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P450

P450

Cat. No. Product Name CAS No. Information
CSN20409 VT-1598 2089320-99-8 VT1598 is a highly-selective broad spectrum fungal CYP51 inhibitor exhibiting excellent potency against yeast dermatophyte and mold fungal pathogens
CSN17762 VT-464 Racemate 1375603-36-3 VT-464 racemate is the racemate form of VT-464 which is a potent CYP17 lyase inhibitor h-Lyase IC5069 nMinhibition
CSN19052 VT-464 R-Enantiomer 1375603-38-5 VT-464 R-enantiomer is the R-enantiomer with unknown activity of VT-464 which is a potent CYP17 lyase inhibitor h-Lyase IC5069 nM
CSN12213 Voriconazole   137234-62-9 Voriconazole is a second-generation triazole antifungal used to treat serious fungal infections by inhibiting the synthesis of ergosterol the major sterol of the fungal cell membrane
CSN12100 TMS   24144-92-1 TMS is a very selective and potent competitive inhibitor of P450 1B1 CYP1A1
CSN19048 Talarozole R-Enantiomer 870093-23-5 Talarozole R-enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne.
CSN12919 Talarozole 201410-53-9 Talarozole is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne.
CSN12728 TAK-700 426219-18-3 TAK-700 is a potent and highly selective human 1720-lyase inhibitor with IC50 of 38 nM exhibits 1000-fold selectivity over other CYPs eg 11-hydroxylase and CYP3A4
CSN11915 Seratrodast   112665-43-7 Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist.
CSN11894 Saperconazole 110588-57-3 Saperconazole is a broad-spectrum antifungal triazole and has potent activity against Aspergillus with an MIC90 of 019 mgL
CSN19400 Ramatroban   116649-85-5 Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis.
CSN11818 Quinidine   56-54-2 Quinidine is prototypical CYP2D6 inhibitor and also blocks muscarinic and alpha-adrenergic neurotransmission
CSN11771 Proadifen HCl   62-68-0 Proadifen HCl is a nonspecific cytochrome P450 inhibitor, its also a noncompetitive inhibitor of acetylcholine nicotinic receptors with IC50 of 19 M in mouse skeletal muscle.
CSN11753 Posaconazole   171228-49-2 Posaconazole is a broad-spectrum triazole antifungi it inhibits the growth of fungi by inhibiting the lanosterol 14-demethylase enzyme which results in a disruption the synthesis of ergosterol a key sterol necessary for fungal cell membrane integrity and for the function of certain membrane-bound proteins
CSN19175 PF-4981517 1390637-82-7 PF-4981517 is a potent and selective inhibitor of CYP3A4 P450 with IC50 of 003 M exhibits 500-fold selectivity over CYP3A5 and CYP3A7
CSN11643 Ozagrel Sodium 130952-46-4 Ozagrel sodium salt is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor
CSN16475 Ozagrel   82571-53-7 Ozagrel is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor
CSN16785 Ozagrel HCl   78712-43-3 Ozagrel hydrochloride is a selective thromboxane A2 TXA2 synthetase inhibitor with IC50 of 11 nM for rabbit platelet used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia
CSN20004 Oteseconazole 1340593-59-0 Oteseconazole is a tetrazole antifungal agent potentially for the treatment of candidal vaginal infection by inhibiting sterol 14-demethylase CYP51
CSN18337 Orteronel 566939-85-3 Orteronel is a highly selective inhibitor of human 1720-lyase with IC50 of 38 nM and exhibits 1000-fold selectivity over other CYPs such as 11-hydroxylase and CYP3A4
CSN16614 Naringin   10236-47-2 Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.
CSN11433 Metyrapone   54-36-4 Metyrapone is an inhibitor of cytochrome P450-mediated -1 hydroxylase activity and CYP11B1
CSN12625 Methoxsalen   298-81-7 Methoxsalen is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juicefruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. It is a potent suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight.
