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P450
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN20409 | VT-1598 | 2089320-99-8 | VT1598 is a highly-selective broad spectrum fungal CYP51 inhibitor exhibiting excellent potency against yeast dermatophyte and mold fungal pathogens |
| CSN17762 | VT-464 Racemate | 1375603-36-3 | VT-464 racemate is the racemate form of VT-464 which is a potent CYP17 lyase inhibitor h-Lyase IC5069 nMinhibition |
| CSN19052 | VT-464 R-Enantiomer | 1375603-38-5 | VT-464 R-enantiomer is the R-enantiomer with unknown activity of VT-464 which is a potent CYP17 lyase inhibitor h-Lyase IC5069 nM |
| CSN12213 | Voriconazole | 137234-62-9 | Voriconazole is a second-generation triazole antifungal used to treat serious fungal infections by inhibiting the synthesis of ergosterol the major sterol of the fungal cell membrane |
| CSN12100 | TMS | 24144-92-1 | TMS is a very selective and potent competitive inhibitor of P450 1B1 CYP1A1 |
| CSN19048 | Talarozole R-Enantiomer | 870093-23-5 | Talarozole R-enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne. |
| CSN12919 | Talarozole | 201410-53-9 | Talarozole is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne. |
| CSN12728 | TAK-700 | 426219-18-3 | TAK-700 is a potent and highly selective human 1720-lyase inhibitor with IC50 of 38 nM exhibits 1000-fold selectivity over other CYPs eg 11-hydroxylase and CYP3A4 |
| CSN11915 | Seratrodast | 112665-43-7 | Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist. |
| CSN11894 | Saperconazole | 110588-57-3 | Saperconazole is a broad-spectrum antifungal triazole and has potent activity against Aspergillus with an MIC90 of 019 mgL |
| CSN19400 | Ramatroban | 116649-85-5 | Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis. |
| CSN11818 | Quinidine | 56-54-2 | Quinidine is prototypical CYP2D6 inhibitor and also blocks muscarinic and alpha-adrenergic neurotransmission |
| CSN11771 | Proadifen HCl | 62-68-0 | Proadifen HCl is a nonspecific cytochrome P450 inhibitor, its also a noncompetitive inhibitor of acetylcholine nicotinic receptors with IC50 of 19 M in mouse skeletal muscle. |
| CSN11753 | Posaconazole | 171228-49-2 | Posaconazole is a broad-spectrum triazole antifungi it inhibits the growth of fungi by inhibiting the lanosterol 14-demethylase enzyme which results in a disruption the synthesis of ergosterol a key sterol necessary for fungal cell membrane integrity and for the function of certain membrane-bound proteins |
| CSN19175 | PF-4981517 | 1390637-82-7 | PF-4981517 is a potent and selective inhibitor of CYP3A4 P450 with IC50 of 003 M exhibits 500-fold selectivity over CYP3A5 and CYP3A7 |
| CSN11643 | Ozagrel Sodium | 130952-46-4 | Ozagrel sodium salt is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor |
| CSN16475 | Ozagrel | 82571-53-7 | Ozagrel is an antiplatelet agent working as a thromboxane A2 synthesis inhibitor |
| CSN16785 | Ozagrel HCl | 78712-43-3 | Ozagrel hydrochloride is a selective thromboxane A2 TXA2 synthetase inhibitor with IC50 of 11 nM for rabbit platelet used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia |
| CSN20004 | Oteseconazole | 1340593-59-0 | Oteseconazole is a tetrazole antifungal agent potentially for the treatment of candidal vaginal infection by inhibiting sterol 14-demethylase CYP51 |
| CSN18337 | Orteronel | 566939-85-3 | Orteronel is a highly selective inhibitor of human 1720-lyase with IC50 of 38 nM and exhibits 1000-fold selectivity over other CYPs such as 11-hydroxylase and CYP3A4 |
| CSN16614 | Naringin | 10236-47-2 | Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes. |
| CSN11433 | Metyrapone | 54-36-4 | Metyrapone is an inhibitor of cytochrome P450-mediated -1 hydroxylase activity and CYP11B1 |
| CSN12625 | Methoxsalen | 298-81-7 | Methoxsalen is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juicefruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. It is a potent suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. |
| CSN16342 | Memantine HCl | 41100-52-1 | Memantine HCl an amantadine derivative with low to moderate-affinity for NMDA receptors inhibit CYP2B6 and CYP2D6 with Ki of 051 nM and 949 M respectively is used for the treatment of Alzheimers disease |
