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P450

P450

Cat. No. Product Name CAS No. Information
CSN19052 VT-464 R-Enantiomer 1375603-38-5 VT-464 R-enantiomer is the R-enantiomer with unknown activity of VT-464 which is a potent CYP17 lyase inhibitor h-Lyase IC5069 nM
CSN19048 Talarozole R-Enantiomer 870093-23-5 Talarozole R-enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne.
CSN12919 Talarozole 201410-53-9 Talarozole is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne.
CSN12728 TAK-700 426219-18-3 TAK-700 is a potent and highly selective human 1720-lyase inhibitor with IC50 of 38 nM exhibits 1000-fold selectivity over other CYPs eg 11-hydroxylase and CYP3A4
CSN23249 Stiripentol   49763-96-4 Stiripentol is an antiepileptic drug that can inhibit the synaptosomal uptake of GABA, increase the activation of GABAA receptors, its also a microsomal cytochrome P450 (CYP) isoforms CYP3A4, CYP1A2, and CYP2C19 inhibitor.
CSN11915 Seratrodast   112665-43-7 Seratrodast is a potent and selective thromboxane A2 receptor (TP) antagonist.
CSN16433 Schisandrin A   61281-38-7 Schisandrin A is a naturally occuring agonist of the adiponectin receptor 2 with an IC50 value of 3.5 M.
CSN19881 Salvianolic Acid C 115841-09-3 Salvianolic acid C, a natural product isolated and purified from the root of Salvia miltiorrhiza Bge. with antioxidant effect, exhibits potent XOD inhibitory activity with an IC(50) of 9.07 M, and enhances the inhibitory effects on sEH might be efficient ways to improve its cardiovascular protective and anti-inflammatory effects.
CSN19400 Ramatroban   116649-85-5 Ramatroban is a thromboxane A(2) (TxA(2)) antagonist marketed for allergic rhinitis.
CSN11818 Quinidine   56-54-2 Quinidine is prototypical CYP2D6 inhibitor and also blocks muscarinic and alpha-adrenergic neurotransmission
CSN11771 Proadifen HCl   62-68-0 Proadifen HCl is a nonspecific cytochrome P450 inhibitor, its also a noncompetitive inhibitor of acetylcholine nicotinic receptors with IC50 of 19 M in mouse skeletal muscle.
CSN12413 Piperine   94-62-2 Piperine is a major alkaloid isolated from the P. longum fruits which possesses anti-inflammatory and antiarthritic effects.
CSN19175 PF-4981517 1390637-82-7 PF-4981517 is a potent and selective inhibitor of CYP3A4 P450 with IC50 of 003 M exhibits 500-fold selectivity over CYP3A5 and CYP3A7
CSN16785 Ozagrel HCl   78712-43-3 Ozagrel HCl is a selective thromboxane A(2) (TXA(2)) synthetase inhibitor with IC50 of 11 nM for rabbit platelet, used for the improvement of postoperative cerebrovascular contraction and accompanying cerebral ischaemia.
CSN25582 NVP-VID-400 174262-13-6 NVP-VID-400 is an inhibitor of both CYP51 and CYP24A1.
CSN25221 NTP42 2055599-51-2 NTP42 is a TxA2 Synthetase antagonist with IC50 value of 3.278nM.
CSN16614 Naringin     10236-47-2 Naringin is a flavanone glycoside, which exerts a variety of pharmacological effects such as antioxidant activity, blood lipid lowering, anticancer activity, and inhibition of cytochrome P450 enzymes.
CSN14183 N-Nornuciferine 4846-19-9 N-Nornuciferine, a natural product isolated and purified from the fruits of Piper nigrum, can competitively inhibit CYP2D6 activity with Ki values of 2.34 uM.
CSN12625 Methoxsalen   298-81-7 Methoxsalen is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juicefruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. It is a potent suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight.
CSN16342 Memantine HCl   41100-52-1 Memantine HCl an amantadine derivative with low to moderate-affinity for NMDA receptors inhibit CYP2B6 and CYP2D6 with Ki of 051 nM and 949 M respectively is used for the treatment of Alzheimers disease
CSN19969 Linderane 13476-25-0 Linderane, a natural product isolated and purified from the roots of Lindera aggregata( Sims) Kosterm, is an inactivator of CYP2C9.
CSN13003 Itraconazole   84625-61-6 Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent.
CSN20292 HET0016 339068-25-6 HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE in human renal microsomes with an IC50 of 8.9 nM, selectively inhibiting CYP4A and 4F isoforms.
CSN16601 Ginsenoside Ro 34367-04-9 Ginsenoside Ro, a natural product isolated and purified from the root of Panax ginseng C. A. Mey., is reported to have anti-infllammtory, anti-hepatitic activities, and showed inhibitory activity against 5R with IC(50) value of 259.4 m
CSN15655 Ginsenoside F1 53963-43-2 Ginsenoside F1, a metabolite of ginsenoside Rg1 isolated and purified from the roots of Panax ginseng C.A.Mey., is reported to be antiaging and antioxidative, and to have beneficial effects on skin.
