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PDGFR
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN12856 | TSU-68 (Random Configuration) | 252916-29-3 | TSU-68 is a multiple receptor tyrosine kinase inhibitor with IC50 of 2.1 M, 8 nM and 1.2 M for VEGF-R1, PDGF-R and FGF-R1, respectively and has greatest potency against PDGFR autophosphorylation. |
| CSN10166 | Trapidil | 15421-84-8 | Trapidil, a vasodilator and an antiplatelet drug, is also a PDGF antagonist that can inhibit the proliferation of the PDGF-producing glioma cells. |
| CSN17231 | Toceranib Phosphate | 874819-74-6 | Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFR. |
| CSN15964 | Toceranib | 356068-94-5 | Toceranib is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFR. |
| CSN12411 | Sunitinib Malate | 341031-54-7 | Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 Flk-1 and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit |
| CSN16761 | Sunitinib | 557795-19-4 | Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 Flk-1 and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit |
| CSN20031 | SU6668 | 210644-62-5 | SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFR, VEGFR2 (Flk-1KDR), FGFR1 activity in vitro (IC50 0.01, 0.1, 3.9, and 3.8 M, respectively) and PDGFVEGFbFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target serthr kinases Aurora A, Aurora B, TBK1 (NAKT2K), and AMPK (IC50 0.85, 0.047, 1.4, and 1.8 M, respectively), as well as non-receptor TKs Lyn and Yes (IC50 4.3 and 5.8 M, respectively). |
| CSN23135 | SU 16f | 251356-45-3 | SU16f is a potent and selective platelet-derived growth factor receptor-β (PDGFRβ) inhibitor[1]. |
| CSN15795 | SU14813 Maleate | 849643-15-8 | SU14813 maleate is an oral multitargeted tyrosine kinase inhibitor TKI targeting vascular endothelial growth factor receptors VEGFR platelet-derived growth factor receptors PDGFR Kit and fms-like tyrosine kinase 3 FLT-3 |
| CSN12692 | SU14813(Random Configuration) | 627908-92-3 | SU14813 is an oral multitargeted tyrosine kinase inhibitor TKI targeting vascular endothelial growth factor receptors VEGFR platelet-derived growth factor receptors PDGFR Kit and fms-like tyrosine kinase 3 FLT-3 |
| CSN20166 | SU11652 | 326914-10-7 | SU11652 is a sunitinib analog with anti-tyrosine-kinase activity also is identified as a potential inhibitor for Leishmania major Lm nucleoside diphosphate kinases NDK and structural studies indicated that this molecule binds to the active site of LmNDK in a similar conformation to nucleotides mimicking natural substrates |
| CSN16131 | Sennoside B | 128-57-4 | Sennoside B inhibits PDGF-stimulated cell proliferation its a kind of irritant laxative isolated from rhei rhizome and leaves of Cassia angustifolia |
| CSN19118 | PP58 | 212391-58-7 | PP58 is a tool compounds in epigenetics. |
| CSN16549 | PP121 | 1092788-83-4 | PP-121 is a multi-targeted inhibitor of PDGFR Hck mTOR VEGFR2 Src and Abl with IC50 of 2 nM 8 nM 10 nM 12 nM 14 nM and 18 nM also inhibits DNA-PK with IC50 of 60 nM |
| CSN21067 | Ponatinib HCl | 1114544-31-8 | Ponatinib is a multi-targeted kinase inhibitor with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src respectively. |
| CSN17429 | Masitinib Mesylate | 1048007-93-7 | Masitinib Mesylate is an inhibitor for Kit and PDGFR with IC50 of 200 nM and 540800 nM weak inhibition to ABL and c-Fms |
| CSN12262 | Masitinib | 790299-79-5 | Masitinib is an inhibitor for Kit and PDGFR with IC50 of 200 nM and 540 nM800 nM weak inhibition to ABL and c-Fms |
| CSN22791 | DMPQ 2HCl | 1123491-15-5 | DMPQ 2HCl is a potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) with IC50 of 80 nM. |
| CSN12987 | Crenolanib | 670220-88-9 | Crenolanib is a potent class III RTKs inhibitor with Kd values of 3.2nM, 2.1nM and 0.74nM for PDGFR, PDGFR and FLT3. |
| CSN16419 | CP-673451 | 343787-29-1 | CP-673451 is a selective inhibitor of PDGFR with IC50 of 10 nM1 nM in cell-free assays exhibits 450-fold selectivity over other angiogenic receptors has antiangiogenic and antitumor activity |
| CSN20482 | CGP-53716 | 152459-94-4 | CGP-53716 is a selective tyrosine kinase inhibitor of PDGFR |
| CSN12169 | AG 1296 | 146535-11-7 | AG 1296 is an inhibitor of PDGFR with IC50 of 0.3-0.5 M, no activity to EGFR. |
| CSN17731 | AC710 Mesylate | 1351522-05-8 | AC710 mesylate is a potent selective PDGFR-family kinases inhibitor with Kd values of 06 nM10 nM13 nM10 nM for FLT3KITPDGFRPDGFR respectively |
| CSN17730 | AC710 | 1351522-04-7 | AC710 is a potent selective PDGFR-family kinases inhibitor with Kd values of 06 nM10 nM13 nM10 nM for FLT3KITPDGFRPDGFR respectively |
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