|PF-3758309 is an inhbitor of PAKs with IC50 of 13 nM for PAK4 which inhbits tumor growth in HCT116 A549 M24met and other xenograft tumor models
|PAK4-IN-1 is an inhibitor of p21-activated kinases PAKs with IC50 of 100 nM in MTT assay
|NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM).
|NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1 a serine-threonine kinase that is upregulated in many cancers NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay
|LCH-7749944 is a novel and potent p21-activated kinase 4 (PAK4) inhibitor that suppresses proliferation and invasion in human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and causes successful inhibition of EGFR activity.
|IPA-3 is a selective non-ATP competitive PAK1 inhibitor with IC50 of 25 M no inhibition to group II PAKs PAKs 4-6
|G-5555 is a selective PAK1 inhibitor Ki37 nM
|FRAX597 a small-molecule pyridopyrimidinone is a potent and ATP competitive inhibitor of the group I PAKs PAK1 IC50 8 nM PAK2 IC50 13 nM PAK3 IC50 19 nM
|FRAX486 is a selective inhibitor of group I PAKs with IC50s of 825395 553 nM for PAK1PAK2PAK3 respectivelt and less potent for PAK4 IC50779 nM
|FRAX-1036 is a potent and selective PAK1 inhibitor
|APTO-253 is a small molecule with potent anti-tumor activity in cancer cells via induction of the gene that expresses the Kruppel-like factor 4 (KLF4) master transcription factor, leading to cell cycle inhibition and programmed cell death.