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PAK
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN17173 | PF-3758309 | 898044-15-0 | PF-3758309 is an inhbitor of PAKs with IC50 of 13 nM for PAK4 which inhbits tumor growth in HCT116 A549 M24met and other xenograft tumor models |
| CSN17983 | KPT 9274 ( ATG-019) | 1643913-93-2 | PAK4-IN-1 is an inhibitor of p21-activated kinases PAKs with IC50 of 100 nM in MTT assay |
| CSN26728 | NVS-PAK1-C | 2250019-95-3 | NVS-PAK1-C is a potent, ATP-competitive and specific allosteric PAK1 inhibitor probe with IC50 values of 5 nM and 6 nM for dephosphorylated PAK1 and phosphorylated PAK1, respectively. NVS-PAK1-C is also against dephosphorylated PAK2 (IC50=270 nM) and phosphorylated PAK2 (IC50=720 nM)[1]. |
| CSN20017 | NVS-PAK1-1 | 1783816-74-9 | NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1 a serine-threonine kinase that is upregulated in many cancers NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay |
| CSN25301 | LCH-7749944 | 796888-12-5 | LCH-7749944 is a novel and potent p21-activated kinase 4 (PAK4) inhibitor that suppresses proliferation and invasion in human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and causes successful inhibition of EGFR activity. |
| CSN18267 | IPA-3 | 42521-82-4 | IPA-3 is a selective non-ATP competitive PAK1 inhibitor with IC50 of 25 M no inhibition to group II PAKs PAKs 4-6 |
| CSN17987 | G-5555 | 1648863-90-4 | G-5555 is a selective PAK1 inhibitor Ki37 nM |
| CSN15824 | FRAX597 | 1286739-19-2 | FRAX597 a small-molecule pyridopyrimidinone is a potent and ATP competitive inhibitor of the group I PAKs PAK1 IC50 8 nM PAK2 IC50 13 nM PAK3 IC50 19 nM |
| CSN17596 | FRAX486 | 1232030-35-1 | FRAX486 is a selective inhibitor of group I PAKs with IC50s of 825395 553 nM for PAK1PAK2PAK3 respectivelt and less potent for PAK4 IC50779 nM |
| CSN17853 | FRAX1036 | 1432908-05-8 | FRAX-1036 is a potent and selective PAK1 inhibitor |
| CSN18571 | APTO-253 | 916151-99-0 | APTO-253 is a small molecule with potent anti-tumor activity in cancer cells via induction of the gene that expresses the Kruppel-like factor 4 (KLF4) master transcription factor, leading to cell cycle inhibition and programmed cell death. |
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