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PD-1/PD-L1

PD-1/PD-L1

Cat. No. Product Name CAS No. Information
CSN28490 PROTAC PD-1/PD-L1 degrader-1 2447066-37-5 PROTAC PD-1/PD-L1 degrader-1, a PD-1/PD-L1 degrader, inhibits PD-1/PD-L1 interaction with an IC50 of 39.2 nM. PROTAC PD-1/PD-L1 degrader-1 significantly restores the immunity repressed in a co-culture model of Hep3B/OS-8/hPD-L1 and CD3 T cells. PROTAC PD-1/PD-L1 degrader-1 moderately reduces the protein levels of PD-L1 in a lysosome-dependent manner.
CSN17334 BMS-202   1675203-84-5 PD1-PDL1 inhibitor 2 is an inhibitor of the PD-1 (Programmed death- 1) PD-Ll (Programmed death-ligand 1) proteinprotein interaction with IC50 of 18 nM.
CSN16212 BMS-1 1675201-83-8 PD-1PD-L1 inhibitor 1 is a small-molecule inhibitor of PD-1PD-L1 interaction with IC50 of 6 nM.
CSN19235 PD-1/PD-L1-IN 3 1629654-95-0 PD-1/PD-L1 Inhibitor 3 is capable of inhibiting the interaction of PD-L1 with PD-1 and with CD80.
CSN20302 PD-1-PDL1 Inhibitor C1a HCl 2108101-94-4 PD-1-PD-L1 inhibitor C1a is a potential inhibitor of PD-1PD-L1 interaction which exhibits the structures capped on one side of the channel of PD-L1 homodimer
CSN23861 PD-1-IN-17 1673560-66-1 PD-1-IN-17 is a programmed cell death-1 (PD-1) inhibitor extracted from patent WO2015033301A1, Compound 12, inhibits 92% splenocyte proliferation at 100 nM[1].
CSN24495 BMS-1166 1818314-88-3 BMS-1166 can disrupt PD-1/PD-L1 interaction with IC50 value of 1.4nM. It can antagonize the inhibitory effect of PD-1/PD-L1 immune checkpoint on T cell activation.
CSN26733 BMS-1001 hydrochloride 2113650-04-5 BMS-1001 HCl is an orally active human PD-L1/PD-1 immune checkpoint inhibitor. BMS-1001 HCl exhibits low-toxicity in cells. BMS-1001 binds to human PD-L1 and blocks its interaction with PD-1.
CSN24471 CA-170 1673534-76-3 AUPM-170 is one of CA-170 analogues extracted from patent WO 2015033299 A1, compound example 4.
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