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PDK is a kinase enzyme which acts to inactivate the enzyme pyruvate dehydrogenase by phosphorylating it using ATP.


Cat. No. Product Name CAS No. Information
CSN17521 PS-48 1180676-32-7 PS48 is a phosphoinositide-dependent protein kinase-1 PDK1 activator with Kd value of 103 M and binds exclusively to the PIF-binding pocket of PDK1 distinct from the ATP binding site
CSN33232 PS210 1221962-86-2 PS-210 is a selective activator of PDK1 activator. It acts by binding to the PIF-pocket allosteric docking site.
CSN17379 MP7 1001409-50-2 PDK1 inhibitor is a potent and selective inhibitor of PDK1 with potential as anticancer agent
CSN25617 PDK4-IN-1 hydrochloride 2310262-11-2 PDK-4 Inhibitor compound 8c HCl is an allosteric PDK-4 inhibitor with IC50 value of 84nM.
CSN12988 OSU-03012 (AR-12) 742112-33-0 OSU-03012 is a potent inhibitor of recombinant PDK-1 with IC50 of 5 M and 2-fold increase in potency over OSU-02067
CSN27211 JX06   729-46-4 JX06 is a selective covalent PDK1 inhibitor with IC50 values of 49, 101 and 313nM for PDK-1, PDK-2 and PDK-3, respectively.
CSN17589 GSK2334470 1227911-45-6 GSK2334470 is a PDK1 inhibitor with IC50 of 10 nM with no activity at other close related AGC-kinases
CSN12711 BX795   702675-74-9 BX795 is a potent and selective dual inhibitor of TBK1PDK1 with IC50s of 2 nM6 nM respectively also inhibit Aurora B and IB kinase IKK
CSN19146 BX517 850717-64-5 BX517 is a potent and selective inhibitor of PDK1 with IC50 of 6 nM
CSN17175 BX-912 702674-56-4 BX-912 is a selective inhibitor of 3-Phosphoinositide-dependent Kinase-1 PDK1 with IC50 of 12 nM showing 10 fold selectivity over PKA PKC C-Kit EGFR etc
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