CSN12387 Galaterone 851983-85-2 Galeterone is a selective CYP17 inhibitor and androgen receptor (AR) antagonist with IC50 of 300 nM and 384 nM, respectively, and is a potent inhibitor of human prostate tumor growth.
CSN22095 Furafylline 80288-49-9 Furafylline is a potent and selective inhibitor of human cytochrome P450IA2 with IC50 of 0.07 μM.
CSN13053 Fluconazole   86386-73-4 Fluconazole an inhibitor of CYP2C19 CYP2C9 and CYP3A4 is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections
CSN23291 Flavone   525-82-6 Flavone can effect CYP P450 activity its a class of flavonoids with antioxidant anti-proliferative anti-tumor anti-microbial estrogenic acetyl cholinesterase anti-inflammatory activities and are also used in cancer cardiovascular disease neurodegenerative disorders etc
CSN22890 DMU2139   1821143-80-9 DMU2139 is a selective inhibitor of CYP1B1 with IC50 of 9 nM
CSN25347 Dazoxiben HCl 74226-22-5 Dazoxiben hydrochloride is a potent, orally active thromboxane (TX) synthase inhibitor that reduces the formation of blood clots.
CSN15806 Cobicistat 1004316-88-4 Cobicistat is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM
CSN14022 Chrysosplenetin 603-56-5 Chrysosplenetin, a natural product isolated and purified from the herbs of Laggera pterodonta, is a metabolic inhibitor of artemisinin.
CSN21322 CGS 15435 95853-92-2 CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes.
CSN20970 Cephaeline HCl 5853-29-2 Cephaeline HCl is a selective CYP2D6 inhibtor with IC50 of 121 μM.
CSN19045 CDD3506 197913-15-8 CDD3506 is used for elevating high density lipoprotein cholesterol HDL by inducing hepaticcytochrome P450IIIA CYP3Aactivity
CSN19044 CDD3505 173865-33-3 CDD3505 is used for elevating high density lipoprotein cholesterol HDL by inducing hepaticcytochrome P450IIIA CYP3Aactivity
CSN21515 Bergaptin 7380-40-7 Bergaptin is a competitive inhibitor of CYP1A1 with Ki of 10.7 nM.
CSN17375 Baicalein   491-67-8 Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor
CSN12255 Apigenin   520-36-5 Apigenin is a potent P450 inhibitor for CYP2C9 with Ki of 2 M, its a natural product isolated and purified from the root of Scutellaria indica L..
CSN12906 Alizarin 72-48-0 Alizarin strongly inhibits P450 isoform CYP1A1, CYP1A2 and CYP1B1 with IC50 of 6.210.0 and 2.7 M respectively, weakly inhibits CYP2A6 and CYP2E1, and does not inhibit CYP2C19, CYP3A4 and CYP3A5.
CSN12448 Acetyl Shikonin 24502-78-1 Acetyl shikonin, a natural product isolated and purified from the roots of Lithosperraum erythrorhizon Sieb. et Zucc., inhibits the generation of NADPH oxidase complex in the activation of respiratory burst of PMNs, but does not directly inhibit the activity of NADPH oxidase already generated, and is a non-selective cytochrome P450 inhibitor.
CSN21988 Abiraterone Metabolite 1 1940176-03-3 Abiraterone metabolite 1 is a 5β-reduced metabolite of abiraterone which inhibits CYP17A1, blocks androgen synthesis and prolongs survival in prostate cancer.
CSN12221 8-Geranyloxypsoralen 7437-55-0 8-Geranyloxypsoralen, a natural product isolated and purified from the herbs of Seseli mairei Wolff., inhibits -secretase (BACE1) activity in non-competitive manner, with the IC(50) values 25.0 uM. 8-Geranyloxypsoralen possesses nematicidal activities, the median lethal concentrations (LC(50)) is 188.3 mg L against B. xylophilus and is 117.5 mgL against P. redivivus.
CSN14706 8α-(2-Methylacryloyloxy)hirsutinolide 13-O-Acetate 67667-71-4 8-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate is a natural product isolated and purified from the herbs of Vernonia cinerea showing inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.
CSN10264 7,8-Benzoflavone 604-59-1 7,8-benzoflavone is a natural product isolated and purified from Passiflora, and it binds to human cytochrome P450 3A4 reveals complex fluorescence quenching.
CSN15033 6',7'-Dihydroxybergamottin Acetonide 684217-08-1 6,7-Dihydroxybergamottin acetonide is a natural product isolated and purified from the peels of Citrus maxima, and is a potent inhibitor of CYP3A activity, being primarily responsible for the effects of grapefruit juice on cytochrome P450 activity in humans.
CSN11536 5-Methoxypsoralen   484-20-8 5-Methoxypsoralen, a naturally occurring linear furocoumarin, has been successfully used in combination with ultraviolet (UV) A irradiation psoralen plus UV (PUVA) to manage psoriasis and vitiligo and inhibits proliferation in the human hepatocellular carcinoma cell line.
CSN19374 3-Cyano-7-Ethoxycoumarin 117620-77-6 3-Cyano-7-ethoxycoumarin is a fluorogenic cytochrome P-450 substrate that generates blue fluorescent product upon enzyme cleavage
CSN25382 Quinidine   56-54-2
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