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PDGFR
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN25326 | Tyrphostin AG1433 | 168835-90-3 | Tyrphostin AG1433 is a tyrosine kinases inhibitor and also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50s of 5.0 μM and 9.3 μM, respectively. |
| CSN21277 | Tyrosine kinase-IN-1 | 705946-27-6 | Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor with IC50s of 4, 20, 4, 2 nM for KDR, Flt-1, FGFR1 and PDGFRα, respectively. |
| CSN12856 | Orantinib | 252916-29-3 | TSU-68 is a multiple receptor tyrosine kinase inhibitor with IC50 of 2.1 M, 8 nM and 1.2 M for VEGF-R1, PDGF-R and FGF-R1, respectively and has greatest potency against PDGFR autophosphorylation. |
| CSN10166 | Trapidil | 15421-84-8 | Trapidil, a vasodilator and an antiplatelet drug, is also a PDGF antagonist that can inhibit the proliferation of the PDGF-producing glioma cells. |
| CSN17231 | Toceranib phosphate | 874819-74-6 | Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFR. |
| CSN15964 | Toceranib | 356068-94-5 | Toceranib is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFR. |
| CSN12411 | Sunitinib Malate | 341031-54-7 | Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 Flk-1 and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit |
| CSN16761 | Sunitinib | 557795-19-4 | Sunitinib is a multi-targeted RTK inhibitor targeting VEGFR2 Flk-1 and PDGFR with IC50 of 80 nM and 2 nM and also inhibits c-Kit |
| CSN20031 | (Z)-Orantinib | 210644-62-5 | SU6668 is a cell-permeable indolinone compound that acts as a potent ATP-competitive inhibitor against RTKs (receptor tyrosine kinases) Kit, PDGFR, VEGFR2 (Flk-1KDR), FGFR1 activity in vitro (IC50 0.01, 0.1, 3.9, and 3.8 M, respectively) and PDGFVEGFbFGF-mediated angiogenesis and tumor development. Although initially characterized as an RTK inhibitor, SU6668 is now also known to target serthr kinases Aurora A, Aurora B, TBK1 (NAKT2K), and AMPK (IC50 0.85, 0.047, 1.4, and 1.8 M, respectively), as well as non-receptor TKs Lyn and Yes (IC50 4.3 and 5.8 M, respectively). |
| CSN23135 | SU16f | 251356-45-3 | SU16f is a potent and selective platelet-derived growth factor receptor-β (PDGFRβ) inhibitor[1]. |
| CSN15795 | SU14813 maleate | 849643-15-8 | SU14813 maleate is an oral multitargeted tyrosine kinase inhibitor TKI targeting vascular endothelial growth factor receptors VEGFR platelet-derived growth factor receptors PDGFR Kit and fms-like tyrosine kinase 3 FLT-3 |
| CSN12692 | SU14813 | 627908-92-3 | SU14813 is an oral multitargeted tyrosine kinase inhibitor TKI targeting vascular endothelial growth factor receptors VEGFR platelet-derived growth factor receptors PDGFR Kit and fms-like tyrosine kinase 3 FLT-3 |
| CSN20166 | SU11652 | 326914-10-7 | SU11652 is a sunitinib analog with anti-tyrosine-kinase activity also is identified as a potential inhibitor for Leishmania major Lm nucleoside diphosphate kinases NDK and structural studies indicated that this molecule binds to the active site of LmNDK in a similar conformation to nucleotides mimicking natural substrates |
| CSN27849 | Seralutinib | 1619931-27-9 | Seralutinib is a potent and novel inhaled PDGFR inhibitor, used in the study for pulmonary arterial hypertension. |
| CSN16131 | Sennoside B | 128-57-4 | Sennoside B inhibits PDGF-stimulated cell proliferation its a kind of irritant laxative isolated from rhei rhizome and leaves of Cassia angustifolia |
| CSN19118 | PP58 | 212391-58-7 | PP58 is a tool compounds in epigenetics. |
| CSN16549 | PP121 | 1092788-83-4 | PP-121 is a multi-targeted inhibitor of PDGFR Hck mTOR VEGFR2 Src and Abl with IC50 of 2 nM 8 nM 10 nM 12 nM 14 nM and 18 nM also inhibits DNA-PK with IC50 of 60 nM |
