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P450
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN19052 | VT-464 R-Enantiomer | 1375603-38-5 | VT-464 R-enantiomer is the R-enantiomer with unknown activity of VT-464 which is a potent CYP17 lyase inhibitor h-Lyase IC5069 nM |
| CSN19048 | Talarozole R-Enantiomer | 870093-23-5 | Talarozole R-enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne. |
| CSN12919 | Talarozole | 201410-53-9 | Talarozole is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne. |
| CSN23249 | Stiripentol | 49763-96-4 | Stiripentol is an antiepileptic drug that can inhibit the synaptosomal uptake of GABA, increase the activation of GABAA receptors, its also a microsomal cytochrome P450 (CYP) isoforms CYP3A4, CYP1A2, and CYP2C19 inhibitor. |
| CSN11915 | Seratrodast | 112665-43-7 | Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist. |
| CSN16433 | Schisandrin A | 61281-38-7 | Schisandrin A is a naturally occuring agonist of the adiponectin receptor 2 with an IC50 value of 3.5 M. |
| CSN19881 | Salvianolic Acid C | 115841-09-3 | Salvianolic acid C, a natural product isolated and purified from the root of Salvia miltiorrhiza Bge. with antioxidant effect, exhibits potent XOD inhibitory activity with an IC(50) of 9.07 M, and enhances the inhibitory effects on sEH might be efficient ways to improve its cardiovascular protective and anti-inflammatory effects. |
| CSN19400 | Ramatroban | 116649-85-5 | Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. |
| CSN11771 | Proadifen HCl | 62-68-0 | Proadifen HCl is a nonspecific cytochrome P450 inhibitor, its also a noncompetitive inhibitor of acetylcholine nicotinic receptors with IC50 of 19 M in mouse skeletal muscle. |
| CSN12413 | Piperine | 94-62-2 | Piperine is a major alkaloid isolated from the P. longum fruits which possesses anti-inflammatory and antiarthritic effects. |
| CSN16785 | Ozagrel HCl | 78712-43-3 | Ozagrel HCl is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia. |
| CSN25582 | NVP-VID-400 | 174262-13-6 | NVP-VID-400 is an inhibitor of both CYP51 and CYP24A1. |
| CSN25221 | NTP42 | 2055599-51-2 | NTP42 is a TxA2 Synthetase antagonist with IC50 value of 3.278nM. |
| CSN16614 | Naringin | 10236-47-2 | Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes. |
| CSN14183 | N-Nornuciferine | 4846-19-9 | N-Nornuciferine, a natural product isolated and purified from the fruits of Piper nigrum, can competitively inhibit CYP2D6 activity with Ki values of 2.34 uM. |
| CSN12625 | Methoxsalen | 298-81-7 | Methoxsalen is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juicefruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. It is a potent suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. |
| CSN27390 | Mefentrifluconazole | 1417782-03-6 | Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent. Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM). |
| CSN19969 | Linderane | 13476-25-0 | Linderane, a natural product isolated and purified from the roots of Lindera aggregata( Sims) Kosterm, is an inactivator of CYP2C9. |
| CSN13003 | Itraconazole | 84625-61-6 | Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. |
| CSN20292 | HET0016 | 339068-25-6 | HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms. |
| CSN16601 | Ginsenoside Ro | 34367-04-9 | Ginsenoside Ro, a natural product isolated and purified from the root of Panax ginseng C. A. Mey., is reported to have anti-infllammtory, anti-hepatitic activities, and showed inhibitory activity against 5R with IC(50) value of 259.4 m |
| CSN15655 | Ginsenoside F1 | 53963-43-2 | Ginsenoside F1, a metabolite of ginsenoside Rg1 isolated and purified from the roots of Panax ginseng C.A.Mey., is reported to be antiaging and antioxidative, and to have beneficial effects on skin. |
| CSN12387 | Galaterone | 851983-85-2 | Galeterone is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth. |
| CSN22095 | Furafylline | 80288-49-9 | Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with IC50 of 0.07 μM. |
| CSN13053 | Fluconazole | 86386-73-4 | Fluconazole an inhibitor of CYP2C19 CYP2C9 and CYP3A4 is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections |
| CSN23291 | Flavone | 525-82-6 | Flavone can effect CYP P450 activity its a class of flavonoids with antioxidant anti-proliferative anti-tumor anti-microbial estrogenic acetyl cholinesterase anti-inflammatory activities and are also used in cancer cardiovascular disease neurodegenerative disorders etc |
