 nM, 70-fold selectivity over other PI3K family members. |
| CSN12265 | PI-103 | 371935-74-9 | PI-103 is a potent inhibitor with low IC50 values against recombinant PI3K isoforms p110alpha IC50 2 nM p110beta IC50 3 nM p110delta IC50 3 nM and p110gamma IC50 15 nM less potent to mTORDNA-PK with IC50 of 30 nM23 nM |
| CSN13906 | PI-103 HCl | 371935-79-4 | PI-103 HCl is a potent PI3K/Akt and mTOR inhibitor with IC50 values of 2 nM for recombinant PI3K isoform p110α and 30 nM for mTOR. |
| CSN17655 | PF-4989216 | 1276553-09-3 | PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM 142 nM 65 nM 1 nM and 110 nM for p110 p110 p110 p110 and VPS34 respectively |
| CSN16085 | PF-04691502 | 1013101-36-4 | PF-04691502 is an ATP-competitive PI3K mTOR dual inhibitor with Ki of 18 nM21 nM16 nM19 nM and 16 nM little activity against either Vps34 AKT PDK1 p70S6K MEK ERK p38 or JNK |
| CSN17801 | ON 146040 | 1404231-34-0 | ON 146040 is the first dual PI3K and BCR-ABL inhibitor that targets the STAT3 and STAT5 pathways and inhibits PI3K isoforms with IC50 of 1420 nM |
| CSN13693 | NVP-BKM120 HCl | 1312445-63-8 | NVP-BKM120 HclBKM120 is a selective PI3K inhibitor of p110 with IC50 of 52 nM166 nM116 nM262 nM respectively Reduced potency against VPS34 mTOR DNAPK with little activity to PI4K |
| CSN17646 | MLN1117 | 1268454-23-4 | MLN1117 is a selective p110 inhibitor with IC50 of 15 nM. |
| CSN11346 | LY294002 | 154447-36-6 | LY294002 is the first synthetic molecule known to inhibit p110α, p110β and p110δ with IC50 of 0.5 μM, 0.57 μM, 0.97 μM. |
| CSN20673 | Leniolisib | 1354690-24-6 | Leniolisib is a potent and selective PI3K inhibitor currently in used for the treatment of immunodeficiency disorders. |
| CSN12216 | KY 12420 | 19545-26-7 | KY 12420 is the first described PI3K inhibitor with IC50 of 3 nM in a cell-free assay, with little selectivity within the PI3K family. It also blocks autophagosome formation and potently inhibits DNA-PKATM with IC50 of 16 nM and 150 nM in cell-free assays. |
| CSN16586 | KU-0060648 | 881375-00-4 | KU-0060648 is a dual inhibitor of DNA-PK and PI3K PI3K PI3K with IC50 of 86 nM and 4 nM 05 nM 01 nM respectively and with less inhibition of PI3K with IC50 of 059 M |
| CSN21128 | IPI-3063 | 1425043-73-7 | IPI-3063 is a potent and selective PI3K p110 inhibitor with an IC50 of 2.51.2 nM. |
| CSN12474 | GSK2126458 | 1086062-66-9 | GSK2126458 is a highly selective and potent inhibitor of PI3K with Ki of 0.019 nM/0.13 nM/0.024 nM/0.06 nM and 0.18 nM/0.3 nM for p110α/β/δ/γ, mTORC1/2 , respectively. |
| CSN17123 | GNE-477 | 1032754-81-6 | GNE-477 is a potent and efficacious dual PI3KmTOR inhibitor with IC50 of 4 nM for PI3K Ki of 21 nM for mTOR |
| CSN17784 | GNE-317 | 1394076-92-6 | GNE-317 is a potent PI3KmTOR inhibitor that can cross the bloodbrain barrier and shows potent suppression of the PI3K pathway in the brain of mice with intact BBB |
| CSN15869 | GDC-0980 | 1032754-93-0 | GDC-0980 is a potent, class I PI3K inhibitor for PI3K with IC50 of 5 nM27 nM7 nM14 nM in cell-free assays |
| CSN12429 | GDC-0941 | 957054-30-7 | GDC-0941 is a potent inhibitor of PI3K with IC50 of 3 nM, with modest selectivity against p110(11-fold) and p110(25-fold). |
| CSN16999 | GDC-0032 | 1282512-48-4 | GDC-0032 is a potent, next-generation isoform-sparing PI3K inhibitor targeting PI3K with IC50 of 0.29 nM0.12 nM0.97nM, 10 fold selective over PI3K. |
