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p53
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN17139 | YH239-EE | 1364488-67-4 | YH239-EE ethyl ester of the free carboxylic acid compound YH239 is a potent p53-MDM2 antagonizing and apoptosis-inducing agent |
| CSN26409 | Amifostine thiol dihydrochloride | 14653-77-1 | WR-1065 dihydrochloride can protect normal tissues from the toxic effects of certain cancer drugs and activate p53 through a JNK-dependent signaling pathway and also exhibits broad spectrum antiviral activity in vitro. |
| CSN16937 | Tenovin-3 | 1011301-27-1 | Tenovin-3 is able to increase p53 levels determined in MCF-7 cells treated for 6 hr at 10 M |
| CSN15970 | Tenovin-1 | 380315-80-0 | Tenovin-1 is an inhibitor of SIRT1 and SIRT2 and an activator of p21 and p53 It protects against MDM2-mediated p53 degradation which involves ubiquitination and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2 |
| CSN13427 | Serdemetan | 881202-45-5 | Serdemetan acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells and inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53 |
| CSN15939 | RITA | 213261-59-7 | RITA induced both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks. It is MDM2-p53 interaction inhibitor and activates p53 expression. |
| CSN11769 | PRIMA-1 | 5608-24-2 | PRIMA-1 is a mutant p53 reactivator It induces apoptosis and inhibits growth of human tumors with mutant p53 |
| CSN19860 | Plumbagin | 481-42-5 | Plumbagin is an anticancer agent, induces G2M cell cycle arrest and apoptosis in A549 cells through JNK-dependent p53 Ser15 phosphorylation and inhibits A549 and MDA-MD-231 tumour xenograft growth in nude mice. |
| CSN25246 | PK11007 | 874146-69-7 | PK11007 is mild thiol alkylator with anticancer activity in several cell lines, especially those with mutationally compromised p53. |
| CSN22900 | PK11000 | 38275-34-2 | PK11007 is a p53 targeting compond anti-tumor activities |
| CSN11696 | Pifithrin-μ | 64984-31-2 | Pifithrin- is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy. |
| CSN18356 | Pifithrin-β | 60477-34-1 | Pifithrin- is a potent p53 inhibitor with IC50 of 23 M in an antiproliferative assay in the human ovarian carcinoma cell line, IGROV-1. |
| CSN16583 | Pifithrin-α hydrobromide | 63208-82-2 | Pifithrin- hydrobromide is an inhibitor of p53 inhibiting p53-dependent transactivation of p53-responsive genes |
| CSN16420 | Pifithrin-β hydrobromide | 511296-88-1 | Pifithrin- hydrobromide is a potent p53 inhibitor with IC50 of 23 M in an antiproliferative assay in the human ovarian carcinoma cell line, IGROV-1. |
| CSN13166 | p53 and MDM2 proteins-interaction-inhibitor (racemic) | 939983-14-9 | p53 and MDM2 proteins-interaction-inhibitor racemate is an inhibitor of the interaction between p53 and MDM2 proteins |
| CSN12393 | p53 and MDM2 proteins-interaction-inhibitor (chiral) | 939981-37-0 | p53 and MDM2 proteins-interaction-inhibitor chiral is an inhibitor of the interaction between p53 and MDM2 proteins |
| CSN18899 | 2-(4-((4S,5R)-2-(4-(tert-Butyl)-2-ethoxyphenyl)-4,5-bis(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole-1-carbonyl)piperazin-1-yl)-1-morpholinoethanone dihydrochloride | 2070009-27-5 | p53 and MDM2 proteins-interaction-inhibitor 2HCl is an inhibitor of the interaction between p53 and MDM2 proteins. |
| CSN16560 | NSC319726 | 71555-25-4 | NSC319726 is a mutant p53R175 reactivator inhibiting growth of fibroblasts expressing the p53R175 mutation IC50 8 nM and showing no inhibition for p53 wild-type cells |
| CSN25232 | NSC-207895 | 58131-57-0 | NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator. |
| CSN15898 | MI-773 | 1303607-07-9 | MI-773 is an orally available spiro-oxindole HDM2 human double minute 2 antagonist with potential antineoplastic activity |
| CSN17245 | Kevetrin hydrochloride | 66592-89-0 | Kevetrin HCl is an activator of the tumor suppressor protein p53 with potential antineoplastic activity |
| CSN20519 | CP-31398 dihydrochloride | 1217195-61-3 | CP-31398 2HCl is a p53 stabilizing agent which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. |
| CSN23315 | COTI-2 | 1039455-84-9 | COTI-2 is an orally available thiosemicarbazone and mutant p53 activator with potential antineoplastic activity |
| CSN22315 | CBL0137 hydrochloride | 1197397-89-9 | CBL0137 HCl is a metabolically stable curaxin that activates p53 with an EC50 value of 0.37 M and inhibits NF-B with an EC50 of 0.47 M. |
| CSN17044 | Eprenetapopt | 5291-32-7 | APR-246 is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types |
| CSN23065 | RETRA HCl | 1173023-52-3 | Antitumor agent; suppresses mutant p53-bearing cancer cells |
| CSN17736 | Navtemadlin | 1352066-68-2 | AMG-232 is a highly potent selective and orally bioavailable piperidinone inhibitor of the MDM2-p53 interaction SPR KD 0045 nM SJSA-1 EdU IC5091 nM |
| CSN19769 | [10]-Shogaol | 36752-54-2 | 10-Shogaol a natural product isolated and purified from the rhizomes of Zingber officinale Rosc an antioxidant for human skin cell growth and a migration enhancer with potential to be a wound repair agent has similar metabolic profiles to 6-shogaol and exhibit similar toxicity toward human colon cancer cells |
| CSN15662 | Pinocembrin | 480-39-7 | ()-Pinocembrin could inhibit p53 expression causing a lower BaxBcl-2 ratio and the release of cytochrome c that shows a neuroprotective effects. ()-Pinocembrin can be extracted from the fruit of alpinia katsunadia hayata with antioxidant and anti-inflammatory antivities. |
| CSN27795 | MS7972 | 352553-42-5 |
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