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P2X Receptor
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN33170 | Sivopixant | 2414285-40-6 | Sivopixant is a P2X3 receptor antagonist. |
| CSN24482 | RO-3 | 1026582-88-6 | RO-3 is a selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist. |
| CSN19854 | Ro-51 | 1050670-85-3 | Ro 51 is a potent dual P2X3 and P2X23 antagonist IC50 values are 2 and 5 nM for rP2X3 and hP2X23 respectively |
| CSN21970 | PSB-12062 | 55476-47-6 | PSB-12062 is a potent and selective P2X4 antagonist with IC50 of 1.38 μM for human P2X4. |
| CSN21352 | BzATP triethylammonium salt | 112898-15-4 | Prototypic P2X7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP EC50 07 M in HEK 293 cells EC50 values are 36 and 285 M for rat and mouse receptors respectively Exhibits partial agonist activity at P2X1 pEC50 87 and P2Y1 receptors and can be used as a photoaffinity label for ATPase |
| CSN21404 | BzATP | 81790-82-1 | Prototypic P2X7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP EC50 07 M in HEK 293 cells EC50 values are 36 and 285 M for rat and mouse receptors respectively Exhibits partial agonist activity at P2X1 pEC50 87 and P2Y1 receptors and can be used as a photoaffinity label for ATPase |
| CSN26314 | PPADS tetrasodium | 192575-19-2 | PPADS tetrasodiuma is a non-selective antagonist of P2X receptor. It blocks recombinant P2X1, -2, -3, -5 with IC50s ranging from 1 to 2.6 μM. |
| CSN16004 | NF449 octasodium | 627034-85-9 | NF449 is a potent purinergic receptor antagonist that displays high selectivity for P2X1 IC50 values are 028 069 120 1820 47000 and 300000 nM for rP2X1 rP2X15 rP2X23 rP2X3 rP2X2 and P2X4 receptors respectively Provides antithrombotic protection in vivo Also acts as a Gs-selective antagonist |
| CSN20323 | NF023 hexasodium | 104869-31-0 | NF023 a subtype-selective competitive and reversible P2X1 receptor antagonist displays IC50 values of 021 289 50 and 100 M for human P2X1 P2X3 P2X2 and P2X4-mediated responses respectively |
| CSN20216 | JNJ-54175446 | 1627902-21-9 | JNJ-54175446 is a potent and selective P2X7 Receptor Antagonist |
| CSN19839 | JNJ-47965567 | 1428327-31-4 | JNJ 47965567 is a potent and selective P2X7 antagonist pIC50 values are 83 75 and 72 for human mouse and rat receptors respectively |
| CSN18197 | GW791343 trihydrochloride | 309712-55-8 | GW791343 3HCl is a P2X7 allosteric modulator and exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2). |
| CSN16798 | GW791343 dihydrochloride | 1019779-04-4 | GW791343 2HCl is a P2X7 allosteric modulator exhibiting species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2). |
| CSN22409 | Gefapixant | 1015787-98-0 | Gefapixant is an orally active P2X3 receptor (P2X3R) antagonist with IC50s of 30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X23 heterotrimeric receptors. |
| CSN10731 | CTP Disodium Dihydrate | 81012-87-5 | CTP Disodium Dihydrate is a P2X4 purinergic receptor agonist |
| CSN22173 | CE-224535 | 724424-43-5 | CE-224535 is a selective P2X7 receptor antagonist |
| CSN25312 | BX430 | 688309-70-8 | BX430 is selective P2X4 allosteric antagonist with IC50 of 0.54 μM. |
| CSN19027 | AZD9056 hydrochloride | 345303-91-5 | AZD9056 HCl is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases. |
| CSN27579 | AZ10606120 dihydrochloride | 607378-18-7 | AZ10606120 dihydrochloride is a selective, high affinity antagonist for P2X7 receptor (P2X7R) at human and rat with an IC50 of ~10 nM. AZ10606120 dihydrochloride is little or no effect at other P2XR subtypes. AZ10606120 dihydrochloride has anti-depressant effects and reduces tumour growth . |
| CSN16154 | AF-353 | 865305-30-2 | AF-353 is a potent and orally bioavailable P2X3P2X23 receptor antagonist inhibits human and rat P2X3 pIC50 80 |
| CSN19020 | A-804598 | 1125758-85-1 | A-804598 is a competitive and selective P2X7 receptor antagonist with IC50 of 10 nM 9 nM and 11 nM in rat mouse and human P2X7 receptors respectively |
| CSN13107 | A-740003 | 861393-28-4 | A-740003 is potent selective and competitive P2X7 receptor antagonist IC50 values are 18 and 40 nM for rat and human receptors respectively |
| CSN19024 | A-317491 sodium salt hydrate | N/A | A-317491 sodium is a non-nucleotide P2X3 and P2X23 receptor antagonist which inhibits calcium flux mediated by the receptors |
| CSN18291 | A-317491 | 475205-49-3 | A-317491 is a potent and selective non-nucleotide antagonist of P2X3 and P2X23 receptors with Ki values of 22 nM and 9 nM for human P2X3 and P2X23 receptors |
| CSN18547 | A 438079 | 899507-36-9 | A 438079 is a competitive P2X7 receptor antagonist pIC50 69 for the inhibition of Ca2 influx in the human recombinant P2X7 cell line |
| CSN18546 | A 438079 hydrochloride | 899431-18-6 | A 438079 hydrochloride is a competitive P2X7 receptor antagonist pIC50 69 for the inhibition of Ca2 influx in the human recombinant P2X7 cell line |
| CSN79293 | GSK-1482160 | 1001389-72-5 |
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