Platelet-derived Growth Factor Receptor | Protein Tyrosine Kinase/RTK| CSNpharm

PDGFR

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Cat. No.	Product Name	CAS No.	Information
CSN12856	TSU-68 (Random Configuration)	252916-29-3	TSU-68 is a multiple receptor tyrosine kinase inhibitor with IC50 of 2.1 M, 8 nM and 1.2 M for VEGF-R1, PDGF-R and FGF-R1, respectively and has greatest potency against PDGFR autophosphorylation.
CSN10166	Trapidil	15421-84-8	Trapidil, a vasodilator and an antiplatelet drug, is also a PDGF antagonist that can inhibit the proliferation of the PDGF-producing glioma cells.
CSN17231	Toceranib Phosphate	874819-74-6	Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFR.
CSN15964	Toceranib	356068-94-5	Toceranib is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFR.
CSN12411	Sunitinib Malate	341031-54-7	Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 Flk-1 and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit
CSN16761	Sunitinib	557795-19-4	Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 Flk-1 and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit
CSN20031	SU6668	210644-62-5	SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFR, VEGFR2 (Flk-1KDR), FGFR1 activity in vitro (IC50 0.01, 0.1, 3.9, and 3.8 M, respectively) and PDGFVEGFbFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target serthr kinases Aurora A, Aurora B, TBK1 (NAKT2K), and AMPK (IC50 0.85, 0.047, 1.4, and 1.8 M, respectively), as well as non-receptor TKs Lyn and Yes (IC50 4.3 and 5.8 M, respectively).
CSN15795	SU14813 Maleate	849643-15-8	SU14813 maleate is an oral multitargeted tyrosine kinase inhibitor TKI targeting vascular endothelial growth factor receptors VEGFR platelet-derived growth factor receptors PDGFR Kit and fms-like tyrosine kinase 3 FLT-3
CSN12692	SU14813(Random Configuration)	627908-92-3	SU14813 is an oral multitargeted tyrosine kinase inhibitor TKI targeting vascular endothelial growth factor receptors VEGFR platelet-derived growth factor receptors PDGFR Kit and fms-like tyrosine kinase 3 FLT-3
CSN20166	SU11652	326914-10-7	SU11652 is a sunitinib analog with anti-tyrosine-kinase activity also is identified as a potential inhibitor for Leishmania major Lm nucleoside diphosphate kinases NDK and structural studies indicated that this molecule binds to the active site of LmNDK in a similar conformation to nucleotides mimicking natural substrates
CSN16131	Sennoside B	128-57-4	Sennoside B inhibits PDGF-stimulated cell proliferation its a kind of irritant laxative isolated from rhei rhizome and leaves of Cassia angustifolia
CSN16549	PP121	1092788-83-4	PP-121 is a multi-targeted inhibitor of PDGFR Hck mTOR VEGFR2 Src and Abl with IC50 of 2 nM 8 nM 10 nM 12 nM 14 nM and 18 nM also inhibits DNA-PK with IC50 of 60 nM
CSN17429	Masitinib Mesylate	1048007-93-7	Masitinib Mesylate is an inhibitor for Kit and PDGFR with IC50 of 200 nM and 540800 nM weak inhibition to ABL and c-Fms
CSN12262	Masitinib	790299-79-5	Masitinib is an inhibitor for Kit and PDGFR with IC50 of 200 nM and 540 nM800 nM weak inhibition to ABL and c-Fms
CSN12987	Crenolanib	670220-88-9	Crenolanib is a potent class III RTKs inhibitor with Kd values of 3.2nM, 2.1nM and 0.74nM for PDGFR, PDGFR and FLT3.
CSN16419	CP-673451	343787-29-1	CP-673451 is a selective inhibitor of PDGFR with IC50 of 10 nM1 nM in cell-free assays exhibits 450-fold selectivity over other angiogenic receptors has antiangiogenic and antitumor activity
CSN20482	CGP-53716	152459-94-4	CGP-53716 is a selective tyrosine kinase inhibitor of PDGFR
CSN12169	AG 1296	146535-11-7	AG 1296 is an inhibitor of PDGFR with IC50 of 0.3-0.5 M, no activity to EGFR.
CSN17731	AC710 Mesylate	1351522-05-8	AC710 mesylate is a potent selective PDGFR-family kinases inhibitor with Kd values of 06 nM10 nM13 nM10 nM for FLT3KITPDGFRPDGFR respectively
CSN17730	AC710	1351522-04-7	AC710 is a potent selective PDGFR-family kinases inhibitor with Kd values of 06 nM10 nM13 nM10 nM for FLT3KITPDGFRPDGFR respectively
CSN22791	DMPQ 2HCl	1123491-15-5
CSN23135	SU 16f	251356-45-3

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