CSN16342 Memantine HCl   41100-52-1 Memantine HCl an amantadine derivative with low to moderate-affinity for NMDA receptors inhibit CYP2B6 and CYP2D6 with Ki of 051 nM and 949 M respectively is used for the treatment of Alzheimers disease
CSN16776 Ketoconazole   65277-42-1 Ketoconazole is an imidazole anti-fungal agent which inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 019 mM and 022 mM respectively
CSN13003 Itraconazole   84625-61-6 Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent.
CSN11218 Isbogrel 89667-40-3 Isbogrel a -pyridylalkenoic acid derivative is a thromboxane A2 synthetase inhibitor that also shows thromboxane A2 antagonism
CSN12387 Galaterone 851983-85-2 Galeterone is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth.
CSN13053 Fluconazole   86386-73-4 Fluconazole an inhibitor of CYP2C19 CYP2C9 and CYP3A4 is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections
CSN23291 Flavone   525-82-6 Flavone can effect CYP P450 activity its a class of flavonoids with antioxidant anti-proliferative anti-tumor anti-microbial estrogenic acetyl cholinesterase anti-inflammatory activities and are also used in cancer cardiovascular disease neurodegenerative disorders etc
CSN10150 FICZ   172922-91-7 FICZ is a tryptophan-derived high affinity Ah receptor ligand and an efficient inducer of CYP1A1 gene expression in short time incubation 05 h experiments It is also a potent aryl hydrocarbon receptor AHR agonist and also has the qualities of a perfect substrate for mammalian CYP1 enzymes
CSN22890 DMU2139   1821143-80-9 DMU2139 is a selective inhibitor of CYP1B1 with IC50 of 9 nM
CSN10830 Diosmetin   520-34-3 Diosmetin is a bioflavonoid found in spearmint oregano and many other plants and is an agonist of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity
CSN17441 Dafadine-A 1065506-69-5 Dafadine-A an analog of dafadine is an inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans and also inhibits the mammalian ortholog of DAF-9 CYP27A1
CSN20275 CYP11B1 Inhibitor C25 2101952-78-5 CYP11B1 inhibitor C25 is a CYP11B1 inhibitor of pyridylmethyl isoxazole type with improved pharmacological profile for the treatment of Cushings disease
CSN15806 Cobicistat 1004316-88-4 Cobicistat is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM
CSN10660 Clarithromycin   81103-11-9 Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor
CSN21322 CGS 15435 95853-92-2 CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes.
CSN19045 CDD3506 197913-15-8 CDD3506 is used for elevating high density lipoprotein cholesterol HDL by inducing hepaticcytochrome P450IIIA CYP3Aactivity
CSN19044 CDD3505 173865-33-3 CDD3505 is used for elevating high density lipoprotein cholesterol HDL by inducing hepaticcytochrome P450IIIA CYP3Aactivity
CSN10419 Bergaptol 486-60-2 Bergaptol is a hydroxylated psoralen isolated and purified from the root of Notopterygium incisum that acts as a potent inhibitor of debenzylation activity of CYP3A4 enzyme with an IC50 value of 2492 M
CSN10357 Avasimibe   166518-60-1 Avasimibe is an ACAT inhibitor with IC50 of 33 M it also inhibits human P450 isoenzymes CYP2C9 CYP1A2 and CYP2C19 with IC50 of 29139 and 265 M respectively
CSN12255 Apigenin   520-36-5 Apigenin is a potent P450 inhibitor for CYP2C9 with Ki of 2 M, its a natural product isolated and purified from the root of Scutellaria indica L..
CSN12906 Alizarin 72-48-0 Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.210.0 and 2.7 M respectively, weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5.
CSN22313 ABT   1614-12-6 ABT is a non-specific cytochrome P450 CYP inhibitor
CSN10264 7,8-Benzoflavone 604-59-1 7,8-benzoflavone is a natural product isolated and purified from Passiflora, and it binds to human cytochrome P450 3A4 reveals complex fluorescence quenching.
CSN19374 3-Cyano-7-Ethoxycoumarin 117620-77-6 3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage
CSN19771 25R-Inokosterone 19682-38-3 25R-Inokosterone has a role on cytochrome P450 from a hormone-resistant cell line
CSN22146 1-Ethynylnaphthalene 15727-65-8 1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1
CSN20292 HET0016 339068-25-6
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