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OXTR

OXTR

Cat. No. Product Name CAS No. Information
CSN22478 OT Antagonist 3 925703-75-9 OT antagonist 3 is an oxytocin OT antagonist extracted from patent WO2007017752A1
CSN25228 LIT-001 TFA 2245072-21-1 LIT-001 is the first nonpeptide oxytocin receptor agonist.
CSN22443 L-368,899 HCl 160312-62-9 L-368,899 HCl is a potent, selective, orally bioavailable, non-peptide oxytocin receptor antagonist, with IC50s of 8.9 nM and 26 nM for rat uterus and human uterus oxytocin receptor, respectively, used as a tocolytic agent.
CSN29535 Atosiban acetate 914453-95-5 Atosiban is an inhibitor of the hormones oxytocin and vasopressin. It is used as an intravenous medication as a labour repressant (tocolytic) to halt premature labor. Atosiban inhibits the oxytocin-mediated release of inositol trisphosphate from the myometrial cell membrane. As a result, there is reduced release of intracellular, stored calcium from the sarcoplasmic reticulum of myometrial cells, and reduced influx of Ca2+ from the extracellular space through voltage gated channels. In addition, atosiban suppresses oxytocin-mediated release of PGE and PGF from the decidua. In human pre-term labor, atosiban, at the recommended dosage, antagonizes uterine contractions and induces uterine quiescence. The onset of uterus relaxation following atosiban is rapid, uterine contractions being significantly reduced within 10 minutes to achieve stable uterine quiescence.
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