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P450
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN26275 | Tetrahydropiperine | 23434-88-0 | Tetrahydropiperine is a cyclohexyl analogue of piperine that inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50=23 µM). |
| CSN23249 | Stiripentol | 49763-96-4 | Stiripentol is an antiepileptic drug that can inhibit the synaptosomal uptake of GABA, increase the activation of GABAA receptors, its also a microsomal cytochrome P450 (CYP) isoforms CYP3A4, CYP1A2, and CYP2C19 inhibitor. |
| CSN16433 | Schisandrin A | 61281-38-7 | Schisandrin A is a naturally occuring agonist of the adiponectin receptor 2 with an IC50 value of 3.5 M. |
| CSN13587 | Ritonavir | 155213-67-5 | Ritonavir is both an HIV protease inhibitor and a Cytochrome P450 3A inhibitor. |
| CSN13587 | Ritonavir | 155213-67-5 | Ritonavir is both an HIV protease inhibitor and a Cytochrome P450 3A inhibitor. |
| CSN19933 | Rhodionin | 85571-15-9 | Rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administered drugs |
| CSN19400 | Ramatroban | 116649-85-5 | Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. |
| CSN26727 | Ozagrel sodium | 189224-26-8 | Ozagrel Sodium, also known as KCT-0809 and Cataclot, is a thromboxane A2 synthase inhibitor used to treat cerebrovascular diseases. |
| CSN10122 | Oxolamine citrate | 1949-20-8 | Oxolamine citrate is a cough suppressant, and a molecule involved in pharmacological studies including antiinflammatory agents, drugs that shift energy metabolism from mitochondrial respiration to glycolysis and effect on warfarin anticoagulant properties. It is an inhibitor of CYP2B1/2. |
| CSN25582 | SDZ285428 | 174262-13-6 | NVP-VID-400 is an inhibitor of both CYP51 and CYP24A1. |
| CSN25221 | NTP42 | 2055599-51-2 | NTP42 is a TxA2 Synthetase antagonist with IC50 value of 3.278nM. |
| CSN27390 | Mefentrifluconazole | 1417782-03-6 | Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent. Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM). |
| CSN29462 | 17-ODYA | 34450-18-5 | LTB ω-hydroxylase inhibitor. |
| CSN26286 | Isosilybin | 72581-71-6 | Isosilybin is a flavonoid from milk thistle. It can inhibit CYP3A4 induction with an IC50 of 74 μM. |
| CSN20292 | HET0016 | 339068-25-6 | HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms. |
| CSN26726 | Gemfibrozil 1-O-β-glucuronide | 91683-38-4 | Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM[1][2]. |
| CSN12256 | Galangin | 548-83-4 | Galangin functions as an antagonist of the aryl hydrocarbon receptor and also inhibits CYP1A1 (IC50 1 M). It belongs to flavonoids and can be extracted from the rhizome of Zingiber officinale Roscoe with anti-inflammatory properties. |
| CSN22095 | Furafylline | 80288-49-9 | Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with IC50 of 0.07 μM. |
| CSN29463 | 7-Ethoxyresorufin | 5725-91-7 | Fluorometric CYP450 substrate. |
| CSN29461 | Resorufin methyl ether | 5725-89-3 | Fluorometric CYP450 substrate. |
| CSN27199 | DMU2105 | 1031063-36-1 | DMU2105 is a potent CYP1B1 inhibitor with IC50 value of 10nM for human CYP1B1 enzyme bound to yeast-derived microsomes (Sacchrosomes™). |
| CSN25347 | Dazoxiben | 74226-22-5 | Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots. |
| CSN32917 | Dapaconazole | 1269726-67-1 | Dapaconazole,a CYP51 inhibitor is an antifungal drug candidate. |
| CSN32500 | CFG920 | 1260006-20-9 | CFG920 is a CYP17 inhibitor, is also an orally available inhibitor of the CYP17A1. |
| CSN26553 | Casopitant mesylate | 414910-30-8 | Casopitant mesylate is the mesylate salt of a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK1 receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK1 receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema. |
| CSN26724 | BI 653048 | 1198784-72-3 | BI-653048 is a glucocorticoid agonist. |
| CSN21515 | Bergamottin | 7380-40-7 | Bergaptin is a competitive inhibitor of CYP1A1 with Ki of 10.7 nM. |
| CSN12448 | Acetylshikonin | 24502-78-1 | Acetyl shikonin, a natural product isolated and purified from the roots of Lithosperraum erythrorhizon Sieb. et Zucc., inhibits the generation of NADPH oxidase complex in the activation of respiratory burst of PMNs, but does not directly inhibit the activity of NADPH oxidase already generated, and is a non-selective cytochrome P450 inhibitor. |
| CSN26155 | 6-Aminochrysene | 2642-98-0 | 6-aminochrysene was a potent inducer of CYP1A1 in rat. |
| CSN15033 | 6',7'-Dihydroxybergamottin Acetonide | 684217-08-1 | 6,7-Dihydroxybergamottin acetonide is a natural product isolated and purified from the peels of Citrus maxima, and is a potent inhibitor of CYP3A activity, being primarily responsible for the effects of grapefruit juice on cytochrome P450 activity in humans. |
| CSN11536 | Bergapten | 484-20-8 | 5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation psoralen plus UV (PUVA) to manage psoriasis and vitiligo and inhibits proliferation in the human hepatocellular carcinoma cell line. |
| CSN26147 | (3-(Pyridin-3-yl)isoxazol-5-yl)methanamine | 543713-43-5 | 5-Aminomethyl-3-(pyridin-3-yl)isoxazole |
| CSN29472 | (S)-Mephenytoin | 70989-04-7 | (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19, also known as mephenytoin 4-hydroxylase. |
| CSN28668 | β-Naphthoflavone | 6051-87-2 | |
| CSN41685 | (S)-Mirtazapine | 61337-87-9 | |
| CSN33797 | Revexepride | 219984-49-3 | |
| CSN37149 | Rhodiosin | 86831-54-1 | |
| CSN80842 | Tacrine | 321-64-2 |
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