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P-gp

P-gp

Cat. No. Product Name CAS No. Information
CSN12903 Zosuquidar 167354-41-8 Zosuquidar is P-gp modulator that inhibited Pgp-ATPase activity 50-60 at 2 and 10M and had no effect at 008 and 04M measured by P-gp ATPase activity
CSN12751 Zosuquidar trihydrochloride 167465-36-3 Zosuquidar 3HCl is the 3HCl form of Zosuquidar. Zosuquidar is P-gp modulator that inhibited Pgp-ATPase activity 50-60% at 2 and 10μM and had no effect at 0.08 and 0.4μM.
CSN12910 Tariquidar 206873-63-4 Tariquidar is a potent and selective noncompetitive inhibitor of P-glycoprotein with Kd of 51 nM reverses drug resistance in MDR cell Lines
CSN13177 Sinapine thiocyanate 7431-77-8 Sinapine, an alkaloid isolated and purified from the seeds of Raphanus sativus L., possess antioxidant and radio-protective activities, downregulats multi-drug resistance 1 (MDR1) expression.
CSN22057 Sinapine 18696-26-9 Sinapine is an alkaloid from seeds of the cruciferous species which shows antioxidant and radio-protective activities and decreases expression of P-glycoprotein in Caco-2 cells.
CSN16588 SC144 895158-95-9 SC144 showed its function through both exhibiting potent cytotoxicity, by itself or synergism with other compounds, against a panel of drug-sensitive and drug-resistant cancer cell lines, and targeting to gp130.
CSN18576 SC144 hydrochloride 917497-70-2 SC144 HCl is the first-in-class orally active small-molecule gp130 inhibitor (IC50 = 0.72 μM) which blocks cytokine-triggered gp130 signaling.
CSN25413 RCGD423 108237-91-8 RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.
CSN13555 Isosinensetin 17290-70-9 Isosinensetin exhibits HIV-1 protease inhibiting and antioxidant activities. It is a natural product isolated and purified from the fruit of Citrus aurantium L..
CSN23176 GP130 receptor agonist-1 339303-87-6 gp130-agonist-2 is a brain penetrant gp130 agonist which protects against NMDA-induced toxicity and increases STAT3 phosphorylation.
CSN14838 Epimedokoreanin B 161068-53-7 Epimedokoreanin B is a natural product isolated and purified from the herbs of Epimedium brevicornum
CSN10894 Elacridar   143664-11-3 Elacridar is a P-glycoprotein inhibitor, and has been used both in vitro and in vivo as a tool inhibitor of P-glycoprotein (Pgp) to investigate the role of transporters in the disposition of various test molecules.
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