| CSN16776 | Ketoconazole | 65277-42-1 | Ketoconazole is an imidazole anti-fungal agent which inhibits cyclosporine oxidase and testosterone 6 beta-hydroxylase with IC50 of 019 mM and 022 mM respectively |
| CSN13003 | Itraconazole | 84625-61-6 | Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. |
| CSN11218 | Isbogrel | 89667-40-3 | Isbogrel a -pyridylalkenoic acid derivative is a thromboxane A2 synthetase inhibitor that also shows thromboxane A2 antagonism |
| CSN12387 | Galaterone | 851983-85-2 | Galeterone is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth. |
| CSN13053 | Fluconazole | 86386-73-4 | Fluconazole an inhibitor of CYP2C19 CYP2C9 and CYP3A4 is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections |
| CSN23291 | Flavone | 525-82-6 | Flavone can effect CYP P450 activity its a class of flavonoids with antioxidant anti-proliferative anti-tumor anti-microbial estrogenic acetyl cholinesterase anti-inflammatory activities and are also used in cancer cardiovascular disease neurodegenerative disorders etc |
| CSN10150 | FICZ | 172922-91-7 | FICZ is a tryptophan-derived high affinity Ah receptor ligand and an efficient inducer of CYP1A1 gene expression in short time incubation 05 h experiments It is also a potent aryl hydrocarbon receptor AHR agonist and also has the qualities of a perfect substrate for mammalian CYP1 enzymes |
| CSN22890 | DMU2139 | 1821143-80-9 | DMU2139 is a selective inhibitor of CYP1B1 with IC50 of 9 nM |
| CSN10830 | Diosmetin | 520-34-3 | Diosmetin is a bioflavonoid found in spearmint oregano and many other plants and is an agonist of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity |
| CSN17441 | Dafadine-A | 1065506-69-5 | Dafadine-A an analog of dafadine is an inhibitor of DAF-9 cytochrome P450 in the nematode Caenorhabditis elegans and also inhibits the mammalian ortholog of DAF-9 CYP27A1 |
| CSN20275 | CYP11B1 Inhibitor C25 | 2101952-78-5 | CYP11B1 inhibitor C25 is a CYP11B1 inhibitor of pyridylmethyl isoxazole type with improved pharmacological profile for the treatment of Cushings disease |
| CSN15806 | Cobicistat | 1004316-88-4 | Cobicistat is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM |
| CSN10660 | Clarithromycin | 81103-11-9 | Clarithromycin is a macrolide antibiotic and a CYP3A4 inhibitor |
| CSN21322 | CGS 15435 | 95853-92-2 | CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes. |
| CSN19045 | CDD3506 | 197913-15-8 | CDD3506 is used for elevating high density lipoprotein cholesterol HDL by inducing hepaticcytochrome P450IIIA CYP3Aactivity |
| CSN19044 | CDD3505 | 173865-33-3 | CDD3505 is used for elevating high density lipoprotein cholesterol HDL by inducing hepaticcytochrome P450IIIA CYP3Aactivity |
| CSN10419 | Bergaptol | 486-60-2 | Bergaptol is a hydroxylated psoralen isolated and purified from the root of Notopterygium incisum that acts as a potent inhibitor of debenzylation activity of CYP3A4 enzyme with an IC50 value of 2492 M |
| CSN10357 | Avasimibe | 166518-60-1 | Avasimibe is an ACAT inhibitor with IC50 of 33 M it also inhibits human P450 isoenzymes CYP2C9 CYP1A2 and CYP2C19 with IC50 of 29139 and 265 M respectively |
| CSN12255 | Apigenin | 520-36-5 | Apigenin is a potent P450 inhibitor for CYP2C9 with Ki of 2 M, its a natural product isolated and purified from the root of Scutellaria indica L.. |
| CSN12906 | Alizarin | 72-48-0 | Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.210.0 and 2.7 M respectively, weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5. |
| CSN22313 | ABT | 1614-12-6 | ABT is a non-specific cytochrome P450 CYP inhibitor |
| CSN10264 | 7,8-Benzoflavone | 604-59-1 | 7,8-benzoflavone is a natural product isolated and purified from Passiflora, and it binds to human cytochrome P450 3A4 reveals complex fluorescence quenching. |
| CSN19374 | 3-Cyano-7-Ethoxycoumarin | 117620-77-6 | 3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage |
| CSN19771 | 25R-Inokosterone | 19682-38-3 | 25R-Inokosterone has a role on cytochrome P450 from a hormone-resistant cell line |
| CSN22146 | 1-Ethynylnaphthalene | 15727-65-8 | 1-Ethynylnaphthalene is a selective inhibitor of cytochrome P450 1B1 |
| CSN20292 | HET0016 | 339068-25-6 |
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