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P-gp
| Cat. No. | Product Name | CAS No. | Information |
|---|---|---|---|
| CSN12903 | Zosuquidar | 167354-41-8 | Zosuquidar is P-gp modulator that inhibited Pgp-ATPase activity 50-60 at 2 and 10M and had no effect at 008 and 04M measured by P-gp ATPase activity |
| CSN12751 | Zosuquidar 3HCl | 167465-36-3 | Zosuquidar 3HCl is the 3HCl form of Zosuquidar. Zosuquidar is P-gp modulator that inhibited Pgp-ATPase activity 50-60% at 2 and 10μM and had no effect at 0.08 and 0.4μM. |
| CSN12182 | Valspodar | 121584-18-7 | Valspodar is a P-glycoprotein P-gp inhibitor widely used in preclinical and clinical studies for overcoming multidrug resistance MDR |
| CSN14774 | Taxinine B | 18457-44-8 | Taxinine B, a natural product isolated and purified from the barks of Taxus chinensis, can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells, and shows stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA). |
| CSN18364 | Tariquidar Methanesulfonate Hydrate | 625375-83-9 | Tariquidar methanesulfonate is a potent and specific inhibitor of P-glycoprotein P-gp with the high affinity Kd5109 nM |
| CSN12910 | Tariquidar | 206873-63-4 | Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 51 nM reverses drug resistance in MDR cell Lines |
| CSN13177 | Sinapine Thiocyanate | 7431-77-8 | Sinapine, an alkaloid isolated and purified from the seeds of Raphanus sativus L., possess antioxidant and radio-protective activities, downregulats multi-drug resistance 1 (MDR1) expression. |
| CSN22057 | Sinapine | 18696-26-9 | Sinapine is an alkaloid from seeds of the cruciferous species which shows antioxidant and radio-protective activities and decreases expression of P-glycoprotein in Caco-2 cells. |
| CSN19434 | Schizandrin | 7432-28-2 | Schizandrin is a natural product possessing antioxidant and anti-inflammatory activities. |
| CSN16588 | SC144 | 895158-95-9 | SC144 showed its function through both exhibiting potent cytotoxicity, by itself or synergism with other compounds, against a panel of drug-sensitive and drug-resistant cancer cell lines, and targeting to gp130. |
| CSN18576 | SC144 HCl | 917497-70-2 | SC144 HCl is the first-in-class orally active small-molecule gp130 inhibitor (IC50 = 0.72 μM) which blocks cytokine-triggered gp130 signaling. |
| CSN13555 | Isosinensetin | 17290-70-9 | Isosinensetin exhibits HIV-1 protease inhibiting and antioxidant activities. It is a natural product isolated and purified from the fruit of Citrus aurantium L.. |
| CSN15743 | HM30181 | 849675-66-7 | HM30181 is a potent and selective inhibitor of P-glycoprotein |
| CSN20429 | Heliosterpenoid B | N/A | Heliosterpenoid B is a natural product isolated and purfied from the whole plants of Euphorbia helioscopia being potent inhibitors of P-glycoprotein ABCB1 |
| CSN20428 | Heliosterpenoid A | 2109805-68-5 | Heliosterpenoid A is a natural product isolated and purfied from the whole plants of Euphorbia helioscopia being potent inhibitors of P-glycoprotein ABCB1 and exhibiting cytotoxicity against MDA-MB-231 cell lines |
| CSN23176 | UCLA GP130 2 | 339303-87-6 | gp130-agonist-2 is a brain penetrant gp130 agonist which protects against NMDA-induced toxicity and increases STAT3 phosphorylation. |
| CSN14838 | Epimedokoreanin B | 161068-53-7 | Epimedokoreanin B is a natural product isolated and purified from the herbs of Epimedium brevicornum |
| CSN10894 | Elacridar | 143664-11-3 | Elacridar is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules. |
| CSN13175 | Elacridar HCl | 143851-98-3 | Elacridar HCl is a P-glycoprotein (P-gp) inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-gp to investigate the role of transporters in the disposition of various test molecules. |
| CSN17662 | Dofequidar | 129716-58-1 | Dofequidar is a quinoline compound which can reverse P-glycoprotein P-gp-mediated MDR |
| CSN17917 | Dofequidar Fumarate | 153653-30-6 | Dofequidar fumarate an orally active quinoline compound has been reported to overcome MDR by inhibiting ABCB1P-gp ABCC1MDR-associated protein 1 or both |
| CSN22768 | CP 100356 HCl | 142715-48-8 | CP 100356 HCl is a high affinity P-glycoprotein (P-gp) inhibitor with Kis of 58 and 94 nM for mouse Pgp1a and Pgp1b isoforms. |
| CSN25413 | RCGD423 | 108237-91-8 |
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