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P450
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN12919 | Talarozole | 201410-53-9 | Talarozole is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne. |
| CSN23249 | Stiripentol | 49763-96-4 | Stiripentol is an antiepileptic drug that can inhibit the synaptosomal uptake of GABA, increase the activation of GABAA receptors, its also a microsomal cytochrome P450 (CYP) isoforms CYP3A4, CYP1A2, and CYP2C19 inhibitor. |
| CSN11915 | Seratrodast | 112665-43-7 | Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist. |
| CSN16433 | Schisandrin A | 61281-38-7 | Schisandrin A is a naturally occuring agonist of the adiponectin receptor 2 with an IC50 value of 3.5 M. |
| CSN19881 | Salvianolic Acid C | 115841-09-3 | Salvianolic acid C, a natural product isolated and purified from the root of Salvia miltiorrhiza Bge. with antioxidant effect, exhibits potent XOD inhibitory activity with an IC(50) of 9.07 M, and enhances the inhibitory effects on sEH might be efficient ways to improve its cardiovascular protective and anti-inflammatory effects. |
| CSN19400 | Ramatroban | 116649-85-5 | Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. |
| CSN11771 | Proadifen HCl | 62-68-0 | Proadifen HCl is a nonspecific cytochrome P450 inhibitor, its also a noncompetitive inhibitor of acetylcholine nicotinic receptors with IC50 of 19 M in mouse skeletal muscle. |
| CSN12413 | Piperine | 94-62-2 | Piperine is a major alkaloid isolated from the P. longum fruits which possesses anti-inflammatory and antiarthritic effects. |
| CSN20411 | ONO-1301 | 176391-41-6 | ONO-1301 is a non-prostanoid prostaglandin I2 mimetic coumpound with inhibitory activity against thromboxane A2 synthase It is also a long-acting prostacyclin agonist loaded in PLGA microspheres prepared using different molecular weights of PLGA |
| CSN25582 | NVP-VID-400 | 174262-13-6 | NVP-VID-400 is an inhibitor of both CYP51 and CYP24A1. |
| CSN16614 | Naringin | 10236-47-2 | Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes. |
| CSN12625 | Methoxsalen | 298-81-7 | Methoxsalen is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juicefruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. It is a potent suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. |
| CSN13003 | Itraconazole | 84625-61-6 | Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. |
| CSN24909 | Sparteine | 492-08-0 | Inhibition of human CYP2D6 expressed in Escherichia coli JM109 |
| CSN16601 | Ginsenoside Ro | 34367-04-9 | Ginsenoside Ro, a natural product isolated and purified from the root of Panax ginseng C. A. Mey., is reported to have anti-infllammtory, anti-hepatitic activities, and showed inhibitory activity against 5R with IC(50) value of 259.4 m |
| CSN22095 | Furafylline | 80288-49-9 | Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with IC50 of 0.07 μM. |
| CSN25347 | Dazoxiben HCl | 74226-22-5 | Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots. |
| CSN14022 | Chrysosplenetin | 603-56-5 | Chrysosplenetin, a natural product isolated and purified from the herbs of Laggera pterodonta, is a metabolic inhibitor of artemisinin. |
| CSN21322 | CGS 15435 | 95853-92-2 | CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes. |
| CSN21515 | Bergaptin | 7380-40-7 | Bergaptin is a competitive inhibitor of CYP1A1 with Ki of 10.7 nM. |
| CSN12255 | Apigenin | 520-36-5 | Apigenin is a potent P450 inhibitor for CYP2C9 with Ki of 2 M, its a natural product isolated and purified from the root of Scutellaria indica L.. |
| CSN12906 | Alizarin | 72-48-0 | Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.210.0 and 2.7 M respectively, weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5. |
| CSN22313 | ABT | 1614-12-6 | ABT is a non-specific cytochrome P450 CYP inhibitor |
| CSN12221 | 8-Geranyloxypsoralen | 7437-55-0 | 8-Geranyloxypsoralen, a natural product isolated and purified from the herbs of Seseli mairei Wolff., inhibits -secretase (BACE1) activity in non-competitive manner, with the IC(50) values 25.0 uM. 8-Geranyloxypsoralen possesses nematicidal activities, the median lethal concentrations (LC(50)) is 188.3 mg L against B. xylophilus and is 117.5 mgL against P. redivivus. |
| CSN26155 | 6-Aminochrysene | 2642-98-0 | 6-aminochrysene was a potent inducer of CYP1A1 in rat. |
| CSN11536 | 5-Methoxypsoralen | 484-20-8 | 5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation psoralen plus UV (PUVA) to manage psoriasis and vitiligo and inhibits proliferation in the human hepatocellular carcinoma cell line. |
| CSN19374 | 3-Cyano-7-Ethoxycoumarin | 117620-77-6 | 3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage |
| CSN22146 | 1-Ethynylnaphthalene | 15727-65-8 | 1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1 |
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