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P450

P450

Cat. No. Product Name CAS No. Information
CSN12919 Talarozole 201410-53-9 Talarozole is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne.
CSN23249 Stiripentol   49763-96-4 Stiripentol is an antiepileptic drug that can inhibit the synaptosomal uptake of GABA, increase the activation of GABAA receptors, its also a microsomal cytochrome P450 (CYP) isoforms CYP3A4, CYP1A2, and CYP2C19 inhibitor.
CSN11915 Seratrodast   112665-43-7 Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist.
CSN16433 Schisandrin A   61281-38-7 Schisandrin A is a naturally occuring agonist of the adiponectin receptor 2 with an IC50 value of 3.5 M.
CSN19881 Salvianolic Acid C 115841-09-3 Salvianolic acid C, a natural product isolated and purified from the root of Salvia miltiorrhiza Bge. with antioxidant effect, exhibits potent XOD inhibitory activity with an IC(50) of 9.07 M, and enhances the inhibitory effects on sEH might be efficient ways to improve its cardiovascular protective and anti-inflammatory effects.
CSN19400 Ramatroban   116649-85-5 Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis.
CSN11771 Proadifen HCl   62-68-0 Proadifen HCl is a nonspecific cytochrome P450 inhibitor, its also a noncompetitive inhibitor of acetylcholine nicotinic receptors with IC50 of 19 M in mouse skeletal muscle.
CSN12413 Piperine   94-62-2 Piperine is a major alkaloid isolated from the P. longum fruits which possesses anti-inflammatory and antiarthritic effects.
CSN20411 ONO-1301 176391-41-6 ONO-1301 is a non-prostanoid prostaglandin I2 mimetic coumpound with inhibitory activity against thromboxane A2 synthase It is also a long-acting prostacyclin agonist loaded in PLGA microspheres prepared using different molecular weights of PLGA
CSN25582 NVP-VID-400 174262-13-6 NVP-VID-400 is an inhibitor of both CYP51 and CYP24A1.
CSN16614 Naringin 10236-47-2 Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.
CSN12625 Methoxsalen   298-81-7 Methoxsalen is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juicefruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. It is a potent suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight.
CSN13003 Itraconazole   84625-61-6 Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent.
CSN24909 Sparteine 492-08-0 Inhibition of human CYP2D6 expressed in Escherichia coli JM109
CSN16601 Ginsenoside Ro 34367-04-9 Ginsenoside Ro, a natural product isolated and purified from the root of Panax ginseng C. A. Mey., is reported to have anti-infllammtory, anti-hepatitic activities, and showed inhibitory activity against 5R with IC(50) value of 259.4 m
CSN22095 Furafylline 80288-49-9 Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with IC50 of 0.07 μM.
CSN25347 Dazoxiben HCl 74226-22-5 Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots.
CSN14022 Chrysosplenetin 603-56-5 Chrysosplenetin, a natural product isolated and purified from the herbs of Laggera pterodonta, is a metabolic inhibitor of artemisinin.
CSN21322 CGS 15435 95853-92-2 CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes.
CSN21515 Bergaptin 7380-40-7 Bergaptin is a competitive inhibitor of CYP1A1 with Ki of 10.7 nM.
CSN12255 Apigenin   520-36-5 Apigenin is a potent P450 inhibitor for CYP2C9 with Ki of 2 M, its a natural product isolated and purified from the root of Scutellaria indica L..
CSN12906 Alizarin 72-48-0 Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.210.0 and 2.7 M respectively, weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5.
CSN22313 ABT   1614-12-6 ABT is a non-specific cytochrome P450 CYP inhibitor
CSN12221 8-Geranyloxypsoralen 7437-55-0 8-Geranyloxypsoralen, a natural product isolated and purified from the herbs of Seseli mairei Wolff., inhibits -secretase (BACE1) activity in non-competitive manner, with the IC(50) values 25.0 uM. 8-Geranyloxypsoralen possesses nematicidal activities, the median lethal concentrations (LC(50)) is 188.3 mg L against B. xylophilus and is 117.5 mgL against P. redivivus.
CSN26155 6-Aminochrysene 2642-98-0 6-aminochrysene was a potent inducer of CYP1A1 in rat.
CSN11536 5-Methoxypsoralen   484-20-8 5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation psoralen plus UV (PUVA) to manage psoriasis and vitiligo and inhibits proliferation in the human hepatocellular carcinoma cell line.
CSN19374 3-Cyano-7-Ethoxycoumarin 117620-77-6 3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage
CSN22146 1-Ethynylnaphthalene 15727-65-8 1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1
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