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PAK

PAK

Cat. No. Product Name CAS No. Information
CSN20017 NVS-PAK1-1 1783816-74-9 NVS-PAK1-1 is a potent allosteric inhibitor of p21-activated kinase PAK1 a serine-threonine kinase that is upregulated in many cancers NVS-PAK1-1 has an IC50 value of 5 nM for dephoshorylated PAK1 and 6 nM for phosphorylated PAK1 in an in vitro dephosphorylation assay
CSN25301 LCH 7749944 796888-12-5 LCH-7749944 is a novel and potent p21-activated kinase 4 (PAK4) inhibitor that suppresses proliferation and invasion in human gastric cancer cells through downregulation of PAK4/c-Src/EGFR/cyclin D1 pathway and causes successful inhibition of EGFR activity.
CSN18267 IPA-3 42521-82-4 IPA-3 is a selective non-ATP competitive PAK1 inhibitor with IC50 of 25 M no inhibition to group II PAKs PAKs 4-6
CSN18571 APTO-253 916151-99-0 APTO-253 is a small molecule with potent anti-tumor activity in cancer cells via induction of the gene that expresses the Kruppel-like factor 4 (KLF4) master transcription factor, leading to cell cycle inhibition and programmed cell death.
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