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PARP

PARP

Cat. No. Product Name CAS No. Information
CSN13593 XAV-939     284028-89-3 XAV-939 is a selective Wnt pathway -catenin-mediated transcription inhibitor and axin stabilizing agent with IC50 values of 11 and 4 nM for the inhibition of TNKS1 and TNKS2 respectively
CSN15823 WIKI4   838818-26-1 WIKI4 is a potent inhibitor of Wnt-catenin signaling EC50 75 nM and inhibits auto-ADP-ribosylation of tankyrase 2 TNKS2 IC50 15 nM
CSN12302 Veliparib     912444-00-9 Veliparib is a potent inhibitor of PARP1 and PARP2 with Ki of 52 nM and 29 nM respectively
CSN12301 Veliparib 2HCl 912445-05-7 Veliparib dihydrochloride is a potent inhibitor of PARP1 and PARP2 with Ki of 52 nM and 29 nM respectively
CSN17138 UPF-1069 1048371-03-4 UPF 1069 is a selective PARP2 inhibitor with IC50 of 03 M which is 27-fold selective against PARP1
CSN13901 Rucaparib Phosphate 459868-92-9 Rucaparib phosphate is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains.
CSN13914 Rucaparib   283173-50-2 Rucaparib is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains.
CSN23902 RK-287107 2171386-10-8 RK-287107 is a novel tankyrase-specific inhibitor with IC50 values of 14.3 nM and 10.6 nM for tankyrase-1 and tankyrase-2, respectively.
CSN17163 PJ34 344458-19-1 PJ34 is a potent specific inhibitor of PARPl2 with IC50 of 110 nM and 86 nM respectively
CSN13594 PJ34 HCl 344458-15-7 PJ34 HCl is a potent specific inhibitor of PARP-l2 with IC50 of 110 nM and 86 nM
CSN11806 Picolinamide   1452-77-3 Picolinamide is found to be a strong inhibitor of poly ADP-ribose synthetase of nuclei from rat pancreatic islet cells
CSN12345 Olaparib     763113-22-0 Olaparib is a potent PARP inhibitor with IC50 of 5 and 1 nM for PARP1 and PARP2, respectively.
CSN19737 OL-1 2051582-06-8 OL-1 is a PARP1 inhibitor with apoptosis-inducing mechanisms in triple-negative breast cancer
CSN13750 NVP-TNKS656 1419949-20-4 NVP-TNKS656 is a highly potent selective and orally active TNKS2 inhibitor with IC50 of 6 nM showing 300 fold selectivity against PARP1 and PARP2
CSN10181 NU1025 90417-38-2 NU1025 is a potent PARP inhibitor with IC50 of 400 nM
CSN16905 MN-64   92831-11-3 MN-64 is an inhibitor of tankyrases showed 6 nM potency against tankyrase 1 isoenzyme selectivity and Wnt signaling inhibition
CSN17416 MK-4827 Tosylate 1038915-73-9 MK-4827 tosylate is a selective inhibitor of PARP1PARP2 with IC50 of 38 nM21 nM and with great activity in cancer cells with mutant BRCA-1 and BRCA-2 and 330-fold selective against PARP3 V-PARP and Tank1
CSN21302 MK-4827 R-enantiomer 1038915-58-0 MK-4827 R-enantiomer is an excellent PARP1 inhibitor with IC50 of 2.4 nM.
CSN13146 MK-4827   1038915-60-4 MK-4827 is an excellent PARP1 and PARP2 inhibitor with IC50 of 38 and 21 nM respectively
CSN17415 MK-4827 HCl 1038915-64-8 MK-4827 hydrochloride is a selective inhibitor of PARP1PARP2 with IC50 of 38 nM21 nM showing great activity in cancer cells with mutant BRCA-1 and BRCA-2 and is 330-fold selective against PARP3 V-PARP and Tank1
CSN19194 ME0328   1445251-22-8 ME0328 is a potent and selective PARP inhibitor with IC50 of 089 M for PARP3 about 7-fold selectivity over PARP1
CSN19692 LT-626 1207456-03-8 LT-626 functions as an effective radiosensitizer during fractionated radiation treatment leading to significant decrease in tumor burden and doubling the median survival
CSN16009 JW 55 664993-53-7 JW 55 is a potent and selective -catenin signaling pathway inhibitor which functions via inhibition of the PARP domain of tankyrase 1 and tankyrase 2 TNKS12 JW55 decreases auto-PARsylation of TNKS12 in vitro with IC50s of 19 M and 830 nM respectively
CSN17047 INO-1001   3544-24-9 INO-1001 is a potent inhibitor of PARP with IC50 of 50 nM in CHO cells and a mediator of oxidant-induced myocyte dysfunction during reperfusion.
CSN17770 G007-LK 1380672-07-0 G007-LK is a potent and selective tankyrase inhibitor with IC50 of 46 nM and 25 nM for TNKS12 respectively
CSN17497 E-7449 1140964-99-3 E7449 is an orally bioavailable potent small molecule inhibitor of PARP1 and PARP2 and enhances the efficacy of radiotherapy and chemotherapy and has potent single agent anticancer activity in BRCA-deficient tumors
CSN12304 BSI-201   160003-66-7 BSI-201 is a PARP1 inhibitor with demonstrated effectiveness in triple-negative breast cancer (TNBC).
CSN15885 BMN-673   1207456-01-6 BMN-673 is a PARP12 inhibitor with IC50 of 0.57 nM for PARP1.
CSN16087 BMN-673 8R,9S 1207456-00-5 BMN-673 8R9S is an enantiomer of BMN-673 which is a PARP12 inhibitor with IC50 of 057 nM for PARP1
CSN12830 BGP-15   66611-37-8 BGP-15 is a nicotinic amidoxime derivative with PARP inhibitory activity It has been demonstrated that BGP-15 protects against ischemia-reperfusion injury
CSN21993 Pamiparib 1446261-44-4 BGB-290 shows potent DNA-trapping activity with IC50 of 13 nM In the cellular assays BGB-290 inhibits intracellular PAR formation with an IC50 of 024 nM
CSN10401 Benzamide   55-21-0 Benzamide an inhibitor of poly ADP-ribose polymerase is a derivative of benzoic acid
CSN16496 AZD2461   1174043-16-3 AZD2461 is a PARP inhibitor which has the potential to avoid the olaparib resistence mediated by Pgp
CSN17985 AZ6102 1645286-75-4 AZ6102 is a potent TNKS12 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells
CSN18861 AZ1366 1645286-58-3 AZ1366 inhibits tankyrase as a cotreatment strategy with EGFR inhibition in an identifiable subset of EGFR-driven NSCLC
CSN17188 AG-14361 328543-09-5 AG14361 is a potent inhibitor of PARP1 with Ki of 5 nM
CSN16464 A-966492 934162-61-5 A-966492 is a potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 15 nM respectively
CSN22652 4-HQN   491-36-1 4-HQN is a PARP inhibitor with IC50 of 95 M
CSN23081 Rucaparib Camsylate 1327258-57-0
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