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P2X Receptor

P2X Receptor

Cat. No. Product Name CAS No. Information
CSN19854 Ro 51 1050670-85-3 Ro 51 is a potent dual P2X3 and P2X23 antagonist IC50 values are 2 and 5 nM for rP2X3 and hP2X23 respectively
CSN21352 BzATP Triethylammonium Salt 112898-15-4 Prototypic P2X7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP EC50 07 M in HEK 293 cells EC50 values are 36 and 285 M for rat and mouse receptors respectively Exhibits partial agonist activity at P2X1 pEC50 87 and P2Y1 receptors and can be used as a photoaffinity label for ATPase
CSN21404 BzATP 81790-82-1 Prototypic P2X7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP EC50 07 M in HEK 293 cells EC50 values are 36 and 285 M for rat and mouse receptors respectively Exhibits partial agonist activity at P2X1 pEC50 87 and P2Y1 receptors and can be used as a photoaffinity label for ATPase
CSN16004 NF449 627034-85-9 NF449 is a potent purinergic receptor antagonist that displays high selectivity for P2X1 IC50 values are 028 069 120 1820 47000 and 300000 nM for rP2X1 rP2X15 rP2X23 rP2X3 rP2X2 and P2X4 receptors respectively Provides antithrombotic protection in vivo Also acts as a Gs-selective antagonist
CSN20323 NF023 104869-31-0 NF023 a subtype-selective competitive and reversible P2X1 receptor antagonist displays IC50 values of 021 289 50 and 100 M for human P2X1 P2X3 P2X2 and P2X4-mediated responses respectively
CSN11254 KN-62 127191-97-3 KN-62 is a selective and potent inhibitor of calmodulin-dependent protein kinase II CaMK-II with IC50 of 09 M KN-62 also displays noncompetitive antagonism at P2X7 receptors in HEK293 cells with an IC50 value of approximately 15 nM
CSN20216 JNJ-54175446 1627902-21-9 JNJ-54175446 is a potent and selective P2X7 Receptor Antagonist
CSN19839 JNJ 47965567 1428327-31-4 JNJ 47965567 is a potent and selective P2X7 antagonist pIC50 values are 83 75 and 72 for human mouse and rat receptors respectively
CSN18197 GW791343 3HCl 309712-55-8 GW791343 trihydrochloride is a P2X7 allosteric modulator and exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 pIC50 69 - 72
CSN16798 GW791343 2HCl 1019779-04-4 GW791343 dihydrochloride is a P2X7 allosteric modulator exhibiting species-specific activity and acts as a negative allosteric modulator of human P2X7 pIC50 69 - 72
CSN22409 Gefapixant 1015787-98-0 Gefapixant is an orally active P2X3 receptor (P2X3R) antagonist with IC50s of 30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X23 heterotrimeric receptors.
CSN10731 CTP Disodium Dihydrate   81012-87-5 CTP Disodium Dihydrate is a P2X4 purinergic receptor agonist
CSN22173 CE-224535 724424-43-5 CE-224535 is a selective P2X7 receptor antagonist
CSN19027 AZD9056 HCl 345303-91-5 AZD9056 hydrochloride is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases.
CSN16154 AF-353 865305-30-2 AF-353 is a potent and orally bioavailable P2X3P2X23 receptor antagonist inhibits human and rat P2X3 pIC50 80
CSN18509 A 839977 870061-27-1 A-839977 is a selective P2X7 antagonist and blocks BzATP-evoked calcium influx at recombinant human rat and mouse P2X7 receptors IC50 values are 20 42 and 150 nM respectively
CSN19020 A-804598   1125758-85-1 A-804598 is a competitive and selective P2X7 receptor antagonist with IC50 of 10 nM 9 nM and 11 nM in rat mouse and human P2X7 receptors respectively
CSN13107 A-740003 861393-28-4 A-740003 is potent selective and competitive P2X7 receptor antagonist IC50 values are 18 and 40 nM for rat and human receptors respectively
CSN19024 A-317491 Sodium Hydrate N/A A-317491 sodium is a non-nucleotide P2X3 and P2X23 receptor antagonist which inhibits calcium flux mediated by the receptors
CSN18291 A-317491   475205-49-3 A-317491 is a potent and selective non-nucleotide antagonist of P2X3 and P2X23 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X23 receptors
CSN18547 A 438079 899507-36-9 A 438079 is a competitive P2X7 receptor antagonist pIC50 69 for the inhibition of Ca2 influx in the human recombinant P2X7 cell line
CSN18546 A 438079 HCl   899431-18-6 A 438079 hydrochloride is a competitive P2X7 receptor antagonist pIC50 69 for the inhibition of Ca2 influx in the human recombinant P2X7 cell line
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