| CSN17639 | Duvelisib R-Enantiomer | 1261590-48-0 | Duvelisib R-enantiomer is a selective PI3K inhibitor with Ki and IC50 of 23 pM243 pM and 1 nM50 nM |
| CSN13707 | Duvelisib | 1201438-56-3 | Duvelisib is a selective PI3K inhibitor with Ki and IC50 of 23 pM243 pM and 1 nM50 nM, highly selective for PI3K than other protein kinases. |
| CSN15117 | Dehydroglyasperin C | 199331-35-6 | Dehydroglyasperin C a natural product isolated and purified from the roots of Glycyrrhiza uralensis Fisch suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K |
| CSN15881 | CZC-24832 | 1159824-67-5 | CZC-24832 is the first selective PI3K inhibitor with IC50 of 27 nM, with 10-fold selectivity over PI3K and 100-fold selectivity over PI3K and PI3K. |
| CSN17841 | CAL-130 | 1431697-74-3 | CAL-130 is a phosphoinositide 3-kinase PI3K inhibitor It is reported that combined inhibition of PI3K as therapy for T cell acute lymphoblastic leukemia T-ALL |
| CSN17842 | CAL-130 HCl | 1431697-78-7 | CAL-130 Hydrochloride is a phosphoinositide 3-kinase PI3K inhibitor It is reported that combined inhibition of PI3K as therapy for T cell acute lymphoblastic leukemia T-ALL |
| CSN12930 | CAL-101 | 870281-82-6 | CAL-101 is a selective p110 inhibitor with IC50 of 2.5 nM, shown to have 40- to 300-fold greater selectivity for p110 than p110, and 400- to 4000-fold selectivity to p110 than C2, hVPS34, DNA-PK and mTOR. |
| CSN13168 | BKM-120 | 944396-07-0 | BKM120 is a selective PI3K inhibitor of p110 with IC50 of 52 nM166 nM116 nM262 nM in cell-free assays respectively |
| CSN17405 | BEZ235 Tosylate | 1028385-32-1 | BEZ235 tosylate is a dual PI3K and mTOR kinase inhibitor with IC50 values of 4, 75, 7, 5 nM for PI3K, , , , respectively. |
| CSN12260 | BEZ235 | 915019-65-7 | BEZ235 is a dual ATP-competitive PI3K and mTOR inhibitor for p110 and mTOR(p70S6K) with IC50 of 4 nM 5 nM 7 nM 75 nM 6 nM in cell-free assays, respectively. Inhibits ATR with IC50 of 21 nM in 3T3TopBP1-ER cell. |
| CSN17605 | BEBT-908 | 1235449-52-1 | BEBT-908 is a PI3K inhibitor with an IC50 0.1 M, and also inhibits HDAC (0.1 M IC50 1 M) . |
| CSN16946 | AZD8835 | 1620576-64-8 | AZD8835 ia a mixed inhibitor of PI3K and PI3K with IC50 of 62 nM and 57 nM respectively also with selectivity against PI3K IC50431 nM and PI3K IC5090 nM |
| CSN13098 | AS-605240 | 648450-29-7 | AS-605240 selectively inhibits PI3K with IC50 of 8 nM over 30-fold and 75-fold selective for PI3K than PI3K and PI3K in cell-free assays respectively |
| CSN19171 | AS-604850 | 648449-76-7 | AS-604850 is a selective, ATP-competitive PI3K inhibitor with IC50 of 250 nM, showing over 80-fold selectivity for PI3K than PI3K, and being 18-fold selective for PI3K than PI3K. |
| CSN16052 | AS-252424 | 900515-16-4 | AS-252424 is a potent PI3K inhibitor with IC50 of 30 nM in a cell-free assay with 30-fold selectivity for PI3K than PI3K and low inhibitory activity towards PI3K |
| CSN13709 | Alpelisib | 1217486-61-7 | Alpelisib is a potent and selective PI3Kα inhibitor with IC50 of 5 nM, liitle or no effect on PI3Kβ/γ/δ. |
| CSN16673 | A66 | 1166227-08-2 | A66 is a potent and specific p110 inhibitor with IC50 of 32 nM 100 fold selectivity for p110 over other class-I PI3K isoforms |
| CSN19389 | 3-Methyladenine | 5142-23-4 | 3-Methyladenine is a selective PI3K inhibitor for Vps34 and PI3K with IC50 of 25 M and 60 M. |
| CSN17198 | GSK2269557 | 1254036-71-9 | |
| CSN24176 | ME-401 | 1595129-71-7 |
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