| CSN22890 | DMU2139 | 1821143-80-9 | DMU2139 is a selective inhibitor of CYP1B1 with IC50 of 9 nM |
| CSN27199 | DMU2105 | 1031063-36-1 | DMU2105 is a potent CYP1B1 inhibitor with IC50 value of 10nM for human CYP1B1 enzyme bound to yeast-derived microsomes (Sacchrosomes™). |
| CSN25347 | Dazoxiben HCl | 74226-22-5 | Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots. |
| CSN15806 | Cobicistat | 1004316-88-4 | Cobicistat is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM |
| CSN14022 | Chrysosplenetin | 603-56-5 | Chrysosplenetin, a natural product isolated and purified from the herbs of Laggera pterodonta, is a metabolic inhibitor of artemisinin. |
| CSN21322 | CGS 15435 | 95853-92-2 | CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes. |
| CSN20970 | Cephaeline HCl | 5853-29-2 | Cephaeline HCl is a selective CYP2D6 inhibtor with IC50 of 121 μM. |
| CSN19045 | CDD3506 | 197913-15-8 | CDD3506 is used for elevating high density lipoprotein cholesterol HDL by inducing hepaticcytochrome P450IIIA CYP3Aactivity |
| CSN19044 | CDD3505 | 173865-33-3 | CDD3505 is used for elevating high density lipoprotein cholesterol HDL by inducing hepaticcytochrome P450IIIA CYP3Aactivity |
| CSN21515 | Bergaptin | 7380-40-7 | Bergaptin is a competitive inhibitor of CYP1A1 with Ki of 10.7 nM. |
| CSN17375 | Baicalein | 491-67-8 | Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor |
| CSN12255 | Apigenin | 520-36-5 | Apigenin is a potent P450 inhibitor for CYP2C9 with Ki of 2 M, its a natural product isolated and purified from the root of Scutellaria indica L.. |
| CSN12906 | Alizarin | 72-48-0 | Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.210.0 and 2.7 M respectively, weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5. |
| CSN12448 | Acetyl Shikonin | 24502-78-1 | Acetyl shikonin, a natural product isolated and purified from the roots of Lithosperraum erythrorhizon Sieb. et Zucc., inhibits the generation of NADPH oxidase complex in the activation of respiratory burst of PMNs, but does not directly inhibit the activity of NADPH oxidase already generated, and is a non-selective cytochrome P450 inhibitor. |
| CSN21988 | Abiraterone Metabolite 1 | 1940176-03-3 | Abiraterone metabolite 1 is a 5β-reduced metabolite of abiraterone which inhibits CYP17A1, blocks androgen synthesis and prolongs survival in prostate cancer. |
| CSN12221 | 8-Geranyloxypsoralen | 7437-55-0 | 8-Geranyloxypsoralen, a natural product isolated and purified from the herbs of Seseli mairei Wolff., inhibits -secretase (BACE1) activity in non-competitive manner, with the IC(50) values 25.0 uM. 8-Geranyloxypsoralen possesses nematicidal activities, the median lethal concentrations (LC(50)) is 188.3 mg L against B. xylophilus and is 117.5 mgL against P. redivivus. |
| CSN14706 | 8α-(2-Methylacryloyloxy)hirsutinolide 13-O-Acetate | 67667-71-4 | 8-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate is a natural product isolated and purified from the herbs of Vernonia cinerea showing inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. |
| CSN10264 | 7,8-Benzoflavone | 604-59-1 | 7,8-benzoflavone is a natural product isolated and purified from Passiflora, and it binds to human cytochrome P450 3A4 reveals complex fluorescence quenching. |
| CSN26155 | 6-Aminochrysene | 2642-98-0 | 6-aminochrysene was a potent inducer of CYP1A1 in rat. |
| CSN15033 | 6',7'-Dihydroxybergamottin Acetonide | 684217-08-1 | 6,7-Dihydroxybergamottin acetonide is a natural product isolated and purified from the peels of Citrus maxima, and is a potent inhibitor of CYP3A activity, being primarily responsible for the effects of grapefruit juice on cytochrome P450 activity in humans. |
| CSN11536 | 5-Methoxypsoralen | 484-20-8 | 5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation psoralen plus UV (PUVA) to manage psoriasis and vitiligo and inhibits proliferation in the human hepatocellular carcinoma cell line. |
| CSN26147 | 5-Aminomethyl-3-(pyridin-3-yl)isoxazole | 543713-43-5 | 5-Aminomethyl-3-(pyridin-3-yl)isoxazole |
| CSN19374 | 3-Cyano-7-Ethoxycoumarin | 117620-77-6 | 3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage |
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