| CSN21067 | Ponatinib hydrochloride | 1114544-31-8 | Ponatinib is a multi-targeted kinase inhibitor with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src respectively. |
| CSN23025 | PD0166285 dihydrochloride | 212391-63-4 | PD 166285 inhibited Src nonreceptor tyrosine kinase, fibroblast growth factor receptor-1, epidermal growth factor receptor and platelet-derived growth factor receptor beta subunit (PDGFR-beta), tyrosine kinases with half-maximal inhibitory potencies (IC50 values) of 8.4 +/- 2.3 nM (n = 6), 39.3 +/- 2.8 nM (n = 16), 87.5 +/- 13.7 nM (n = 6) and 98.3 +/- 7.9 nM (n = 16), respectively. |
| CSN12340 | Pazopanib | 444731-52-6 | Pazopanib is a multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR FGFR c-Kit and c-Fms with IC50 of 10 nM 30 nM 47 nM 84 nM 74 nM 140 nM and 146 nM respectively |
| CSN27706 | NVP-ACC789 | 300842-64-2 | NVP-ACC789 is a selective VEGFR inhibitor with IC50 values of 0.02μM, 0.18μM and 0.38μM for VEGFR2, VEGFR3 and VEGFR1, respectively, as well as with less potency to PDGFR-β with IC50 value of 1.4μM. |
| CSN17429 | Masitinib mesylate | 1048007-93-7 | Masitinib Mesylate is an inhibitor for Kit and PDGFR with IC50 of 200 nM and 540800 nM weak inhibition to ABL and c-Fms |
| CSN12262 | Masitinib | 790299-79-5 | Masitinib is an inhibitor for Kit and PDGFR with IC50 of 200 nM and 540 nM800 nM weak inhibition to ABL and c-Fms |
| CSN22791 | DMPQ dihydrochloride | 1123491-15-5 | DMPQ 2HCl is a potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) with IC50 of 80 nM. |
| CSN32934 | Crenolanib besylate | 670220-93-6 | Crenolanib is an orally bioavailable small molecule, targeting the platelet-derived growth factor receptor (PDGFR). |
| CSN12987 | Crenolanib | 670220-88-9 | Crenolanib is a potent class III RTKs inhibitor with Kd values of 3.2nM, 2.1nM and 0.74nM for PDGFR, PDGFR and FLT3. |
| CSN16419 | CP-673451 | 343787-29-1 | CP-673451 is a selective inhibitor of PDGFR with IC50 of 10 nM1 nM in cell-free assays exhibits 450-fold selectivity over other angiogenic receptors has antiangiogenic and antitumor activity |
| CSN20482 | CGP-53716 | 152459-94-4 | CGP-53716 is a selective tyrosine kinase inhibitor of PDGFR |
| CSN15883 | Agerafenib | 1188910-76-0 | CEP-32496 is an inhibitor of BRAF V600E (IC50 14 nM), WT (IC50 34 nM) and c-Raf (IC50 39 nM). It also exhibits certain inhibitory activity against Abl-1, c-Kit, Ret, PDGFR and VEGFR2. |
| CSN10361 | Axitinib | 319460-85-0 | Axitinib is a multi-target inhibitor of VEGFR1 VEGFR2 VEGFR3 PDGFR and c-Kit with IC50 of 01 nM 02 nM 01-03 nM 16 nM and 17 nM in Porcine aorta endothelial cells respectively |
| CSN26521 | (Z)-SKI V | 927429-51-4 | and a Kd of 3.06 μM. (Z)-SKI V inhibits Aurora A with an IC50 of 1.34 μM. (Z)-SKI V, a benzofuran derivative, has extensive cytotoxic effects on cancer cell lines[1]. |
| CSN12169 | Tyrphostin AG1296 | 146535-11-7 | AG 1296 is an inhibitor of PDGFR with IC50 of 0.3-0.5 μM, no activity to EGFR. It also inhibits FGFR and c-Kit with IC50 of 12.3 μM and 1.8 μM in Swiss 3T3 cells. |
| CSN17731 | AC710 Mesylate | 1351522-05-8 | AC710 mesylate is a potent selective PDGFR-family kinases inhibitor with Kd values of 06 nM10 nM13 nM10 nM for FLT3KITPDGFRPDGFR respectively |
| CSN17730 | AC710 | 1351522-04-7 | AC710 is a potent selective PDGFR-family kinases inhibitor with Kd values of 06 nM10 nM13 nM10 nM for FLT3KITPDGFRPDGFR respectively |
| CSN26199 | SKLB 610 | 1125780-41-7 | |
| CSN40579 | N-(p-Coumaroyl) Serotonin | 68573-24-0 | |
| CSN42653 | N-Desmethyl imatinib mesylate | 404844-03-7 | |
| CSN50397 | N-Desmethyl imatinib | 404844-02-6 |
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