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PDGFR

PDGFR

Cat. No. Product Name CAS No. Information
CSN25326 Tyrphostin AG1433 168835-90-3 Tyrphostin AG1433 is a tyrosine kinases inhibitor and also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively.
CSN21277 Tyrosine kinase-IN-1 705946-27-6 Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively.
CSN12856 Orantinib 252916-29-3 TSU-68 is a multiple receptor tyrosine kinase inhibitor with IC50 of 2.1 M, 8 nM and 1.2 M for VEGF-R1, PDGF-R and FGF-R1, respectively and has greatest potency against PDGFR autophosphorylation.
CSN10166 Trapidil 15421-84-8 Trapidil, a vasodilator and an antiplatelet drug, is also a PDGF antagonist that can inhibit the proliferation of the PDGF-producing glioma cells.
CSN17231 Toceranib phosphate   874819-74-6 Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFR.
CSN15964 Toceranib   356068-94-5 Toceranib is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFR.
CSN12411 Sunitinib Malate   341031-54-7 Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 Flk-1 and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit
CSN16761 Sunitinib   557795-19-4 Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 Flk-1 and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit
CSN20031 (Z)-Orantinib 210644-62-5 SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFR, VEGFR2 (Flk-1KDR), FGFR1 activity in vitro (IC50 0.01, 0.1, 3.9, and 3.8 M, respectively) and PDGFVEGFbFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target serthr kinases Aurora A, Aurora B, TBK1 (NAKT2K), and AMPK (IC50 0.85, 0.047, 1.4, and 1.8 M, respectively), as well as non-receptor TKs Lyn and Yes (IC50 4.3 and 5.8 M, respectively).
CSN23135 SU16f 251356-45-3 SU16f is a potent and selective platelet-derived growth factor receptor-β (PDGFRβ) inhibitor[1].
CSN15795 SU14813 maleate 849643-15-8 SU14813 maleate is an oral multitargeted tyrosine kinase inhibitor TKI targeting vascular endothelial growth factor receptors VEGFR platelet-derived growth factor receptors PDGFR Kit and fms-like tyrosine kinase 3 FLT-3
CSN12692 SU14813 627908-92-3 SU14813 is an oral multitargeted tyrosine kinase inhibitor TKI targeting vascular endothelial growth factor receptors VEGFR platelet-derived growth factor receptors PDGFR Kit and fms-like tyrosine kinase 3 FLT-3
CSN20166 SU11652 326914-10-7 SU11652 is a sunitinib analog with anti-tyrosine-kinase activity also is identified as a potential inhibitor for Leishmania major Lm nucleoside diphosphate kinases NDK and structural studies indicated that this molecule binds to the active site of LmNDK in a similar conformation to nucleotides mimicking natural substrates
CSN27849 Seralutinib 1619931-27-9 Seralutinib is a potent and novel inhaled PDGFR inhibitor, used in the study for pulmonary arterial hypertension.
CSN16131 Sennoside B 128-57-4 Sennoside B inhibits PDGF-stimulated cell proliferation its a kind of irritant laxative isolated from rhei rhizome and leaves of Cassia angustifolia
CSN19118 PP58 212391-58-7 PP58 is a tool compounds in epigenetics.
CSN16549 PP121 1092788-83-4 PP-121 is a multi-targeted inhibitor of PDGFR Hck mTOR VEGFR2 Src and Abl with IC50 of 2 nM 8 nM 10 nM 12 nM 14 nM and 18 nM also inhibits DNA-PK with IC50 of 60 nM
CSN21067 Ponatinib hydrochloride 1114544-31-8 Ponatinib is a multi-targeted kinase inhibitor with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src respectively.
CSN23025 PD0166285 dihydrochloride 212391-63-4 PD 166285 inhibited Src nonreceptor tyrosine kinase, fibroblast growth factor receptor-1, epidermal growth factor receptor and platelet-derived growth factor receptor beta subunit (PDGFR-beta), tyrosine kinases with half-maximal inhibitory potencies (IC50 values) of 8.4 +/- 2.3 nM (n = 6), 39.3 +/- 2.8 nM (n = 16), 87.5 +/- 13.7 nM (n = 6) and 98.3 +/- 7.9 nM (n = 16), respectively.
