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P450
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN23249 | Stiripentol | 49763-96-4 | Stiripentol is an antiepileptic drug that can inhibit the synaptosomal uptake of GABA, increase the activation of GABAA receptors, its also a microsomal cytochrome P450 (CYP) isoforms CYP3A4, CYP1A2, and CYP2C19 inhibitor. |
| CSN11915 | Seratrodast | 112665-43-7 | Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist. |
| CSN16433 | Schisandrin A | 61281-38-7 | Schisandrin A is a naturally occuring agonist of the adiponectin receptor 2 with an IC50 value of 3.5 M. |
| CSN19400 | Ramatroban | 116649-85-5 | Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. |
| CSN11771 | Proadifen HCl | 62-68-0 | Proadifen HCl is a nonspecific cytochrome P450 inhibitor, its also a noncompetitive inhibitor of acetylcholine nicotinic receptors with IC50 of 19 M in mouse skeletal muscle. |
| CSN12413 | Piperine | 94-62-2 | Piperine is a major alkaloid isolated from the P. longum fruits which possesses anti-inflammatory and antiarthritic effects. |
| CSN25582 | NVP-VID-400 | 174262-13-6 | NVP-VID-400 is an inhibitor of both CYP51 and CYP24A1. |
| CSN16614 | Naringin | 10236-47-2 | Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes. |
| CSN12625 | Methoxsalen | 298-81-7 | Methoxsalen is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juicefruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. It is a potent suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. |
| CSN13003 | Itraconazole | 84625-61-6 | Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. |
| CSN16601 | Ginsenoside Ro | 34367-04-9 | Ginsenoside Ro, a natural product isolated and purified from the root of Panax ginseng C. A. Mey., is reported to have anti-infllammtory, anti-hepatitic activities, and showed inhibitory activity against 5R with IC(50) value of 259.4 m |
| CSN22095 | Furafylline | 80288-49-9 | Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with IC50 of 0.07 μM. |
| CSN25347 | Dazoxiben HCl | 74226-22-5 | Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots. |
| CSN14022 | Chrysosplenetin | 603-56-5 | Chrysosplenetin, a natural product isolated and purified from the herbs of Laggera pterodonta, is a metabolic inhibitor of artemisinin. |
| CSN21322 | CGS 15435 | 95853-92-2 | CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes. |
| CSN12255 | Apigenin | 520-36-5 | Apigenin is a potent P450 inhibitor for CYP2C9 with Ki of 2 M, its a natural product isolated and purified from the root of Scutellaria indica L.. |
| CSN12906 | Alizarin | 72-48-0 | Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.210.0 and 2.7 M respectively, weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5. |
| CSN22313 | ABT | 1614-12-6 | ABT is a non-specific cytochrome P450 CYP inhibitor |
| CSN26155 | 6-Aminochrysene | 2642-98-0 | 6-aminochrysene was a potent inducer of CYP1A1 in rat. |
| CSN11536 | 5-Methoxypsoralen | 484-20-8 | 5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation psoralen plus UV (PUVA) to manage psoriasis and vitiligo and inhibits proliferation in the human hepatocellular carcinoma cell line. |
| CSN19374 | 3-Cyano-7-Ethoxycoumarin | 117620-77-6 | 3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage |
| CSN22146 | 1-Ethynylnaphthalene | 15727-65-8 | 1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1 |
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