PGE synthesis (prostaglandin E synthase, PGES), which converts cyclooxygenase (COX)-derived prostaglandin (PG) H2 to PGE2, occurs in multiple forms with distinct enzymatic properties, modes of expression, cellular and subcellular localizations and intracellular functions. Cytosolic PGES (cPGES) is a cytosolic protein that is constitutively expressed in a wide variety of cells and tissues and is associated with heat shock protein 90 (Hsp90). Membrane-associated PGES (mPGES), the expression of which is stimulus-inducible and is downregulated by anti-inflammatory glucocorticoids, is a perinuclear protein belonging to the microsomal glutathione S-transferase (GST) family.
|Cat. No.||Product Name||CAS No.||Information|
|CSN12019||Suprofen||40828-46-4||Suprofen is a COX12 inhibitor and a non-steroidal anti-inflammatory drug (NSAID).|
|CSN16384||Pranoprofen||52549-17-4||Pranoprofen is a non-steroidal COX inhibitor with anti-inflammatory effects, used in treatment of ophthalmology.|
|CSN11044||Flurbiprofen||5104-49-4||Flurbiprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity.|
|CSN10466||Bismuth Subsalicylate||14882-18-9||Bismuth subsalicylate is the active ingredient in Pepto-Bismol and inhibits prostaglandin GH Synthase 12|