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p38 MAPK
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN16728 | VX-745 | 209410-46-8 | VX-745 is a potent and selective inhibitor of p38 with IC50 of 10 nM, 22-fold greater selectivity versus p38 and no inhibition to p38. |
| CSN21102 | UM-164 | 903564-48-7 | UM-164 is a potent dual c-Srcp38 kinase inhibitor that exhibits potent anti-TNBC activity in xenograft models UM-164 inhibits p38 kinase and binds to an inactive c-Src conformation |
| CSN15958 | TAK-715 | 303162-79-0 | TAK-715 is a p38 MAPK inhibitor for p38 with IC50 of 7.1 nM, being 28-fold selective for p38 over p38, showing no inhibition to p38, JNK1, ERK1, IKK, MEKK1 or TAK1. |
| CSN13149 | SKF-86002 | 72873-74-6 | SKF-86002 is a potent inhibitor of p38 MAP kinase with IC50 of 0.5-1 M and inhibits LPS-induced IL-1 and TNF- production in human monocytes (IC50 1 M). |
| CSN27555 | SD-169 | 1670-87-7 | SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation. |
| CSN18176 | SD-06 | 271576-80-8 | SD-06 is a p38 MAP kinase inhibitor and inhibits p38 with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats(83 inhibition at 1mgkg, po). |
| CSN16503 | Scopoletin | 92-61-5 | Scopoletin has important anti-inflammatory activity by inhibiting the phosphorylation of NF-B and p38 MAPK. |
| CSN13746 | SB-242235 | 193746-75-7 | SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 10 M |
| CSN11899 | SB-203580 | 152121-47-6 | SB-203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 M. |
| CSN11899 | SB-203580 | 152121-47-6 | SB-203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 M. |
| CSN12267 | SB-202190 | 152121-30-7 | SB-202190 is a highly selective potent and cell-permeable inhibitor of p38 MAP kinase with IC50 values of 50 nM and 100 nM for p38 and p38 respectively also shows slightly weaker activity for BRD4 Kd34 M |
| CSN12897 | SB-239063 | 193551-21-2 | SB 239063 is a potent, selective and oral active p38 MAPK inhibitor with IC50 of 44 nM for recombinant purified p38. |
| CSN13817 | PD169316 | 152121-53-4 | PD169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor (IC50 89 nM). |
| CSN17386 | p38 MAPK-IN-1 | 1006378-90-0 | p38 MAPK-IN-1 is a potent and selective inhibitor of p38 MAPK with IC50 of 68 nM shows sustained levels low clearance and good bioavailability |
| CSN14542 | Neoechinulin A | 51551-29-2 | Neoechinulin A, a natural product isolated and purified from Aspergillus chevalieri with anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits, and ameliorate rotenone toxicity by activating a cytoprotective machinery that requires ATP and antioxidant/anti-nitration activities. |
| CSN23347 | Methyl Ferulate | 2309-07-1 | Methyl Ferulate is a naturally-occurring phenolic with antioxidant activities and inhibits the release of pro-inflammatory cytokines, blocks the expression of COX-2, and reduces nitric oxide generation from LPS-stimulated macrophages. |
| CSN22457 | MAPK13-IN-1 | 229002-10-2 | MAPK13-IN-1 is a MAPK13 (p38δ) inhibitor, with an IC50 of 620 nM. |
| CSN18346 | Losmapimod | 585543-15-3 | Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38 and p38, respectively. |
| CSN22233 | ITX5061 | 1252679-52-9 | ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 SR-B1 |
| CSN22404 | FR 167653 | 158876-66-5 | FR-167653 is a selective p38 MAPK inhibitor |
| CSN22405 | FR 167653 Free Base | 158876-65-4 | FR 167653 Free Base is a selective p38 MAPK inhibitor. |
| CSN10856 | Doramapimod | 285983-48-4 | Doramapimod is a highly selective p38 MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKC. |
| CSN19015 | Dehydrocorydaline Chloride | 10605-03-5 | Dehydrocorydaline chloride is an alkaloidal that has anti-inflammatory and anti-cancer activities |
| CSN18737 | BMS-582949 | 623152-17-0 | BMS-582949 is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13 nM,inhibiting both p38 kinase activity and activation of p38. |
| CSN22609 | AZ304 | 942507-42-8 | AZ304 is an inhibitor of BRAF and can target many kinases The IC50s for wild type BRAF V600E mutant BRAF and wild type CRAF are 79 nM 38 nM and 68 nM respectively It can also inhibit p38 IC50 6 nM and CSF1R IC50 35 nM |
| CSN19014 | Acumapimod | 836683-15-9 | Acumapimod is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 M for p38. |
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