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p38 MAPK

p38 MAPK

Cat. No. Product Name CAS No. Information
CSN16728 VX-745 209410-46-8 VX-745 is a potent and selective inhibitor of p38 with IC50 of 10 nM, 22-fold greater selectivity versus p38 and no inhibition to p38.
CSN16018 VX-702   745833-23-2 VX-702 is a highly selective inhibitor of p38 MAPK with IC50 of 4 -20 nM.
CSN15958 TAK-715 303162-79-0 TAK-715 is a p38 MAPK inhibitor for p38 with IC50 of 7.1 nM, being 28-fold selective for p38 over p38, showing no inhibition to p38, JNK1, ERK1, IKK, MEKK1 or TAK1.
CSN18029 TA-02 1784751-19-4 TA-02 is a p38 MAPK inhibitor with IC50 of 20 nM
CSN13149 SKF-86002   72873-74-6 SKF-86002 is a potent inhibitor of p38 MAP kinase with IC50 of 0.5-1 M and inhibits LPS-induced IL-1 and TNF- production in human monocytes (IC50 1 M).
CSN17172 Skepinone-L 1221485-83-1 Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor.
CSN18176 SD-06 271576-80-8 SD-06 is a p38 MAP kinase inhibitor and inhibits p38 with an IC50 value of 170 nM and inhibits LPS-stimulated TNF-release in rats(83 inhibition at 1mgkg, po).
CSN16503 Scopoletin   92-61-5 Scopoletin has important anti-inflammatory activity by inhibiting the phosphorylation of NF-B and p38 MAPK.
CSN18198 SCIO-469 309913-83-5 SCIO-469 is a selective ATP-competitive p38 inhibitor with IC50 of 9 nM for p38α in vitro, about 10-fold selectivity for p38α over p38β, and at least 2000-fold selectivity for p38α over an in vitro panel of 20 other kinases, including other MAK kinases.
CSN13746 SB-242235 193746-75-7 SB-242235 is a potent and selective p38 MAP kinase inhibitor with IC50 of 10 M
CSN11899 SB-203580   152121-47-6 SB-203580 is a p38 MAPK inhibitor with IC50 of 0.3-0.5 M.
CSN18506 SB-203580 HCl 869185-85-3 SB-203580 hydrochloride is a p38 MAPK inhibitor with IC50 of 03-05 M
CSN12267 SB-202190 152121-30-7 SB-202190 is a highly selective potent and cell-permeable inhibitor of p38 MAP kinase with IC50 values of 50 nM and 100 nM for p38 and p38 respectively also shows slightly weaker activity for BRD4 Kd34 M
CSN12897 SB-239063 193551-21-2 SB 239063 is a potent, selective and oral active p38 MAPK inhibitor with IC50 of 44 nM for recombinant purified p38.
CSN18788 R1487 HCl 449808-64-4 R1487 hydrochloride is highly potent and highly selective inhibitors of p38
CSN13463 PH-797804 586379-66-0 PH-797804 is a pyridinone inhibitor of p38 with IC50 of 26 nM, being 4-fold selective versus p38 and does not inhibit JNK2.
CSN19212 Pexmetinib 945614-12-0 Pexmetinib is a potent, orally bioavailable, dual p38 MAPKTie-2 inhibitor with IC50 of 4 nM18 nM in a HEK-293 cell line.
CSN13817 PD169316 152121-53-4 PD169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor (IC50 89 nM).
CSN19013 Pamapimod 449811-01-2 Pamapimod is a selective inhibitor of p38 mitogen-activated protein kinase. It inhibits p38 and p38 enzymatic activity with IC50 values of 0.0140.002 and 0.48 0.04 mM, respectively with no activity against p38delta or p38gamma isoforms.
CSN17386 p38 MAPK-IN-1 1006378-90-0 p38 MAPK-IN-1 is a potent and selective inhibitor of p38 MAPK with IC50 of 68 nM shows sustained levels low clearance and good bioavailability
CSN20238 NJK14047 1800576-41-3 NJK14047 is a selective biphenyl amide p38 MAPK inhibitor which can be used in anti-viral approach targeting hepatitis B virus
CSN22457 MAPK13-IN-1 229002-10-2 MPAK13-IN-1 is a MAPK13 p38 inhibitor with an IC50 of 620 nM
CSN16041 LY2228820 862507-23-1 LY2228820 is a potent p38MAPK inhibitor with IC50 of 7 nM and 3 nM for p38MAPK and p38MAPK.
CSN18346 Losmapimod   585543-15-3 Losmapimod is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38 and p38, respectively.
CSN22233 ITX5061 1252679-52-9 ITX5061 is a type II inhibitor of p38 MAPK and also an antagonist of scavenger receptor B1 SR-B1
CSN22404 FR 167653 158876-66-5 FR-167653 is a selective p38 MAPK inhibitor
CSN22405 FR 167653 Free Base 158876-65-4 FR-167653 is a selective p38 MAPK inhibitor
CSN10856 Doramapimod   285983-48-4 Doramapimod is a highly selective p38 MAPK inhibitor with Kd of 0.1 nM, 330-fold greater selectivity versus JNK2, weak inhibition for c-RAF, Fyn and Lck, insignificant inhibition of ERK-1, SYK, IKK2, ZAP-70, EGFR, HER2, PKA, PKC, PKC.
CSN19850 Deoxynivalenol 51481-10-8 Deoxynivalenol is a tricothecene mycotoxin and potent protein synthesis inhibitor
CSN19015 Dehydrocorydaline Chloride 10605-03-5 Dehydrocorydaline chloride is an alkaloidal that has anti-inflammatory and anti-cancer activities
CSN20299 CBS-3595 452056-93-8 CBS-3595 is a dual p38 MAPKPDE-4 inhibitor with activity against TNF -related diseases.
CSN18737 BMS-582949 623152-17-0 BMS-582949 is a potent and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor with IC50 of 13 nM,inhibiting both p38 kinase activity and activation of p38.
CSN18566 BMS-582949 HCl 912806-16-7 BMS-582949 hydrochloride is a highly selective p38 MAPK inhibitor, inhibits p38 with IC50 of 13 nM.
CSN22119 AZD7624 1095004-78-6 AZD7624 is an inhaled p38 inhibitor, with potent anti-inflammatory activity.
CSN22609 AZ304   942507-42-8 AZ304 is an inhibitor of BRAF and can target many kinases The IC50s for wild type BRAF V600E mutant BRAF and wild type CRAF are 79 nM 38 nM and 68 nM respectively It can also inhibit p38 IC50 6 nM and CSF1R IC50 35 nM
CSN19014 Acumapimod 836683-15-9 Acumapimod is an orally active p38 MAP kinase inhibitor, with an IC50 of less than 1 M for p38.
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