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p53

p53

Cat. No. Product Name CAS No. Information
CSN17139 YH239-EE 1364488-67-4 YH239-EE ethyl ester of the free carboxylic acid compound YH239 is a potent p53-MDM2 antagonizing and apoptosis-inducing agent
CSN16937 Tenovin-3   1011301-27-1 Tenovin-3 is able to increase p53 levels determined in MCF-7 cells treated for 6 hr at 10 M
CSN15970 Tenovin 1   380315-80-0 Tenovin-1 is an inhibitor of SIRT1 and SIRT2 and an activator of p21 and p53 It protects against MDM2-mediated p53 degradation which involves ubiquitination and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2
CSN13427 JNJ-26854165 881202-45-5 Serdemetan acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells and inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53
CSN11769 PRIMA-1   5608-24-2 PRIMA-1 is a mutant p53 reactivator It induces apoptosis and inhibits growth of human tumors with mutant p53
CSN19860 Plumbagin 481-42-5 Plumbagin is an anticancer agent, induces G2M cell cycle arrest and apoptosis in A549 cells through JNK-dependent p53 Ser15 phosphorylation and inhibits A549 and MDA-MD-231 tumour xenograft growth in nude mice.
CSN22900 PK11007   38275-34-2 PK11007 is a p53 targeting compond anti-tumor activities
CSN11696 Pifithrin-μ 64984-31-2 Pifithrin- is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.
CSN18356 Pifithrin-β 60477-34-1 Pifithrin- is a potent p53 inhibitor with IC50 of 23 M in an antiproliferative assay in the human ovarian carcinoma cell line, IGROV-1.
CSN16583 Pifithrin-α Hydrobromide 63208-82-2 Pifithrin- hydrobromide is an inhibitor of p53 inhibiting p53-dependent transactivation of p53-responsive genes
CSN16420 Pifithrin-β Hydrobromide   511296-88-1 Pifithrin- hydrobromide is a potent p53 inhibitor with IC50 of 23 M in an antiproliferative assay in the human ovarian carcinoma cell line, IGROV-1.
CSN13166 p53 and MDM2 Proteins-interaction-inhibitor Racemic 939983-14-9 p53 and MDM2 proteins-interaction-inhibitor racemate is an inhibitor of the interaction between p53 and MDM2 proteins
CSN18899 p53 and MDM2 proteins-interaction-inhibitor 2HCl 2070009-27-5 p53 and MDM2 proteins-interaction-inhibitor dihydrochloride is an inhibitor of the interaction between p53 and MDM2 proteins
CSN12393 p53 and MDM2 Proteins-interaction-inhibitor Chiral 939981-37-0 p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins
CSN16560 NSC 319726   71555-25-4 NSC319726 is a mutant p53R175 reactivator inhibiting growth of fibroblasts expressing the p53R175 mutation IC50 8 nM and showing no inhibition for p53 wild-type cells
CSN15898 MI-773 1303607-07-9 MI-773 is an orally available spiro-oxindole HDM2 human double minute 2 antagonist with potential antineoplastic activity
CSN17245 Kevetrin HCl   66592-89-0 Kevetrin HCl is an activator of the tumor suppressor protein p53 with potential antineoplastic activity
CSN20519 CP-31398 2HCl 1217195-61-3 CP-31398 dihydrochloride is a p53 stabilizing agent which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53
CSN23315 COTI-2   1039455-84-9 COTI-2 is an orally available thiosemicarbazone and mutant p53 activator with potential antineoplastic activity
CSN17044 APR-246 5291-32-7 APR-246 is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types
CSN17736 AMG-232 1352066-68-2 AMG-232 is a highly potent selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction SPR KD 0045 nM SJSA-1 EdU IC5091 nM
CSN19769 10-Shogaol 36752-54-2 10-Shogaol a natural product isolated and purified from the rhizomes of Zingber officinale Rosc an antioxidant for human skin cell growth and a migration enhancer with potential to be a wound repair agent has similar metabolic profiles to 6-shogaol and exhibit similar toxicity toward human colon cancer cells
CSN23065 RETRA HCl 1173023-52-3
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