CSN12340 Pazopanib   444731-52-6 Pazopanib is a multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR FGFR c-Kit and c-Fms with IC50 of 10 nM 30 nM 47 nM 84 nM 74 nM 140 nM and 146 nM respectively
CSN27706 NVP-ACC789   300842-64-2 NVP-ACC789 is a selective VEGFR inhibitor with IC50 values of 0.02μM, 0.18μM and 0.38μM for VEGFR2, VEGFR3 and VEGFR1, respectively, as well as with less potency to PDGFR-β with IC50 value of 1.4μM.
CSN17429 Masitinib mesylate 1048007-93-7 Masitinib Mesylate is an inhibitor for Kit and PDGFR with IC50 of 200 nM and 540800 nM weak inhibition to ABL and c-Fms
CSN12262 Masitinib 790299-79-5 Masitinib is an inhibitor for Kit and PDGFR with IC50 of 200 nM and 540 nM800 nM weak inhibition to ABL and c-Fms
CSN22791 DMPQ dihydrochloride 1123491-15-5 DMPQ 2HCl is a potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) with IC50 of 80 nM.
CSN32934 Crenolanib besylate 670220-93-6 Crenolanib is an orally bioavailable small molecule, targeting the platelet-derived growth factor receptor (PDGFR).
CSN12987 Crenolanib 670220-88-9 Crenolanib is a potent class III RTKs inhibitor with Kd values of 3.2nM, 2.1nM and 0.74nM for PDGFR, PDGFR and FLT3.
CSN16419 CP-673451 343787-29-1 CP-673451 is a selective inhibitor of PDGFR with IC50 of 10 nM1 nM in cell-free assays exhibits 450-fold selectivity over other angiogenic receptors has antiangiogenic and antitumor activity
CSN20482 CGP-53716 152459-94-4 CGP-53716 is a selective tyrosine kinase inhibitor of PDGFR
CSN15883 Agerafenib 1188910-76-0 CEP-32496 is an inhibitor of BRAF V600E (IC50 14 nM), WT (IC50 34 nM) and c-Raf (IC50 39 nM). It also exhibits certain inhibitory activity against Abl-1, c-Kit, Ret, PDGFR and VEGFR2.
CSN10361 Axitinib 319460-85-0 Axitinib is a multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR and c-Kit with IC50 of 01 nM 02 nM 01-03 nM 16 nM and 17 nM in Porcine aorta endothelial cells respectively
CSN26521 (Z)-SKI V 927429-51-4 and a Kd of 3.06 μM. (Z)-SKI V inhibits Aurora A with an IC50 of 1.34 μM. (Z)-SKI V, a benzofuran derivative, has extensive cytotoxic effects on cancer cell lines[1].
CSN12169 Tyrphostin AG1296   146535-11-7 AG 1296 is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR. It also inhibits FGFR and c-Kit with IC50 of 12.3 μM and 1.8 μM in Swiss 3T3 cells.
CSN17731 AC710 Mesylate 1351522-05-8 AC710 mesylate is a potent selective PDGFR-family kinases inhibitor with Kd values of 06 nM10 nM13 nM10 nM for FLT3KITPDGFRPDGFR respectively
CSN17730 AC710 1351522-04-7 AC710 is a potent selective PDGFR-family kinases inhibitor with Kd values of 06 nM10 nM13 nM10 nM for FLT3KITPDGFRPDGFR respectively
CSN26199 SKLB 610 1125780-41-7
CSN40579 N-(p-Coumaroyl) Serotonin 68573-24-0
CSN42653 N-Desmethyl imatinib mesylate 404844-03-7
CSN50397 N-Desmethyl imatinib 404844-02-6
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