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PARP
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN13593 | XAV-939 | 284028-89-3 | XAV-939 is a selective Wnt pathway -catenin-mediated transcription inhibitor and axin stabilizing agent with IC50 values of 11 and 4 nM for the inhibition of TNKS1 and TNKS2 respectively |
| CSN15823 | WIKI4 | 838818-26-1 | WIKI4 is a potent inhibitor of Wnt-catenin signaling EC50 75 nM and inhibits auto-ADP-ribosylation of tankyrase 2 TNKS2 IC50 15 nM |
| CSN12302 | Veliparib | 912444-00-9 | Veliparib is a potent inhibitor of PARP1 and PARP2 with Ki of 52 nM and 29 nM respectively |
| CSN12301 | Veliparib 2HCl | 912445-05-7 | Veliparib 2HCl is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM, respectively. |
| CSN17138 | UPF-1069 | 1048371-03-4 | UPF 1069 is a selective PARP2 inhibitor with IC50 of 03 M which is 27-fold selective against PARP1 |
| CSN13901 | Rucaparib Phosphate | 459868-92-9 | Rucaparib phosphate is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains. |
| CSN13914 | Rucaparib | 283173-50-2 | Rucaparib is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains. |
| CSN23902 | RK-287107 | 2171386-10-8 | RK-287107 is a novel tankyrase-specific inhibitor with IC50 values of 14.3 nM and 10.6 nM for tankyrase-1 and tankyrase-2, respectively. |
| CSN27229 | (S)-5-((1-(3-Oxo-3-(4-(5-(trifluoromethyl)pyrimidin-2-yl)piperazin-1-yl)propoxy)propan-2-yl)amino)-4-(trifluoromethyl)pyridazin-3(2H)-one | 2381037-82-5 | RBN-2397 is a potent, accross species and orally active NAD+ competitive inhibitor of PARP7 (IC50<3 nM). RBN-2397 selectively binds to PARP7 (Kd=0.001 μM) and restores IFN signaling. RBN-2397 has the potential for the study of advanced or metastatic solid tumors . |
| CSN17163 | PJ34 | 344458-19-1 | PJ34 is a potent specific inhibitor of PARPl2 with IC50 of 110 nM and 86 nM respectively |
| CSN13594 | PJ34 HCl | 344458-15-7 | PJ34 HCl is a potent specific inhibitor of PARP-l2 with IC50 of 110 nM and 86 nM |
| CSN11806 | Picolinamide | 1452-77-3 | Picolinamide is found to be a strong inhibitor of poly ADP-ribose synthetase of nuclei from rat pancreatic islet cells |
| CSN23081 | Rucaparib Camsylate | 1327258-57-0 | PARP inhibitor |
| CSN12345 | Olaparib | 763113-22-0 | Olaparib is a potent PARP inhibitor with IC50 of 5 and 1 nM for PARP1 and PARP2, respectively. |
| CSN19737 | OL-1 | 2051582-06-8 | OL-1 is a PARP1 inhibitor with apoptosis-inducing mechanisms in triple-negative breast cancer |
| CSN13750 | NVP-TNKS656 | 1419949-20-4 | NVP-TNKS656 is a highly potent selective and orally active TNKS2 inhibitor with IC50 of 6 nM showing 300 fold selectivity against PARP1 and PARP2 |
| CSN27556 | Nudifloramide | 701-44-0 | Nudifloramide (2PY) is one of the end products of nicotinamide-adenine dinucleotide (NAD) degradation. Nudifloramide significantly inhibits poly(ADP-ribose) polymerase (PARP-1) activity in vitro. |
| CSN10181 | NU1025 | 90417-38-2 | NU1025 is a potent PARP inhibitor with IC50 of 400 nM |
| CSN19131 | Niraparib Metabolite M1 | 1476777-06-6 | Niraparib metabolite M1 is a metabolite of niraparib, which acts as a poly (ADP-Ribose) polymerase (PARP) inhibitor. |
| CSN16905 | MN-64 | 92831-11-3 | MN-64 is an inhibitor of tankyrases showed 6 nM potency against tankyrase 1 isoenzyme selectivity and Wnt signaling inhibition |
| CSN17416 | MK-4827 Tosylate | 1038915-73-9 | MK-4827 tosylate is a selective inhibitor of PARP1PARP2 with IC50 of 38 nM21 nM and with great activity in cancer cells with mutant BRCA-1 and BRCA-2 and 330-fold selective against PARP3 V-PARP and Tank1 |
| CSN21302 | MK-4827 R-enantiomer | 1038915-58-0 | MK-4827 R-enantiomer is an excellent PARP1 inhibitor with IC50 of 2.4 nM. |
