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P450

P450

Cat. No. Product Name CAS No. Information
CSN26275 Tetrahydropiperine 23434-88-0 Tetrahydropiperine is a cyclohexyl analogue of piperine that inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50=23 µM).
CSN23249 Stiripentol   49763-96-4 Stiripentol is an antiepileptic drug that can inhibit the synaptosomal uptake of GABA, increase the activation of GABAA receptors, its also a microsomal cytochrome P450 (CYP) isoforms CYP3A4, CYP1A2, and CYP2C19 inhibitor.
CSN16433 Schisandrin A   61281-38-7 Schisandrin A is a naturally occuring agonist of the adiponectin receptor 2 with an IC50 value of 3.5 M.
CSN13587 Ritonavir   155213-67-5 Ritonavir is both an HIV protease inhibitor and a Cytochrome P450 3A inhibitor.
CSN13587 Ritonavir   155213-67-5 Ritonavir is both an HIV protease inhibitor and a Cytochrome P450 3A inhibitor.
CSN19933 Rhodionin 85571-15-9 Rhodionin can inhibit cytochrome P450 2D6 non-competitively with high specificity which could have implications for interactions with co-administered drugs
CSN19400 Ramatroban   116649-85-5 Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis.
CSN26727 Ozagrel sodium 189224-26-8 Ozagrel Sodium, also known as KCT-0809 and Cataclot, is a thromboxane A2 synthase inhibitor used to treat cerebrovascular diseases.
CSN10122 Oxolamine citrate 1949-20-8 Oxolamine citrate is a cough suppressant, and a molecule involved in pharmacological studies including antiinflammatory agents, drugs that shift energy metabolism from mitochondrial respiration to glycolysis and effect on warfarin anticoagulant properties. It is an inhibitor of CYP2B1/2.
CSN25582 SDZ285428 174262-13-6 NVP-VID-400 is an inhibitor of both CYP51 and CYP24A1.
CSN25221 NTP42 2055599-51-2 NTP42 is a TxA2 Synthetase antagonist with IC50 value of 3.278nM.
CSN27390 Mefentrifluconazole 1417782-03-6 Mefentrifluconazole is a novel azole derivative and used as an agrochemical broad-spectrum antifungal agent. Mefentrifluconazole is a potent, selective and orally active fungal CYP51 (Kd= 0.5 nM) inhibitor, but shows less inhibitory activity on human aromatase (IC50=0.92 μM).
CSN29462 17-ODYA 34450-18-5 LTB ω-hydroxylase inhibitor.
CSN26286 Isosilybin 72581-71-6 Isosilybin is a flavonoid from milk thistle. It can inhibit CYP3A4 induction with an IC50 of 74 μM.
CSN20292 HET0016 339068-25-6 HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms.
CSN26726 Gemfibrozil 1-O-β-glucuronide 91683-38-4 Gemfibrozil 1-O-β-Glucuronide, a metabolite of Gemfibrozil (CI-719; HY-B0258), is a potent and competitive P450 (CYP) isoform CYP2C8 inhibitor with an IC50 of 4.07 μM[1][2].
CSN12256 Galangin   548-83-4 Galangin functions as an antagonist of the aryl hydrocarbon receptor and also inhibits CYP1A1 (IC50 1 M). It belongs to flavonoids and can be extracted from the rhizome of Zingiber officinale Roscoe with anti-inflammatory properties.
CSN22095 Furafylline 80288-49-9 Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with IC50 of 0.07 μM.
CSN29463 7-Ethoxyresorufin 5725-91-7 Fluorometric CYP450 substrate.
CSN29461 Resorufin methyl ether 5725-89-3 Fluorometric CYP450 substrate.
CSN27199 DMU2105 1031063-36-1 DMU2105 is a potent CYP1B1 inhibitor with IC50 value of 10nM for human CYP1B1 enzyme bound to yeast-derived microsomes (Sacchrosomes™).
CSN25347 Dazoxiben 74226-22-5 Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots.
CSN32917 Dapaconazole 1269726-67-1 Dapaconazole,a CYP51 inhibitor is an antifungal drug candidate.
CSN32500 CFG920 1260006-20-9 CFG920 is a CYP17 inhibitor, is also an orally available inhibitor of the CYP17A1.
CSN26553 Casopitant mesylate 414910-30-8 Casopitant mesylate is the mesylate salt of a centrally-acting neurokinin 1 (NK1) receptor antagonist with antidepressant and antiemetic activities. Casopitant competitively binds to and blocks the activity of the NK1 receptor, thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in antiemetic effects. SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK1 receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema.
CSN26724 BI 653048 1198784-72-3 BI-653048 is a glucocorticoid agonist.
CSN21515 Bergamottin 7380-40-7 Bergaptin is a competitive inhibitor of CYP1A1 with Ki of 10.7 nM.
CSN12448 Acetylshikonin 24502-78-1 Acetyl shikonin, a natural product isolated and purified from the roots of Lithosperraum erythrorhizon Sieb. et Zucc., inhibits the generation of NADPH oxidase complex in the activation of respiratory burst of PMNs, but does not directly inhibit the activity of NADPH oxidase already generated, and is a non-selective cytochrome P450 inhibitor.
CSN26155 6-Aminochrysene 2642-98-0 6-aminochrysene was a potent inducer of CYP1A1 in rat.
CSN15033 6',7'-Dihydroxybergamottin Acetonide 684217-08-1 6,7-Dihydroxybergamottin acetonide is a natural product isolated and purified from the peels of Citrus maxima, and is a potent inhibitor of CYP3A activity, being primarily responsible for the effects of grapefruit juice on cytochrome P450 activity in humans.
CSN11536 Bergapten   484-20-8 5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation psoralen plus UV (PUVA) to manage psoriasis and vitiligo and inhibits proliferation in the human hepatocellular carcinoma cell line.
CSN26147 (3-(Pyridin-3-yl)isoxazol-5-yl)methanamine 543713-43-5 5-Aminomethyl-3-(pyridin-3-yl)isoxazole
CSN29472 (S)-Mephenytoin 70989-04-7 (S)-Mephenytoin is a substrate of the cytochrome P450 (CYP) isoform CYP2C19, also known as mephenytoin 4-hydroxylase.
CSN28668 β-Naphthoflavone 6051-87-2
CSN41685 (S)-Mirtazapine 61337-87-9
CSN33797 Revexepride 219984-49-3
CSN37149 Rhodiosin 86831-54-1
CSN80842 Tacrine 321-64-2
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