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PAR

PAR

Cat. No. Product Name CAS No. Information
CSN13782 Vorapaxar 618385-01-6 Vorapaxar is a thrombin receptor protease-activated receptor PAR-1 antagonist
CSN17809 TRAP-6   141136-83-6 TRAP-6 is protease-activated receptor 1 (PAR1) agonist.
CSN23082 RWJ-56110 252889-88-6 RWJ-56110 is a selective protease-activated receptor-1 (PAR1) antagonist. It blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs.
CSN23119 Protease-Activated Receptor-2, amide 190383-13-2 Protease-Activated Receptor-2, amide (SLIGKV-NH2) is a highly potent protease-activated receptor-2 (PAR2) activating peptide.
CSN23110 SCH79797 dihydrochloride 1216720-69-2 Potent, selective non-peptide PAR1 antagonist
CSN13679 Parmodulin 2   423735-93-7 ML-161 is an allosteric and reversible inhibitor of proteinase-activated receptor 1 PAR1 with IC50 of 026 M
CSN24477 I-191 1690172-25-8 I-191 inhibited PAR2 binding of and activation by structurally distinct PAR2 agonists (trypsin, peptide, nonpeptide) at nanomolar concentrations.
CSN25350 GB-88 1416435-96-5 GB-88 is an oral, selective non-peptide antagonist of PAR2. It inhibits PAR2 activated Ca2+ release with an IC50 of 2 µM.
CSN22822 FR-171113 173904-50-2 FR 171113 is a protease-activated receptor 1 (PAR1) antagonist.
CSN24830 ENMD-1068 789488-77-3 ENMD-1068 is a PAR2 anatagonist with IC50 value of 1.2mM.
CSN22353 AZ3451 2100284-59-9 AZ3451 is a protease-activated receptor-2 (PAR2) antagonist.
CSN21664 PAR-4 Agonist Peptide, amide 352017-71-1 AY-NH2 is a peptide agonist of proteinase-activated receptor 4 (PAR4) that induces aggregation of platelets in vitro. 
CSN24081 Atopaxar 751475-53-3 Atopaxar, also known as E5555, is a potent and orally-active PAR-1 inhibitor. E5555 inhibited the binding of a high-affinity thrombin receptor-activating peptide ([(3)H]haTRAP) to PAR-1 with a half maximal inhibitory concentration (IC(50)) value of 0.019μM. E5555 showed potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC(50) values of 0.064 and 0.031μM, respectively. E5555 showed potent and selective inhibitory effects on guinea pig platelet aggregation induced by thrombin and TRAP with IC(50) values of 0.13 and 0.097μM, respectively. E5555 could be a therapeutic option for atherothrombotic disease.
CSN18572 AC-55541   916170-19-9 AC-55541 is a small-molecule protease-activated receptor 2 PAR2 agonist and activates PAR2 signaling in cellular proliferation assays phosphatidylinositol hydrolysis assays and Ca2 mobilization assays with potencies ranging from 200 to 1000 nM
CSN22664 AC-264613 1051487-82-1 AC 264613 is a potent and selective protease-activated receptor 2 (PAR2) agonist with pEC50 = 7.5.
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