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p38 MAPK

p38 MAPK

Cat. No. Product Name CAS No. Information
CSN16728 VX-745 209410-46-8 VX-745 is a potent and selective inhibitor of p38 with IC50 of 10 nM, 22-fold greater selectivity versus p38 and no inhibition to p38.
CSN15958 TAK-715 303162-79-0 TAK-715 is a p38 MAPK inhibitor for p38 with IC50 of 7.1 nM, being 28-fold selective for p38 over p38, showing no inhibition to p38, JNK1, ERK1, IKK, MEKK1 or TAK1.
CSN13149 SKF-86002   72873-74-6 SKF-86002 is a potent inhibitor of p38 MAP kinase with IC50 of 0.5-1 M and inhibits LPS-induced IL-1 and TNF- production in human monocytes (IC50 1 M).
CSN27555 SD-169 1670-87-7 SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation.
CSN18176 SD-06 271576-80-8 SD-06 is a p38 MAP kinase inhibitor and inhibits p38 with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats(83 inhibition at 1mgkg, po).
CSN16503 Scopoletin   92-61-5 Scopoletin has important anti-inflammatory activity by inhibiting the phosphorylation of NF-B and p38 MAPK.
CSN13746 SB-242235 193746-75-7 SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 10 M
CSN11899 SB-203580   152121-47-6 SB-203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 M.
CSN11899 SB-203580   152121-47-6 SB-203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 M.
CSN12267 SB-202190 152121-30-7 SB-202190 is a highly selective potent and cell-permeable inhibitor of p38 MAP kinase with IC50 values of 50 nM and 100 nM for p38 and p38 respectively also shows slightly weaker activity for BRD4 Kd34 M
CSN12897 SB-239063 193551-21-2 SB 239063 is a potent, selective and oral active p38 MAPK inhibitor with IC50 of 44 nM for recombinant purified p38.
CSN13817 PD169316 152121-53-4 PD169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor (IC50 89 nM).
CSN14542 Neoechinulin A 51551-29-2 Neoechinulin A, a natural product isolated and purified from Aspergillus chevalieri with anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits, and ameliorate rotenone toxicity by activating a cytoprotective machinery that requires ATP and antioxidant/anti-nitration activities.
CSN23347 Methyl Ferulate   2309-07-1 Methyl Ferulate is a naturally-occurring phenolic with antioxidant activities and inhibits the release of pro-inflammatory cytokines, blocks the expression of COX-2, and reduces nitric oxide generation from LPS-stimulated macrophages.
CSN22404 FR 167653 158876-66-5 FR-167653 is a selective p38 MAPK inhibitor
CSN22405 FR 167653 Free Base 158876-65-4 FR 167653 Free Base is a selective p38 MAPK inhibitor.
CSN10856 Doramapimod   285983-48-4 Doramapimod is a highly selective p38 MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKC.
CSN19015 Dehydrocorydaline Chloride 10605-03-5 Dehydrocorydaline chloride is an alkaloidal that has anti-inflammatory and anti-cancer activities
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