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p53

p53

Cat. No. Product Name CAS No. Information
CSN11769 PRIMA-1   5608-24-2 PRIMA-1 is a mutant p53 reactivator It induces apoptosis and inhibits growth of human tumors with mutant p53
CSN19860 Plumbagin 481-42-5 Plumbagin is an anticancer agent, induces G2M cell cycle arrest and apoptosis in A549 cells through JNK-dependent p53 Ser15 phosphorylation and inhibits A549 and MDA-MD-231 tumour xenograft growth in nude mice.
CSN25246 PK11007 874146-69-7 PK11007 is mild thiol alkylator with anticancer activity in several cell lines, especially those with mutationally compromised p53.
CSN22900 PK11000   38275-34-2 PK11007 is a p53 targeting compond anti-tumor activities
CSN11696 Pifithrin-μ 64984-31-2 Pifithrin- is a specific p53 inhibitor by reducing its affinity to Bcl-xL and Bcl-2, and also inhibits HSP70 function and autophagy.
CSN18356 Pifithrin-β 60477-34-1 Pifithrin- is a potent p53 inhibitor with IC50 of 23 M in an antiproliferative assay in the human ovarian carcinoma cell line, IGROV-1.
CSN16583 Pifithrin-α Hydrobromide 63208-82-2 Pifithrin- hydrobromide is an inhibitor of p53 inhibiting p53-dependent transactivation of p53-responsive genes
CSN16560 NSC 319726   71555-25-4 NSC319726 is a mutant p53R175 reactivator inhibiting growth of fibroblasts expressing the p53R175 mutation IC50 8 nM and showing no inhibition for p53 wild-type cells
CSN25232 NSC 207895 58131-57-0 NSC-207895 (XI-006), a DNA damaging agent, is an anticancer agent and p53 activator.
CSN15898 MI-773 1303607-07-9 MI-773 is an orally available spiro-oxindole HDM2 human double minute 2 antagonist with potential antineoplastic activity
CSN17245 Kevetrin HCl   66592-89-0 Kevetrin HCl is an activator of the tumor suppressor protein p53 with potential antineoplastic activity
CSN20998 DehydropachyMic acid 77012-31-8 Dehydropachymic acid is extracted from the root of wolfiporia cocos (Schw.) Ryv. with antiinflammatory activity.
CSN20519 CP-31398 2HCl 1217195-61-3 CP-31398 2HCl is a p53 stabilizing agent which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53.
CSN17044 APR-246 5291-32-7 APR-246 is a small organic molecule that has been shown to restore tumour-suppressor function primarily to mutant p53 and also to induce cell death in various cancer types
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