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PGE synthesis (prostaglandin E synthase, PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG) H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions. Cytosolic PGES (cPGES) is a cytosolic protein that is constitutively expressed in a wide variety of cells and tissues and is associated with heat shock protein 90 (Hsp90). Membrane-associated PGES (mPGES), the expression of which is stimulus-inducible and is downregulated by anti-inflammatory glucocorticoids, is a perinuclear protein belonging to the microsomal glutathione S-transferase (GST) family.

PG Synthase

Cat. No. Product Name CAS No. Information
CSN12019 Suprofen   40828-46-4 Suprofen is a COX12 inhibitor and a non-steroidal anti-inflammatory drug (NSAID).
CSN16384 Pranoprofen   52549-17-4 Pranoprofen is a non-steroidal COX inhibitor with anti-inflammatory effects, used in treatment of ophthalmology.
CSN18534 MF63 892549-43-8 MF63 is a selective mPGES-1 inhibitor with an IC50 of 0.9 nM and 1.3 nM for pig mPGES-1 and human mPGES-1 enzyme, respectively.
CSN17603 hPGDS-IN-1 1234708-04-3 hPGDS-IN-1 is a hPGDS inhibitor ,with IC50 of 12 nM in the Fluorescence Polarization Assay or the EIA assay.
CSN12831 HPGDS Inhibitor 1 1033836-12-2 HPGDS inhibitor 1 is a selective Hematopoietic Prostaglandin D Synthase (HPGDS) inhibitor with an IC50 Value of 0.7 nM.
CSN24192 GSK-2894631A 2101626-26-8 GSK-2894631A is a highly potent and selective HPGDS inhibitor with IC50 value of 9.9nM.
CSN11044 Flurbiprofen   5104-49-4 Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.
CSN27768 AT-56   162640-98-4 AT 56 is an orally active L-PGDS inhibitor with IC50 value of 95μM. It inhibits the production of PGD2 from PGH2 in vitro, with no effect on PGE2 or PGF2α production.
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