| CSN13146 | MK-4827 | 1038915-60-4 | MK-4827 is an excellent PARP1 and PARP2 inhibitor with IC50 of 38 and 21 nM respectively |
| CSN17415 | MK-4827 HCl | 1038915-64-8 | MK-4827 HCl is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM, showing great activity in cancer cells with mutant BRCA-1 and BRCA-2, and is > 330-fold selective against PARP3, V-PARP and Tank1. |
| CSN19194 | ME0328 | 1445251-22-8 | ME0328 is a potent and selective PARP inhibitor with IC50 of 089 M for PARP3 about 7-fold selectivity over PARP1 |
| CSN19692 | LT-626 | 1207456-03-8 | LT-626 functions as an effective radiosensitizer during fractionated radiation treatment leading to significant decrease in tumor burden and doubling the median survival |
| CSN16009 | JW 55 | 664993-53-7 | JW 55 is a potent and selective -catenin signaling pathway inhibitor which functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 TNKS12 JW55 decreases auto-PARsylation of TNKS12 in vitro with IC50s of 19 M and 830 nM respectively |
| CSN17047 | INO-1001 | 3544-24-9 | INO-1001 is a potent inhibitor of PARP with IC50 of 50 nM in CHO cells and a mediator of oxidant-induced myocyte dysfunction during reperfusion. |
| CSN24184 | GeA-69 | 2143475-98-1 | GeA-69 is a selective PARP14 inhibitor with Kd value of 2.1 µM, targeting on macrodomain 2. |
| CSN17770 | G007-LK | 1380672-07-0 | G007-LK is a potent and selective tankyrase inhibitor with IC50 of 46 nM and 25 nM for TNKS12 respectively |
| CSN17497 | E-7449 | 1140964-99-3 | E7449 is an orally bioavailable potent small molecule inhibitor of PARP1 and PARP2 and enhances the efficacy of radiotherapy and chemotherapy and has potent single agent anticancer activity in BRCA-deficient tumors |
| CSN25274 | BYK204165 | 1104546-89-5 | BYK204165 is a potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor (pIC50 values are 5.38 and 7.35 for PARP-2 and PARP-1 respectively). |
| CSN12304 | BSI-201 | 160003-66-7 | BSI-201 is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC). |
| CSN15885 | BMN-673 | 1207456-01-6 | BMN-673 is a PARP12 inhibitor with IC50 of 0.57 nM for PARP1. |
| CSN16087 | BMN-673 8R,9S | 1207456-00-5 | BMN-673 8R9S is an enantiomer of BMN-673 which is a PARP12 inhibitor with IC50 of 057 nM for PARP1 |
| CSN12830 | BGP-15 | 66611-37-8 | BGP-15 is a nicotinic amidoxime derivative with PARP inhibitory activity It has been demonstrated that BGP-15 protects against ischemia-reperfusion injury |
| CSN21993 | Pamiparib | 1446261-44-4 | BGB-290 shows potent DNA-trapping activity with IC50 of 13 nM In the cellular assays BGB-290 inhibits intracellular PAR formation with an IC50 of 024 nM |
| CSN10401 | Benzamide | 55-21-0 | Benzamide an inhibitor of poly ADP-ribose polymerase is a derivative of benzoic acid |
| CSN16496 | AZD2461 | 1174043-16-3 | AZD2461 is a PARP inhibitor which has the potential to avoid the olaparib resistence mediated by Pgp |
| CSN17985 | AZ6102 | 1645286-75-4 | AZ6102 is a potent TNKS12 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells |
| CSN18861 | AZ1366 | 1645286-58-3 | AZ1366 inhibits tankyrase as a cotreatment strategy with EGFR inhibition in an identifiable subset of EGFR-driven NSCLC |
| CSN17188 | AG-14361 | 328543-09-5 | AG14361 is a potent inhibitor of PARP1 with Ki of 5 nM |
| CSN16464 | A-966492 | 934162-61-5 | A-966492 is a potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 15 nM respectively |
| CSN22652 | 4-HQN | 491-36-1 | 4-HQN is a PARP inhibitor with IC50 of 95 M |
| CSN23547 | 3-Methoxybenzamide | 5813-86-5 | 3-Methoxybenzamide is a competitive poly(ADP-ribose) synthetase inhibitor with Ki value < 2 μM and also inhibits ADP-ribosyltransferase (ADPRT). |
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